<?xml version='1.0' encoding='UTF-8'?>
<entrySet xmlns="http://psi.hupo.org/mi/mif300" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://psi.hupo.org/mi/mif300 https://raw.githubusercontent.com/HUPO-PSI/miXML/master/3.0/src/MIF300.xsd" level="3" version="0" minorVersion="0">
  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>DIP</shortLabel>
        <fullName>Database of Interacting Proteins</fullName>
      </names>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
      </xref>
      <attributeList>
        <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
        <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
        <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Selective adapter recruitment and differential signaling networks by VEGF vs. shear stress.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="17496149" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="doi" dbAc="MI:0574" id="10.1073/pnas.0703088104" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15636652" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-22829" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Selective adapter recruitment and differential signaling networks by VEGF vs. shear stress.</attribute>
            <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
            <attribute name="publication year" nameAc="MI:0886">2007</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Wang Y.,  Chang J.,  Chen KD.,  Li S.,  Li JY.,  Wu C.,  Chien S.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="imex" dbAc="MI:0670" id="IM-22829" refType="imex-primary" refTypeAc="MI:0662"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-261476X" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="pubmed" dbAc="MI:0446" id="17496149" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="doi" dbAc="MI:0574" id="10.1073/pnas.0703088104" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="9913">
            <names>
              <shortLabel>bovin</shortLabel>
              <fullName>Bos taurus (Bovine)</fullName>
              <alias type="synonym" typeAc="MI:1041">Bovine</alias>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>anti bait coip</shortLabel>
            <fullName>anti bait coimmunoprecipitation</fullName>
            <alias type="synonym" typeAc="MI:1041">anti bait coip</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0006" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-976" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="7708014" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>western blot</shortLabel>
            <fullName>western blot</fullName>
            <alias type="go synonym" typeAc="MI:0303">Immuno blot</alias>
            <alias type="synonym" typeAc="MI:1041">Immuno blot</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Wang Y., Chang J., Chen KD., Li S., Li JY., Wu C., Chien S.</attribute>
          <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-261476X</attribute>
          <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
          <attribute name="publication year" nameAc="MI:0886">2007</attribute>
          <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
          <attribute name="title" nameAc="MI:1091">Selective adapter recruitment and differential signaling networks by VEGF vs. shear stress.</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>q28197_bovin</shortLabel>
          <alias type="gene name" typeAc="MI:0301">flk-1</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q28197" version="65" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15636707" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016301" version="TrEMBL_84"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013783" version="TrEMBL_84"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-60946N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9913">
          <names>
            <shortLabel>bovin</shortLabel>
            <fullName>Bos taurus (Bovine)</fullName>
            <alias type="synonym" typeAc="MI:1041">Bovine</alias>
          </names>
        </organism>
        <sequence>PNNQSSSEKRVEVTDCSDGVFCKMLTISEVIGNDTGAYKCFYQDTDMGSVLYVYVQDYRSPFIASVSDQHEVVYITENKNKTVVIPCLGTVSDLNVSLCARYPEKRFAPDGNRISWDSQKGFSIPSY</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein Q28197 original sequence version: 65</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>a6h720_bovin</shortLabel>
          <fullName>Cytoplasmic protein</fullName>
          <alias type="gene name" typeAc="MI:0301">NCK2</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="A6H720" version="62" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSBTAP00000020230" version="TrEMBL_124" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSBTAP00000072385" version="TrEMBL_124" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15636671" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSBTAG00000015205" version="TrEMBL_124" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSBTAT00000020230" version="TrEMBL_124" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSBTAT00000069542" version="TrEMBL_124" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001784" version="TrEMBL_124"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005783" version="TrEMBL_124"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" version="TrEMBL_124"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030838" version="TrEMBL_124"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0033137" version="TrEMBL_124"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042102" version="TrEMBL_124"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045944" version="TrEMBL_124"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1903912" version="TrEMBL_124"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000980" version="TrEMBL_124"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001452" version="TrEMBL_124"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR017304" version="TrEMBL_124"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR028524" version="TrEMBL_124"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR035559" version="TrEMBL_124"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR035560" version="TrEMBL_124"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR035561" version="TrEMBL_124"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR035883" version="TrEMBL_124"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036028" version="TrEMBL_124"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036860" version="TrEMBL_124"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-BTA-3928664" version="TrEMBL_124"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-BTA-4420097" version="TrEMBL_124"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-BTA-9013420" version="TrEMBL_124"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001092506.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_005212836.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-60945N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9913">
          <names>
            <shortLabel>bovin</shortLabel>
            <fullName>Bos taurus (Bovine)</fullName>
            <alias type="synonym" typeAc="MI:1041">Bovine</alias>
          </names>
        </organism>
        <sequence>MTEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSLKKGSLVKNIKDTLGLGRTRRKTSARDASPTPSTDAEFPANGGGADRIYDLSIPAVVKFAYAAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQVGWFPSNYVLEELDEAAGDAPGGSSLRPGATLSNGQGARALQVVQTLYPFSSVTEEELNFDKGETMEVIEKPENDPEWWRCRNARGQVGLVPKNYVVVLSEGPAPHAGSGPAGPARAGRFAGREWYYGNVTRHQAECALNARGVQGDFLVRDSESSPSDFSVSLKASGKNKHFKVQLVDNVYCIGQRRFHTMDELVEHYKKAPIFTSEHGEKLYLVRALQ</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein A6H720 original sequence version: 62</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4" imexId="IM-22829-1">
        <names>
          <shortLabel>nck2-flk_1-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="dip" dbAc="MI:0465" id="DIP-196861E" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15636720" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-22829-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="9913">
                <names>
                  <shortLabel>bovin</shortLabel>
                  <fullName>Bos taurus (Bovine)</fullName>
                  <alias type="synonym" typeAc="MI:1041">Bovine</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
          <participant id="6">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="9913">
                <names>
                  <shortLabel>bovin</shortLabel>
                  <fullName>Bos taurus (Bovine)</fullName>
                  <alias type="synonym" typeAc="MI:1041">Bovine</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
      </interaction>
    </interactionList>
  </entry>
</entrySet>