DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Targeting C-reactive protein for the treatment of cardiovascular disease. Targeting C-reactive protein for the treatment of cardiovascular disease. Nature 2006 imex curation Pepys MB., Hirschfield GM., Tennent GA., Gallimore JR., Kahan MC., Bellotti V., Hawkins PN., Myers RM., Smith MD., Polara A., Cobb AJ., Ley SV., Aquilina JA., Robinson CV., Sharif I., Gray GA., Sabin CA., Jenvey MC., Kolstoe SE., Thompson D., Wood SP. Only protein-protein interactions human Homo sapiens Human tem transmission electron microscopy tem predetermined predetermined participant predetermined Pepys MB., Hirschfield GM., Tennent GA., Gallimore JR., Kahan MC., Bellotti V., Hawkins PN., Myers RM., Smith MD., Polara A., Cobb AJ., Ley SV., Aquilina JA., Robinson CV., Sharif I., Gray GA., Sabin CA., Jenvey MC., Kolstoe SE., Thompson D., Wood SP. DIP original experiment: DIP-254047X Nature 2006 IMEx Targeting C-reactive protein for the treatment of cardiovascular disease. Targeting C-reactive protein for the treatment of cardiovascular disease. Targeting C-reactive protein for the treatment of cardiovascular disease. Nature 2006 imex curation Pepys MB., Hirschfield GM., Tennent GA., Gallimore JR., Kahan MC., Bellotti V., Hawkins PN., Myers RM., Smith MD., Polara A., Cobb AJ., Ley SV., Aquilina JA., Robinson CV., Sharif I., Gray GA., Sabin CA., Jenvey MC., Kolstoe SE., Thompson D., Wood SP. Only protein-protein interactions human Homo sapiens Human x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Pepys MB., Hirschfield GM., Tennent GA., Gallimore JR., Kahan MC., Bellotti V., Hawkins PN., Myers RM., Smith MD., Polara A., Cobb AJ., Ley SV., Aquilina JA., Robinson CV., Sharif I., Gray GA., Sabin CA., Jenvey MC., Kolstoe SE., Thompson D., Wood SP. DIP original experiment: DIP-254048X Nature 2006 IMEx Targeting C-reactive protein for the treatment of cardiovascular disease. Targeting C-reactive protein for the treatment of cardiovascular disease. Targeting C-reactive protein for the treatment of cardiovascular disease. Nature 2006 imex curation Pepys MB., Hirschfield GM., Tennent GA., Gallimore JR., Kahan MC., Bellotti V., Hawkins PN., Myers RM., Smith MD., Polara A., Cobb AJ., Ley SV., Aquilina JA., Robinson CV., Sharif I., Gray GA., Sabin CA., Jenvey MC., Kolstoe SE., Thompson D., Wood SP. Only protein-protein interactions human Homo sapiens Human molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Pepys MB., Hirschfield GM., Tennent GA., Gallimore JR., Kahan MC., Bellotti V., Hawkins PN., Myers RM., Smith MD., Polara A., Cobb AJ., Ley SV., Aquilina JA., Robinson CV., Sharif I., Gray GA., Sabin CA., Jenvey MC., Kolstoe SE., Thompson D., Wood SP. DIP original experiment: DIP-254046X Nature 2006 IMEx Targeting C-reactive protein for the treatment of cardiovascular disease. Targeting C-reactive protein for the treatment of cardiovascular disease. Targeting C-reactive protein for the treatment of cardiovascular disease. Nature 2006 imex curation Pepys MB., Hirschfield GM., Tennent GA., Gallimore JR., Kahan MC., Bellotti V., Hawkins PN., Myers RM., Smith MD., Polara A., Cobb AJ., Ley SV., Aquilina JA., Robinson CV., Sharif I., Gray GA., Sabin CA., Jenvey MC., Kolstoe SE., Thompson D., Wood SP. Only protein-protein interactions human Homo sapiens Human ms of complexes mass spectrometry studies of complexes ms of complexes predetermined predetermined participant predetermined Pepys MB., Hirschfield GM., Tennent GA., Gallimore JR., Kahan MC., Bellotti V., Hawkins PN., Myers RM., Smith MD., Polara A., Cobb AJ., Ley SV., Aquilina JA., Robinson CV., Sharif I., Gray GA., Sabin CA., Jenvey MC., Kolstoe SE., Thompson D., Wood SP. DIP original experiment: DIP-254049X Nature 2006 IMEx Targeting C-reactive protein for the treatment of cardiovascular disease. crp_human C-reactive protein CRP PTX1 protein protein human Homo sapiens Human MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTELSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWESASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMWDFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP 669228636A8544F6 crp-6 4 5 unspecified role unspecified role unspecified role unspecified role Region 19-224 Region 19-224 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human direct interaction direct interaction crp-7 3 5 unspecified role unspecified role unspecified role unspecified role Region 19-224 Region 19-224 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human direct interaction direct interaction crp-8 1 5 unspecified role unspecified role unspecified role unspecified role Region 19-224 Region 19-224 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human direct interaction direct interaction crp-9 2 5 unspecified role unspecified role unspecified role unspecified role Region 19-224 Region 19-224 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human direct interaction direct interaction