DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nature structural & molecular biology 2006 imex curation Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. DIP original experiment: DIP-66183X Nature structural & molecular biology 2006 IMEx Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nature structural & molecular biology 2006 imex curation Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. DIP original experiment: DIP-217321X Nature structural & molecular biology 2006 IMEx Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nature structural & molecular biology 2006 imex curation Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. DIP original experiment: DIP-66193X Nature structural & molecular biology 2006 IMEx Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nature structural & molecular biology 2006 imex curation Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. DIP original experiment: DIP-66185X Nature structural & molecular biology 2006 IMEx Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nature structural & molecular biology 2006 imex curation Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. Only protein-protein interactions in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. DIP original experiment: DIP-66186X Nature structural & molecular biology 2006 IMEx Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nature structural & molecular biology 2006 imex curation Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. Only protein-protein interactions in vitro In vitro nmr nuclear magnetic resonance NMR NMR nmr predetermined predetermined participant predetermined Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. DIP original experiment: DIP-66184X Nature structural & molecular biology 2006 IMEx Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nature structural & molecular biology 2006 imex curation Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. Only protein-protein interactions in vitro In vitro fluorescence spectr classical fluorescence spectroscopy fluorescence spectr predetermined predetermined participant predetermined Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. DIP original experiment: DIP-66189X Nature structural & molecular biology 2006 IMEx Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nature structural & molecular biology 2006 imex curation Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. Only protein-protein interactions in vitro In vitro fluorescence spectr classical fluorescence spectroscopy fluorescence spectr predetermined predetermined participant predetermined Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. DIP original experiment: DIP-66190X Nature structural & molecular biology 2006 IMEx Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nature structural & molecular biology 2006 imex curation Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. Only protein-protein interactions in vitro In vitro fluorescence spectr classical fluorescence spectroscopy fluorescence spectr predetermined predetermined participant predetermined Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. DIP original experiment: DIP-217318X Nature structural & molecular biology 2006 IMEx Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nature structural & molecular biology 2006 imex curation Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. DIP original experiment: DIP-66182X Nature structural & molecular biology 2006 IMEx Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nature structural & molecular biology 2006 imex curation Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. Only protein-protein interactions in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. DIP original experiment: DIP-217317X Nature structural & molecular biology 2006 IMEx Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nature structural & molecular biology 2006 imex curation Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. Only protein-protein interactions in vitro In vitro fluorescence spectr classical fluorescence spectroscopy fluorescence spectr predetermined predetermined participant predetermined Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. DIP original experiment: DIP-66191X Nature structural & molecular biology 2006 IMEx Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nature structural & molecular biology 2006 imex curation Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. Only protein-protein interactions in vitro In vitro fluorescence spectr classical fluorescence spectroscopy fluorescence spectr predetermined predetermined participant predetermined Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. DIP original experiment: DIP-66192X Nature structural & molecular biology 2006 IMEx Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nature structural & molecular biology 2006 imex curation Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. Only protein-protein interactions in vitro In vitro nmr nuclear magnetic resonance NMR NMR nmr predetermined predetermined participant predetermined Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. DIP original experiment: DIP-66194X Nature structural & molecular biology 2006 IMEx Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nature structural & molecular biology 2006 imex curation Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. Only protein-protein interactions in vitro In vitro fluorescence spectr classical fluorescence spectroscopy fluorescence spectr predetermined predetermined participant predetermined Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. DIP original experiment: DIP-217320X Nature structural & molecular biology 2006 IMEx Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nature structural & molecular biology 2006 imex curation Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. DIP original experiment: DIP-66187X Nature structural & molecular biology 2006 IMEx Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nature structural & molecular biology 2006 imex curation Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. Only protein-protein interactions in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. DIP original experiment: DIP-66188X Nature structural & molecular biology 2006 IMEx Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nature structural & molecular biology 2006 imex curation Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith CH., Frappier L. DIP original experiment: DIP-217319X Nature structural & molecular biology 2006 IMEx Molecular recognition of p53 and MDM2 by USP7/HAUSP. mdm2_human E3 ubiquitin-protein ligase Mdm2 MDM2 p53-binding protein Mdm2 Oncoprotein Mdm2 Double minute 2 protein RING-type E3 ubiquitin transferase Mdm2 protein protein human Homo sapiens Human MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP DIP protein Q00987 original sequence version: 93 DIP protein Q00987-1 original sequence version: 192 DIP protein Q00987 original sequence version: 88 DIP protein Q00987 original sequence version: 180 DIP protein Q00987 original sequence version: 188 DIP protein Q00987 original sequence version: 189 DIP protein Q00987 original sequence version: 115 DIP protein Q00987-1 original sequence version: null DIP protein Q00987 original sequence version: 149 DIP protein Q00987 original sequence version: 146 DIP protein Q00987 original sequence version: 140 DIP protein Q00987 original sequence version: 183 DIP protein Q00987 original sequence version: 145 DIP protein Q00987 original sequence version: 182 DIP protein Q00987 original sequence version: 151 DIP protein Q00987 original sequence version: 156 DIP protein Q00987-1 original sequence version: 160 DIP protein Q00987 original sequence version: 160 DIP protein Q00987 original sequence version: 168 DIP protein Q00987 original sequence version: 186 DIP protein Q00987 original sequence version: 206 F37CE163876BC983 ebna1_ebvb9 Epstein-Barr nuclear antigen 1 EBNA1 BKRF1 protein protein ebvb9 Epstein-Barr virus (strain B95-8) (HHV-4) Human herpesvirus 4 HHV-4 MSDEGPGTGPGNGLGEKGDTSGPEGSGGSGPQRRGGDNHGRGRGRGRGRGGGRPGAPGGSGSGPRHRDGVRRPQKRPSCIGCKGTHGGTGAGAGAGGAGAGGAGAGGGAGAGGGAGGAGGAGGAGAGGGAGAGGGAGGAGGAGAGGGAGAGGGAGGAGAGGGAGGAGGAGAGGGAGAGGGAGGAGAGGGAGGAGGAGAGGGAGAGGAGGAGGAGAGGAGAGGGAGGAGGAGAGGAGAGGAGAGGAGAGGAGGAGAGGAGGAGAGGAGGAGAGGGAGGAGAGGGAGGAGAGGAGGAGAGGAGGAGAGGAGGAGAGGGAGAGGAGAGGGGRGRGGSGGRGRGGSGGRGRGGSGGRRGRGRERARGGSRERARGRGRGRGEKRPRSPSSQSSSSGSPPRRPPPGRRPFFHPVGEADYFEYHQEGGPDGEPDVPPGAIEQGPADDPGEGPSTGPRGQGDGGRRKKGGWFGKHRGQGGSNPKFENIAEGLRALLARSHVERTTDEGTWVAGVFVYGGSKTSLYNLRRGTALAIPQCRLTPLSRLPFGMAPGPGPQPGPLRESIVCYFMVFLQTHIFAEVLKDAIKDLVMTKPAPTCNIRVTVCSFDDGVDLPPWFPPMVEGAAAEGDDGDDGDEGGDGDEGEEGQE 4D161653E16FC341 4D161653E16FC341 p53_human Cellular tumor antigen p53 TP53 P53 Tumor suppressor p53 Phosphoprotein p53 Antigen NY-CO-13 protein protein human Homo sapiens Human MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD DIP protein P04637 original sequence version: 121 DIP protein P04637 original sequence version: 115 DIP protein P04637-1 original sequence version: 224 DIP protein P04637 original sequence version: 117 DIP protein P04637-1 original sequence version: 226 DIP protein P04637 original sequence version: 226 DIP protein P04637 original sequence version: 212 DIP protein P04637 original sequence version: 220 DIP protein P04637-1 original sequence version: 220 DIP protein P04637-1 original sequence version: 145 DIP protein P04637 original sequence version: 146 DIP protein P04637 original sequence version: 145 DIP protein P04637 original sequence version: 166 DIP protein P04637-1 original sequence version: 166 DIP protein P04637 original sequence version: 169 DIP protein P04637 original sequence version: 177 DIP protein P04637 original sequence version: 175 DIP protein P04637-1 original sequence version: 175 DIP protein P04637-1 original sequence version: 172 DIP protein P04637-1 original sequence version: 169 DIP protein P04637 original sequence version: 170 DIP protein P04637 original sequence version: 172 DIP protein P04637-1 original sequence version: 194 DIP protein P04637 original sequence version: 196 DIP protein P04637 original sequence version: 185 DIP protein P04637-1 original sequence version: 191 DIP protein P04637 original sequence version: 191 DIP protein P04637 original sequence version: 180 DIP protein P04637-1 original sequence version: 197 DIP protein P04637 original sequence version: 183 DIP protein P04637-1 original sequence version: 183 DIP protein P04637-1 original sequence version: 185 DIP protein P04637 original sequence version: 199 DIP protein P04637 original sequence version: 201 DIP protein P04637 original sequence version: 189 DIP protein P04637 original sequence version: 235 DIP protein P04637 original sequence version: 230 DIP protein P04637 original sequence version: 234 DIP protein P04637-1 original sequence version: 234 DIP protein P04637-1 original sequence version: 235 DIP protein P04637 original sequence version: 239 DIP protein P04637-1 original sequence version: 212 DIP protein P04637-1 original sequence version: 213 DIP protein P04637 original sequence version: 213 DIP protein P04637 original sequence version: 206 DIP protein P04637-1 original sequence version: 188 DIP protein P04637-1 original sequence version: 228 DIP protein P04637 original sequence version: 208 DIP protein P04637 original sequence version: 240 DIP protein P04637-1 original sequence version: 240 DIP protein P04637 original sequence version: 204 DIP protein P04637-1 original sequence version: 204 DIP protein P04637-1 original sequence version: 209 DIP protein P04637-1 original sequence version: 203 DIP protein P04637 original sequence version: 221 DIP protein P04637-1 original sequence version: 152 DIP protein P04637 original sequence version: 217 DIP protein P04637-1 original sequence version: 140 DIP protein P04637 original sequence version: 215 DIP protein P04637 original sequence version: 214 DIP protein P04637-1 original sequence version: 182 DIP protein P04637 original sequence version: 182 DIP protein P04637 original sequence version: 188 DIP protein P04637 original sequence version: 192 DIP protein P04637-1 original sequence version: 192 DIP protein P04637 original sequence version: 218 DIP protein P04637-1 original sequence version: 218 AD5C149FD8106131 ubp7_human Ubiquitin carboxyl-terminal hydrolase 7 USP7 HAUSP Ubiquitin thioesterase 7 Ubiquitin-specific-processing protease 7 Deubiquitinating enzyme 7 Herpesvirus-associated ubiquitin-specific protease protein protein human Homo sapiens Human MNHQQQQQQQKAGEQQLSEPEDMEMEAGDTDDPPRITQNPVINGNVALSDGHNTAEEDMEDDTSWRSEATFQFTVERFSRLSESVLSPPCFVRNLPWKIMVMPRFYPDRPHQKSVGFFLQCNAESDSTSWSCHAQAVLKIINYRDDEKSFSRRISHLFFHKENDWGFSNFMAWSEVTDPEKGFIDDDKVTFEVFVQADAPHGVAWDSKKHTGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQKTDPKDPANYILHAVLVHSGDNHGGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVYIRESKLSEVLQAVTDHDIPQQLVERLQEEKRIEAQKRKERQEAHLYMQVQIVAEDQFCGHQGNDMYDEEKVKYTVFKVLKNSSLAEFVQSLSQTMGFPQDQIRLWPMQARSNGTKRPAMLDNEADGNKTMIELSDNENPWTIFLETVDPELAASGATLPKFDKDHDVMLFLKMYDPKTRSLNYCGHIYTPISCKIRDLLPVMCDRAGFIQDTSLILYEEVKPNLTERIQDYDVSLDKALDELMDGDIIVFQKDDPENDNSELPTAKEYFRDLYHRVDVIFCDKTIPNDPGFVVTLSNRMNYFQVAKTVAQRLNTDPMLLQFFKSQGYRDGPGNPLRHNYEGTLRDLLQFFKPRQPKKLYYQQLKMKITDFENRRSFKCIWLNSQFREEEITLYPDKHGCVRDLLEECKKAVELGEKASGKLRLLEIVSYKIIGVHQEDELLECLSPATSRTFRIEEIPLDQVDIDKENEMLVTVAHFHKEVFGTFGIPFLLRIHQGEHFREVMKRIQSLLDIQEKEFEKFKFAIVMMGRHQYINEDEYEVNLKDFEPQPGNMSHPRPWLGLDHFNKAPKRSRYTYLEKAIKIHN DIP protein Q93009 original sequence version: 71 DIP protein Q93009 original sequence version: 67 DIP protein Q93009-1 original sequence version: 180 DIP protein Q93009 original sequence version: 173 DIP protein Q93009 original sequence version: 91 DIP protein Q93009 original sequence version: 163 DIP protein Q93009 original sequence version: 176 DIP protein Q93009-1 original sequence version: 128 DIP protein Q93009 original sequence version: 128 F1A5A5C421396E45 ebna1-usp7-2 16 20 unspecified role unspecified role bait bait 395-450 binding region 395-450 binding region sufficient to bind sufficient binding region sufficient to bind full dna sequence full identification by DNA sequencing full dna sequence certain certain sequence position certain certain certain sequence position certain GST tag GST tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag full dna sequence full identification by DNA sequencing full dna sequence n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli 22 unspecified role unspecified role prey prey 62-205 binding region 62-205 binding region sufficient to bind sufficient binding region sufficient to bind full dna sequence full identification by DNA sequencing full dna sequence certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction ebna1-usp7-3 12 20 unspecified role unspecified role neutral component neutral component 441-450 binding region 441-450 binding region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain in vitro In vitro 22 unspecified role unspecified role neutral component neutral component 1-205 binding region 1-205 binding region sufficient to bind sufficient binding region sufficient to bind full dna sequence full identification by DNA sequencing full dna sequence certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction tp53-usp7-8 10 21 unspecified role unspecified role bait bait 356-365 binding region 356-365 binding region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain GST tag GST tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag full dna sequence full identification by DNA sequencing full dna sequence n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli 22 unspecified role unspecified role prey prey 62-205 binding region 62-205 binding region sufficient to bind sufficient binding region sufficient to bind full dna sequence full identification by DNA sequencing full dna sequence certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction tp53-usp7-9 6 21 unspecified role unspecified role neutral component neutral component 358-367 binding region 358-367 binding region sufficient to bind sufficient binding region sufficient to bind full dna sequence full identification by DNA sequencing full dna sequence certain certain sequence position certain certain certain sequence position certain in vitro In vitro 22 unspecified role unspecified role neutral component neutral component 62-205 binding region 62-205 binding region sufficient to bind sufficient binding region sufficient to bind full dna sequence full identification by DNA sequencing full dna sequence certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction tp53-usp7-10 7 21 unspecified role unspecified role neutral component neutral component 356-365 binding region 356-365 binding region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain in vitro In vitro 22 unspecified role unspecified role neutral component neutral component gion gion sufficient to bind sufficient binding region sufficient to bind full dna sequence full identification by DNA sequencing full dna sequence certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction mdm2-usp7-5 8 19 unspecified role unspecified role neutral component neutral component 143-150 binding region 143-150 binding region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain in vitro In vitro 22 unspecified role unspecified role neutral component neutral component 1-205 binding region 1-205 binding region sufficient to bind sufficient binding region sufficient to bind full dna sequence full identification by DNA sequencing full dna sequence certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction mdm2-usp7-6 3 19 unspecified role unspecified role neutral component neutral component 141-150 binding region 141-150 binding region sufficient to bind sufficient binding region sufficient to bind full dna sequence full identification by DNA sequencing full dna sequence certain certain sequence position certain certain certain sequence position certain in vitro In vitro 22 unspecified role unspecified role neutral component neutral component 54-205 binding region 54-205 binding region sufficient to bind sufficient binding region sufficient to bind full dna sequence full identification by DNA sequencing full dna sequence certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction ebna1-usp7-4 14 20 unspecified role unspecified role neutral component neutral component 441-450 binding region 441-450 binding region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain in vitro In vitro 22 unspecified role unspecified role neutral component neutral component 1-205 binding region 1-205 binding region sufficient to bind sufficient binding region sufficient to bind full dna sequence full identification by DNA sequencing full dna sequence certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction mdm2-usp7-7 4 19 unspecified role unspecified role unspecified role unspecified role 1-160 binding region 1-160 binding region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain GST tag GST tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag full dna sequence full identification by DNA sequencing full dna sequence n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli 22 unspecified role unspecified role unspecified role unspecified role 62-205 binding region 62-205 binding region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction mdm2-usp7-8 5 19 unspecified role unspecified role unspecified role unspecified role 1-160 binding region 1-160 binding region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain GST tag GST tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag full dna sequence full identification by DNA sequencing full dna sequence n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli 22 unspecified role unspecified role unspecified role unspecified role 62-205 binding region 62-205 binding region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction tp53-usp7-11 1 21 unspecified role unspecified role neutral component neutral component 358-367 binding region 358-367 binding region sufficient to bind sufficient binding region sufficient to bind full dna sequence full identification by DNA sequencing full dna sequence certain certain sequence position certain certain certain sequence position certain in vitro In vitro 22 unspecified role unspecified role neutral component neutral component 54-205 binding region 54-205 binding region sufficient to bind sufficient binding region sufficient to bind full dna sequence full identification by DNA sequencing full dna sequence certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction ebna1-usp7-5 17 20 unspecified role unspecified role neutral component neutral component 395-450 binding region 395-450 binding region sufficient to bind sufficient binding region sufficient to bind full dna sequence full identification by DNA sequencing full dna sequence certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 22 unspecified role unspecified role neutral component neutral component 62-205 binding region 62-205 binding region sufficient to bind sufficient binding region sufficient to bind full dna sequence full identification by DNA sequencing full dna sequence certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction mdm2-usp7-9 13 19 unspecified role unspecified role neutral component neutral component 152-161 binding region 152-161 binding region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain in vitro In vitro 22 unspecified role unspecified role neutral component neutral component 1-205 binding region 1-205 binding region sufficient to bind sufficient binding region sufficient to bind full dna sequence full identification by DNA sequencing full dna sequence certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction mdm2-usp7-10 11 19 unspecified role unspecified role unspecified role unspecified role 1-160 binding region 1-160 binding region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain GST tag GST tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag full dna sequence full identification by DNA sequencing full dna sequence n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli 22 unspecified role unspecified role unspecified role unspecified role 62-205 binding region 62-205 binding region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction 1 nodeMerge04 2011-10-21 mdm2-usp7-11 9 19 unspecified role unspecified role neutral component neutral component 143-150 binding region 143-150 binding region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain in vitro In vitro 22 unspecified role unspecified role neutral component neutral component 1-205 binding region 1-205 binding region sufficient to bind sufficient binding region sufficient to bind full dna sequence full identification by DNA sequencing full dna sequence certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction 1 nodeMerge04 2011-10-21 mdm2-usp7-12 18 19 unspecified role unspecified role unspecified role unspecified role 1-160 binding region 1-160 binding region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain GST tag GST tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag full dna sequence full identification by DNA sequencing full dna sequence n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli 22 unspecified role unspecified role unspecified role unspecified role 62-205 binding region 62-205 binding region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction 1 nodeMerge04 2011-10-21 mdm2-usp7-13 15 19 unspecified role unspecified role neutral component neutral component 152-161 binding region 152-161 binding region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain in vitro In vitro 22 unspecified role unspecified role neutral component neutral component 1-205 binding region 1-205 binding region sufficient to bind sufficient binding region sufficient to bind full dna sequence full identification by DNA sequencing full dna sequence certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction 1 nodeMerge04 2011-10-21 mdm2-usp7-14 2 19 unspecified role unspecified role neutral component neutral component 141-150 binding region 141-150 binding region sufficient to bind sufficient binding region sufficient to bind full dna sequence full identification by DNA sequencing full dna sequence certain certain sequence position certain certain certain sequence position certain in vitro In vitro 22 unspecified role unspecified role neutral component neutral component 54-205 binding region 54-205 binding region sufficient to bind sufficient binding region sufficient to bind full dna sequence full identification by DNA sequencing full dna sequence certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction 1 nodeMerge04 2011-10-21