DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Crystal structure of IRF-3 in complex with CBP. Crystal structure of IRF-3 in complex with CBP. Structure (London, England : 1993) 2005 imex curation Qin BY., Liu C., Srinath H., Lam SS., Correia JJ., Derynck R., Lin K. Only protein-protein interactions ecolx Escherichia coli pull down pull down predetermined predetermined participant predetermined Qin BY., Liu C., Srinath H., Lam SS., Correia JJ., Derynck R., Lin K. DIP original experiment: DIP-132830X Structure (London, England : 1993) 2005 IMEx Crystal structure of IRF-3 in complex with CBP. Crystal structure of IRF-3 in complex with CBP. Crystal structure of IRF-3 in complex with CBP. Structure (London, England : 1993) 2005 imex curation Qin BY., Liu C., Srinath H., Lam SS., Correia JJ., Derynck R., Lin K. Only protein-protein interactions ecolx Escherichia coli x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Qin BY., Liu C., Srinath H., Lam SS., Correia JJ., Derynck R., Lin K. DIP original experiment: DIP-132832X Structure (London, England : 1993) 2005 IMEx Crystal structure of IRF-3 in complex with CBP. Crystal structure of IRF-3 in complex with CBP. Crystal structure of IRF-3 in complex with CBP. Structure (London, England : 1993) 2005 imex curation Qin BY., Liu C., Srinath H., Lam SS., Correia JJ., Derynck R., Lin K. Only protein-protein interactions ecolx Escherichia coli solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Qin BY., Liu C., Srinath H., Lam SS., Correia JJ., Derynck R., Lin K. DIP original experiment: DIP-132833X Structure (London, England : 1993) 2005 IMEx Crystal structure of IRF-3 in complex with CBP. Crystal structure of IRF-3 in complex with CBP. Crystal structure of IRF-3 in complex with CBP. Structure (London, England : 1993) 2005 imex curation Qin BY., Liu C., Srinath H., Lam SS., Correia JJ., Derynck R., Lin K. Only protein-protein interactions ecolx Escherichia coli ion exchange chrom ion exchange chromatography IEC IEC ion exchange chrom predetermined predetermined participant predetermined Qin BY., Liu C., Srinath H., Lam SS., Correia JJ., Derynck R., Lin K. DIP original experiment: DIP-132831X Structure (London, England : 1993) 2005 IMEx Crystal structure of IRF-3 in complex with CBP. Crystal structure of IRF-3 in complex with CBP. Crystal structure of IRF-3 in complex with CBP. Structure (London, England : 1993) 2005 imex curation Qin BY., Liu C., Srinath H., Lam SS., Correia JJ., Derynck R., Lin K. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Qin BY., Liu C., Srinath H., Lam SS., Correia JJ., Derynck R., Lin K. DIP original experiment: DIP-132834X Structure (London, England : 1993) 2005 IMEx Crystal structure of IRF-3 in complex with CBP. cbp_human CREB-binding protein CREBBP CBP Histone lysine acetyltransferase CREBBP Protein-lysine acetyltransferase CREBBP protein protein human Homo sapiens Human MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSALSSELSLVGDTTGDTLEKFVEGL DIP protein Q92793 original sequence version: 134 DIP protein Q92793-1 original sequence version: 171 DIP protein Q92793 original sequence version: 171 DIP protein Q92793 original sequence version: 185 DIP protein Q92793 original sequence version: 106 DIP protein Q92793 original sequence version: 104 DIP protein Q92793 original sequence version: 112 DIP protein Q92793 original sequence version: 135 DIP protein Q92793 original sequence version: 139 DIP protein Q92793 original sequence version: 157 DIP protein Q92793 original sequence version: 177 DIP protein Q92793 original sequence version: 168 DIP protein Q92793-1 original sequence version: 174 DIP protein Q92793 original sequence version: 146 DIP protein Q92793 original sequence version: 161 DIP protein Q92793 original sequence version: 172 3BEA9B8558BA1A5E irf3_human Interferon regulatory factor 3 IRF3 protein protein human Homo sapiens Human MGTPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEATGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNSGVGDFSQPDTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEPCPQPLRSPSLDNPTPFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTLPGWPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVSEELLPNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEGSGRSPRYALWFCVGESWPQDQPWTKRLVMVKVVPTCLRALVEMARVGGASSLENTVDLHISNSHPLSLTSDQYKAYLQDLVEGMDFQGPGES DIP protein Q14653 original sequence version: 96 DIP protein Q14653 original sequence version: 75 DIP protein Q14653 original sequence version: 95 DIP protein Q14653-1 original sequence version: 128 DIP protein Q14653 original sequence version: 119 F536676FA78B0110 crebbp-irf3-10 5 6 unspecified role unspecified role bait bait human Homo sapiens Human 7 unspecified role unspecified role prey prey Region 173-394 Region 173-394 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range Q14653:p.[Leu322Ala;Pro324Ala;Ile326Ala;Val327Ala;Leu329Ala;Ile330Ala] L322A/P324A/I326A/V327A/L329A/I330A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain I A certain certain sequence position certain certain certain sequence position certain L A certain certain sequence position certain certain certain sequence position certain V A certain certain sequence position certain certain certain sequence position certain I A certain certain sequence position certain certain certain sequence position certain P A certain certain sequence position certain certain certain sequence position certain L A This feature has been corrected as a result of our quality control procedures. The original label was 'L322A/P324A/I326A/V327A/L329A/I330A'. Wed May 02 19:28:25 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu322ala,pro324ala,ile326ala,val327ala,leu329ala,ile330ala' Tue Jun 30 19:19:01 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Leu322Ala;Pro324Ala;Ile326Ala;Val327Ala;Leu329Ala;Ile330Ala]' Q14653:p.Ser221Ala S221A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain S A This feature has been corrected as a result of our quality control procedures. The original label was 'S221A'. Wed May 02 18:35:26 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ser221ala' Tue Jun 30 16:00:44 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ser221Ala' Q14653:p.[Glu201Ala;Glu203Ala] E201A/E203A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain E A certain certain sequence position certain certain certain sequence position certain E A This feature has been corrected as a result of our quality control procedures. The original label was 'E201A/E203A'. Wed May 02 16:51:22 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'glu201ala,glu203ala' Tue Jun 30 18:16:44 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Glu201Ala;Glu203Ala]' Q14653:p.[Cys371Ala;Leu375Ala;Met378Ala] C371A/L375A/M378A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain M A certain certain sequence position certain certain certain sequence position certain L A certain certain sequence position certain certain certain sequence position certain C A This feature has been corrected as a result of our quality control procedures. The original label was 'C371A/L375A/M378A'. Wed May 02 14:36:52 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'cys371ala,leu375ala,met378ala' Tue Jun 30 17:11:24 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Cys371Ala;Leu375Ala;Met378Ala]' human Homo sapiens Human physical association physical association irf3-crebbp-1 1 6 unspecified role unspecified role prey prey Region 2067-2112 Region 2067-2112 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 7 unspecified role unspecified role bait bait Region 173-394 Region 173-394 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli physical association physical association crebbp-irf3-11 2 6 unspecified role unspecified role unspecified role unspecified role Region 2067-2112 Region 2067-2112 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 7 unspecified role unspecified role unspecified role unspecified role Region 173-394 Region 173-394 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction crebbp-irf3-12 4 6 unspecified role unspecified role unspecified role unspecified role Region 2067-2112 Region 2067-2112 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 7 unspecified role unspecified role unspecified role unspecified role Region 173-394 Region 173-394 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction crebbp-irf3-13 3 6 unspecified role unspecified role unspecified role unspecified role Region 2067-2112 Region 2067-2112 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 7 unspecified role unspecified role unspecified role unspecified role Region 173-394 Region 173-394 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction