<?xml version='1.0' encoding='UTF-8'?>
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  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>DIP</shortLabel>
        <fullName>Database of Interacting Proteins</fullName>
      </names>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
      </xref>
      <attributeList>
        <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
        <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
        <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="16472737" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="doi" dbAc="MI:0574" id="10.1016/j.str.2005.09.022" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15567506" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-8346" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1.</attribute>
            <attribute name="journal" nameAc="MI:0885">Structure (London, England : 1993)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2006</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Panneerselvam S.,  Marx A.,  Mandelkow EM.,  Mandelkow E.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="imex" dbAc="MI:0670" id="IM-8346" refType="imex-primary" refTypeAc="MI:0662"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-66149X" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="pubmed" dbAc="MI:0446" id="16472737" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="doi" dbAc="MI:0574" id="10.1016/j.str.2005.09.022" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="562">
            <names>
              <shortLabel>ecolx</shortLabel>
              <fullName>Escherichia coli</fullName>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>x-ray diffraction</shortLabel>
            <fullName>x-ray crystallography</fullName>
            <alias type="go synonym" typeAc="MI:0303">X-ray</alias>
            <alias type="synonym" typeAc="MI:1041">X-ray</alias>
            <alias type="synonym" typeAc="MI:1041">x-ray diffraction</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0114" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1272" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Panneerselvam S., Marx A., Mandelkow EM., Mandelkow E.</attribute>
          <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-66149X</attribute>
          <attribute name="journal" nameAc="MI:0885">Structure (London, England : 1993)</attribute>
          <attribute name="publication year" nameAc="MI:0886">2006</attribute>
          <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
          <attribute name="title" nameAc="MI:1091">Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1.</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>mark2_rat</shortLabel>
          <fullName>Serine/threonine-protein kinase MARK2</fullName>
          <alias type="gene name" typeAc="MI:0301">Mark2</alias>
          <alias type="gene name synonym" typeAc="MI:0302">ELKL motif kinase 1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">MAP/microtubule affinity-regulating kinase 2</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="O08679" version="47" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSRNOP00000028763" version="SP_166" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15567525" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSRNOG00000021184" version="SP_166" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSRNOT00000028763" version="SP_166" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000226" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000287" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001764" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004674" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005524" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005884" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006468" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008289" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010976" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016020" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016055" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016328" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0018105" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030010" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030425" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0035556" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045180" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045197" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0046777" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0047485" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0048156" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0050321" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0050770" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051493" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0061564" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070507" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071963" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0106310" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0106311" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1904526" version="SP_166"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000719" version="SP_166"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001772" version="SP_166"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008271" version="SP_166"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011009" version="SP_166"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR015940" version="SP_166"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR017441" version="SP_166"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR028375" version="SP_166"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="O08679" version="SP_166"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0097427" version="SP_166"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1Y8G" version="SP_166"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1ZMU" version="SP_166"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1ZMV" version="SP_166"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1ZMW" version="SP_166"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2R0I" version="SP_166"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2WZJ" version="SP_166"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_067731.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-29029N"/>
          <secondaryRef db="rgd" dbAc="MI:0483" id="708483"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10116">
          <names>
            <shortLabel>rat</shortLabel>
            <fullName>Rattus norvegicus (Rat)</fullName>
            <alias type="synonym" typeAc="MI:1041">Rat</alias>
          </names>
        </organism>
        <sequence>MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMLRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRSSDQAVPAIPTSNSYSKKTQSNNAENKRPEEETGRKASSTAKVPASPLPGLDRKKTTPTPSTNSVLSTSTNRSRNSPLLDRASLGQASIQNGKDSTAPQRVPVASPSAHNISSSSGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPFGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLNEPESKDRVETLRPHVVGGGGTDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHERYMLLCVHGTPGHENFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein O08679 original sequence version: 47</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="3" imexId="IM-8346-1">
        <names>
          <shortLabel>mark2-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="dip" dbAc="MI:0465" id="DIP-57030E" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15567574" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-8346-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="4">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <featureList>
              <feature id="5">
                <names>
                  <shortLabel>Catalytic Domain 39-364</shortLabel>
                  <fullName>Catalytic Domain 39-364</fullName>
                </names>
                <xref>
                  <primaryRef db="intact" dbAc="MI:0469" id="EBI-15567579" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <featureType>
                  <names>
                    <shortLabel>sufficient to bind</shortLabel>
                    <fullName>sufficient binding region</fullName>
                    <alias type="synonym" typeAc="MI:1041">sufficient to bind</alias>
                  </names>
                  <xref>
                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0442" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608899" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                  </xref>
                </featureType>
                <featureRangeList>
                  <featureRange>
                    <startStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </startStatus>
                    <begin position="39"/>
                    <endStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </endStatus>
                    <end position="364"/>
                  </featureRange>
                </featureRangeList>
              </feature>
            </featureList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="562">
                <names>
                  <shortLabel>ecolx</shortLabel>
                  <fullName>Escherichia coli</fullName>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>direct interaction</shortLabel>
            <fullName>direct interaction</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
      </interaction>
    </interactionList>
  </entry>
</entrySet>