DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Structural basis of ubiquitin recognition by the deubiquitinating protease USP2. Structural basis of ubiquitin recognition by the deubiquitinating protease USP2. Structure (London, England : 1993) 2006 imex curation Renatus M., Parrado SG., D'Arcy A., Eidhoff U., Gerhartz B., Hassiepen U., Pierrat B., Riedl R., Vinzenz D., Worpenberg S., Kroemer M. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Renatus M., Parrado SG., D'Arcy A., Eidhoff U., Gerhartz B., Hassiepen U., Pierrat B., Riedl R., Vinzenz D., Worpenberg S., Kroemer M. DIP original experiment: DIP-66342X Structure (London, England : 1993) 2006 IMEx Structural basis of ubiquitin recognition by the deubiquitinating protease USP2. Structural basis of ubiquitin recognition by the deubiquitinating protease USP2. Structural basis of ubiquitin recognition by the deubiquitinating protease USP2. Structure (London, England : 1993) 2006 imex curation Renatus M., Parrado SG., D'Arcy A., Eidhoff U., Gerhartz B., Hassiepen U., Pierrat B., Riedl R., Vinzenz D., Worpenberg S., Kroemer M. Only protein-protein interactions in vitro In vitro enzymatic study enzymatic study predetermined predetermined participant predetermined Renatus M., Parrado SG., D'Arcy A., Eidhoff U., Gerhartz B., Hassiepen U., Pierrat B., Riedl R., Vinzenz D., Worpenberg S., Kroemer M. DIP original experiment: DIP-66343X Structure (London, England : 1993) 2006 IMEx Structural basis of ubiquitin recognition by the deubiquitinating protease USP2. Structural basis of ubiquitin recognition by the deubiquitinating protease USP2. Structural basis of ubiquitin recognition by the deubiquitinating protease USP2. Structure (London, England : 1993) 2006 imex curation Renatus M., Parrado SG., D'Arcy A., Eidhoff U., Gerhartz B., Hassiepen U., Pierrat B., Riedl R., Vinzenz D., Worpenberg S., Kroemer M. Only protein-protein interactions in vitro In vitro enzymatic study enzymatic study predetermined predetermined participant predetermined Renatus M., Parrado SG., D'Arcy A., Eidhoff U., Gerhartz B., Hassiepen U., Pierrat B., Riedl R., Vinzenz D., Worpenberg S., Kroemer M. DIP original experiment: DIP-66341X Structure (London, England : 1993) 2006 IMEx Structural basis of ubiquitin recognition by the deubiquitinating protease USP2. q5u5u6_human UBB HEL-S-50 hCG_1998947 protein protein human Homo sapiens Human MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGC DIP protein Q5U5U6 original sequence version: 14 33011162F1C48BB1 ubiq_bovin Ubiquitin RPS27A UBA80 UBCEP1 UBA52 UBCEP2 UBB UBC protein protein bovin Bos taurus (Bovine) Bovine MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG C42A35397FFD9B52 uchl3_human Ubiquitin carboxyl-terminal hydrolase isozyme L3 Ubiquitin thioesterase L3 UCHL3 protein protein human Homo sapiens Human MEGQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMDPELLSMVPRPVCAVLLLFPITEKYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGLIHAIANNKDKMHFESGSTLKKFLEESVSMSPEERARYLENYDAIRVTHETSAHEGQTEAPSIDEKVDLHFIALVHVDGHLYELDGRKPFPINHGETSDETLLEDAIEVCKKFMERDPDELRFNAIALSAA DIP protein P15374 original sequence version: 75 8ACACE6E1D86FD55 ubp2_human Ubiquitin carboxyl-terminal hydrolase 2 Ubiquitin-specific-processing protease 2 Deubiquitinating enzyme 2 41 kDa ubiquitin-specific protease USP2 UBP41 Ubiquitin thioesterase 2 protein protein human Homo sapiens Human MSQLSSTLKRYTESARYTDAHYAKSGYGAYTPSSYGANLAASLLEKEKLGFKPVPTSSFLTRPRTYGPSSLLDYDRGRPLLRPDITGGGKRAESQTRGTERPLGSGLSGGSGFPYGVTNNCLSYLPINAYDQGVTLTQKLDSQSDLARDFSSLRTSDSYRIDPRNLGRSPMLARTRKELCTLQGLYQTASCPEYLVDYLENYGRKGSASQVPSQAPPSRVPEIISPTYRPIGRYTLWETGKGQAPGPSRSSSPGRDGMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSRM DIP protein O75604 original sequence version: 57 AFF4DA9344D21812 ubb-uchl3-1 3 4 enzyme target enzyme target substrate substrate unspecified role unspecified role region 1-76 region 1-76 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 6 enzyme enzyme unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction ubb-usp2-1 2 7 enzyme enzyme unspecified role unspecified role Region 259-605 Region 259-605 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 4 enzyme target enzyme target substrate substrate unspecified role unspecified role region 1-76 region 1-76 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction sigma u6253-usp2-1 1 5 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 7 unspecified role unspecified role unspecified role unspecified role Region 259-605 Region 259-605 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction