DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Docking interactions induce exposure of activation loop in the MAP kinase ERK2. Docking interactions induce exposure of activation loop in the MAP kinase ERK2. Structure (London, England : 1993) 2006 imex curation Zhou T., Sun L., Humphreys J., Goldsmith EJ. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Zhou T., Sun L., Humphreys J., Goldsmith EJ. DIP original experiment: DIP-66321X Structure (London, England : 1993) 2006 IMEx Docking interactions induce exposure of activation loop in the MAP kinase ERK2. Docking interactions induce exposure of activation loop in the MAP kinase ERK2. Docking interactions induce exposure of activation loop in the MAP kinase ERK2. Structure (London, England : 1993) 2006 imex curation Zhou T., Sun L., Humphreys J., Goldsmith EJ. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Zhou T., Sun L., Humphreys J., Goldsmith EJ. DIP original experiment: DIP-66320X Structure (London, England : 1993) 2006 IMEx Docking interactions induce exposure of activation loop in the MAP kinase ERK2. mp2k2_human Dual specificity mitogen-activated protein kinase kinase 2 MAP2K2 MEK2 MKK2 PRKMK2 ERK activator kinase 2 MAPK/ERK kinase 2 protein protein human Homo sapiens Human MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV 3401D522515C30A5 mk01_rat Mitogen-activated protein kinase 1 Mapk1 Erk2 Mapk Prkm1 Extracellular signal-regulated kinase 2 Mitogen-activated protein kinase 2 MAP kinase isoform p42 ERT1 protein protein rat Rattus norvegicus (Rat) Rat MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS DIP protein P63086 original sequence version: 127 DIP protein P63086 original sequence version: 1(def) DIP protein P63086 original sequence version: 36 DIP protein P63086 original sequence version: 112 DIP protein P63086 original sequence version: 92 DIP protein P63086 original sequence version: 84 DIP protein P63086 original sequence version: 100 3BBCF22471EDBA0B ptn7_human Tyrosine-protein phosphatase non-receptor type 7 PTPN7 Protein-tyrosine phosphatase LC-PTP Hematopoietic protein-tyrosine phosphatase protein protein human Homo sapiens Human MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP 388A154CC55AC0EE mapk1-ptpn7-3 2 5 unspecified role unspecified role unspecified role unspecified role Region 16-31 Region 16-31 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain in vitro In vitro 4 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction map2k2-mapk1-1 1 3 unspecified role unspecified role unspecified role unspecified role Region 1-16 Region 1-16 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain in vitro In vitro 4 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction