DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. PLoS biology 2005 imex curation Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. Only protein-protein interactions in vitro In vitro phosphotransferase phosphotransferase assay phosphotransferase weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. DIP original experiment: DIP-132434X PLoS biology 2005 IMEx Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. PLoS biology 2005 imex curation Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. Only protein-protein interactions in vitro In vitro phosphotransferase phosphotransferase assay phosphotransferase weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. DIP original experiment: DIP-262159X PLoS biology 2005 IMEx Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. PLoS biology 2005 imex curation Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. Only protein-protein interactions in vitro In vitro phosphotransferase phosphotransferase assay phosphotransferase weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. DIP original experiment: DIP-132447X PLoS biology 2005 IMEx Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. PLoS biology 2005 imex curation Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. Only protein-protein interactions in vitro In vitro phosphotransferase phosphotransferase assay phosphotransferase weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. DIP original experiment: DIP-132436X PLoS biology 2005 IMEx Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. PLoS biology 2005 imex curation Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. Only protein-protein interactions in vitro In vitro phosphotransferase phosphotransferase assay phosphotransferase weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. DIP original experiment: DIP-132442X PLoS biology 2005 IMEx Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. PLoS biology 2005 imex curation Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. Only protein-protein interactions in vitro In vitro phosphotransferase phosphotransferase assay phosphotransferase weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. DIP original experiment: DIP-132435X PLoS biology 2005 IMEx Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. PLoS biology 2005 imex curation Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. Only protein-protein interactions in vitro In vitro phosphotransferase phosphotransferase assay phosphotransferase weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. DIP original experiment: DIP-132444X PLoS biology 2005 IMEx Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. PLoS biology 2005 imex curation Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. Only protein-protein interactions in vitro In vitro phosphotransferase phosphotransferase assay phosphotransferase weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. DIP original experiment: DIP-132437X PLoS biology 2005 IMEx Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. PLoS biology 2005 imex curation Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. Only protein-protein interactions in vitro In vitro phosphotransferase phosphotransferase assay phosphotransferase weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. DIP original experiment: DIP-132441X PLoS biology 2005 IMEx Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. PLoS biology 2005 imex curation Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. Only protein-protein interactions in vitro In vitro phosphotransferase phosphotransferase assay phosphotransferase weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. DIP original experiment: DIP-132438X PLoS biology 2005 IMEx Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. PLoS biology 2005 imex curation Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. Only protein-protein interactions in vitro In vitro phosphotransferase phosphotransferase assay phosphotransferase weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. DIP original experiment: DIP-132433X PLoS biology 2005 IMEx Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. PLoS biology 2005 imex curation Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. Only protein-protein interactions in vitro In vitro phosphotransferase phosphotransferase assay phosphotransferase weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. DIP original experiment: DIP-132445X PLoS biology 2005 IMEx Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. PLoS biology 2005 imex curation Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. Only protein-protein interactions in vitro In vitro phosphotransferase phosphotransferase assay phosphotransferase weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. DIP original experiment: DIP-132439X PLoS biology 2005 IMEx Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. PLoS biology 2005 imex curation Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. Only protein-protein interactions in vitro In vitro phosphotransferase phosphotransferase assay phosphotransferase weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. DIP original experiment: DIP-132440X PLoS biology 2005 IMEx Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. PLoS biology 2005 imex curation Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. Only protein-protein interactions in vitro In vitro phosphotransferase phosphotransferase assay phosphotransferase weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. DIP original experiment: DIP-132446X PLoS biology 2005 IMEx Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. PLoS biology 2005 imex curation Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. Only protein-protein interactions in vitro In vitro phosphotransferase phosphotransferase assay phosphotransferase weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. DIP original experiment: DIP-132431X PLoS biology 2005 IMEx Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. PLoS biology 2005 imex curation Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. Only protein-protein interactions in vitro In vitro phosphotransferase phosphotransferase assay phosphotransferase weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. DIP original experiment: DIP-132432X PLoS biology 2005 IMEx Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. PLoS biology 2005 imex curation Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. Only protein-protein interactions in vitro In vitro phosphotransferase phosphotransferase assay phosphotransferase weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Skerker JM., Prasol MS., Perchuk BS., Biondi EG., Laub MT. DIP original experiment: DIP-132443X PLoS biology 2005 IMEx Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis. phob_ecoli Phosphate regulon transcriptional regulatory protein PhoB phoB b0399 JW0389 protein protein ecoli Escherichia coli (strain K12) MARRILVVEDEAPIREMVCFVLEQNGFQPVEAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKRESMTRDIPVVMLTARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMRRISPMAVEEVIEMQGLSLDPTSHRVMAGEEPLEMGPTEFKLLHFFMTHPERVYSREQLLNHVWGTNVYVEDRTVDVHIRRLRKALEPGGHDRMVQTVRGTGYRFSTRF DIP protein P0AFJ5 original sequence version: 48 DIP protein P0AFJ5 original sequence version: 47 EB46BA282F1F2C23 divj_cauvc Histidine protein kinase DivJ divJ CC_1063 protein protein caucr Caulobacter crescentus (strain ATCC 19089 / CB15) Caulobacter vibrioides MILPTALKSRLALEFETLPDPFRRPAARAAGLDPAHAWRLGWLAAVCLAAAAALFTADSGGWPVWAALGAGALPALVSLIFTREDERTQSWLLVLWAVGGSLAAVLTGGVGGAMAAWCLAPVAAASTQDQPKRLAEGAALALIGACVAALTQLSGLAPAAPTGPLAFVLGFLALVTTGLGLAAGLLIGRRRQGARDDRYASEIIGLETLLDGLPHLAIAVRGQGQVTAVRGAAPPGVTRADLVNRGLTGAAAPGDRQRLTAAIAQAHREGSASLTFNPALGVERVVALDMHRVAPNQLVGVLRDITVERHREHALDQARIDAEALAAGRARFLANMSHELRTPLNAIMGFSDIMRARMFGPLSDRYAEYAELIHESGGHLLDLINDVLDMSKIEAERFELQRGVFDAREAVQAAMRLLRVQSDTAGVQLRGVLPPGELEVDADRRALKQIVLNLVSNALKFTPRGGQVTVTAHGYDGVLEIVVADTGVGISPEDLERLGRPYEQAGGAEQRARGTGLGLSLVRAFAQLHGGEMVIESRLGAGTTVSVRLPVLLAPMVAATPTPPAAPEAPSAPEPAPTVEEPPPASLGDNVIAFAPR 802B532B749B37EA 802B532B749B37EA q9a7i2_cauvc CC_1741 protein protein caucr Caulobacter crescentus (strain ATCC 19089 / CB15) Caulobacter vibrioides MNAASKKILIADDDSSIRLVLSQAFTRLGYQVRATGNATTLLKWVTDGEGDLVVTDVMMPDENVFDVLPRIRKERPKLPIIVMSAQNTLLTAVNAADAGAFEYVSKPFDLDDVTAAARRALSRPADTEASKAQARAMRDERLPLIGRSAPMQEVYRTIARLVGADLTVLILGESGTGKELVARALHELGRRRDGKFVVINLAAVPRERVEAELFGRGEGDNGRLVEADGGTLFLDEIGDMPLDAQTRLLRVIDGTEPVINPKTGRRPNVRIIAATNRDLRGLIQQGLFREDLFFRLNVAPVRLPPLRDRAEDIPDLARTFLLRAAREGLPAKTIDQGALDRLKSHPWPGNVRELENLMRRMCALYAEELITSRIVDRELQDHAPAVRAEEGPVTLSTLVERHLASHFADQPDGVPAPGLYDRILEEVERPLIQLTLSATRGNQVRAAEILGLNRNTLRKKIQDLGVEMTRGRR 0D7CD6DF6AF18FA3 ompr_ecoli DNA-binding dual transcriptional regulator OmpR ompR ompB kmt b3405 JW3368 Transcriptional regulatory protein OmpR protein protein ecoli Escherichia coli (strain K12) MQENYKILVVDDDMRLRALLERYLTEQGFQVRSVANAEQMDRLLTRESFHLMVLDLMLPGEDGLSICRRLRSQSNPMPIIMVTAKGEEVDRIVGLEIGADDYIPKPFNPRELLARIRAVLRRQANELPGAPSQEEAVIAFGKFKLNLGTREMFREDEPMPLTSGEFAVLKALVSHPREPLSRDKLMNLARGREYSAMERSIDVQISRLRRMVEEDPAHPRYIQTVWGLGYVFVPDGSKA DIP protein P0AA16 original sequence version: 50 823CA7720E9A1D2A chey_ecoli Chemotaxis protein CheY cheY b1882 JW1871 protein protein ecoli Escherichia coli (strain K12) MADKELKFLVVDDFSTMRRIVRNLLKELGFNNVEEAEDGVDALNKLQAGGYGFVISDWNMPNMDGLELLKTIRADGAMSALPVLMVTAEAKKENIIAAAQAGASGYVVKPFTAATLEEKLNKIFEKLGM DIP protein P0AE67 original sequence version: 95 DIP protein P0AE67 original sequence version: 56 DIP protein P0AE67 original sequence version: 96 E4B60B8A73DA14DC cpxr_ecoli Transcriptional regulatory protein CpxR cpxR b3912 JW3883 yiiA protein protein ecoli Escherichia coli (strain K12) MNKILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALDLLDDSIDLLLLDVMMPKKNGIDTLKALRQTHQTPVIMLTARGSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSHWSEQQQNNDNGSPTLEVDALVLNPGRQEASFDGQTLELTGTEFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPDRKDGHPWFKTLRGRGYLMVSAS DIP protein P0AE88 original sequence version: 47 DIP protein P0AE88 original sequence version: 42 DIP protein P0AE88 original sequence version: 78 667FC2B246082F46 q9a223_cauvc cenR CC_3743 protein protein caucr Caulobacter crescentus (strain ATCC 19089 / CB15) Caulobacter vibrioides MFRLMAQRKTLLLIDDDDDLRGALAEQLALHEEFAVNEASSAGEGVKLSRELKPDLILLDVDLPDMDGREACRLMRKNGVTAPVIMLTAAASDSDTILGLESGANDYVTKPFRFGVLLARIRAQLRSYEASEDALFRIGPYEFRPSAKLLVDEKQKKVRLTEKETNILKYLYRAGSKPVSREELLTEVWGYNAGVTTHTLETHVYRLRQKIEPDPTVARILITEMGGYRLQP 7F35AF97957D5CD4 q9a379_cauvc CC_3325 protein protein caucr Caulobacter crescentus (strain ATCC 19089 / CB15) Caulobacter vibrioides MKVALLDDDQSHNALVASVLEPAGFVCTSFTTPSRLLAELRKQTFDLIILDWNMPELSGVETLKLLREDPATAPPVLLLTSRSVEADLVEGLNAGADDYIVKPLQPQVLLARVNAVVRRIHRPASQPQTEQYGHYRLDPGAQTASWNGQVEALTPKEFQLASLLFSNLSRPLSREYLLRRIWGQRPDLETRTLDAHVSRLRSKLHLRPSNGFRLSTVYGFGYRLEACDPDTAGGGD EBB4318BD94F0AEB q9a377_cauvc Histidine kinase CC_3327 protein protein caucr Caulobacter crescentus (strain ATCC 19089 / CB15) Caulobacter vibrioides MRETGSRPSRSGERRLSWLWLAMAASLVFAVFAVRPPSRIDNVLYDVLTRANAHPADDSILIVDIDDRSLARMGAWPWGRDTHARMVDQLTQAGAKTIVYDVLFSQPSRDPAQDRALGEAIARSGRVYLPEFLIDGGEQAPPRVVGSISEIARGAAGVGLAHVRFDDDGVVRRMAPFEANGPSLKPDLMTVVHRATRPPGSPDVTRGNEQTLLISFAGPPSIYRHASFASVLDGEVPRELIAGRTVFVGLTAPGLGPAFPTPVTPDAASMTGVQLQASVLDALRSGRMITPAGPWSRVGFSLTLLWLLMIGFMALPPRANLLLTIGLCLVGLAYSAALFWLGHIWLSPITTVIGLQLVALIWGWGRLGQVNDLIGRELARVRAVVRGRGAKPAAFSGDVVTRQASSLGDAITRMDDLRRFSADALFSLPDATLVANEQGRVIAANAAAQALFKPHQATLNGASLADLINLLDPLGRRFELDWPQATDRHDPIDLHLPDGRAFQLQTVLRRDEHGGPAGWIVRLADISILTAAMRQREQALQLLTHDMRSPQTSILALLATTPDLPKETADRIAAYARRTLALADGFVQLARAEVTPVSLEPLDLADVAVEAIDEVWPQSLQRKIRIEQVGGEAPLMVLGDRSVLARTFVNLLGNALKYSPSGSTITVNLAEQPSPSGPVACIAIADQGPGFSREEAATAFRPFQRFERPGHELASNGVGLGLAFVQAAVARHGGEVSCRSEPGVGAEFTVRLPRHGVVQGG 5669C8814FDB0A17 q9abd9_cauvc Histidine kinase CC_0289 protein protein caucr Caulobacter crescentus (strain ATCC 19089 / CB15) Caulobacter vibrioides MPLANTPQTDPRRDPAGAPWSLWIGPGALLGLAVSGLAEPMPAVLAALAVGGAGVFLNRRKAVAAGVAPNALAQPVAKPVEPPFAAILDRLPDPLMVIAAEEADDLTGRRFLFANAAARELFKIQHAGALLVTAVRHPRVLEAVDEALFGGIEGMAEFETGGVQGRSWLAYARPLKETVGRSRLALLALRDETDARRSERTRADFLANASHELRTPLASLSGFIETLRGHAKDDPGARDKFLAIMLAQAERMSRLIDDLMSLSRIELNEHIAPLGRVDLSMAVIDVIDALGPQARDKALTFDPVLPPRGGAVVDGDRDQIIQVIQNLVDNAIKYTPSGGVVRVEVFPSLAAEAAAAARDPSAPRMSLLTPDHDPVERYAMLRVIDRGPGLAREHLPRLTERFYRVEGQKSGDRSGTGLGLAIVKHIMNRHRGGLTVESVQGEGAAFAVYLPMAKGEARMSSTTPPAEAGSA 4C29B8925CDE12F5 envz_ecoli Sensor histidine kinase EnvZ Osmolarity sensor protein EnvZ envZ ompB perA tpo b3404 JW3367 protein protein ecoli Escherichia coli (strain K12) MRRLRFSPRSSFARTLLLIVTLLFASLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLVVPPAFRREIYRELGISLYSNEAAEEAGLRWAQHYEFLSHQMAQQLGGPTEVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMMSEQDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNAVLGEVIAAESGYEREIETALYPGSIEVKMHPLSIKRAVANMVVNAARYGNGWIKVSSGTEPNRAWFQVEDDGPGIAPEQRKHLFQPFVRGDSARTISGTGLGLAIVQRIVDNHNGMLELGTSERGGLSIRAWLPVPVTRAQGTTKEG DIP protein P0AEJ4 original sequence version: 89 DIP protein P0AEJ4 original sequence version: 50 D58444D038722146 q9aar6_cauvc Histidine kinase cenK CC_0530 protein protein caucr Caulobacter crescentus (strain ATCC 19089 / CB15) Caulobacter vibrioides MVEPGSPSEDKTQKPRKRFPWPGGLSARLLLFTAVVVNFGGLLILPPALAAYEEQWLLDRVRAGELASTIAESDPELRVSDAVANQMFDQAGAVTVAVQVDGARRLVLPPKQPFETPYLVDLRRQNPGSWLAAPFYTLTSPKGSMVRVMAEPRFRKAEFIEVVLPDAPLKARLVAYFWQLAGVTIFVATLAGVLVYAFLNIFLVRPMQRITRAMEAFRSDPDDPAARIVLSNRRDEIGRAELELDRMQADLLAALSSKARLAALGEAVAKINHDLRNMLTSAQMASDRLAALGDPKVAQALPRLERALDRAINLASDVMAYGKSKEPEPVIRVIPLRPALDMAAEDAGLSAQGVSLETVIGPREQVLADPDQLHRILTNLLRNAREAIEGAPDRGGKGKVFVELRRADGSSVLRLSDDGPGVPERARANLFQPFVGSVRRGGTGLGLAIARELAQGHGGDLALVETGPGGSVFDLTLSGAPDPLPETPSEPGDRAADAPAG F9AF37958248126B phop_ecoli Transcriptional regulatory protein PhoP phoP b1130 JW1116 protein protein ecoli Escherichia coli (strain K12) MRVLVVEDNALLRHHLKVQIQDAGHQVDDAEDAKEADYYLNEHIPDIAIVDLGLPDEDGLSLIRRWRSNDVSLPILVLTARESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRNSGLASQVISLPPFQVDLSRRELSINDEVIKLTAFEYTIMETLIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAQYPQEVITTVRGQGYLFELR DIP protein P23836 original sequence version: 95 2EFF27E3923D43EF q45976_cauvi divK protein protein cauce Caulobacter crescentus Caulobacter crescentus MTKKVLIVEDNELNMKLFHDLLEAQGYETLQTREGLSALSIARENKPDLILMDIQLPEISGLEVTKWLKEDDDLAHIPVVAVTAFAMKGDEERIREGGCEAYISKPISVVHFLETIKRLLERQPA DIP protein Q45976 original sequence version: 55 5C70277599EEEDB4 cpxa_ecoli Sensor histidine kinase CpxA ecfB eup ssd JW3882 b3911 cpxA protein protein ecoli Escherichia coli (strain K12) MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLDSEQRQGLMIEQHVEAELANDPPNDLMWWRRLFRAIDKWAPPGQRLLLVTTEGRVIGAERSEMQIIRNFIGQADNADHPQKKKYGRVELVGPFSVRDGEDNYQLYLIRPASSSQSDFINLLFDRPLLLLIVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLGTALLRRRSGESKELERIETEAQRLDSMINDLLVMSRNQQKNALVSETIKANQLWSEVLDNAAFEAEQMGKSLTVNFPPGPWPLYGNPNALESALENIVRNALRYSHTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPLYKRS DIP protein P0AE82 original sequence version: 53 DIP protein P0AE82 original sequence version: 81 720EE4A62885BA33 q9a7i3_cauvc Histidine kinase CC_1740 protein protein caucr Caulobacter crescentus (strain ATCC 19089 / CB15) Caulobacter vibrioides MATEALKAAAFDLSPEPALVVDHDGGLVAVNEAAEALFGHGLSLLARGRFRAALPPGSVLVSLLDRAVFEGCLVREHGVEVNLFGQPPFEADGAAVPLGDGSVLLTLHVKGVLGVDRSADAAGLRSVVGLGKMLAHEIKNPLAGIRGAAQLLKTGASAVDQPLAQLIVDETDRIRRLVDRMEAFSEQAPTMREPVNIHQVLDRVRALVANGVADGLTLKESYDPSLPPVWGDEDHLIQIFLNLMKNAAEAAHMRGDDRGVLSIHTAWRPGVRVRGADGKATSGAPIEVRVIDNGPGVPATLRDHLFQPFVTTKSNGTGLGLALVTKLVTAHGGLIDFESEPGRTVFRVLLPVAPEAASGDVRA 0BBA426765997B00 q9a913_cauvc Histidine kinase CC_1181 protein protein caucr Caulobacter crescentus (strain ATCC 19089 / CB15) Caulobacter vibrioides MILSRRGAPLFVQALELVIVTLVAAQLISIAVIFTLPPPPPEFYRSSEIVRALKTGQPVQPRDGRLLVVKQDGSIRAGNPETPRRADFKAGIGKALGVPANRVELQIDNGPRFFVRRTPVTPPRPDAPPAGANGRPGAREPFAREGGAPGGGDNARSAQARDEPLIFGDFKVGVRQSDGRWLVVEPKPTLRFDSWQQRILLILLLSVIAVTPLAWLFARRLAQPITAFADAAERLGKDPRTPPLNMTGSGEVVAAASAFNMMQERLRRYVEDRTAMVGAIAHDLRTPLTRLKFRIEAAPEDIRPKLAADIDQMEAMISATLGFVRDTNRPAERTKLELSSLLESVMDEAAETGGDATVERSEKTVIEGDPVALKRLVSNLVENALKYGGRARGRVFSEDGMAIIEIDDDGPGVPPAELERVFEPFYRGEPSRNRETGGIGLGLAVVRSLARAHGGDVVLANRLGGGLRATVKLPA 5178BCAF86706349 q9aa48_cauvc CC_0758 protein protein caucr Caulobacter crescentus (strain ATCC 19089 / CB15) Caulobacter vibrioides MTDAPVVHVVDDDESARESLAFLLESADFEVVAYASAPAFLDALPQARPGVVITDVRMPEMSGQDLVARLSALKVKMPIVMITGHGDIPMAVEAMRSGVIDFLEKPFSESRMLDALKRAFATVEAAPVSDDQAVILKRIESLSERERQVLDGVVAGHANKVIARDLGISPRTVEIYRAKLMTKMQADNLAALVRMTLSVRGG 0B08659C96C1CA03 plec_cauvc Non-motile and phage-resistance protein pleC CC_2482 protein protein caucr Caulobacter crescentus (strain ATCC 19089 / CB15) Caulobacter vibrioides MGRHGGPAAAGPTAPSAVRAKAVNAPSQVFVRIAILAALLLLAVYTAFGVHRLQREAMAQPGGAPLAAKADLIAGRVDANLAAQRAGLSAAADLLKRDPGATMDAAETTLRAAGGEAAAVAVVSEAGVVAVAGRDDGADWKAAALAAGASGRTNWVGSVGETGRLYVATTTSLDRARAFVIASGDASRLVADPEKGESGALALPDGKLIAARGRGVQGAGALREAFALSIEDLGDGPAAVRGQAADGALLDVAVRPVAQGALLAVAAAPTRSVANLDRQVMEGAFSLLVPLGVGIALALLLMIQSRKAEVAHREFIDSERRFRLAVEAARCGIWEWDLNGDQVYLSDVTGAMFGWGGGGVVSGQDLLERISIDHRERVRQALANAAMYGAFDVSFRVPASEQGARSLWIDARGQGFGKPGSEGHARIIGVALDVTEERIAQARAQAAENRLRDAIESVSEAFVLWDRQGRLLMCNRNYRSVFSLEPKILKPGAARAEVNRFAALAIKQDHPAPDGAKGVREAEMMDGRWIQISERRTAEGGLVMTAADITAIKTQEEARRRNEEQLQNAVAGLERSQEQLAELARKYETEKVKAESANKAKSEFLANMSHELRTPLNAINGFSEIMMNEMFGPLGDQRYKGYSQDIHSSGQHLLALINDILDMSKIEAGKMNLKFESMHLEDVAEDAVRLVRNRAEAAGLKLDIDFPQLPEIEADYRAVKQVLLNLLSNAIKFTPRAGSVTVRAEVRRDPFGDLIKVSVTDTGIGIAKEDLARLAKPFEQVESQFSKTTQGTGLGLALTKSLITMHDGVLEMHSTPGEGTTVSFTLPVRHSDQKITRDFVAA DCFF4F092DE2CBF8 DCFF4F092DE2CBF8 q9a4r4_cauvc CC_2766 protein protein caucr Caulobacter crescentus (strain ATCC 19089 / CB15) Caulobacter vibrioides MRILLVEDDPDLTRQLKLALADAGYAVDHAPDGEEAQYLGENEPYDAVILDLGLPKVDGVSVLERWRRGNVTTPVLILTARGAWSDKVAGFDAGADDYLAKPFHTEELLARLRALLRRSAGHAAPSLSCGALRLDPRAARASVNGEPLRLTSLEYRLLHYMIMHQGRVIGRTELVEHLYDQDFDRDSNTIEVFIGRLRKKLGADRIETVRGLGYRLAALPGEDAA 33A671A814C444C7 q9a912_cauvc CC_1182 protein protein caucr Caulobacter crescentus (strain ATCC 19089 / CB15) Caulobacter vibrioides MENVQNAAQSELEAVRGAPSRILIVDDDPGIRDVVSDFLAKHGYVVETAQDGRTMEQVLARGPIDLIVLDVMLPGEDGLAICRRLSATPEAPAIIMLSAMGEETDRIVGLELGADDYLPKPCNPRELLARVRAVLRRRQEPRAVDDAMGAACEFAGWRLDLVRRELRSPQSIVVNLSSGEFSLLRAFVERPQRVLTRDQLLDLARGRDSDAYDRAIDVQISRLRRKLDDGGGSELIRTIRSEGYMFTAKVVRTP 74EE1102C7AB2D09 phor_ecoli Phosphate regulon sensor protein PhoR phoR nmpB b0400 JW0390 protein protein ecoli Escherichia coli (strain K12) MLERLSWKRLVLELLLCCLPAFILGAFFGYLPWFLLASVTGLLIWHFWNLLRLSWWLWVDRSMTPPPGRGSWEPLLYGLHQMQLRNKKRRRELGNLIKRFRSGAESLPDAVVLTTEEGGIFWCNGLAQQILGLRWPEDNGQNILNLLRYPEFTQYLKTRDFSRPLNLVLNTGRHLEIRVMPYTHKQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMNEQPLEGAVREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTHLLNEKVDVPMMLRVVEREAQTLSQKKQTFTFEIDNGLKVSGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPHGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVNHHESRLNIESTVGKGTRFSFVIPERLIAKNSD DIP protein P08400 original sequence version: 113 DIP protein P08400 original sequence version: null 33883582AF4B883C q9aa47_cauvc Histidine kinase CC_0759 protein protein caucr Caulobacter crescentus (strain ATCC 19089 / CB15) Caulobacter vibrioides MTFRKPPPTMKPTRSLSASLFSDPHPAAYLAAFAAVMATAVARLYLPEAFTAPSSFLLFVPAVLISAALGGVGPGVFGTTFAWAAVWWVTRDIPFDLVSGLSAAIFLSVGFGMAVGGGWFHAARRRAAAVNDHLRSILDTVPDAVVVIDRAGIMTSFSPAAQRMFGWSEAEAIGKNVSLLMPEPYQSAHDGYLDRYARTGEKRIIGAGRVVVGRRKDGSTFPMELAVGETRGPTPSFTGFIRDLTERQETETRLQELQNELVHVSRLTAMGEMASTLAHELNQPLSAIANLLTGSRRLMDRGREADQAKVRDAIDRAAAQALRAGEVIHRMRDFARRGASEREVESLSKLIEEASALALIGEKERQVDVRLKLDPKADDVFADRVQIQQVLLNLIRNGIDAMQAQEPRKRALLIRTGLTEEGWSEVSVADTGPGIAPEVLERLFQPFMTTKPQGMGVGLSISRSIIEAHGGRIWAEANPGGGALFRFTLPPAESLAGEKETIDD 9C59A5BD08CBA771 pled_cauvc Response regulator PleD pleD CC_2462 Stalked cell differentiation-controlling protein protein protein caucr Caulobacter crescentus (strain ATCC 19089 / CB15) Caulobacter vibrioides MSARILVVDDIEANVRLLEAKLTAEYYEVSTAMDGPTALAMAARDLPDIILLDVMMPGMDGFTVCRKLKDDPTTRHIPVVLITALDGRGDRIQGLESGASDFLTKPIDDVMLFARVRSLTRFKLVIDELRQREASGRRMGVIAGAAARLDGLGGRVLIVDDNERQAQRVAAELGVEHRPVIESDPEKAKISAGGPVDLVIVNAAAKNFDGLRFTAALRSEERTRQLPVLAMVDPDDRGRMVKALEIGVNDILSRPIDPQELSARVKTQIQRKRYTDYLRNNLDHSLELAVTDQLTGLHNRRYMTGQLDSLVKRATLGGDPVSALLIDIDFFKKINDTFGHDIGDEVLREFALRLASNVRAIDLPCRYGGEEFVVIMPDTALADALRIAERIRMHVSGSPFTVAHGREMLNVTISIGVSATAGEGDTPEALLKRADEGVYQAKASGRNAVVGKAA D44909D42B581516 D44909D42B581516 chea_ecoli Chemotaxis protein CheA cheA b1888 JW1877 protein protein ecoli Escherichia coli (strain K12) MSMDISDFYQTFFDEADELLADMEQHLLVLQPEAPDAEQLNAIFRAAHSIKGGAGTFGFSVLQETTHLMENLLDEARRGEMQLNTDIINLFLETKDIMQEQLDAYKQSQEPDAASFDYICQALRQLALEAKGETPSAVTRLSVVAKSEPQDEQSRSQSPRRIILSRLKAGEVDLLEEELGHLTTLTDVVKGADSLSAILPGDIAEDDITAVLCFVIEADQITFETVEVSPKISTPPVLKLAAEQAPTGRVEREKTTRSNESTSIRVAVEKVDQLINLVGELVITQSMLAQRSSELDPVNHGDLITSMGQLQRNARDLQESVMSIRMMPMEYVFSRYPRLVRDLAGKLGKQVELTLVGSSTELDKSLIERIIDPLTHLVRNSLDHGIELPEKRLAAGKNSVGNLILSAEHQGGNICIEVTDDGAGLNRERILAKAASQGLTVSENMSDDEVAMLIFAPGFSTAEQVTDVSGRGVGMDVVKRNIQKMGGHVEIQSKQGTGTTIRILLPLTLAILDGMSVRVADEVFILPLNAVMESLQPREADLHPLAGGERVLEVRGEYLPIVELWKVFNVAGAKTEATQGIVVILQSGGRRYALLVDQLIGQHQVVVKNLESNYRKVPGISAATILGDGSVALIVDVSALQAINREQRMANTAA DIP protein P07363 original sequence version: 116 DIP protein P07363 original sequence version: 144 DIP protein P07363 original sequence version: 157 009B824154E269B4 phoq_ecoli Sensor protein PhoQ phoQ Sensor histidine protein kinase/phosphatase PhoQ JW1115 b1129 protein protein ecoli Escherichia coli (strain K12) MKKLLRLFFPLSLRVRFLLATAAVVLVLSLAYGMVALIGYSVSFDKTTFRLLRGESNLFYTLAKWENNKLHVELPENIDKQSPTMTLIYDENGQLLWAQRDVPWLMKMIQPDWLKSNGFHEIEADVNDTSLLLSGDHSIQQQLQEVREDDDDAEMTHSVAVNVYPATSRMPKLTIVVVDTIPVELKSSYMVWSWFIYVLSANLLLVIPLLWVAAWWSLRPIEALAKEVRELEEHNRELLNPATTRELTSLVRNLNRLLKSERERYDKYRTTLTDLTHSLKTPLAVLQSTLRSLRSEKMSVSDAEPVMLEQISRISQQIGYYLHRASMRGGTLLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPEISFVGEQNDFVEVMGNVLDNACKYCLEFVEISARQTDEHLYIVVEDDGPGIPLSKREVIFDRGQRVDTLRPGQGVGLAVAREITEQYEGKIVAGESMLGGARMEVIFGRQHSAPKDE DIP protein P23837 original sequence version: 114 DIP protein P23837 original sequence version: 123 DIP protein P23837 original sequence version: 151 89C6D97A3C9B8809 q9a4r5_cauvc Histidine kinase CC_2765 protein protein caucr Caulobacter crescentus (strain ATCC 19089 / CB15) Caulobacter vibrioides MKLLDLRRRSLVRRLVLIAGIWTLLVVLIAGVFLTAQFRDAAIRRFDQSLAVLADDLYAGSSVENGQLRAPFLTDIRATRVYSGRYWVILDKQPDGAMTPIERSRSLFDSDLMLSSAQIDQLEAAPGKTQYFDMRGPQDKPLRAAAVQARLPGYPDPVVFLAAEDRSPIDADADRFARITAFALLILGGGLILAVVVQVRFGLQPLFQLRREVAHVRRGKAERVDGRYPEELEPLAAELNALLAHNQEVVERQRTHVGNLAHALKTPLSVMLTEASQQPGQLAEVVTRQAQTMREQVDHHLRRARAAARSQTSGERTPVEPILDELAVTLERIFQDKADGRGVEIDWRCPEDLCFQGEKQDLMELAGNVMENAGKWCRGKIRVDAVRTGEARMTLTVDDDGPGLTPDERAQALKRGQRLDENAPGSGLGLSIVDELARAYGGSVQLGESPLGGLRVSLDLPCAES 4BA7EDD7CA6F8E4F q9abd5_cauvc Phosphate regulon transcriptional regulatory protein PhoB CC_0294 protein protein caucr Caulobacter crescentus (strain ATCC 19089 / CB15) Caulobacter vibrioides MTPYVLVVEDEDALATLLHYNLDKEGYRVGVAGDGEEALIMANERAPDLVILDWMLPKVSGIEVCRRLRGRAETRNVPIIMLTARGEETDRIRGLDTGADDYVVKPFSMVELTARVRAVLRRIRPGLADDRITVGDIIIDRVAHRVKRSGKEIHLGPTEFRLLDYLMQHPGRVFSREQLLDAVWGSDVYVEARTVDVHIGRLRKALNGTTDADPIRTVRSAGYSLDMDAA E7CD33BE159BECFB cheb_ecoli Protein-glutamate methylesterase/protein-glutamine glutaminase cheB Chemotaxis response regulator protein-glutamate methylesterase/glutamine deamidase JW1872 b1883 Methyl-accepting chemotaxis proteins-specific methylesterase/deamidase protein protein ecoli Escherichia coli (strain K12) MSKIRVLSVDDSALMRQIMTEIINSHSDMEMVATAPDPLVARDLIKKFNPDVLTLDVEMPRMDGLDFLEKLMRLRPMPVVMVSSLTGKGSEVTLRALELGAIDFVTKPQLGIREGMLAYNEMIAEKVRTAAKASLAAHKPLSAPTTLKAGPLLSSEKLIAIGASTGGTEAIRHVLQPLPLSSPALLITQHMPPGFTRSFADRLNKLCQIGVKEAEDGERVLPGHAYIAPGDRHMELSRSGANYQIKIHDGPAVNRHRPSVDVLFHSVAKQAGRNAVGVILTGMGNDGAAGMLAMRQAGAWTLAQNEASCVVFGMPREAINMGGVCEVVDLSQVSQQMLAKISAGQAIRI DIP protein P07330 original sequence version: 99 6F3D1AFB8D23D3F5 envz-ompr-1 16 22 phosphate acceptor phosphate acceptor unspecified role unspecified role ecolx Escherichia coli 29 phosphate donor phosphate donor unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction cc3325-cc3327-1 3 26 phosphate acceptor phosphate acceptor unspecified role unspecified role ecolx Escherichia coli 27 phosphate donor phosphate donor unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction cc0530-cc3743-1 5 25 phosphate acceptor phosphate acceptor unspecified role unspecified role ecolx Escherichia coli 30 phosphate donor phosphate donor unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction cc1181-cc1182-1 8 39 phosphate acceptor phosphate acceptor unspecified role unspecified role ecolx Escherichia coli 35 phosphate donor phosphate donor unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction chea-cheb-2 17 47 phosphate acceptor phosphate acceptor unspecified role unspecified role ecolx Escherichia coli 43 phosphate donor phosphate donor unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction divj-pled-3 10 42 phosphate acceptor phosphate acceptor unspecified role unspecified role ecolx Escherichia coli 20 phosphate donor phosphate donor unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction cc0758-cc0759-1 7 36 phosphate acceptor phosphate acceptor unspecified role unspecified role ecolx Escherichia coli 41 phosphate donor phosphate donor unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction cc0289-cc0294-1 18 46 phosphate acceptor phosphate acceptor unspecified role unspecified role ecolx Escherichia coli 28 phosphate donor phosphate donor unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction chea-chey-2 11 23 phosphate acceptor phosphate acceptor unspecified role unspecified role ecolx Escherichia coli 43 phosphate donor phosphate donor unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction cc1740-cc1741-1 12 21 phosphate acceptor phosphate acceptor unspecified role unspecified role ecolx Escherichia coli 34 phosphate donor phosphate donor unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction divj-divk-2 13 20 phosphate donor phosphate donor unspecified role unspecified role ecolx Escherichia coli 32 phosphate acceptor phosphate acceptor unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction cpxa-cpxr-1 1 24 phosphate acceptor phosphate acceptor unspecified role unspecified role ecolx Escherichia coli 33 phosphate donor phosphate donor unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction plec-pled-3 14 37 phosphate donor phosphate donor unspecified role unspecified role ecolx Escherichia coli 42 phosphate acceptor phosphate acceptor unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction phop-phoq-1 6 31 phosphate acceptor phosphate acceptor unspecified role unspecified role ecolx Escherichia coli 44 phosphate donor phosphate donor unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction phob-phor-1 4 19 phosphate acceptor phosphate acceptor unspecified role unspecified role ecolx Escherichia coli 40 phosphate donor phosphate donor unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction divk-plec-1 9 32 phosphate acceptor phosphate acceptor unspecified role unspecified role ecolx Escherichia coli 37 phosphate donor phosphate donor unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction cc2765-cc2766-1 15 38 phosphate acceptor phosphate acceptor unspecified role unspecified role ecolx Escherichia coli 45 phosphate donor phosphate donor unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction chea-chey-4 2 23 phosphate acceptor phosphate acceptor unspecified role unspecified role ecolx Escherichia coli 43 phosphate donor phosphate donor unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction 1 nodeMerge04 2014-11-28