DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Cbl promotes clustering of endocytic adaptor proteins. Cbl promotes clustering of endocytic adaptor proteins. Nature structural & molecular biology 2005 imex curation Jozic D., Cárdenes N., Deribe YL., Moncalián G., Hoeller D., Groemping Y., Dikic I., Rittinger K., Bravo J. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Jozic D., Cárdenes N., Deribe YL., Moncalián G., Hoeller D., Groemping Y., Dikic I., Rittinger K., Bravo J. DIP original experiment: DIP-255129X Nature structural & molecular biology 2005 IMEx Cbl promotes clustering of endocytic adaptor proteins. Cbl promotes clustering of endocytic adaptor proteins. Cbl promotes clustering of endocytic adaptor proteins. Nature structural & molecular biology 2005 imex curation Jozic D., Cárdenes N., Deribe YL., Moncalián G., Hoeller D., Groemping Y., Dikic I., Rittinger K., Bravo J. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Jozic D., Cárdenes N., Deribe YL., Moncalián G., Hoeller D., Groemping Y., Dikic I., Rittinger K., Bravo J. DIP original experiment: DIP-255130X Nature structural & molecular biology 2005 IMEx Cbl promotes clustering of endocytic adaptor proteins. Cbl promotes clustering of endocytic adaptor proteins. Cbl promotes clustering of endocytic adaptor proteins. Nature structural & molecular biology 2005 imex curation Jozic D., Cárdenes N., Deribe YL., Moncalián G., Hoeller D., Groemping Y., Dikic I., Rittinger K., Bravo J. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Jozic D., Cárdenes N., Deribe YL., Moncalián G., Hoeller D., Groemping Y., Dikic I., Rittinger K., Bravo J. DIP original experiment: DIP-255128X Nature structural & molecular biology 2005 IMEx Cbl promotes clustering of endocytic adaptor proteins. Cbl promotes clustering of endocytic adaptor proteins. Cbl promotes clustering of endocytic adaptor proteins. Nature structural & molecular biology 2005 imex curation Jozic D., Cárdenes N., Deribe YL., Moncalián G., Hoeller D., Groemping Y., Dikic I., Rittinger K., Bravo J. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Jozic D., Cárdenes N., Deribe YL., Moncalián G., Hoeller D., Groemping Y., Dikic I., Rittinger K., Bravo J. DIP original experiment: DIP-255131X Nature structural & molecular biology 2005 IMEx Cbl promotes clustering of endocytic adaptor proteins. Cbl promotes clustering of endocytic adaptor proteins. Cbl promotes clustering of endocytic adaptor proteins. Nature structural & molecular biology 2005 imex curation Jozic D., Cárdenes N., Deribe YL., Moncalián G., Hoeller D., Groemping Y., Dikic I., Rittinger K., Bravo J. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Jozic D., Cárdenes N., Deribe YL., Moncalián G., Hoeller D., Groemping Y., Dikic I., Rittinger K., Bravo J. DIP original experiment: DIP-255132X Nature structural & molecular biology 2005 IMEx Cbl promotes clustering of endocytic adaptor proteins. Cbl promotes clustering of endocytic adaptor proteins. Cbl promotes clustering of endocytic adaptor proteins. Nature structural & molecular biology 2005 imex curation Jozic D., Cárdenes N., Deribe YL., Moncalián G., Hoeller D., Groemping Y., Dikic I., Rittinger K., Bravo J. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Jozic D., Cárdenes N., Deribe YL., Moncalián G., Hoeller D., Groemping Y., Dikic I., Rittinger K., Bravo J. DIP original experiment: DIP-255127X Nature structural & molecular biology 2005 IMEx Cbl promotes clustering of endocytic adaptor proteins. Cbl promotes clustering of endocytic adaptor proteins. Cbl promotes clustering of endocytic adaptor proteins. Nature structural & molecular biology 2005 imex curation Jozic D., Cárdenes N., Deribe YL., Moncalián G., Hoeller D., Groemping Y., Dikic I., Rittinger K., Bravo J. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip predetermined predetermined participant predetermined Jozic D., Cárdenes N., Deribe YL., Moncalián G., Hoeller D., Groemping Y., Dikic I., Rittinger K., Bravo J. DIP original experiment: DIP-255133X Nature structural & molecular biology 2005 IMEx Cbl promotes clustering of endocytic adaptor proteins. arhg7_rat Rho guanine nucleotide exchange factor 7 Arhgef7 Pak3bp Pixb Beta-Pix PAK-interacting exchange factor beta protein protein rat Rattus norvegicus (Rat) Rat MTDNANSQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREIKPSEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETEHEYSKELQSVLSTYLWPLQTSEKLSSANTSYLMGNLEEISSFQQVLVQSLEECTKSPEAQQRVGGCFLSLMPQMRTLYLAYCANHPSAVSVLTEHSEDLGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQEVRKRKELELQILTEPIRSWEGDDIKTLGSVTYMSQVTIQCAGSEEKNERYLLLFPNLLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLHEWVEHLQRQTKVTSVSNPTIKPHSVPSHTLPSHPLTPSSKHADSKPVALTPAYHTLPHPSHHGTPHTTISWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSRSPKTMKKLLPKRKPERKPSDEEFAVRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDEVQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL DIP protein O55043 original sequence version: 116 17CDE7DD96ADEA53 q13191-1 E3 ubiquitin-protein ligase CBL-B Casitas B-lineage lymphoma proto-oncogene b RING finger protein 56 RING-type E3 ubiquitin transferase CBL-B SH3-binding protein CBL-B Signal transduction protein CBL-B Nbla00127 CBLB RNF56 protein protein human Homo sapiens Human MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL DIP protein Q13191-1 original sequence version: 149 DIP protein Q13191 original sequence version: 116 DIP protein Q13191 original sequence version: 123 DIP protein Q13191-1 original sequence version: 141 DIP protein Q13191 original sequence version: 149 pak Pak peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) DATPPPVIAPRPEHTKSVYTR q96b97-1 SH3 domain-containing kinase-binding protein 1 Human Src family kinase-binding protein 1 SH3KBP1 CD2-binding protein 3 CIN85 Cbl-interacting protein of 85 kDa protein protein human Homo sapiens Human MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK DIP protein Q96B97-1 original sequence version: 123 Interacts with CBL. mint 3BD350FCDB14BD4C arhgef7-pak-1 4 10 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 8 unspecified role unspecified role unspecified role unspecified role Region 5-66 Region 5-66 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction arhgef7-cblb-1 1 8 unspecified role unspecified role unspecified role unspecified role Region 5-66 Region 5-66 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 9 unspecified role unspecified role unspecified role unspecified role Region 899-914 Region 899-914 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Q13191-1:p.Arg904Ala R904A mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain R A This feature has been corrected as a result of our quality control procedures. The original label was 'R904A'. Wed May 02 20:00:46 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg904ala' Tue Jun 30 16:52:26 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg904Ala' in vitro In vitro direct interaction direct interaction cblb-sh3kbp1-16 6 11 unspecified role unspecified role unspecified role unspecified role Region 1-58 Region 1-58 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 9 unspecified role unspecified role unspecified role unspecified role Region 902-912 Region 902-912 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain in vitro In vitro direct interaction direct interaction sh3kbp1-cblb-8 7 11 unspecified role unspecified role prey prey human Homo sapiens Human 11 unspecified role unspecified role bait bait Region 1-328 Region 1-328 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human Homo sapiens Human 9 unspecified role unspecified role prey prey human Homo sapiens Human association association arhgef7-cblb-2 3 8 unspecified role unspecified role unspecified role unspecified role Region 5-66 Region 5-66 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 9 unspecified role unspecified role unspecified role unspecified role Region 899-914 Region 899-914 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain in vitro In vitro direct interaction direct interaction pak-sh3kbp1-1 5 11 unspecified role unspecified role unspecified role unspecified role Region 1-58 Region 1-58 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 10 unspecified role unspecified role unspecified role unspecified role in vitro In vitro direct interaction direct interaction cblb-sh3kbp1-17 2 11 unspecified role unspecified role unspecified role unspecified role Region 1-58 Region 1-58 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 9 unspecified role unspecified role unspecified role unspecified role Region 899-914 Region 899-914 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain in vitro In vitro direct interaction direct interaction