UniProt UniProt http://www.uniprot.org A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. Genes & development 2016 imex curation Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA., Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA. jeremy.daniel@cpr.ku.dk 22-Jun-2016: Contacted by IntAct-Help. Only protein-protein interactions imex curation mouse-b-cell Mus musculus B-cell b-cell B-cell [B lymphocyte; B-lymphocyte; B cell; B-cells] anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA., Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA. AICDA/Aid -/- B cells have been used jeremy.daniel@cpr.ku.dk Accepted 2016-APR-26 AT 09:18 BST AT 09:18 BST by MGT Genes & development 2016 Only protein-protein interactions imex curation imex curation A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. Genes & development 2016 imex curation Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA., Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA. jeremy.daniel@cpr.ku.dk 22-Jun-2016: Contacted by IntAct-Help. Only protein-protein interactions imex curation mouse-b-cell Mus musculus B-cell b-cell B-cell [B lymphocyte; B-lymphocyte; B cell; B-cells] anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA., Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA. Cells were stimulated for 3 days in an IgG3 inducing condition. Mouse cells with in-frame knocked in GFP-tag at the Paxip1/Ptip locus have been used jeremy.daniel@cpr.ku.dk Accepted 2016-APR-26 AT 09:18 BST AT 09:18 BST by MGT Genes & development 2016 Only protein-protein interactions imex curation imex curation A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. Genes & development 2016 imex curation Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA., Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA. jeremy.daniel@cpr.ku.dk 22-Jun-2016: Contacted by IntAct-Help. Only protein-protein interactions imex curation mouse-embryonic_fibroblast Mus musculus embryonic fibroblasts embryonic_fibroblast Embryonic fibroblast Fibroblasts taken from an embryonic as opposed to a foetal or adult source. Foetus is defined as the stage at which tissue diferentiation is initiated. Tissue taken from an embryonic as opposed to a foetal or adult source. Embryo is defined as the development stage prior to organ formation. confocal microscopy confocal microscopy immunostaining immunostaining Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA., Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA. Mouse Paxip1/Ptip -/- cells have been used jeremy.daniel@cpr.ku.dk Accepted 2016-APR-26 AT 09:18 BST AT 09:18 BST by MGT Genes & development 2016 Only protein-protein interactions imex curation imex curation A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. Genes & development 2016 imex curation Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA., Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA. jeremy.daniel@cpr.ku.dk 22-Jun-2016: Contacted by IntAct-Help. Only protein-protein interactions imex curation in vitro In vitro thermal shift thermal shift binding thermal shift predetermined predetermined participant predetermined Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA., Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA. Constructs/proteins used:- His-STREP-HA-TEV-PTIP and His-FLAG-HA-TEV-PA1 - both N-terminally tagged and expressed in E.coli. jeremy.daniel@cpr.ku.dk Accepted 2016-APR-26 AT 09:18 BST AT 09:18 BST by MGT Genes & development 2016 Only protein-protein interactions imex curation imex curation A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. Genes & development 2016 imex curation Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA., Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA. jeremy.daniel@cpr.ku.dk 22-Jun-2016: Contacted by IntAct-Help. Only protein-protein interactions imex curation in vitro In vitro pull down pull down anti tag western anti tag western blot anti tag western Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA., Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA. Constructs/proteins used:- His-STREP-HA-TEV-PTIP and His-FLAG-HA-TEV-PA1 - both N-terminally tagged and expressed in E.coli. jeremy.daniel@cpr.ku.dk Accepted 2016-APR-26 AT 09:18 BST AT 09:18 BST by MGT Genes & development 2016 Only protein-protein interactions imex curation imex curation A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. Genes & development 2016 imex curation Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA., Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA. jeremy.daniel@cpr.ku.dk 22-Jun-2016: Contacted by IntAct-Help. Only protein-protein interactions imex curation mouse-embryonic_fibroblast Mus musculus embryonic fibroblasts embryonic_fibroblast Embryonic fibroblast Fibroblasts taken from an embryonic as opposed to a foetal or adult source. Foetus is defined as the stage at which tissue diferentiation is initiated. Tissue taken from an embryonic as opposed to a foetal or adult source. Embryo is defined as the development stage prior to organ formation. fluorescence imaging fluorescence microscopy fluorescence imaging immunostaining immunostaining Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA., Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA. MEFs were irradiated jeremy.daniel@cpr.ku.dk Accepted 2016-APR-26 AT 09:18 BST AT 09:18 BST by MGT Genes & development 2016 Only protein-protein interactions imex curation imex curation A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. Genes & development 2016 imex curation Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA., Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA. jeremy.daniel@cpr.ku.dk 22-Jun-2016: Contacted by IntAct-Help. Only protein-protein interactions imex curation mouse-b-cell Mus musculus B-cell b-cell B-cell [B lymphocyte; B-lymphocyte; B cell; B-cells] anti tag coip anti tag coimmunoprecipitation anti tag coip sequence tag sequence tag identification sequence tag Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA., Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA. SILAC-based quantitative proteomic analysis was performed; identification by mass spectrometry Mouse cells with in-frame knocked in GFP-tag at the Paxip1/Ptip locus have been used jeremy.daniel@cpr.ku.dk Accepted 2016-APR-26 AT 09:18 BST AT 09:18 BST by MGT Genes & development 2016 Only protein-protein interactions imex curation imex curation A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. Genes & development 2016 imex curation Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA., Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA. jeremy.daniel@cpr.ku.dk 22-Jun-2016: Contacted by IntAct-Help. Only protein-protein interactions imex curation mouse-embryonic_fibroblast Mus musculus embryonic fibroblasts embryonic_fibroblast Embryonic fibroblast Fibroblasts taken from an embryonic as opposed to a foetal or adult source. Foetus is defined as the stage at which tissue diferentiation is initiated. Tissue taken from an embryonic as opposed to a foetal or adult source. Embryo is defined as the development stage prior to organ formation. anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA., Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA. PTIP-/- MEFs jeremy.daniel@cpr.ku.dk Accepted 2016-APR-26 AT 09:18 BST AT 09:18 BST by MGT Genes & development 2016 Only protein-protein interactions imex curation imex curation A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. Genes & development 2016 imex curation Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA., Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA. jeremy.daniel@cpr.ku.dk 22-Jun-2016: Contacted by IntAct-Help. Only protein-protein interactions imex curation in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA., Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA. Constructs/proteins used:- His-STREP-HA-TEV-PTIP and His-FLAG-HA-TEV-PA1 - both N-terminally tagged and expressed in E.coli. jeremy.daniel@cpr.ku.dk Accepted 2016-APR-26 AT 09:18 BST AT 09:18 BST by MGT Genes & development 2016 Only protein-protein interactions imex curation imex curation A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. Genes & development 2016 imex curation Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA., Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA. jeremy.daniel@cpr.ku.dk 22-Jun-2016: Contacted by IntAct-Help. Only protein-protein interactions imex curation mouse-b-cell Mus musculus B-cell b-cell B-cell [B lymphocyte; B-lymphocyte; B cell; B-cells] anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA., Starnes LM., Su D., Pikkupeura LM., Weinert BT., Santos MA., Mund A., Soria R., Cho YW., Pozdnyakova I., Kubec Højfeldt M., Vala A., Yang W., López-Méndez B., Lee JE., Peng W., Yuan J., Ge K., Montoya G., Nussenzweig A., Choudhary C., Daniel JA. Mouse Paxip1/Ptip -/- cells have been used jeremy.daniel@cpr.ku.dk Accepted 2016-APR-26 AT 09:18 BST AT 09:18 BST by MGT Genes & development 2016 Only protein-protein interactions imex curation imex curation wdr5_mouse WD repeat-containing protein 5 Wdr5 Big Big3 BMP2-induced 3-kb gene protein WD repeat-containing protein BIG-3 protein protein mouse Mus musculus Mouse MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC DIP protein P61965 original sequence version: 124 DIP protein P61965 original sequence version: 118 4BF30914A2250286 pgr1a_mouse PAXIP1-associated glutamate-rich protein 1A Pagr1a Pa1 Pagr PAXIP1-associated protein 1 PTIP-associated protein 1 protein protein mouse Mus musculus Mouse MSLALGHGTIAGSTAAPLSEEGEVTSGLQALAVEDTGGPSVSASKAEEEGKGSQEEAGREGSRPEEALEAPSAASDERAEGEAEDWCVPCSDEEVELPANGQSWMPPPSEIQRLYELLATQGTLELQAEILPRRPPTPEAQSEEERSDEEPEAKEEEEEKPHMPTEFDFDDEPMTPKDSLIDRRRTPGSSARSQKREARLDKVLSDMKRHKKLEEQILRTGRDLFSLDSEGPSPTSPPLRSSGNSLFPRQRKY AA5E4C4503A5C6FF kdm6a_mouse Lysine-specific demethylase 6A Ubiquitously transcribed X chromosome tetratricopeptide repeat protein Ubiquitously transcribed TPR protein on the X chromosome Kdm6a Utx Histone demethylase UTX [histone H3]-trimethyl-L-lysine(27) demethylase 6A protein protein mouse Mus musculus Mouse MKSCGVSLATAAAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARMKALLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYPKALSAYQRYYSLQSDYWKNAAFLYGLGLVYFHYNAFQWAIKAFQEVLYVDPSFCRAKEIHLRLGLMFKVNTDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQVKATILQQLGWMHHTVDLLGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNATRSKNCSNTSGLAARIKYLQAQLCNLPQGSLQNKTKLLPSIEEAWSLPIPAELTSRQGAMNTAQQNTSDNWSGGNAPPPVEQQTHSWCLTPQKLQHLEQLRANRNNLNPAQKLMLEQLESQFVLMQQHQMRQTGVAQVRPTGILNGPTVDSSLPTNSVSGQQPQLPLTRMPSVSQPGVHTACPRQTLANGPFSAGHVPCSTSRTLGSTDTVLIGNNHVTGSGSNGNVPYLQRNAPTLPHNRTNLTSSTEEPWKNQLSNSTQGLHKGPSSHLAGPNGERPLSSTGPSQHLQAAGSGIQNQNGHPTLPSNSVTQGAALNHLSSHTATSGGQQGITLTKESKPSGNTLTVPETSRQTGETPNSTASVEGLPNHVHQVMADAVCSPSHGDSKSPGLLSSDNPQLSALLMGKANNNVGPGTCDKVNNIHPTVHTKTDNSVASSPSSAISTATPSPKSTEQTTTNSVTSLNSPHSGLHTINGEGMEESQSPIKTDLLLVSHRPSPQIIPSMSVSIYPSSAEVLKACRNLGKNGLSNSSILLDKCPPPRPPSSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWHCESNRSHTTIAKYAQYQASSFQESLREENEKRSHHKDHSDSESTSSDNSGKRRKGPFKTIKFGTNIDLSDDKKWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNNLNFLMGSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEWNKLQNVKSIVPMVHLSWNMARNIKVSDPKLFEMIKYCLLRTLKQCQTLREALIAAGKEIIWHGRTKEEPAHYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCARKTSGNLENFVVLEQYKMEDLMQVYDQFTLAPPLPSASS 293DA417F49EECFF rbbp5_mouse Retinoblastoma-binding protein 5 Rbbp5 protein protein mouse Mus musculus Mouse MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVPSSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSTKGKVQAELSQSLAAGGAISELL DIP protein Q8BX09 original sequence version: 118 DIP protein Q8BX09 original sequence version: 114 7D4E9FD5B38A7EB0 ncoa6_mouse Nuclear receptor coactivator 6 Ncoa6 Aib3 Prip Rap250 Trbp Activating signal cointegrator 2 Amplified in breast cancer protein 3 Cancer-amplified transcriptional coactivator ASC-2 Nuclear receptor coactivator RAP250 Nuclear receptor-activating protein, 250 kDa Peroxisome proliferator-activated receptor-interacting protein Thyroid hormone receptor-binding protein protein protein mouse Mus musculus Mouse MVLDDLPNFEDIYTSLCSSTMGDSEVEFDSGLEDDDTKGDSILEDSTIFVAFKGNIDDKDFKWKLDAILKNVPNLLHMESSKLKVQKVEPWNSVRVTFNIPREAAERLWILAQSNNQQLRDLGILSVQIEGEGAINLALGQNRSQDVRMNGPVASGNSVRMEAGFPMASGPGLIRMTSPAAVMTPQGGNMSSSMMAPGPNPELQPRTPRPASQSDAMDPLLSGLHIQQQSHPSGSLPPAHHSMQPVPVNRQMNPANFPQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLQTRPLQQHQQQPQGIRPQFTAPTQVPVPPGWNQLPSGALQPPPAQGSLGTMTTNQGWKKAPLPSPMQAQLQARPSLATVQTPSHPPPPYPFGSQQASQAHTNFPQMSNPGQFTAPQMKGLQGGPSRVPTPLQQPHLTNKSPASSPSSFQQGSPASSPTVNQTQQQMGPRPPQNNPLSQGFQQPVSSPGRNPMVQQGNVPPNFMVMQQQPPNQGPQSLHPGLGGMPKRLPPGFSAGQANPNFMQGQVPSTTAATPGNSGALQLQANQNVQHAGGQGAGPPQNQMQVSHGPPNMMQPSLMGIHGNINNQQAGSSGVPQVTLGNMQGQPQQGPPSQLMGMHQQIVPSQGQMAQQQGTLNPQNPMILSRAQLMPQGQMMVNAQNQNLGPSPQRMTPPKQMLPQQGPQMMAPHNQMMGPQGQVLLQQNPMIEQIMTNQMQGNKAQFNSQNQSNVMPGPAQIMRGPTPNMQGNMVQFTGQMSGQMLPQQGPVNNSPSQVMGIQGQVLRPPGPSPHMAQQHTDPVTTANNDVNLSQMMPDVSMQQASMVPPHVQSMQGNSASGSHFSGHGVSFNAPFGGAPNGSQMSCGQNPGFPVNKDVTLTSPLLVNLLQSDISAGHFGVNNKQNNTNANKPKKKKPPRKKKNCHQDLNTPDNRPTGLEEVDQQSLPGEQGINLDTTGPKLPDFSNRPPGYPTQPVEQRPLPQMPPQLMQHVAPPPQPPQQQPQPQLPQQQQPPPPSQPQSQQQQQQQQMMMMLMMQQDPKSIRLPVSQNVHPPRGPLNPDSQRMPVQQSGNVPVMVGLQGPASVPPSPDKQRMPMSVNTPMGSNSRKMVYQENPQNSSSSPLGEMSSLPEASGSEVPSVAGGPNNMPSHLVVSQNQLMMTGPKPGPSPLSATQGATPQQPPVNSLPSSHGHHFPNVAAPTQTSRPKTPNRASPRPYYPQTPNNRPPSTEPSEISLSPERLNASIAGLFPPQINIPLPPRPNLNRGFDQQGLNPTTLKAIGQAPSNLTITNPPNFAAPQAHKLDSVVVNSGKQSNPGTTKRASPSNSRRSSPGSSRKTTPSPGRQNSKAPKLTLASQTSTTMLQNMELPRNVLVGPTPLANPPLPGSFPNNTGLNPQNPTVPVPAMGTVLEDNKESVNIPQDSDCQNAQGRKEQVNTELKVVPTQEAKMAVPEDQSKKDGQPLDPNKLPSVEENKNLMSPAMREAPTSLSQLLDNSGAPNVTIKPPGLTDLEVTPPVVSGEDLRKASVIPTLQDPPSKEPSTSLSSPHSSEPCSTLARSELSEVSSNAAPSIPPVMSRPVSSSSISTPLPPNQITVFVTSNPITTSSNTSAALPTHLQSALMSTVVTMPNVGNKVMVSEGQSAAQSNARPQFITPVFINSSSIIQVMKGSQPSTIPATPLTTNSGLMPPSVAVVGPLHIPQNIKFSSAPVTPNVPSSSPAPNIQTGRPLVLSSRATPVQLPSPPCTSSPVVAPNPSVQQVKELNPDEASPQTNTSADQSTLPPSQPTTVVSSLLTNSPGSSANRRSPVSSSKGKGKVDKIGQILLTKACKKVTGSLEKGEEQYGADGETEGPGLEITTPGLMGTEQCSTELDSKTPTPSAPTLLKMTSSPMAPSSTSTGPILPGGALPTSVRSIVTTLVPSELISTAPTTKGNHGGVTSEPLAGGLVEEKVGSHPELLPSIAPSQNLAPKETPATALQGSVARPELEANAAIASGQSCEPKEIVEKSKTLTSRRNSRTEEPTMASESVENGHRKRSSRPASASSSTKDITGAVQSKRRKSK DIP protein Q9JL19 original sequence version: 107 C855F8777167AD48 dpy30_mouse Protein dpy-30 homolog Dpy30 Dpy-30-like protein protein protein mouse Mus musculus Mouse MESEQMLEGQTQVAENPHSEYGLTDSVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN DIP protein Q99LT0 original sequence version: 109 DIP protein Q99LT0 original sequence version: 104 paxi1_mouse PAX-interacting protein 1 Paxip1 Ptip PAX transactivation activation domain-interacting protein protein protein mouse Mus musculus Mouse MSEPAPEVPEELFREVKYYAVGDIDPQVIQLLKAGKAKEVSYNALASHIISEDGDNPEVGEAREVFDLPVVKPSWVTLSVQCGALLPVNGFSPESCQIFFGLTACLSQVSSEDRSALWALVTFHGGSCQLNLNKKCTHLIVPEPKGEKYERAVKRTSIKIVTPDWVLDCVSEKRRKDEAFYHPRLIIYEEEEEEEEEGDNEEQDSQNEGSTEKSSVASSAVASPAEQPCSPKPRAEVSKGELMFDDSSDSSPEKQERSLNWAPAEAPPLNTAQRRLPQGKGPGLINLCANVPPVPGDILPPDMRGNLMAPGQNLQNSERSEILGTWSPAVRTLRNITNNADIQQINRPSNVAHILQSLSAPTKSLEQQVARGQQGHPNASAVLFGQAKGAPETHVLQQHHPPQQPQQQHPALHLQPQIMQLQQQQQQQQQQQQQPQPYPQPPSHQFPQQVHQHQFSQQQLQFPQQPLHPQQQLHRPQQQLQPFQQQHALQQQLHQLQQQQLQHHQLAQLQQQQQQQHNLLQQQQQQQQLQRLQQQQQMQNQAAHLSQASQALQHQVLPQQPLQLSLQPPPQQQQQQQLFGHDPAVEIPEESFLLGCVFAIADYPEQMSDKQLLATWKRIIQAHGGTVDPTFTSRCTHLLCASQVSSMYTQALRERKRCVTAHWLNTVLKKKKLMPPHRALHFPVAFPPGGKPCSQHIISVTGFVDNDRDDLKLMAYLAGAKYTGYLCRSNTVLICKEPSGLKYEKAKEWRIPCVNAQWLGDILLGNFEALRQVQYSRYTAFNMPDPFVPTPHLVLGLLDAWRTPVKVTAELLMGVRLPPKLKPNEVANIQPSSKRARIEDLPPPTKKLTPELTPLVLFTGFEPVQVQQYIKKLYILGGEVAECTKKCTHLIASKVTRTVKFLTAISVVKHIVTPDWLEECFKRQTFIDEQNYILRDAEAEVLFSFSLEESLKRAHVSPLFKTKYFYITPGICPSLATMKAIVECAGGKVLAKQPSFRKLMEHKQNKSLSEIILISCENDLHLCREYFARGIDVHNAEFVLTGVLTQTLDYESYKFN 86762841515A07AB tp53b_mouse TP53-binding protein 1 Tp53bp1 Trp53bp1 protein protein mouse Mus musculus Mouse MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEEDAGSHFSVLSRHLPNLQMHKENPVLDIVSNPEQSAVEQGDSNSSFNEHLKEKKASDPVESSHLGTSGSISQVIERLPQPNRTSSALAVTVEAASLPEEEKEEEELEEEKEGVGANAPGADSLAAEDSASSQLGFGVLELSQSQDVEEHTVPYDVNQEHLQLVTTNSGSSPLSDVDASTAIKCEEQPTEDIAMIEQPSKDIPVTVQPGKGIHVVEEQNLPLVRSEDRPSSPQVSVAAVETKEQVPARELLEEGPQVQPSSEPEVSSTQEDLFDQSSKTASDGCSTPSREEGGCSPVSTPATTLQLLQLSGQKPLVQESLSTNSSDLVAPSPDAFRSTPFIVPSSPTEQGGRKDEPMDMSVIPVGGEPFQKLHDDEAMETEKPLLPSQPAVSPQASTPVSRSTPVFTPGSLPIPSQPEFSHDIFIPSPSLEEPSDDVKKGGGLHSSSLTVECSKTSESEPKNFTDDLGLSMTGDSCKLMLSTSEYSQSSKMESLGSPRTEEDRENTQIDDTEPLSPVSNSKLPADSENVLVTPSQDDQVEMSQNVDKAKEDETEDRGDCKGREDAVAEDVCIDLTCDSGSQAVPSPATRSEALSSVLDQEEAMDTKEHHPEEGFSGSEVEEVPETPCGSHREEPKEEPMESIPLHLSLTETQSEALCLQKEAPKEECPEAMEVETSVISIDSPQKLQVLDQELEHKDPDTWEEATSEDSSVVIVDVKEPSPRADVSCEPLEEVEKCSDSQSWEGVAPEEEPCAENRLDTPEEKRIECDGDSKAETTEKDAVTEDSPQPPLPSVRDEPVRPDQETQQPQVQEKESPVTVDAEVADDKQLGPEGACQQLEKAPACASQSFCESSSETPFHFTLPKEGDIIPPLTGATPPLIGHLKLEPKRHSTPIGISNYPESTIATSDVTSESMVEINDPLLGNEKGDSESAPEMDGKLSLKMKLVSPETEASEESLQFSLEKPTTAERKNGSTAIAEPVASLQKPVPVFGCIYEAQQEKEAQSEAPPSAPDRANLLHFPSAQEEDKERPDVTPKLRQSEQPVKPVGPVMDDAAPEDSASPVSQQRASQEQRASQEPFSPAEDVMETDLLEGLAANQDRPSKMLMDRPTQSNIGIQTVDHSLCAPETVSAATQTVKSVCEQGTSTAEQNSGKQDATVQTERGSGEKPASAPVDDTESLHSQGEEEFEMPQPPHGHVLHRHMRTIREVRTLVTRVITDVYYVDGTEVERKVTEETEEPIVECQECETEVSPSQTGGSSGDLGDISSFSSKASSSHHTSSGTSLSAIHSSGSSGRGAGPLKGKASGTEAADFALPSSRGGPGKLSPRKGISQTGAPVCEEDGDAGLGIRQGGKAPVTPRGRGRRGRPPSRTTGTRETVVSGPLGVEDISPSMSPDDKSFTRIMPRVPDSTKRTDASSSTLRRSDSPEIPFQAATGSSDGLDSSSSGNSFVGLRVVAKWSSNGYFYSGKITRDVGAGKYKLLFDDGYECDVLGKDILLCDPIPLDTEVTALSEDEYFSAGVVKGHRKESGELYYSIEKEGQRKWYKRMAVILSLEQGNRLREQYGLGPYEAVTPLTKAADISLDNLVEGKRKRRSNISSPVTPTAASSSSTTPTRKATESPRASTGVPSGKRKLPTSEEERSPAKRGRKSATVKPGTVGAAEFVSPCETGDNIGEPSVLEEPRGPLPLNKTLFLGYAFLLTMATTSDKLASRSKLLDGPTGSSEEEEEFLEIPPFNKQYTECQLRAGAGYILEDFNEAQCNTAYQCLLIADQHCRTRKYFLCLASGIPCVSHVWVHDSCHANQLQNYRNYLLPAGYSLEEQRILDWQPRENPFQNLKVLLVSDQQQNFLELWSEILMTGGAASVKQHHSSAHNKDIALGVFDVVVTDPSCPASVLKCAEALQLPVVSQEWVIQCLIVGERIGFKQHPKYKHDYVSH F673EA87B3BA1FDE ash2l_mouse Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2-like protein Ash2l protein protein mouse Mus musculus Mouse MAAAGAGPGPGVSAGPGPGAAASATTAEDRETEPVAAGAGEGPSAAPGAEPSSGEAESGDANLVDVSGLETESSNGKDTLEGTGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSASGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLKQTPHSEIIFYKNGVNQGVAYRDIFEGVYFPAISLYKSCTVSINFGPSFKYPPKDLTYHPMSDMGWGAVVEHTLADVLYHVETEVDGRRSPPWEP DIP protein Q91X20 original sequence version: 52 DIP protein Q91X20 original sequence version: 125 DIP protein Q91X20 original sequence version: 120 BEB2A46B7F3E8BA2 kmt2c_mouse Histone-lysine N-methyltransferase 2C Kmt2c Mll3 Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog protein protein mouse Mus musculus Mouse MSSEEDRSAEQQQPPPAPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKSTVEDEDSMDGLETTETENIVETEIKEQSVEEDAETEVDSSKQPVSALQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRVTPGLTLPWKDQPSNKDIDDNSSGTCEKIQNYAPRKQRGQRKERPPQQSAVSCVSVSTQTACEDQAGKLWDELSLVGLPDAIDVQALFDSTGTCWAHHRCVEWSLGICQMEEPLLVNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHFFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQFFCTTCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSSTQWHHNCLICDTCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDQELDSQLKEDYICMYCKHLGAEIDPLHPGNEVEMPELPTDYASGMEIEGTEDEVVFLEQTVNKDVSDHQCRPGIVPDVQVYTEEPQKSNPLESPDTVGLITSESSDNKMNPDLANEIAHEVDTEKTEMLSKGRHVCEEDQNEDRMEVTENIEVLPHQTIVPQEDLLLSEDSEVASKELSPPKSAPETAAPEALLSPHSERSLSCKEPLLTERVQEEMEQKENSEFSTGCVDFEMTLAVDSCDKDSSCQGDKYVELPAEEESTFSSATDLNKADVSSSSTLCSDLPSCDMLHGYPPAFNSAAGSIMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSNHNTVSPPSWAPDTSEGREIFKPRQLSGSAIWSIKVGRGSGFPGKRRPRGAGLSGRGGRGRSKLKSGIGAVVLPGVSAADISSNKDEEENSMHNTVVLFSSSDKFTLQQDMCVVCGSFGQGAEGRLLACSQCGQCYHPYCVSIKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYTQCAPCASLSSCPVCCRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYMPVSNVPSSDCCDSSLVAQIVTKVKELDPPKTYTQDGVCLTESGMSQLQSLTVTAPRRKRTKPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMDDSREGELMDCDGKSESSPEREAGDDETKGIEGTDAIKKRKRKPYRPGIGGFMVRQRSRTGQGKAKRSVVRKDSSGSISEQLPSRDDGWREQLPDTLVDEPVSVAENTDKIKKRYRKRKNKLEETFPAYLQEAFFGKDLLDTSRQNKLSVDNLSEDAAQLSFKTGFLDPSSDPLLSSSSTSAKPGTQGTADDPLADISEVLNTDDDILGIISDDLAKSVDHSDIGPTTADASSLPQPGVSQSSRPLTEEQLDGILSPELDKMVTDGAILGKLYKIPELGGKDVEDLFTAVLSPATTQPAPLPQPPPPPQLLPMHNQDVFSRMPLMNGLIGPSPHLPHNSLPPGSGLGTFPAIAQSPYTDVRDKSPAFNAIASDPNSSWAPTTPSMEGENDTLSNAQRSTLKWEKEEALGEMATVAPVLYTNINFPNLKEEFPDWTTRVKQIAKLWRKASSQERAPYVQKARDNRAALRINKVQMSNDSMKRQQQQDSIDPSSRIDSDLFKDPLKQRESEHEQEWKFRQQMRQKSKQQAKIEATQKLEQVKNEQQQQQQQQQQQQQQQLASQHLLVAPGSDTPSSGAQSPLTPQAGNGNVSPAQTFHKDLFSKHLPGTPASTPSDGVFVKPQPPPPPSTPSRIPVQESLSQSQNSQPPSPQMFSPGSSHSRPPSPVDPYAKMVGTPRPPPGGHSFPRRNSVTPVENCVPLSSVPRPIHMNETSATRPSPARDLCASSMTNSDPYAKPPDTPRPMMTDQFSKPFSLPRSPVISEQSTKGPLTTGTSDHFTKPSPRTDAFQRQRLPDPYAGPSLTPAPLGNGPFKTPLHPPPSQDPYGSVSQTSRRLSVDPYERPALTPRPVDNFSHSQSNDPYSHPPLTPHPAMTESFTHASRAFPQPGTISRSASQDPYSQPPGTPRPLIDSYSQTSGTARSNPDPYSQPPGTPRPNTIDPYSQQPPTPRPSPQTDMFVSSVANQRHTDPYTHHLGPPRPGISVPYSQPPAVPRPRTSEGFTRPSSARPALMPNQDPFLQAAQNRVPGLPGPLIRPPDTCSQTPRPPGPGRIDTFTHASSSAVRDPYDQPPVTPRPHSESFGTSQVVHDLVDRPVPGSEGNFSTSSNLPVSSQGQQFSSVSQLPGPVPTSGGTDTQNTVNMSQADTEKLRQRQKLREIILQQQQQKKIASRQEKGPQDTAVVPHPVPLPHWQPESINQAFTRPPPPYPGSTRSPVIPPLGPRYAVFPKDQRGPYPPEVAGMGMRPHGFRFGFPGAGHGPMPSQDRFHVPQQIQGSGIPPHIRRPMSMEMPRPSNNPPLNNPVGLPQHFPPQGLPVQQHNILGQAFIELRHRAPDGRSRLPFAASPSSVIESPSHPRHGNFLPRPDFPGPRHTDPIRQPSQCLSNQLPVHPNLEQVPPSQQEQGHPAHQSSIVMRPLNHPLSGEFSEAPLSTSTPAETSPDNLEIAGQSSAGLEEKLDSDDPSVKELDVKDLEGVEVKDLDDEDLENLNLDTEDGKGDDLDTLDNLETNDPNLDDLLRSGEFDIIAYTDPELDLGDKKSMFNEELDLNVPIDDKLDNQCASVEPKTRDQGDKTMVLEDKDLPQRKSSVSSEIKTEALSPYSKEEIQSEIKNHDDSRGDADTACSQAASAQTNHSDRGKTALLTTDQDMLEKRCNQENAGPVVSAIQGSTPLPARDVMNSCDITGSTPVLSSLLSNEKCDDSDIRPSGSSPPSLPISPSTHGSSLPPTLIVPPSPLLDNTVNSNVTVVPRINHAFSQGVPVNPGFIQGQSSVNHNLGTGKPTNQTVPLTNQSSTMSGPQQLMIPQTLAQQNRERPLLLEEQPLLLQDLLDQERQEQQQQRQMQAMIRQRSEPFFPNIDFDAITDPIMKAKMVALKGINKVMAQNSLGMPPMVMSRFPFMGPSVAGTQNNDGQTLVPQAVAQDGSITHQISRPNPPNFGPGFVNDSQRKQYEEWLQETQQLLQMQQKYLEEQIGAHRKSKKALSAKQRTAKKAGREFPEEDAEQLKHVTEQQSMVQKQLEQIRKQQKEHAELIEDYRIKQQQQQQQCALAPPILMPGVQPQPPLVPGATSLTMSQPNFPMVPQQLQHQQHTAVISGHTSPARMPSLPGWQSNSASAHLPLNPPRIQPPIAQLSLKTCTPAPGTVSSANPQNGPPPRVEFDDNNPFSESFQERERKERLREQQERQRVQLMQEVDRQRALQQRMEMEQHCLMGAELANRTPVSQMPFYGSDRPCDFLQPPRPLQQSPQHQQQIGPVLQQQNVQQGSVNSPPNQTFMQTNEQRQVGPPSFVPDSPSASGGSPNFHSVKPGHGNLPGSSFQQSPLRPPFTPILPGTSPVANSNVPCGQDPAVTQGQNYSGSSQSLIQLYSDIIPEEKGKKKRTRKKKKDDDAESGKAPSTPHSDCAAPLTPGLSETTSTPAVSSPSELPQQRQQEPVEPVPVPTPNVSAGQPCIESENKLPNSEFIKETSNQQTHVNAEADKPSVETPNKTEEIKLEKAETQPSQEDTKVEEKTGNKIKDIVAGPVSSIQCPSHPVGTPTTKGDTGNELLKHLLKNKKASSLLTQKPEGTLSSDESSTKDGKLIEKQSPAEGLQTLGAQMQGGFGGGNSQLPKTDGASENKKQRSKRTQRTGEKAAPRSKKRKKDEEEKQAMYSSSDSFTHLKQQNNLSNPPTPPASLPPTPPPMACQKMANGFATTEELAGKAGVLVSHEVARALGPKPFQLPFRPQDDLLARAIAQGPKTVDVPASLPTPPHNNHEELRIQDHYGDRDTPDSFVPSSSPESVVGVEVNKYPDLSLVKEEPPEPVPSPIIPILPSISGKNSESRRNDIKTEPGTLFFTSPFGSSPNGPRSGLISVAITLHPTAAENISSVVAAFSDLLHVRIPNSYEVSNAPDVPPMGLVSSHRVNPSLEYRQHLLLRGPPPGSANPPRLATSYRLKQPNVPFPPTSNGLSGYKDSSHGPAEGASLRPQWCCHCKVVILGSGVRKSCKDLTFVNKGSRENTKRMEKDIVFCSNNCFILYSSAAQAKNSDNKESLPSLPQSPMKEPSKAFHQYSNNISTLDVHCLPQFQEKVSPPASPPISFPPAFEAAKVESKPDELKVTVKLKPRLRTVPVGLEDCRPLNKKWRGMKWKKWSIHIVIPKGTFKPPCEDEIDEFLKKLGTCLKPDPVPKDCRKCCFCHEEGDGLTDGPARLLNLDLDLWVHLNCALWSTEVYETQAGALINVELALRRGLQMKCVFCHKTGATSGCHRFRCTNIYHFTCATKAQCMFFKDKTMLCPMHKPKGIHEQQLSYFAVFRRVYVQRDEVRQIASIVQRGERDHTFRVGSLIFHTIGQLLPQQMQAFHSPKALFPVGYEASRLYWSTRYANRRCRYLCSIEEKDGRPVFVIRIVEQGHEDLVLSDSSPKDVWDKILEPVACVRKKSEMLQLFPAYLKGEDLFGLTVSAVARIAESLPGVEACENYTFRYGRNPLMELPLAVNPTGCARSEPKMSAHVKRFVLRPHTLNSTSTSKSFQSTVTGELNAPYSKQFVHSKSSQYRRMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAPNCVAEVVTFERGHKIIISSNRRIQKGEELCYDYKFDFEDDQHKIPCHCGAVNCRKWMN DIP protein Q8BRH4 original sequence version: 121 0B896490B081BA6C kmt2d_mouse Histone-lysine N-methyltransferase 2D Kmt2d ALL1-related protein Mll2 Mll4 Myeloid/lymphoid or mixed-lineage leukemia protein 2 protein protein mouse Mus musculus Mouse MDSQKPPAEDKDSDPAADGLAAPEKPGATEPDLPILCIGEVSVPGSGGSRPQKPPHDCSRGPARRCALCNCGEPGLHGQRELQRFELPSDWPGFPVVPSGGNSGPCEAVLPKEDASQIGFPEGLTPAHLGEPGGHCWAHHWCAAWSAGVWGQEGPELCGVDKAIFSGISQRCSHCARFGASVPCRSPGCSRLYHFPCATASGSFLSMKTLQLLCPEHSDGAAHLEEARCAVCEGPGQLCDLLFCTSCGHHYHGACLDTALTARKRASWQCPECKVCQSCRKPGNDSKMLVCETCDKGYHTFCLKPPMEDLPAHSWKCKTCRLCRACGAGSAELNPNSEWFENYSLCHRCHKAQGSQPVTSVAEQHPAVCSRLSPPEPGEIPIDAPDALYVACQGQPKGGHVTSMQPKELAPLQCEAKPLGRAGTQLEAQLEAPLHEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPTEESPLSPPPESSPFSPLEGCPPSPALDTPLSPPPEASPLSPPFEESPLSPPPEELPSSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEDSPLSPPPEASRLSPPPEDSPMSPPPEDSPMSPPPEVSRFLPLPVLSHLSPLPEVSRLSPPPEESPLSPPPEDSPASPPPEASRLSPPPEDSPASPPPEASRLSRPREDSPASPPPEDSLVSLPMEESPLSPLPEELRLCPQPEEPYLSPQPEEPRLCPQPEELPLSPQSEEPCLSPVLVEPGPSSQPEEPHLSPVPQEPHLSPQPEEPHLSPQPQQLHLSPHSEEPCLSPMPEEPCLSPQPEELNGPPQPAEPPEEPSQSSAPKELSLFSPSGEPPLPPMLGEPALSEPGEPPLSPLPEELPLSLSGEPVLSPQLMPPDPLPPPLSPIIPAAAPPALSPLGELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPGSPLGPASPILMERLPPPCSPLLPHSLPPPTPPPSHCSPPALPLSVPSPLSPVQKAVDVSDEAELHEMETDKGPEPECPALEPRATSPLPSPLGDLSCPAPSPAPALDDFSGLGEDTAPLDGTGQMSGSLAGELKGSPVLLDPEELTPVTPMEVYGPECKQAGQGSPCEEQEEPGAPMAPMPPTLIKSDIVNEISNLSQGDASASFPGSEPLLGSPDPEGGGSLSMELGVSTDVSPARDEGSLRLCTDSLPETDDSLLCDTGTATSGGKAEGDKGRRRSSPARSRIKQGRSSSFPGRRRPRGGAAHGGRGRGRARLKSTTSSVETLVADIDSSPSKEEEEEDDDTMQNTVVLFSNTDKFVLMQDMCVVCGSFGRGAEGHLLACSQCSQCYHPYCVNSKITKVMLLKGWRCVECIVCEVCGQASDPSRLLLCDDCDISYHTYCLDPPLLTVPKGGWKCKWCVSCMQCGAASPGFHCEWQNSYTHCGPCASLVTCPVCHAPYVEEDLLIQCRHCERWMHAGCESLFTEDEVEQAADEGFDCVSCQPYVVKPVVPVAPPELVPVKVKEPEPQFFRFEGVWLTETGMAVLRNLTMSPLHKRRQRRGRLGLPGEAGLEGSEPSDALGPDDKKDGDLDTDDLLKGEGGVEQMECEIKLEGPASPDVELGKEETEESKKRKRKPYRPGIGGFMVRQRKSHTRVKRGPAAQAEVLSGDGQPDEVMPADLPAEGSVEQSLAEGDEKKKQQRRARKKSKLEDMFPAYLQAAFFGKDLLDLSRKALFAVGVGRPGFGLGASKPRADGGSDRKELMTAMHKGDDGPDVADEESHGPEGTADLPGLEDGGVKASPVPSDPEKPGTPGEGVLSSDLDRIPTEELPKMESKDLQQLFKDVLGSEREQHLGCGTPGLEGGRTSLQRPFLQGGLALGSLPSSSPMDSYPGLCQSPFLDSRERGGFFSPEPGEPDSPWTGSGGTTPSTPTTPTTEGEGDGLSYNQRSLQRWEKDEELGQLSTISPVLYANINFPNLKQDYPDWSSRCKQIMKLWRKVPAADKAPYLQKAKDNRAAHRISKVQKQAESQISKQAKMGDIARKTDRPALHLRIPSQPGALGSPPPAAAPTIFLGSPTTPAGLSTSADGFLKPPAGTVPGPDSPGELFLKLPPQVPAQVPSQDPFGLAPAYAPEPRFSAAPPTYPPYPSPTGAPAQPPMLGTTTRPGTGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVAGGKASEPLLSPPPFGESRKSLEVKKEELGASSPGYGPPNLGCVDSPSAGPHLGGLELKAPDVFKAPLTPRASQVEPQSPGLGLRAQEPPPAQALAPSPPSHPDVFRSGPYPDPYAQPPLTPRPQPPPPESCCAPPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHKPPRPQPPEVAFKAGPLAHTPLGAGGFPAALPSGPAGELHAKVPSGQPTNFARSPGTGTFVGTPSPMRFTFPQGVGEPSLKPPVPQPGLPSPHGINSHFGPGPTLGKPQSTNYAVATGNFHPSGSPLGPNSGPTGEGYGLSPLRPASVLPPPAPDGSLPYLTHGASQRVGITSPVEKREDPGATMSSSSLATPELSSAQDAGISSLSQTELEKQRQRQRLRELLIRQQIQRNTLRQEKETAAAAAGAVGPPGNWGAEPSSPAFEQLSRGQTPFTGSQDRSSIVGLPASKLGGPTLGPGAFSSDDRLARPLPPATPSSMDMNSRQLVGGSQAFYQRTPYPGSLPLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLWQQQQQQQQQQQQQAAAAAAATSMRLAMSARFPSTPGPELGRQALGSPLAGIPTRLPGPAEPVPGPAGPAQFIELRHNVQKGLGPGVSPFPGQGPPQRPRFYPVSEELHRLAPEGLRGLAVPGLPSQKPSALPAPELNNSLHQTPHAKGPALASGLELVSRPPSNTELSRPPLALEAGKLPCEDPELDDDFDAHKALEDDEELAHLGLGVDVAKGDDELGTLENLETNDPHLDDLLNGDEFDLLAYTDPELDTGDKKDIFNEHLRLVESANEKAEREALLRGVEPVSLGPEERPPPAPDNSEPRLTSVLPEVKPKVEEGGRHPSPCQFTINTPKVEPAPPATSLSLGLKPGQTVMGTRDTRGGVGTGSFPSSGHTAEKGPFGATGGTPAHLLNPSSLSGPAASSLLEKFELESGALTLPSGHAAAGDELDKMESSLVASELPLLIEDLLEHEKKELQKKQQLSAQTVLPAQQQQQQQQQQQQQQQQHTLLPTPGPAQALPLPHEPGPPQQLALGIGSTRQPGLGQSMVPIQPPAHALQQRLAPSVAMVSNQGHMLSGQQAGQTGLVPQQSSQPVLAQKPMSAMPASMCMKPQQLAMQQQQLANSFFPDTDLDKFAAEDIIDPIAKAKMVALKGIKKVMAQGSIGVAPGMNRQQVSLLAQRLSGGSGSDLQNHVAPGSGQERNAGDPAQPRPNPPTFAQGVINEADQRQYEEWLFHTQQLLQMQLKVLEEQIGVHRKSRKALCAKQRTAKKAGREFPEADAEKLKLVTEQQSKIQKQLDQVRKQQKEHTNLMAEYRNKQQQQQQQQQQQQQQQHSAVLAVSPSQNPRVLTKLPGQLLPAHGLQPPQAPPGGQAGGLRLPPGGMVLPGQSGGPFLNTTLAQQQQQQHSGVAGSLTGPPGSFFPGNLALRSLGPDSRLLQERQLQLQQQRMQLAQKLQQQQQQQQQQQQQQHLLGQVAIQQQQGPGVQNQALGPKPQGLLPPSNHQGLLVQQLSPQQSQGSQGLLGPAQVTVLQQQQQQQQHSGALGPQGPHRQVLMTQSRVLSSPQLAQQGHSLMGHRLLTAQQQQQQQQQQQQQQQQQQQQQQQQQGSMTGLSQLQQGMMSHGGQPKMSAQALGSLQQQQQQLQQQQMLQQQQLQQQQQQLQQQQQQQQLQQQQQQQLQLQQQQQQQQQHLQHQQQQQQQLQQQQQLQQQQQQQLHLQQQLHQQQQLQLQQQQMGLLNQNRTLLSPQQQQQQQQQQQQQQQQQQQQQQQQQQVTLGPGLPVKPLQHFSSSGALGPTLLLTGKEQNNAETALPSEVTEGPSTHQGGPPAVGTAPEPMSVEPGEVKPSISGDSQLLLVQSQAQSQATSVQLQPPLRLPGQPQPQVNLLHTAGGGSHGQQLGSGSSSESPAVPHLLAQPSVSLGEQPGPMAQNLLGSQQPLGLDRPIQNNTGSQPPKSGPAPQSGQGPPGAGVMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPFQEPGTQPSPLQGLLGCQPQPGGFSVSQTGPLQELGAGSRPQGPPRLPVPQGALSTGPVLGPAHPTPPPSSPQEPKRPSQLPSPSAQLTPTHPGTPKPQGPALELPPGRVSPAAAQLADTFFGKGLGPWDPSDNLTEAQKPEQSSLVPGHLDQVNGQVVHEPSQLSIKQEPREEPCALGAQTVKREANGEPAGAPGTSNHLLLAGSRSEAGHLLLQKLLRAKNVQLGAGRGPEGLRAEINGHIDSKLSGLEQKLQGTSSNKEDAATRKPLPAKPKRVQKTSDRLPSSRKKLRKEDGVRANEALLKQLKQELSQLPLTEPTITANFSLFAPFGSGCLVSGQSQLRGAFGSGALHTGPDYYSQLLTKNNLSNPPTPPSSLPPTPPPSVQQKMVNGVTPSDELGERPKDTASAQDSEGALRDAAEVKSLDLLAALPTPPHNQTEDVRMESDEDSDSPDSIVPASSPESILGEEAPRFPQLGSGRWEQDNRALSPVIPIIPRTGIPVFPDTKPYGVLDLEVPGKLPATAWEKGKGSEVSVMLTVSAAAAKNLNGVMVAVAELLSMKIPNSYEVLFPDGPARAGLEPKKGEAEGPGGKEKGLSGKGPDTGPDWLKQFDAVLPGYTLKSQLDILSLLKQESPAPEPSIQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPAEPMVELQAERPAEPPIPSPLPLASSPESARPKPRARPPEESEDSRPPRLKKWKGVRWKRLRLLLTIQKGSGHQEDEREVAEFMEQFGTALRPSKVPRDNRRCCFCHEEGDGATDGPARLLNLDLDLWVHLNCALWSTEVYETQGGALMNVEVALHRGLLTKCSLCQRTGATSSCNRMRCPNVYHFACAIRAKCMFFKDKTMLCPVHKIKGPCEQELSSFAVFRRVYIERDEVKQIASIIQRGERLHMFRVGGLVFHAIGQLLPHQMADFHSATALYPVGYEATRIYWSLRTNNRRCCYRCSISENNGRPEFVIKVIEQGLEDLVFTDASPQAVWNRIIEPVAAMRKEADMLRLFPEYLKGEELFGLTVHAVLRIAESLPGVESCQNYLFRYGRHPLMELPLMINPTGCARSEPKILTHYKRPHTLNSTSMSKAYQSTFTGETNTPYSKQFVHSKSSQYRRLRTEWKNNVYLARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGIYMFRINNEHVIDATLTGGPARYINHSCAPNCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQFDFEDDQHKIPCHCGAWNCRKWMN 37A0E5D319A5F1A6 paxip1-ash2l-6 2 17 unspecified role unspecified role bait bait c-terminus gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range 12 unspecified role unspecified role prey prey 14 unspecified role unspecified role prey prey 19 unspecified role unspecified role prey prey association association 1B paxip1-ash2l-11 10 17 unspecified role unspecified role bait bait nucl transfection nucleic acid transfection nucl transfection n-terminus gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range brct domain 5-6 required to bind necessary binding region required to bind range range certain certain sequence position certain A construct Paxip1/Ptip (delta)BRCT5-6 lacking BRCT domains 5 and 6 retained interaction with Pagr1a/Pa1 but not with Ash2l and Rbbp5. 14 unspecified role unspecified role prey prey 19 unspecified role unspecified role prey prey association association 1D paxip1-pagr1a-1 10 17 unspecified role unspecified role bait bait nucl transfection nucleic acid transfection nucl transfection n-terminus gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range brct comain 1-2 required to bind necessary binding region required to bind range range range range A construct Paxip1/Ptip (delta)BRCT3-6 comprising BRCT domains 1 and 2 followed by the Gln-rich sequence and a not further specified NLS sequence also interacted with Pagr1a/Pa1 but not with Ash2l and Rbbp5. A construct Paxip1/Ptip (delta)BRCT1-2 lacking BRCT domains 1 and 2 does not interact with Pagr1a/Pa1 but retains association with Ash2l and Rbbp5. A Paxip1/Ptip mutant trp75arg interacts with Pagr1a/Pa1. 12 unspecified role unspecified role prey prey physical association physical association 1D and 4C, supplementary 5E paxip1-tp53bp1-6 3 17 unspecified role unspecified role neutral component neutral component nucl transfection nucleic acid transfection nucl transfection n-terminus gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain range range region binding region binding-associated region binding region range range range range 18 unspecified role unspecified role neutral component neutral component colocalization colocalization supplemental 2D and supplemental 3A Cells were irradiated paxip1-ash2l-12 8 17 unspecified role unspecified role bait bait nucl transfection nucleic acid transfection nucl transfection n-terminus gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range brct domain 5-6 required to bind necessary binding region required to bind range range certain certain sequence position certain 14 unspecified role unspecified role prey prey 19 unspecified role unspecified role prey prey association association Supplemental 3B paxip1-pagr1a-3 8 17 unspecified role unspecified role bait bait nucl transfection nucleic acid transfection nucl transfection Q6NZQ4:p.Trp165Arg mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain W R Wed May 02 20:15:09 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'trp165arg' Tue Jun 30 19:50:22 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Trp165Arg' n-terminus gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range 12 unspecified role unspecified role prey prey association association Supp 5D pagr1a-paxip1-1 9 17 unspecified role unspecified role neutral component neutral component brct domain 1-2 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain n-terminus tag tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range His-STREP-HA-TEV tagged ecoli Escherichia coli (strain K12) 12 unspecified role unspecified role neutral component neutral component n-terminus tag tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range His-FLAG-HA-TEV-tagged ecoli Escherichia coli (strain K12) direct interaction direct interaction 4E pagr1a-paxip1-2 5 17 unspecified role unspecified role bait bait brct domain 1-2 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain n-terminus tag tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range His-STREP-HA-TEV tagged ecoli Escherichia coli (strain K12) 12 unspecified role unspecified role prey prey n-terminus tag tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range His-FLAG-HA-TEV-tagged ecoli Escherichia coli (strain K12) direct interaction direct interaction 4D paxip1-tp53bp1-7 10 17 unspecified role unspecified role bait bait nucl transfection nucleic acid transfection nucl transfection brct domain 5-6 required to bind necessary binding region required to bind range range range range n-terminus gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range 18 unspecified role unspecified role prey prey physical association physical association supplemental 3C and 4A Weak interaction in the absence of exogenous DNA damage. paxip1-pagr1a-2 1 17 unspecified role unspecified role bait bait nucl transfection nucleic acid transfection nucl transfection n-terminus gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range brct domain 1-2 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain range range A construct Paxip1/Ptip (delta)BRCT3-6 comprising BRCT domains 1 and 2 followed by the Gln-rich sequence and a not further specified NLS sequence also interacted with Pagr1a/Pa1 but not with Ash2l and Rbbp5. A construct Paxip1/Ptip (delta)BRCT1-2 lacking BRCT domains 1 and 2 does not interact with Pagr1a/Pa1 but retains association with Ash2l and Rbbp5. A Paxip1/Ptip mutant trp75arg interacts with Pagr1a/Pa1. 12 unspecified role unspecified role prey prey physical association physical association supplementary 5E pagr1a-paxip1-3 4 17 unspecified role unspecified role neutral component neutral component brct domain 1-2 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain n-terminus tag tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range His-STREP-HA-TEV tagged ecoli Escherichia coli (strain K12) 12 unspecified role unspecified role neutral component neutral component n-terminus tag tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range His-FLAG-HA-TEV-tagged ecoli Escherichia coli (strain K12) direct interaction direct interaction supplemental 5F pagr1a-paxip1-4 6 17 unspecified role unspecified role neutral component neutral component nucl transfection nucleic acid transfection nucl transfection n-terminus gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range 12 unspecified role unspecified role neutral component neutral component colocalization colocalization 6D paxip1-tp53bp1-8 3 17 unspecified role unspecified role neutral component neutral component nucl transfection nucleic acid transfection nucl transfection c-terminus gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range 18 unspecified role unspecified role neutral component neutral component colocalization colocalization supplemental 2D irradiation paxip1-ash2l-13 7 17 unspecified role unspecified role bait bait n-terminus gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range A trp75arg mutation does not change the association 16 unspecified role unspecified role prey prey 20 unspecified role unspecified role prey prey 21 unspecified role unspecified role prey prey 13 unspecified role unspecified role prey prey 12 unspecified role unspecified role prey prey 14 unspecified role unspecified role prey prey 19 unspecified role unspecified role prey prey 15 unspecified role unspecified role prey prey 11 unspecified role unspecified role prey prey association association 1A, 4A, supplemental Fig. 5A, B and C, supplemental Fig. 1i Using a Paxip1/Ptip construct missing BRCT domains 1 and 2 as bait, Pagr1a/PA1 is lost from the association paxip1-pagr1a-4 7 17 unspecified role unspecified role bait bait c-terminus gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range 12 unspecified role unspecified role prey prey brct domain 1-2 required to bind necessary binding region required to bind range range range range association association Fig. 4A and B paxip1-ash2l-14 10 17 unspecified role unspecified role bait bait nucl transfection nucleic acid transfection nucl transfection n-terminus gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range A construct Paxip1/Ptip (delta)BRCT5-6 lacking BRCT domains 5 and 6 retained interaction with Pagr1a/Pa1 but not with Ash2l and Rbbp5. 12 unspecified role unspecified role prey prey 14 unspecified role unspecified role prey prey 19 unspecified role unspecified role prey prey association association 1D, 4Ci