IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation. The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation. Nature genetics 2014 imex curation Thauvin-Robinet C., Lee JS., Lopez E., Herranz-Pérez V., Shida T., Franco B., Jego L., Ye F., Pasquier L., Loget P., Gigot N., Aral B., Lopes CA., St-Onge J., Bruel AL., Thevenon J., González-Granero S., Alby C., Munnich A., Vekemans M., Huet F., Fry AM., Saunier S., Rivière JB., Attié-Bitach T., Garcia-Verdugo JM., Faivre L., Mégarbané A., Nachury MV. Source of OFD1 traced through contributing authors to PMID:12595504 nachury@stanford.edu, christel.thauvin@chu-dijon.fr 14-Jul-2017: Contacted by IntAct-Help. Only protein-protein interactions human-rpe Human retinal pigment epithelium cell line rpe retinal pigmented epithelial cells anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Thauvin-Robinet C., Lee JS., Lopez E., Herranz-Pérez V., Shida T., Franco B., Jego L., Ye F., Pasquier L., Loget P., Gigot N., Aral B., Lopes CA., St-Onge J., Bruel AL., Thevenon J., González-Granero S., Alby C., Munnich A., Vekemans M., Huet F., Fry AM., Saunier S., Rivière JB., Attié-Bitach T., Garcia-Verdugo JM., Faivre L., Mégarbané A., Nachury MV. Source of OFD1 traced through contributing authors to PMID:12595504 nachury@stanford.edu, christel.thauvin@chu-dijon.fr Accepted 2017-JUN-05 AT 16:20 BST AT 16:20 BST by MGT Nature genetics 2014 imex curation The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation. The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation. Nature genetics 2014 imex curation Thauvin-Robinet C., Lee JS., Lopez E., Herranz-Pérez V., Shida T., Franco B., Jego L., Ye F., Pasquier L., Loget P., Gigot N., Aral B., Lopes CA., St-Onge J., Bruel AL., Thevenon J., González-Granero S., Alby C., Munnich A., Vekemans M., Huet F., Fry AM., Saunier S., Rivière JB., Attié-Bitach T., Garcia-Verdugo JM., Faivre L., Mégarbané A., Nachury MV. Source of OFD1 traced through contributing authors to PMID:12595504 nachury@stanford.edu, christel.thauvin@chu-dijon.fr 14-Jul-2017: Contacted by IntAct-Help. Only protein-protein interactions in vitro In vitro pull down pull down anti tag western anti tag western blot anti tag western Thauvin-Robinet C., Lee JS., Lopez E., Herranz-Pérez V., Shida T., Franco B., Jego L., Ye F., Pasquier L., Loget P., Gigot N., Aral B., Lopes CA., St-Onge J., Bruel AL., Thevenon J., González-Granero S., Alby C., Munnich A., Vekemans M., Huet F., Fry AM., Saunier S., Rivière JB., Attié-Bitach T., Garcia-Verdugo JM., Faivre L., Mégarbané A., Nachury MV. Source of OFD1 traced through contributing authors to PMID:12595504 nachury@stanford.edu, christel.thauvin@chu-dijon.fr Accepted 2017-JUN-05 AT 16:20 BST AT 16:20 BST by MGT Nature genetics 2014 imex curation The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation. The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation. Nature genetics 2014 imex curation Thauvin-Robinet C., Lee JS., Lopez E., Herranz-Pérez V., Shida T., Franco B., Jego L., Ye F., Pasquier L., Loget P., Gigot N., Aral B., Lopes CA., St-Onge J., Bruel AL., Thevenon J., González-Granero S., Alby C., Munnich A., Vekemans M., Huet F., Fry AM., Saunier S., Rivière JB., Attié-Bitach T., Garcia-Verdugo JM., Faivre L., Mégarbané A., Nachury MV. Source of OFD1 traced through contributing authors to PMID:12595504 nachury@stanford.edu, christel.thauvin@chu-dijon.fr 14-Jul-2017: Contacted by IntAct-Help. Only protein-protein interactions human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Thauvin-Robinet C., Lee JS., Lopez E., Herranz-Pérez V., Shida T., Franco B., Jego L., Ye F., Pasquier L., Loget P., Gigot N., Aral B., Lopes CA., St-Onge J., Bruel AL., Thevenon J., González-Granero S., Alby C., Munnich A., Vekemans M., Huet F., Fry AM., Saunier S., Rivière JB., Attié-Bitach T., Garcia-Verdugo JM., Faivre L., Mégarbané A., Nachury MV. Source of OFD1 traced through contributing authors to PMID:12595504 nachury@stanford.edu, christel.thauvin@chu-dijon.fr Accepted 2017-JUN-05 AT 16:20 BST AT 16:20 BST by MGT Nature genetics 2014 imex curation The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation. The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation. Nature genetics 2014 imex curation Thauvin-Robinet C., Lee JS., Lopez E., Herranz-Pérez V., Shida T., Franco B., Jego L., Ye F., Pasquier L., Loget P., Gigot N., Aral B., Lopes CA., St-Onge J., Bruel AL., Thevenon J., González-Granero S., Alby C., Munnich A., Vekemans M., Huet F., Fry AM., Saunier S., Rivière JB., Attié-Bitach T., Garcia-Verdugo JM., Faivre L., Mégarbané A., Nachury MV. Source of OFD1 traced through contributing authors to PMID:12595504 nachury@stanford.edu, christel.thauvin@chu-dijon.fr 14-Jul-2017: Contacted by IntAct-Help. Only protein-protein interactions mouse-imcd3 Mouse inner medullary collecting duct (mIMCD3) cells imcd3 Immortalized inner medullary collecting duct cells immortalized cells from the inner medullary collecting duct cells fluorescence imaging fluorescence microscopy fluorescence imaging tag fluorescence tag visualisation by fluorescence tag fluorescence Thauvin-Robinet C., Lee JS., Lopez E., Herranz-Pérez V., Shida T., Franco B., Jego L., Ye F., Pasquier L., Loget P., Gigot N., Aral B., Lopes CA., St-Onge J., Bruel AL., Thevenon J., González-Granero S., Alby C., Munnich A., Vekemans M., Huet F., Fry AM., Saunier S., Rivière JB., Attié-Bitach T., Garcia-Verdugo JM., Faivre L., Mégarbané A., Nachury MV. Source of OFD1 traced through contributing authors to PMID:12595504 nachury@stanford.edu, christel.thauvin@chu-dijon.fr Accepted 2017-JUN-05 AT 16:20 BST AT 16:20 BST by MGT Nature genetics 2014 imex curation ttc8_human Tetratricopeptide repeat protein 8 TTC8 BBS8 Bardet-Biedl syndrome 8 protein protein protein human Homo sapiens Human MSSEMEPLLLAWSYFRRRKFQLCADLCTQMLEKSPYDQEPDPELPVHQAAWILKARALTEMVYIDEIDVDQEGIAEMMLDENAIAQVPRPGTSLKLPGTNQTGGPSQAVRPITQAGRPITGFLRPSTQSGRPGTMEQAIRTPRTAYTARPITSSSGRFVRLGTASMLTSPDGPFINLSRLNLTKYSQKPKLAKALFEYIFHHENDVKTIHLEDVVLHLGIYPFLLRNKNHIEKNALDLAALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYVAAQKSEAAFPDHVDTQHLIKQLRQHFAML DIP protein Q8TAM2 original sequence version: 114 DIP protein Q8TAM2 original sequence version: 85 013CFB0FDEBF385B c2cd3_human C2 domain-containing protein 3 C2CD3 protein protein human Homo sapiens Human MKQRKGQGSGGSRGRKKRGLSDISPSTSLPPLVEGQLRCFLKLTVNRVIWKIAKPPTCVLVRVRWWGETSDGTLFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDGLPIGRVQINGLAQLSPTHQINGFFTIVSSTSKKLGELQVSLALEPLSETYDSYHPLPTTDMTENVLLSKQGFRENTEPSSTQFQVPSRPRDIHTIKIDGKELAANSSRSTTPRGKDHVCFAENPDTIKDSSFGLQHSLNSGQSLESVTLKGRAPRKQMSLLNSSEFQPQIRTVAKSHSDSCILSSNNLPTKDLLSALLEQGNKLRNAMVISAMKSSPETSMLLDQVHPPINEDSLRASTQIRAFSRNRFKDHIEDHLLPSTENTFWRHDTKADTRAIQLLLGSAELSQGNFWDGLGSPPDSPSPGSDVYCISELNDPQYDQSLLENLFYTAPKSDTSISDFLSEEDDIVPSKKISQSTALARSSKVLESSDHKLKKRSAGKRNRNLVEQQMLSETPEDAQTMTLSVDRLALLGRTHSVRIIIETMGVPPDSPQMTPGKKSYAGPPPKVTTAKKRTFFVEYHFPVGFSESGLGKTALITEVVRLASSKITDGKVKFQQRFVFPVQFGGPMIEHWWNSNLTFQIYVKKTPQKKPEVIGSVSLSLRAVIQSELLSFSDQLPVQQENGQSPFGPLKVTMELITDNKDFTGINTKLSGNTHYTPLCAPTSPNKALPELNQDMTCTKNPQNLNQIHEETAKKAQNLVLPNRKSPSPVAPHPSTFVATPASHNLVNQTNGTTKESALLLHVLLMVPDGKDFISGESEKQSPCNVYLNCKLFSTEEVTRSVIAWGTTQPVFNFSQVIPVSLSSKYLERLKNNVMVIETWNKVRSPGQDKLLGLVKLPLHQFYMSFKDAKISRLLLDAQYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSNQIMALQRLKNEEGTLPPFSPRPAHFLDQPTAASVAMAEDRGNGLMEHCFEIHIEMVKGLAPLQATVWGEADCYVQYYFPVQHSQSSVLKGPEFLENGITLKPFRTATTLCVPDPIFNSEHHHSLLLPAEVPVQRLLLSAFSAQGLVPGGGVQFEIWCRYYYPNVRDQKVAKGTLPLSRICAMVTTQHREDVGIQTFNLPLTPRIENRKELRNQSSGLLDVGLRYRRSPRTAEGVLAARTVSISVQIIRACGLQAAAKALAEREPALQFSATVGVNASVTTHLSFLPQGEQRRTHPVACSFCPEFSHHVEFTCNLVTQHCSGEACFLAELLEFAEVIFAVYHENTKSASDIISIESCKEYLLGVVKVPTKELLIKRSGITGWYPIILPEDGGLPHGLELMQKIVGGLELSISFTHRGDRERVLEAAEHLGWSFENSLKDFVRMDEGEPATVTISTPRLWLPIHCVLLAGHNHIHKNTYCYLRYKFYDHEAFWTPLKKPKESVNKKQIMVTFKASKRAEVTRGPSLLWYFREERLEIQVWRAYGNDSVERPHQTDSWIGSAYVDLARLGERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSLSSHLEPTHELDSMDCSSHSESEQLPRRNDEVQLSPPEVISCHQKSPASTQVPCSSTTAEVRLTQEGPADLDGTFAVSILVERAMHLSLKGSPLTERKVSIPSCCVSFATADESSPVYTQVVENTDSPIWNFQQQSRLSKELLLDPQQTLVFKVWHKGDEERVIGFASVDLSPLLSGFQFVCGWYNITDFSGECQGQIKVAVSPLESLIHFKEERQARRGVETSKSLIPIYSPFSFPASDTYAAFSSHMARQTLDQLAHASSKELDFSSPGRSDTTRSQASRHEEHVQNIRRFHESLHLQGEAPLPCDDKLTTSPLSSQTSILTSLRKNLSELDQIQRYFRQKLTKPFLPLSPQTQTAISQHQESCRDHLGPGASSLDPGSQCILEKSSNLVLQVSSLITDLQTITRDSQAALSSHRARSRSNKATTLPDAQDTEALQERCTMPDEPLVRAPDKGTDSPSPPPLEETSNGGRMLHESLRHAVPITRMQSSEDTEAGPAYSDEDYEEDIIEPRTLNEITTVTDKTSPWSSVISDTSEVISPQPDEVQREGPSCPSPGPFCREELMVKSSFLSSPERAVNPHLPRQGSPSQSLVACECEASKARVGGESASANPQPIPCPTLSGAQQSSTFVGWSSPQTDQNKEPKSEAPAENEAATSELGDSADSFKKLPLNLASQSRRENHKGPPIDSSDIRQRQVTTGSETSTKQSLLLPGPIVVPNFFLPPQQLEASLRMLSLSATLPPAATTDQDKSEATRGALSQRPCRPRPNSLPLNLPEEETLRIARIFSSQYSQKD D559291AEB1B0DA1 ofd1_human Oral-facial-digital syndrome 1 protein Protein 71-7A CXorf5 OFD1 protein protein human Homo sapiens Human MMAQSNMFTVADVLSQDELRKKLYQTFKDRGILDTLKTQLRNQLIHELMHPVLSGELQPRSISVEGSSLLIGASNSLVADHLQRCGYEYSLSVFFPESGLAKEKVFTMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHEELDDSW DIP protein O75665 original sequence version: 119 C2BF4376F89E6738 bbs7_human Bardet-Biedl syndrome 7 protein BBS7 BBS2L1 BBS2-like protein 1 protein protein human Homo sapiens Human MDLILNRMDYLQVGVTSQKTMKLIPASRHRATQKVVIGDHDGVVMCFGMKKGEAAAVFKTLPGPKIARLELGGVINTPQEKIFIAAASEIRGFTKRGKQFLSFETNLTESIKAMHISGSDLFLSASYIYNHYCDCKDQHYYLSGDKINDVICLPVERLSRITPVLACQDRVLRVLQGSDVMYAVEVPGPPTVLALHNGNGGDSGEDLLFGTSDGKLALIQITTSKPVRKWEIQNEKKRGGILCIDSFDIVGDGVKDLLVGRDDGMVEVYSFDNANEPVLRFDQMLSESVTSIQGGCVGKDSYDEIVVSTYSGWVTGLTTEPIHKESGPGEELKINQEMQNKISSLRNELEHLQYKVLQERENYQQSSQSSKAKSAVPSFGINDKFTLNKDDASYSLILEVQTAIDNVLIQSDVPIDLLDVDKNSAVVSFSSCDSESNDNFLLATYRCQADTTRLELKIRSIEGQYGTLQAYVTPRIQPKTCQVRQYHIKPLSLHQRTHFIDHDRPMNTLTLTGQFSFAEVHSWVVFCLPEVPEKPPAGECVTFYFQNTFLDTQLESTYRKGEGVFKSDNISTISILKDVLSKEATKRKINLNISYEINEVSVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQIHEGNTNFLIPEYHCILEEADHLQEEYKKQPAHLERLYGMITDLFIDKFKFKGTNVKTKVPLLLEILDSYDQNALISFFDAA DIP protein Q8IWZ6 original sequence version: 95 DIP protein Q8IWZ6 original sequence version: 66 A7856647969713FF c2cd3_mouse C2 domain-containing protein 3 Hty C2cd3 Protein hearty protein protein mouse Mus musculus Mouse MKQRKGQGPGGGRGRKKRGLSDISPSTSLPPLVEGQLRCFLKLTINKVVWKIAKPPTSVLVRVRWWGETSDGTLFCPRDALQTEPKAVRTTTRYGIRCGPKQFTSYLTDMAVLVLEVITKFDHLPVGRVQISGLAQLSPTHQINGFFTIVSPASKKLGELQVSLALEPLSETYDSYKPLPATEVTKNVLLSERELRENTESSNTQSMIPSRSCRGPAIKIDGKELAGHSSRSTTPRGKDHLYFAENSDAVKGSLCGLQQHLNQGTNVETITLRGKAPQKQLSLLNSSEFQPQISTVAKSHSDSCILSSNTPPAKDLLSALLEQGNKLRNAMLISAMNSNPDTSMLLDKVPPPMTEAIPRSSALNSSENHFKGHSADHLLPLADTGAIQLLLGSAELSQGHFWNGLGSPPDSPTPGSDEYCSSDLNDPQYDQSLLENLFYTVPKSDVGTSELPSEDDGVEPSRTMNQSKASGRSKVVESKEQKQKRAAVKKSRNPIDQQELSRTPGHTPAMSLSVDRLALLGRVHSVRIIVETMGVPPDSPHMTPSRKNFAGKPPKPTAAKKRTFFVEYHFPVGFSKSGLGKTALITEVVRLASSKITDGVVKFQQRFVCPVEFGGPMIEHWWDSNLIFQIYAKKTPQKKPEVIGSASLPLRAVIQSELLSFSSQLPVQQENGLSSLGPLKVTMELVLGHKDFTGISAKLSSSTQPAPVSAATSSDTILPETGQDTACTRNPQSSNKIHEETTKKTQNLVLPDQESANSVASNSSIFMAVPSCNLVHQINGSNKESGLLLHVLLMVPDGKDFVFGEREKQPSCNVYLNCKLFSTEEVTRSVVSWGTAQPVFNFSQVIPVSLTSKCLERLKNNVMIIETWNKVRSPGQDKLLGLVKLPLHQFYMSFKDPKISRLLLDARYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSAQIMMLQRLKNEEGTLPPFSPRPAHFLDQPPVASVAMPEKQGTRLMEHHFEFCVAMVKGLMPLQATVWGEADCYVQYYFPFQDSQPSVLQGPDFLENGITLKPFRTSTTLCVPDPVFNSEHHHSLLLPTDVPVQRLLLSAFSSQGLVPGGGVQFEVWCRYYYPNVRDQMVAKGTLPLSRVCAMVTMQYREDVGMQSFNLPLTSRLEHSKELKNQSSGFLDVGLRYRRSPRTAEGILAARAVSISVHIIRACGLQAAAKALAEQEPALQFSATVGVNASVTAHLSFLPKGEQRQTRPVACSFCPEFSHHIEFPCNLVTQHCSGEACFLAELLEFAEIIFAIYHENTKSVSDITSIQSCKDYLLGIVKVPTKDLLVKRSGITGWYPVILPEDKGLPQDLDLMQKIVGGLELSVSFAHPGDRERVLEAAELLGWSFESIPKDLVKKEEEVPATVTISTPRLWLPIHCVLLAGHMNIHKNTYCYLRYKLYNQEAFWTPLRKPKESTNKNQVLITFKASKRAEVTRSQSLLWYFREEKLEIQVWRAYGNDNLERPHQTDSWIGSAYVDLSRLGEKSPRTLTISGVYPLFGRNASDLSGAALRIHVLLSPLSPHTEPARELDSMDCSSHSESEQHPRKSDALQLSPPHVLQTSPTSTQVHGNSAAAQVCPAQEGPPELAGTFAVSILVERAMHLSLKGSPLTDRKVSVPSCCVSFATATELSPVYTHVVENTDSPIWGFHQQARLSKELLLDPHQTLVFKVWHKGDEERVVGFASVDLSPLLSGFQFICGWYNITDFSGECQGQIKVAISPMESLMHLKEERQARRGIDTPGALIPLFSALSFPASAGCDAFPRPIARHVEGQLAHTSPKEDGLSSPARNGAIRSQAARHEEHVQNIRRFHESLQHGEAVLTSDEKLTTAPSSSHTSILTSLRKNLSELDEIQKYFSQKLSKPFLPFSSQSSPAVSQSQESQRDPVAAGTGRQDPENQCILEKSNHLVSQVSSLISDLQTLTRGSQAALTSQQARSRSRAVTTIPDAQGTEAAGEGSTTLEEPLAGAIEASTDSLPPPVEEPSKGGGMLHESLEQTMPITRVQSIDDTEVGPDYSDEDYEEDIIEPRTLNEITTVTDRTSPWSSFMSDMSEVLSPQPTEVQREGPSCPPEPFPREELKVKSSPQKAVSPQPAQGSPSQSGVCEGGAYKIEVEDLASAKPQPVPSLTFSEAQEGSDSVGWRASQINQVRKPMPEMLAESEAFSSEFSDSSESFETFPLHLPSQSKREDYKDSPAVRQKQVPTGSEVSTRQTLLLPEPVVVPNFFLPPQQLEASLRMISHSPGLPPAATTDQDKSEATRGALAQRPCRPRPYSIPPNLPEEETRRIARIFSSQYSKKTEET 5C0A87CC728245E0 bbs1_human Bardet-Biedl syndrome 1 protein BBS1 BBS2L2 BBS2-like protein 2 protein protein human Homo sapiens Human MAAASSSDSDACGAESNEANSKWLDAHYDPMANIHTFSACLALADLHGDGEYKLVVGDLGPGGQQPRLKVLKGPLVMTESPLPALPAAAATFLMEQHEPRTPALALASGPCVYVYKNLRPYFKFSLPQLPPNPLEQDLWNQAKEDRIDPLTLKEMLESIRETAEEPLSIQSLRFLQLELSEMEAFVNQHKSNSIKRQTVITTMTTLKKNLADEDAVSCLVLGTENKELLVLDPEAFTILAKMSLPSVPVFLEVSGQFDVEFRLAAACRNGNIYILRRDSKHPKYCIELSAQPVGLIRVHKVLVVGSTQDSLHGFTHKGKKLWTVQMPAAILTMNLLEQHSRGLQAVMAGLANGEVRIYRDKALLNVIHTPDAVTSLCFGRYGREDNTLIMTTRGGGLIIKILKRTAVFVEGGSEVGPPPAQAMKLNVPRKTRLYVDQTLREREAGTAMHRAFQTDLYLLRLRAARAYLQALESSLSPLSTTAREPLKLHAVVQGLGPTFKLTLHLQNTSTTRPVLGLLVCFLYNEALYSLPRAFFKVPLLVPGLNYPLETFVESLSNKGISDIIKVLVLREGQSAPLLSAHVNMPGSEGLAAA DIP protein Q8NFJ9 original sequence version: 88 DIP protein Q8NFJ9 original sequence version: 62 DIP protein Q8NFJ9 original sequence version: 67 DIP protein Q8NFJ9-1 original sequence version: 100 94C0C05667FE582D bbs4_human Bardet-Biedl syndrome 4 protein BBS4 protein protein human Homo sapiens Human MAEERVATRTQFPVSTESQKPRQKKAPEFPILEKQNWLIHLHYIRKDYEACKAVIKEQLQETQGLCEYAIYVQALIFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQYQEMEKKVSLLKDNSSLEFDSEMVEMAQKLGAALQVGEALVWTKPVKDPKSKHQTTSTSKPASFQQPLGSNQALGQAMSSAAAYRTLPSGAGGTSQFTKPPSLPLEPEPAVESSPTETSEQIREK DIP protein Q96RK4 original sequence version: 122 DIP protein Q96RK4 original sequence version: 90 59BC9B29355C8E3C bbs5_human Bardet-Biedl syndrome 5 protein BBS5 protein protein human Homo sapiens Human MSVLDALWEDRDVRFDLSAQQMKTRPGEVLIDCLDSIEDTKGNNGDRGRLLVTNLRILWHSLALSRVNVSVGYNCILNITTRTANSKLRGQTEALYILTKCNSTRFEFIFTNLVPGSPRLFTSVMAVHRAYETSKMYRDFKLRSALIQNKQLRLLPQEHVYDKINGVWNLSSDQGNLGTFFITNVRIVWHANMNDSFNVSIPYLQIRSIKIRDSKFGLALVIESSQQSGGYVLGFKIDPVEKLQESVKEINSLHKVYSASPIFGVDYEMEEKPQPLEALTVEQIQDDVEIDSDGHTDAFVAYFADGNKQQDREPVFSEELGLAIEKLKDGFTLQGLWEVMS DIP protein Q8N3I7 original sequence version: 95 DIP protein Q8N3I7 original sequence version: 69 63D67D877FDFD25B pthb1_human Protein PTHB1 PTHB1 Parathyroid hormone-responsive B1 gene protein Bardet-Biedl syndrome 9 protein BBS9 protein protein human Homo sapiens Human MSLFKARDWWSTILGDKEEFDQGCLCLANVDNSGNGQDKIIVGSFMGYLRIFSPHPAKTGDGAQAEDLLLEVDLRDPVLQVEVGKFVSGTEMLHLAVLHSRKLCVYSVSGTLGNVEHGNQCQMKLMYEHNLQRTACNMTYGSFGGVKGRDLICIQSMDGMLMVFEQESYAFGRFLPGFLLPGPLAYSSRTDSFLTVSSCQQVESYKYQVLAFATDADKRQETEQQKLGSGKRLVVDWTLNIGEQALDICIVSFNQSASSVFVLGERNFFCLKDNGQIRFMKKLDWSPSCFLPYCSVSEGTINTLIGNHNNMLHIYQDVTLKWATQLPHIPVAVRVGCLHDLKGVIVTLSDDGHLQCSYLGTDPSLFQAPNVQSRELNYDELDVEMKELQKIIKDVNKSQGVWPMTEREDDLNVSVVVSPNFDSVSQATDVEVGTDLVPSVTVKVTLQNRVILQKAKLSVYVQPPLELTCDQFTFEFMTPDLTRTVSFSVYLKRSYTPSELEGNAVVSYSRPTDRNPDGIPRVIQCKFRLPLKLICLPGQPSKTASHKITIDTNKSPVSLLSLFPGFASQSDDDQVNVMGFHFLGGARITVLASKTSQRYRIQSEQFEDLWLITNELILRLQEYFEKQGVKDFACSFSGSIPLQEYFELIDHHFELRINGEKLEELLSERAVQFRAIQRRLLARFKDKTPAPLQHLDTLLDGTYKQVIALADAVEENQGNLFQSFTRLKSATHLVILLIALWQKLSADQVAILEAAFLPLQEDTQELGWEETVDAAISHLLKTCLSKSSKEQALNLNSQLNIPKDTSQLKKHITLLCDRLSKGGRLCLSTDAAAPQTMVMPGGCTTIPESDLEERSVEQDSTELFTNHRHLTAETPRPEVSPLQGVSE DIP protein Q3SYG4 original sequence version: 47 8E333B7680243B7A bbs2_human Bardet-Biedl syndrome 2 protein BBS2 protein protein human Homo sapiens Human MLLPVFTLKLRHKISPRMVAIGRYDGTHPCLAAATQTGKVFIHNPHTRNQHVSASRVFQSPLESDVSLLNINQAVSCLTAGVLNPELGYDALLVGTQTNLLAYDVYNNSDLFYREVADGANAIVLGTLGDISSPLAIIGGNCALQGFNHEGSDLFWTVTGDNVNSLALCDFDGDGKKELLVGSEDFDIRVFKEDEIVAEMTETEIVTSLCPMYGSRFGYALSNGTVGVYDKTSRYWRIKSKNHAMSIHAFDLNSDGVNELITGWSNGKVDARSDRTGEVIFKDNFSSAIAGVVEGDYRMDGHIQLICCSVDGEIRGYLPGTAEMRGNLMDTSAEQDLIRELSQKKQNLLLELRNYEENAKAELASPLNEADGHRGIIPANTRLHTTLSVSLGNETQTAHTELRISTSNDTIIRAVLIFAEGIFTGESHVVHPSIHNLSSSICIPIVPPKDVPVDLHLKAFVGYRSSTQFHVFESTRQLPRFSMYALTSLDPASEPISYVNFTIAERAQRVVVWLGQNFLLPEDTHIQNAPFQVCFTSLRNGGHLHIKIKLSGEITINTDDIDLAGDIIQSMASFFAIEDLQVEADFPVYFEELRKVLVKVDEYHSVHQKLSADMADHSNLIRSLLVGAEDARLMRDMKTMKSRYMELYDLNRDLLNGYKIRCNNHTELLGNLKAVNQAIQRAGRLRVGKPKNQVITACRDAIRSNNINTLFKIMRVGTASS DIP protein Q9BXC9 original sequence version: 105 DIP protein Q9BXC9 original sequence version: 79 8FA1CDAED725BEAF ofd1_mouse Oral-facial-digital syndrome 1 protein homolog Ofd1 protein protein mouse Mus musculus Mouse MAQSNMPHKSDVLSQDELRKKLYQTFKDRGVLDTLQTQLRNQLIHELMHPVLSGEVKPPSISVEGSALLIGASNSLVADHLQRCGYEYSLSVFFPESGLAKEKIFTMQDLLQLIRINPSSSLYKSLISGFDKENKKGFLMSFLKELAEYYQAKESCDAETQTSTTFPSQVSLAEKFQLIDAQFADGFPHRSKLESLETKLNEYKKEVQHQLQVEMCHKLKYFREAEITKVKMEERRKYEKELAEFQNEFERTCQAKNEALISQEKNSLERIKKHREMESKEIYAQRQLLLNDIALLRGREAELKERIETFELTQKLQEEKIKSEAEALERREQNLKNIEDTYDQKLKTELLKYQLELKDDYITRTNKLLEEERKNKEKTIHLQEELTVINSKKEELSKSVKHMKEVELELESVKAQFLAISKQNHLLNEKVREMSDYSQLKEEKVELQAQNKLLKLQLEETRNENLRLLDRITQPPPELVIFQKELQKTEKAMELEHKDFETHRQALEKQLQSEIENSAQLRTQIAEYDASVKRLTVQVAELKSQLKQTQIALENEVYRNPKHSLIHSLSGLLLSGKMAPHSEDKSGDFLNVPLEQNKVIAGAVMSRVPPYVNTATEASSPESDFEFIASSTKAKVRELEQEAERLEKAFRTYYQRATQNPSTSPQPAKSPPSVNSVAALRSIASSSMDRPVSAEDRVVSEQPLGDMLKEEMSDMSKAFMGSVVSRPRRTSSSTRLSSTPHPKSRRSLDNEMYLEGLGRLHMTSSSPLLDRVSASPAASPSPCPERTAQASPVPSRHSFSGLPEQNACLYQRQTETQDKSELSNVDKQSLKDEKFEPPFRWNKTEQFEAEGLHPAGDMPGIDFAVATQSSRLISYDYPSAVQSQTGEQDEQELWELHMKERRQREEQRHNERQEALERERRELGKLEQERRMIEESLKMEMEEELEKSVQDQKDKSAHCENTLEKYMKIIQQRQEESNADKSSKKSGKECSLVDMMMPSDKDESSPGFSHEEPDDMW F262319D90A4925B c2cd3-ofd1-1 4 9 unspecified role unspecified role neutral component neutral component region gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 15 immunocytochemistry immunocytochemistry tag fluorescence tag visualisation by fluorescence tag fluorescence unspecified role unspecified role neutral component neutral component colocalization colocalization Fig. 2G ofd1-1 1 7 unspecified role unspecified role bait bait 6 unspecified role unspecified role prey prey physical association physical association 2I ofd1-c2cd3-1 2 7 unspecified role unspecified role bait bait region gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined ecoli Escherichia coli (strain K12) 6 unspecified role unspecified role prey prey region gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human-293ft Homo sapiens HEK293FT cell line 293ft HEK293FT cell line physical association physical association 2j bbs1-c2cd3-1 3 6 unspecified role unspecified role prey prey region gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 10 unspecified role unspecified role bait bait region myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association Supp Fig 2A bbs2-c2cd3-1 3 6 unspecified role unspecified role prey prey region gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 14 unspecified role unspecified role bait bait region myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association Supp Fig 2A bbs4-c2cd3-1 3 6 unspecified role unspecified role prey prey region gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 11 unspecified role unspecified role bait bait region myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association Supp Fig 2A ttc8-c2cd3-1 3 6 unspecified role unspecified role prey prey region gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 5 unspecified role unspecified role bait bait region myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association Supp Fig 2A bbs5-c2cd3-1 3 6 unspecified role unspecified role prey prey region gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 12 unspecified role unspecified role bait bait region myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association Supp Fig 2A bbs9-c2cd3-1 3 6 unspecified role unspecified role prey prey region gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 13 unspecified role unspecified role bait bait region myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association Supp Fig 2A bbs7-c2cd3-1 3 8 unspecified role unspecified role bait bait region myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 6 unspecified role unspecified role prey prey region gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association Supp Fig 2A