<?xml version='1.0' encoding='UTF-8'?>
<entrySet xmlns="http://psi.hupo.org/mi/mif300" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://psi.hupo.org/mi/mif300 https://raw.githubusercontent.com/HUPO-PSI/miXML/master/3.0/src/MIF300.xsd" level="3" version="0" minorVersion="0">
  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>DIP</shortLabel>
        <fullName>Database of Interacting Proteins</fullName>
      </names>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
      </xref>
      <attributeList>
        <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
        <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
        <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="17463087" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="doi" dbAc="MI:0574" id="10.1073/pnas.0700664104" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15634272" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-22816" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs.</attribute>
            <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
            <attribute name="publication year" nameAc="MI:0886">2007</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Hasan UA.,  Caux C.,  Perrot I.,  Doffin AC.,  Menetrier-Caux C.,  Trinchieri G.,  Tommasino M.,  Vlach J.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="imex" dbAc="MI:0670" id="IM-22816" refType="imex-primary" refTypeAc="MI:0662"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-261422X" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="pubmed" dbAc="MI:0446" id="17463087" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="doi" dbAc="MI:0574" id="10.1073/pnas.0700664104" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="10116">
            <names>
              <shortLabel>rat</shortLabel>
              <fullName>Rattus norvegicus (Rat)</fullName>
              <alias type="synonym" typeAc="MI:1041">Rat</alias>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>anti bait coip</shortLabel>
            <fullName>anti bait coimmunoprecipitation</fullName>
            <alias type="synonym" typeAc="MI:1041">anti bait coip</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0006" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-976" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="7708014" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>western blot</shortLabel>
            <fullName>western blot</fullName>
            <alias type="go synonym" typeAc="MI:0303">Immuno blot</alias>
            <alias type="synonym" typeAc="MI:1041">Immuno blot</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Hasan UA., Caux C., Perrot I., Doffin AC., Menetrier-Caux C., Trinchieri G., Tommasino M., Vlach J.</attribute>
          <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-261422X</attribute>
          <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
          <attribute name="publication year" nameAc="MI:0886">2007</attribute>
          <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
          <attribute name="title" nameAc="MI:1091">Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs.</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>o08769_rat</shortLabel>
          <fullName>Cyclin-dependent kinase inhibitor 1B</fullName>
          <alias type="gene name" typeAc="MI:0301">Cdkn1b</alias>
          <alias type="gene name synonym" typeAc="MI:0302">p27Kip1</alias>
          <alias type="orf name" typeAc="MI:0306">rCG_29991</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Cyclin-dependent kinase inhibitor p27</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="O08769" version="TrEMBL_36" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSRNOP00000050173" version="TrEMBL_147" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="MINT-1785011" refType="intact-secondary"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7796656" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSRNOG00000007249" version="TrEMBL_147" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSRNOT00000049848" version="TrEMBL_147" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000079" version="TrEMBL_147"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000082" version="TrEMBL_147"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001666" version="TrEMBL_147"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001890" version="TrEMBL_147"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004860" version="TrEMBL_147"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004861" version="TrEMBL_147"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="TrEMBL_147"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" version="TrEMBL_147"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" version="TrEMBL_147"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007219" version="TrEMBL_147"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007346" version="TrEMBL_147"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007507" version="TrEMBL_147"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007605" version="TrEMBL_147"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008219" version="TrEMBL_147"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008284" version="TrEMBL_147"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008285" version="TrEMBL_147"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009749" version="TrEMBL_147"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010942" version="TrEMBL_147"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0014070" version="TrEMBL_147"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016301" version="TrEMBL_147"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0019901" version="TrEMBL_147"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0019903" version="TrEMBL_147"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030308" version="TrEMBL_147"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030544" version="TrEMBL_147"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031116" version="TrEMBL_147"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071407" version="TrEMBL_147"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1902746" version="TrEMBL_147"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:1904706" version="TrEMBL_147"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1905179" version="TrEMBL_147"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003175" version="TrEMBL_147"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR029843" version="TrEMBL_147"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-187577" version="TrEMBL_147"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-198323" version="TrEMBL_147"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051087" version="TrEMBL_147"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-2559582" version="TrEMBL_147"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-2559586" version="TrEMBL_147"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-6804116" version="TrEMBL_147"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-69202" version="TrEMBL_147"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-69231" version="TrEMBL_147"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-69563" version="TrEMBL_147"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-69656" version="TrEMBL_147"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-8849470" version="TrEMBL_147"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-9607240" version="TrEMBL_147"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-9634638" version="TrEMBL_147"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_113950.2"/>
          <secondaryRef db="rgd" dbAc="MI:0483" id="69062"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_006237601.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-44911N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10116">
          <names>
            <shortLabel>rat</shortLabel>
            <fullName>Rattus norvegicus (Rat)</fullName>
            <alias type="synonym" typeAc="MI:1041">Rat</alias>
          </names>
        </organism>
        <sequence>MSNVRVSNGSPSLERMDARQTEHPKPSACRNLFGPVNHEELTRDLEKHCRDMEEASQRKWNFDFQNHKPLEGRYEWQEVERGSLPEFYYRPPRPPKSACKVPAQESLDVSGSRQAVPSIGSQANSEDRHLVDQMPDSSDSPAGLAEQCPGMRKRPAAEDSSSQNKRANRTEENVSDGSPNAGTVEQTPKKPGLRRQT</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein O08769 original sequence version: 83</attribute>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
          <attribute name="crc64">55738078C2C9847F</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>cdk2_rat</shortLabel>
          <fullName>Cyclin-dependent kinase 2</fullName>
          <alias type="gene name" typeAc="MI:0301">Cdk2</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Cell division protein kinase 2</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Cdkn2</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q63699" version="SP_60" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="O09136" version="SP_60" refType="secondary-ac" refTypeAc="MI:0360"/>
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          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-36536N"/>
          <secondaryRef db="rgd" dbAc="MI:0483" id="70486"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-9616222"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-6804756"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-1538133"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-176187"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-176408"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051301" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051321" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051591" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051602" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0060968" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0097123" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0097124" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0097134" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0097135" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0097472" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0106310" version="SP_162"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0106311" version="SP_162"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000719" version="SP_162"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008271" version="SP_162"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011009" version="SP_162"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR017441" version="SP_162"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10116">
          <names>
            <shortLabel>rat</shortLabel>
            <fullName>Rattus norvegicus (Rat)</fullName>
            <alias type="synonym" typeAc="MI:1041">Rat</alias>
          </names>
        </organism>
        <sequence>MENFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGLPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAEGSIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein Q63699 original sequence version: 118</attribute>
          <attribute name="crc64">C8CB3ADCE9B97F88</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4" imexId="IM-22816-1">
        <names>
          <shortLabel>cdk2-cdkn1b-4</shortLabel>
        </names>
        <xref>
          <primaryRef db="dip" dbAc="MI:0465" id="DIP-196832E" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15634291" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-22816-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="10116">
                <names>
                  <shortLabel>rat</shortLabel>
                  <fullName>Rattus norvegicus (Rat)</fullName>
                  <alias type="synonym" typeAc="MI:1041">Rat</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
          <participant id="6">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="10116">
                <names>
                  <shortLabel>rat</shortLabel>
                  <fullName>Rattus norvegicus (Rat)</fullName>
                  <alias type="synonym" typeAc="MI:1041">Rat</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
      </interaction>
    </interactionList>
  </entry>
</entrySet>