IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome. The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome. Molecular cell 2009 imex curation Fabrizio P., Dannenberg J., Dube P., Kastner B., Stark H., Urlaub H., Lührmann R. reinhard.luehrmann@mpi-bpc.mpg.de 11-Apr-2016: Contacted by IntAct-Help. Only protein-protein interactions in vitro In vitro pull down pull down de novo protein sequence de novo protein sequencing by mass spectrometry de novo protein sequence Fabrizio P., Dannenberg J., Dube P., Kastner B., Stark H., Urlaub H., Lührmann R. reinhard.luehrmann@mpi-bpc.mpg.de Accepted 2016-MAR-03 AT 14:14 GMT AT 14:14 GMT by ORCHARD Molecular cell 2009 imex curation I have added features to the actin pre-mRNA and comments for the experimental conditions. I have re-loaded proteins to be sure that only those present in two preparations were added. I have also added the U RNAs (U5 as a single molecule, it' s the first time I see 2 U5) prp45_yeast Pre-mRNA-processing protein 45 YAL032C PRP45 FUN20 protein protein yeast Saccharomyces cerevisiae Baker's yeast MFSNRLPPPKHSQGRVSTALSSDRVEPAILTDQIAKNVKLDDFIPKRQSNFELSVPLPTKAEIQECTARTKSYIQRLVNAKLANSNNRASSRYVTETHQAPANLLLNNSHHIEVVSKQMDPLLPRFVGKKARKVVAPTENDEVVPVLHMDGSNDRGEADPNEWKIPAAVSNWKNPNGYTVALERRVGKALDNENNTINDGFMKLSEALENADKKARQEIRSKMELKRLAMEQEMLAKESKLKELSQRARYHNGTPQTGAIVKPKKQTSTVARLKELAYSQGRDVSEKIILGAAKRSEQPDLQYDSRFFTRGANASAKRHEDQVYDNPLFVQQDIESIYKTNYEKLDEAVNVKSEGASGSHGPIQFTKAESDDKSDNYGA FE5A724186D7FE84 FE5A724186D7FE84 prp4_yeast U4/U6 small nuclear ribonucleoprotein PRP4 PRP4 RNA4 YPR178W P9705.6 Pre-mRNA-processing protein 4 protein protein yeast Saccharomyces cerevisiae Baker's yeast MSKYIALENLPVDLQHKGATQNESTADILKQLPHERLQAVLEKIPEEDLEVRRLLSILKKPEVVENEDVQQRRIRLAEILMVDEIDLENINNMENINGEEVDEEDDEDFFTPATSELIFARRFLINYSLERSRKRLQKEMERHQKFNTRQELLSRRTELQRMANLELAGSQLVSTKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 7CCCA3A92AC0CE78 7CCCA3A92AC0CE78 rse1_yeast Pre-mRNA-splicing factor RSE1 RSE1 YML049C YM9827.03C SAP130 RNA splicing and ER to Golgi transport factor 1 Spliceosome-associated protein 130 protein protein yeast Saccharomyces cerevisiae Baker's yeast MWGGGKMAVVSLSPHTAKMRKLFGQASTTMAYDGLKREAERRTRSDHNITMVAKDDELYLYHLTLKKQTNFVHSCIGHFVDLEAGSKREQSQLCVATETHLELYDTADGELKLIAKFQNLFATITSMKSLDLPHSGSRAKASNWPTFLALTSDSGNLSIVQIIMHAGALRLKTLVNQPLTRTTLRRVSPISYMEIDPNGRCIILSSVEQNKLCFLVDYAQKLRISSPLEIIRPHMVTLDMAVVDVNFNNPCFVTLEIDNAATQLSVHLIFYVLELGLNHIVKKADYLVNPSANFVLSLPDLSRYNITTSLSDNNYDADYDTLFNPFVVIGFENHILVKDMNGFFSLKVEIPKRSITNSRHKNVTIISGIVQKLKNDFFVLLQSNHGDLFKLTVSPDTNDRNRPLVQLSYFDTIQNSHQLHIFKNGYLFALSEMNNNFLFQFEKLGVEKNDFSNVLTSKDPNKSLVFEPSIKLQNLSILSQQLNLNPSIKSQIVSDSPLSIATKHFTNNKIITLTNAVNYSNLISTSLPPNATKLWLIPDPATTGDNNTLLFITFPKKTMILQIDNESMEELTPDEATRSAFKLSQDTTIHTCLMGSHSIIQVCTAELRHIVPTGKSRYSNKLTWVPPAGIRIVCATSSKTQLIISLSNYELVYFKIDVSSDSLIELTTHPELDTMPSKVAIVQDTQHADLLAIADNEGMIKIMSLKDQKEDFLTVISLQLVSEKISDMIMVRDSSIGQLNLHVGLENGVYMKFHIGDVDGSFTDIKRRFLGLKPVSLSYLREISVSLNNEEEEEEEEDDDDEKEEEEINSSGAKWMSCVVCHSSSTWVSYTWKNVWTIRQLKDQNMLSCSKFVNADVAINGVCSISSSGRLNIGRVSNFPTLDNWFHVHESSVNKQENGGGDESNEEEEDEMEEEMEMLQISTFRPRTILSFPNNPKSILFIDNHSGKKQCRISLQIDGECLKFGSSDHLYKILDDIDCVSAAIIDFTRQADHLIICAGDKRLLTYKILVNKDKLSFDIELLHQTEIISPIHAMLKFKNFLLTAMGSTIVLYGLGKKQLLRRSVTQTPVSITKIVSMHQWNYERLAVGDIHESVTLFIWDPAGNVFIPYVDDSVKRHVTVLKFLDEATVIGADRYGNAWTLRSPPECEKIMSNHDPSELSNGAIKYPLDVITLQQKLPNTYDCKFKFQLLNHFFVNDIITDFHILDSLSNSDRPGCIYMGLQGTVGCFIPLLSKGNVFMMGNIENIMAEADDTFYLDYESRKKNNNMRKEDDEEESGSVVLQGRHGIEDEIICEGSCSILGRDHQEYRSYYAPVRKVIDGDLCENFLRLSLNEQEFLAKNLKSVQVEDIIQTINEVRTNYM 4D92837F5C267D67 4D92837F5C267D67 ruxg_yeast Small nuclear ribonucleoprotein G SNP2 YFL017Bw YFL017W-A SMX2 Sm protein G protein protein yeast Saccharomyces cerevisiae Baker's yeast MVSTPELKKYMDKKILLNINGSRKVAGILRGYDIFLNVVLDDAMEINGEDPANNHQLGLQTVIRGNSIISLEALDAI 5C6208B8C5A9AB33 5C6208B8C5A9AB33 lsm6_yeast U6 snRNA-associated Sm-like protein LSm6 LSM6 D9481.18 YDR378C protein protein yeast Saccharomyces cerevisiae Baker's yeast MSGKASTEGSVTTEFLSDIIGKTVNVKLASGLLYSGRLESIDGFMNVALSSATEHYESNNNKLLNKFNSDVFLRGTQVMYISEQKI 74FE40A4509CEF33 74FE40A4509CEF33 prp11_yeast Pre-mRNA-splicing factor PRP11 PRP11 PRP10 RNA11 YDL043C D2711 protein protein yeast Saccharomyces cerevisiae Baker's yeast MNYLEGVGSKKGGGGIASESQFNLQRRKEVESLLSKGENVPYTFQDEKDDQVRSNPYIYKNHSGKLVCKLCNTMHMSWSSVERHLGGKKHGLNVLRRGISIEKSSLGREGQTTHDFRQQQKIIEAKQSLKNNGTIPVCKIATVKNPKNGSVGLAIQVNYSSEVKENSVDSDDKAKVPPLIRIVSGLELSDTKQKGKKFLVIAYEPFENIAIELPPNEILFSENNDMDNNNDGVDELNKKCTFWDAISKLYYVQFFFKQAEQEQADV D8BA3BB27F36F06F D8BA3BB27F36F06F premrna actin yeast pre-mRNA actin yeast rna ribonucleic acid RNA rna yeast Saccharomyces cerevisiae Baker's yeast AUGGAUUCUGGUAUGUUCUAGCGCUUGCACCAUCCCAUUUAACUGUAAGAAGAAUUGCACGGUCCCAAUUGCUCGAGAGAUUUCUCUUUUACCUUUUUUUACUAUUUUUCACUCUCCCAUAACCUCCUAUAUUGACUGAUCUGUAAUAACCACGAUAUUAUUGGAAUAAAUAGGGGCUUGAAAUUUGGAAAAAAAAAAAAAACUGAAAUAUUUUCGUGAUAAGUGAUAGUGAUAUUCUUCUUUUAUUUGCUACUGUUACUAAGUCUCAUGUACUAACAUCGAUUGCUUCAUUCUUUUUGUUGCUAUAUUAUAUGUUUAGAGGUUGCUGCUUUGGUUAUUGAUAACGGUUCUGGUAUGUGUAAAGCCGGUUUUGCCGGUGACGACGCUCCUCGUGCUGUCUUCCCAUCUAUCGUCGGUAGACCAAGACACCAAGGUAUCAUGGUCGGUAUGGGUCAAAAAGACUCCUACGUUGGUGAUGAAGCUCAAUCCAAGAGAGGUAUCUUGACUUUACGUUACCCAAUUGAACACGGUAUUGUCACCAACUGGGACGAUAUGGAAAAGAUCUGGCAUCAUACCUUCUACAACGAAUUGAGAGUUGCCCCAGAAGAACACCCUGUUCUUUUGACUGAAGCUCCAAUGAACCCUAAAUCAAACAGAGAAAAGAUGACUCAAAUUAUGUUUGAAACUUUCAACGUUCCAGCCUUCUACGUUUCCAUCCAAGCCGUUUUGUCCUUGUACUCUUCCGGUAGAACUACUGGUAUUGUUUUGGAUUCCGGUGAUGGUGUUACUCACGUCGUUCCAAUUUACGCUGGUUUCUCUCUACCUCACGCCAUUUUGAGAAUCGAUUUGGCCGGUAGAGAUUUGACUGACUACUUGAUGAAGAUCUUGAGUGAACGUGGUUACUCUUUCUCCACCACUGCUGAAAGAGAAAUUGUCCGUGACAUCAAGGAAAAACUAUGUUACGUCGCCUUGGACUUCGAACAAGAAAUGCAAACCGCUGCUCAAUCUUCUUCAAUUGAAAAAUCCUACGAACUUCCAGAUGGUCAAGUCAUCACUAUUGGUAACGAAAGAUUCAGAGCCCCAGAAGCUUUGUUCCAUCCUUCUGUUUUGGGUUUGGAAUCUGCCGGUAUUGACCAAACUACUUACAACUCCAUCAUGAAGUGUGAUGUCGAUGUCCGUAAGGAAUUAUACGGUAACAUCGUUAUGUCCGGUGGUACCACCAUGUUCCCAGGUAUUGCCGAAAGAAUGCAAAAGGAAAUCACCGCUUUGGCUCCAUCUUCCAUGAAGGUCAAGAUCAUUGCUCCUCCAGAAAGAAAGUACUCCGUCUGGAUUGGUGGUUCUAUCUUGGCUUCUUUGACUACCUUCCAACAAAUGUGGAUCUCAAAACAAGAAUACGACGAAAGUGGUCCAUCUAUCGUUCACCACAAGUGUUUCUAA lsm5_yeast U6 snRNA-associated Sm-like protein LSm5 LSM5 YER146W protein protein yeast Saccharomyces cerevisiae Baker's yeast MSLPEILPLEVIDKTINQKVLIVLQSNREFEGTLVGFDDFVNVILEDAVEWLIDPEDESRNEKVMQHHGRMLLSGNNIAILVPGGKKTPTEAL 84E8A1E8E2F078FE 84E8A1E8E2F078FE urn1_yeast Pre-mRNA-splicing factor URN1 URN1 U2-U5-U6 snRNP, RES complex and NTC-interacting pre-mRNA-splicing factor 1 YPR152C protein protein yeast Saccharomyces cerevisiae Baker's yeast MRGEWQEFKTPAGKKYYYNKNTKQSRWEKPNLKKGSNLESNAKESQTERKPTFSLELVNGWHLIIYNDGTKLYFNDDSKEFKNDISQEDDSRCRSLIESLDKEKLVLLIGVARGYTMREEDIDKILESCNEEIHLFKRNQDEVERKDEISEEAGDVKSPLQESHTGLVSGYGSSSGEEDEEEDEEEDEENEEQIVNQDISIIDDLNRIDTDDIDERNIFFELFDRYKLDKFSTWSLQSKKIENDPDFYKIRDDTVRESLFEEWCGERSGNATAEESDSEDNSEDDSEVLEPTKYHYLAQIVANAGTIAPDTIPQDIRKQQKALYKAYKIKEYIPSKRDQDKFVSQLLFYYKTFDLEQRKEIFCDCLRDHERDFTGAVESLRQDKELIDRWQTLLKAPADSSSIEDILLSIEHRCCVSPIVVTEPRYYVVGILEKTVVWVRWLAAEVGPSSRFTPVGAGNEPINPE B32285888B7DB772 smd2_yeast Small nuclear ribonucleoprotein Sm D2 SMD2 YLR275W L9328.5 snRNP core protein D2 protein protein yeast Saccharomyces cerevisiae Baker's yeast MSSQIIDRPKHELSRAELEELEEFEFKHGPMSLINDAMVTRTPVIISLRNNHKIIARVKAFDRHCNMVLENVKELWTEKKGKNVINRERFISKLFLRGDSVIVVLKTPVE 7287070B10E090C0 7287070B10E090C0 prp5_yeast Pre-mRNA-processing ATP-dependent RNA helicase PRP5 PRP5 RNA5 YBR237W YBR1603 protein protein yeast Saccharomyces cerevisiae Baker's yeast METIDSKQNINRESLLEERRKKLAKWKQKKAQFDAQKEHQTSRNDIVTNSLEGKQTTEKFTERQERVKEELRKRKNEFRKSDEPVSVKPSKKKSKRSKVKKKISFDFSDDDDSEIGVSFRSKEHIQKAPEHDNEKDPLDEFMTSLKEEKMSNSKGMYDRGDILDVEDQLFELGGTDDEDVEDNTDNSNIAKIAKLKAKKRVKQIYYSPEELEPFQKNFYIESETVSSMSEMEVEELRLSLDNIKIKGTGCPKPVTKWSQLGLSTDTMVLITEKLHFGSLTPIQSQALPAIMSGRDVIGISKTGSGKTISYLLPLLRQVKAQRPLSKHETGPMGLILAPTRELALQIHEEVTKFTEADTSIRSVCCTGGSEMKKQITDLKRGTEIVVATPGRFIDILTLNDGKLLSTKRITFVVMDEADRLFDLGFEPQITQIMKTVRPDKQCVLFSATFPNKLRSFAVRVLHSPISITINSKGMVNENVKQKFRICHSEDEKFDNLVQLIHERSEFFDEVQSENDGQSSDVEEVDAKAIIFVSSQNICDFISKKLLNAGIVTCAIHAGKPYQERLMNLEKFKREKNSILLCTEVLSRGLNVPEVSLVIIYNAVKTFAQYVHTTGRTARGSRSGTAITLLLHDELSGAYILSKAMRDEEIKALDPLQAKELQEMSAKFESGMKKGKFRLSKGFGGKGLENIKSKREEAQNKDLELKKNDKRSDDLEKKISNPREGHDSVSESSALIPRLNYELFKESTDGSIIFYAKVYINDLPQIVRWEATKNTTLLFIKHETGCSITNKGKFYPEGKEPKNENDEPKLYLLIEGQDEKDIQLSIELLEQKVKEGVVKAASLSLKSTKY 326AAB3473ED7423 ntc20_yeast Pre-mRNA-splicing factor NTC20 YBR188C YBR1316 NTC20 SNT384 PRP19-associated complex protein 20 Synergistic to PRP19 mutation protein 384 protein protein yeast Saccharomyces cerevisiae Baker's yeast MPSLRDLSLERDQELNQLRARINQLGKTGKEEANDFVGLNISNEPVYDTVIQTGQSSNATNSFVQETIQKTKQKESGQPYIIPQKNEHQRYIDKVCETSDLKAKLAPIMEVLEKKTNEKIKGIIRKRVLQEPDRDNDDSG 15C5234B25213223 15C5234B25213223 cwc2_yeast Pre-mRNA-splicing factor CWC2 CWC2 YDL209C D1041 NTC40 SLC3 Complexed with CEF1 protein 2 PRP19-associated complex protein 40 Synthetic lethal with CLF1 protein 3 protein protein yeast Saccharomyces cerevisiae Baker's yeast MTSWRDKSAKVQVKESELPSSIPAQTGLTFNIWYNKWSQGFAGNTRFVSPFALQPQLHSGKTRGDNDGQLFFCLFFAKGMCCLGPKCEYLHHIPDEEDIGKLALRTEVLDCFGREKFADYREDMGGIGSFRKKNKTLYVGGIDGALNSKHLKPAQIESRIRFVFSRLGDIDRIRYVESKNCGFVKFKYQANAEFAKEAMSNQTLLLPSDKEWDDRREGTGLLVKWANEDPDPAAQKRLQEELKLESLNMMVHLINNNTNSAGTEVNNKNNERLDRTFPEASVDNVKKRLLPLDNGMESDDFIEKLKKVKKNISRENISSKPSVGKLGGPLLDYLSSDED 371734A11DFDB339 371734A11DFDB339 prp31_yeast Pre-mRNA-processing factor 31 PRP31 YGR091W protein protein yeast Saccharomyces cerevisiae Baker's yeast MSSEEDYFDELEYDLADEVNEEKEDIQTKKLTTVNCQTEKFNPFEILPESIELFRTLALISPDRLSLSETAQILPKIVDLKRILQQQEIDFIKLLPFFNEIIPLIKSNIKLMHNFLISLYSRRFPELSSLIPSPLQYSKVISILENENYSKNESDELFFHLENKAKLTREQILVLTMSMKTSFKNKEPLDIKTRTQILEANSILENLWKLQEDIGQYIASKISIIAPNVCFLVGPEIAAQLIAHAGGVLEFSRIPSCNIASIGKNKHLSHELHTLESGVRQEGYLFASDMIQKFPVSVHKQMLRMLCAKVSLAARVDAGQKNGDRNTVLAHKWKAELSKKARKLSEAPSISETKALPIPEDQPKKKRAGRKFRKYKEKFRLSHVRQLQNRMEFGKQEQTVLDSYGEEVGLGMSNTSLQQAVGATSGSRRSAGNQAKLTKVMKHRISEANQQADEFLISLGHNTEQPNLSPEMVQMHKKQHTNPEEETNWFSGHG E39AC6247859FB3B E39AC6247859FB3B msl1_yeast U2 small nuclear ribonucleoprotein B'' YIB9W YIR009W MSL1 protein protein yeast Saccharomyces cerevisiae Baker's yeast MVEPARKKQRIDRDTHHTVAEPVTEAKNTLYVSQLNEKINMQRLRVNLFLLFATFGEVLKVSMNFKKQRGQAFITMRTIDQASLAQISLNGERFFGKPLKVEFSKSETKTL 8FB0974FC30994AE sf3b1_yeast U2 snRNP component HSH155 YMR288W YM8021.14 HSH155 protein protein yeast Saccharomyces cerevisiae Baker's yeast MSHPIQFVNANNSDKSHQLGGQYSIPQDLRENLQKEAARIGENEKDVLQEKMETRTVQNREDSYHKRRFDMKFEPDSDTQTVTSSENTQDAVVPRKRKSRWDVKGYEPPDESSTAVKENSDSALVNVEGIHDLMFFKPSDHKYFADVISKKPIDELNKDEKKERTLSMLLLKIKNGNTASRRTSMRILTDKAVTFGPEMIFNRLLPILLDRSLEDQERHLMIKTIDRVLYQLGDLTKPYVHKILVVAAPLLIDEDPMVRSTGQEIITNLSTVAGLKTILTVMRPDIENEDEYVRNVTSRAAAVVAKALGVNQLLPFINAACHSRKSWKARHTGIKIVQQIGILLGIGVLNHLTGLMSCIKDCLMDDHVPVRIVTAHTLSTLAENSYPYGIEVFNVVLEPLWKGIRSHRGKVLSSFLKAVGSMIPLMDPEYAGYYTTEAMRIIRREFDSPDDEMKKTILLVLQKCSAVESITPKFLREEIAPEFFQKFWVRRVALDRPLNKVVTYTTVTLAKKLGCSYTIDKLLTPLRDEAEPFRTMAVHAVTRTVNLLGTADLDERLETRLIDALLIAFQEQTNSDSIIFKGFGAVTVSLDIRMKPFLAPIVSTILNHLKHKTPLVRQHAADLCAILIPVIKNCHEFEMLNKLNIILYESLGEVYPEVLGSIINAMYCITSVMDLDKLQPPINQILPTLTPILRNKHRKVEVNTIKFVGLIGKLAPTYAPPKEWMRICFELLELLKSTNKEIRRSANATFGFIAEAIGPHDVLVALLNNLKVQERQLRVCTAVAIGIVAKVCGPYNVLPVIMNEYTTPETNVQNGVLKAMSFMFEYIGNMSKDYIYFITPLLEDALTDRDLVHRQTASNVITHLALNCSGTGHEDAFIHLMNLLIPNIFETSPHAIMRILEGLEALSQALGPGLFMNYIWAGLFHPAKNVRKAFWRVYNNMYVMYQDAMVPFYPVTPDNNEEYIEELDLVL 27D26E4252A788E2 27D26E4252A788E2 ysf3_yeast RDS3 complex subunit 10 YSF3 RCP10 YNL138W-A Splicing factor 3b subunit protein protein yeast Saccharomyces cerevisiae Baker's yeast MAEKQRQLKLQKIYKQKYIGLGDESTTREQWQRNVRNDTLNTLQGHSASLEYVSLSRGDLSIRDTRIHLLKSMSPGYKAYLREER 32AC005006433E6D lsm2_yeast U6 snRNA-associated Sm-like protein LSm2 LSM2 Small nuclear ribonucleoprotein D homolog SNP3 SMX5 SNP3 YBL0425 YBL026W protein protein yeast Saccharomyces cerevisiae Baker's yeast MLFFSFFKTLVDQEVVVELKNDIEIKGTLQSVDQFLNLKLDNISCTDEKKYPHLGSVRNIFIRGSTVRYVYLNKNMVDTNLLQDATRREVMTERK C23856268CEE92E2 C23856268CEE92E2 slu7_yeast Pre-mRNA-splicing factor SLU7 SLU7 YDR088C D4483 SLT17 Synthetic lethal with U5 snRNA protein 7 Synthetic lethal with U2 snRNA protein 17 protein protein yeast Saccharomyces cerevisiae Baker's yeast MNNNSRNNENRSTINRNKRQLQQAKEKNENIHIPRYIRNQPWYYKDTPKEQEGKKPGNDDTSTAEGGEKSDYLVHHRQKAKGGALDIDNNSEPKIGMGIKDEFKLIRPQKMSVRDSHSLSFCRNCGEAGHKEKDCMEKPRKMQKLVPDLNSQKNNGTVLVRATDDDWDSRKDRWYGYSGKEYNELISKWERDKRNKIKGKDKSQTDETLWDTDEEIELMKLELYKDSVGSLKKDDADNSQLYRTSTRLREDKAAYLNDINSTESNYDPKSRLYKTETLGAVDEKSKMFRRHLTGEGLKLNELNQFARSHAKEMGIRDEIEDKEKVQHVLVANPTKYEYLKKKREQEETKQPKIVSIGDLEARKVDGTKQSEEQRNHLKDLYG 6405458FC367A7D3 6405458FC367A7D3 rsmb_yeast Small nuclear ribonucleoprotein-associated protein B SMB1 Sm protein B YER029C protein protein yeast Saccharomyces cerevisiae Baker's yeast MSKIQVAHSSRLANLIDYKLRVLTQDGRVYIGQLMAFDKHMNLVLNECIEERVPKTQLDKLRPRKDSKDGTTLNIKVEKRVLGLTILRGEQILSTVVEDKPLLSKKERLVRDKKEKKQAQKQTKLRKEKEKKPGKIAKPNTANAKHTSSNSREIAQPSSSRYNGGNDNIGANRSRFNNEAPPQTRKFQPPPGFKRK 0A1078D5AA241430 0A1078D5AA241430 snu56_yeast 56 kDa U1 small nuclear ribonucleoprotein component YDR240C SNU56 MUD10 protein protein yeast Saccharomyces cerevisiae Baker's yeast MRPRRRGLAYHHTKPKGQLSQGHYPTTSNDGQRRKVGNSEAFQSFDIWKNLDRIRSTKKNAGQFIKGSLLILPMRTEDKQQFDECMDELHKYISKDILRCYPQKEQKDEGMLFYIVLKDFNILDSCFVLSVLLAFQKRLWMAPSEKSYFRVPKNINLTGSFYLPKNIETGRGHIITSYRREQPSSSIVEVGFNVVPDFQQFQVKACHVSKFMNELSNFFSQVEFGKCEANVINYFKREYNRTYSQISLALYELPLIGDGLFDIKSYISKTRPIIETSKAQMIKHISEMKAYNEISGLQGDQFPRQQRPLSNSPSSNSISSSQTIEAGATSYQTQPQRHAVNKPSNVLNSSNRHSGPKTFEDGRYSEGNKPGFMTQDEIKQHCIGTIKASMDAVKKKSSYQILKTYVRCPRQNYIDIVYQNLNDLRSKTNCNIVVLNLNNLHESQMWLESLNTTNYTIFAQAPHPSTIRVISIGGVGEYIVKALELILNILEH 5E0C7A1FD577808F 5E0C7A1FD577808F cwc25_yeast Pre-mRNA-splicing factor CWC25 Complexed with CEF1 protein 25 YNL245C N0901 CWC25 protein protein yeast Saccharomyces cerevisiae Baker's yeast MGSGDLNLLKSWNPKLMKNRKKVWETEQDLITEQQKLNTRLKEIEKERELNELLNESSKDKPETLKNDLALKKSGLEWMYQDAKLSDEKEDYLLGKKKLDSSILNQPATPPVRAATTISASGAATSISSQKKKSKLLKDDPMSKFKVTKQQRRTPDSTKKRAMSQRGKPLSKPAPDLDY C6146E12248E48E8 ru17_yeast U1 small nuclear ribonucleoprotein 70 kDa homolog YIL061C SNP1 U1 small nuclear ribonucleoprotein SNP1 protein protein yeast Saccharomyces cerevisiae Baker's yeast MNYNLSKYPDDVSRLFKPRPPLSYKRPTDYPYAKRQTNPNITGVANLLSTSLKHYMEEFPEGSPNNHLQRYEDIKLSKIKNAQLLDRRLQNWNPNVDPHIKDTDPYRTIFIGRLPYDLDEIELQKYFVKFGEIEKIRIVKDKITQKSKGYAFIVFKDPISSKMAFKEIGVHRGIQIKDRICIVDIERGRTVKYFKPRRLGGGLGGRGYSNRDSRLPGRFASASTSNPAERNYAPRLPRRETSSSAYSADRYGSSTLDARYRGNRPLLSAATPTAAVTSVYKSRNSRTRESQPAPKEAPDY 7D9E47BE66FE1EB8 7D9E47BE66FE1EB8 ruxe_yeast Small nuclear ribonucleoprotein E SME1 YOR159C Sm protein E protein protein yeast Saccharomyces cerevisiae Baker's yeast MSNKVKTKAMVPPINCIFNFLQQQTPVTIWLFEQIGIRIKGKIVGFDEFMNVVIDEAVEIPVNSADGKEDVEKGTPLGKILLKGDNITLITSAD B76D72DA8456F3B5 B76D72DA8456F3B5 isy1_yeast Pre-mRNA-splicing factor ISY1 ISY1 UTR3 YJR050W J1657 NTC30 Interactor of SYF1 PRP19-associated complex protein 30 protein protein yeast Saccharomyces cerevisiae Baker's yeast MSRNVDKANSVLVRFQEQQAESAGGYKDYSRYQRPRNVSKVKSIKEANEWKRQVSKEIKQKSTRIYDPSLNEMQIAELNDELNNLFKEWKRWQWHIDHTLMEKKTKRKRLEDSHVLMNSGKLINGKRYFGRALELPEVKEWLKQSQRQNDGGSINTKCIPKDRNDFYYHGKVTAALTEFEANWTSILKAHYNVPVNEDEEEMSRQTQEIHVPTLADMEHWLVQRRKKKLMDELNL F88D74C247CF590C prp38_yeast Pre-mRNA-splicing factor 38 YGR075C PRP38 Pre-mRNA-processing factor 38 protein protein yeast Saccharomyces cerevisiae Baker's yeast MAVNEFQVESNISPKQLNNQSVSLVIPRLTRDKIHNSMYYKVNLSNESLRGNTMVELLKVMIGAFGTIKGQNGHLHMMVLGGIEFKCILMKLIEIRPNFQQLNFLLNVKNENGFDSKYIIALLLVYARLQYYYLNGNNKNDDDENDLIKLFKVQLYKYSQHYFKLKSFPLQVDCFAHSYNEELCIIHIDELVDWLATQDHIWGIPLGKCQWNKIYNSDEESSSSESESNGDSEDDNDTSSES 62EB225947AF4349 62EB225947AF4349 nam8_yeast Protein NAM8 NAM8 MRE2 YHR086W protein protein yeast Saccharomyces cerevisiae Baker's yeast MSYKQTTYYPSRGNLVRNDSSPYTNTISSETNNSSTSVLSLQGASNVSLGTTGNQLYMGDLDPTWDKNTVRQIWASLGEANINVRMMWNNTLNNGSRSSMGPKNNQGYCFVDFPSSTHAANALLKNGMLIPNFPNKKLKLNWATSSYSNSNNSLNNVKSGNNCSIFVGDLAPNVTESQLFELFINRYASTSHAKIVHDQVTGMSKGYGFVKFTNSDEQQLALSEMQGVFLNGRAIKVGPTSGQQQHVSGNNDYNRSSSSLNNENVDSRFLSKGQSFLSNGNNNMGFKRNHMSQFIYPVQQQPSLNHFTDPNNTTVFIGGLSSLVTEDELRAYFQPFGTIVYVKIPVGKCCGFVQYVDRLSAEAAIAGMQGFPIANSRVRLSWGRSAKQTALLQQAMLSNSLQVQQQQPGLQQPNYGYIPSSTCEAPVLPDNNVSSTMLPGCQILNYSNPYANANGLGSNNFSFYSNNNATNTQATSLLADTSSMDLSGTGGQQVIMQGSEAVVNSTNAMLNRLEQGSNGFMFA 64F198EEFB32A909 64F198EEFB32A909 syf2_yeast Pre-mRNA-splicing factor SYF2 SYF2 NTC31 Synthetic lethal with CDC40 protein 2 PRP19 complex protein 31 YGR129W protein protein yeast Saccharomyces cerevisiae Baker's yeast MDFYKLDEKLKELKRKRVDVSIKSRKLADREIQEVSANRKPRVYSMEDVNDADESVGDTESPEKEKAFHYTVQEYDAWERRHPQGKTGQSQRGGISYDQLAKLSYEKTLRNLATQTQNSSKQDSSADEEDNKNVPKKGRIGKVQKDTKTGKITIADDDKLVNKLAVSLQSESKKRYEARKRQMQNAKTLYGVESFINDKNKQFNEKLSRESKGSE C80B872FCD808E1D lsr1_snr20_u2 yeast small nuclear RNA U2 yeast snrna small nuclear rna snRNA snrna yeast Saccharomyces cerevisiae Baker's yeast ACGAAUCUCUUUGCCUUUUGGCUUAGAUCAAGUGUAGUAUCUGUUCUUUUCAGUGUAACAACUGAAAUGACCUCAAUGAGGCUCAUUACCUUUUAAUUUGUUACAAUACACAUUUUUUGGCACCCAAAAUAAUAAAAUGGACGGGAAGAGACUUUUUAAGCAAGUUGUUUUCCGCUAAUGUCAGGUCUCACUACUUUUUGCUGCUAUUUUUCUUCGCUCAUGGUUUCUUCAUAAGGCGUUUUUAUGAUGGUUUUUCGAAAUUGGUUUUUGAGACGACGGUUGCUCAAGGUUAUUGUUUUUGUUUUCUUCUGGUUGUUUUCUAUUUUCUUUUUUUUAGCUUUCUGUUUCUCCCUUAGUUUGGCUUUUUGCUUCAUACUCUUCCCUGUCUUUCCGAGCCGUUUAUGUCCAACGCGGGAUUUGGUUUUUCUUUAUCGAUGGGAAGAAAUGGUGCUAUAGUAGGUUGGGAGAUAAUAUUUAUGGUAUGGGGUGCUAGUGCGGAUGGGGCGCUCUUAUUGUUGAUUUCUUCGCUCGUCUUCUUUUUCUGGUGGCGCUGCAAGAGGAAGUUUUUCGACUUUGUUAUGAUUUUUGGUUUGCAAGGAAAGGUGUCUUACGAUUCUUUUUUUGAUGUAAUAGGAUAAGCUUGCUUAUCCCCCAAGUAUCGGCCAAAGUUGUUGAUUUUCCUUUUGAAGUGUCCUCGGUUUGAGGGGGUGUAGGGUGGGGUUGGUCUACAAUAAGAGUGUUCCAUUGUUAACGUGCUGGCGUCUUUUACUAUAUUUUUUUUCCCAGUUUAUUUUGUGCUUAUUUUCUCAUUGAGGAGAAGGAGCUCUUCUCGCAGGAUAUAAAUGGAGGUUUGCUAAAGGGGAGGAGAUGUGUUUGUGAGAAUACUGCUGAGAGAGUUCUGGAAGAGAAAAAAAGGAGGCAAUGGAAGGCGUUUGCUGGGAAAAGAGAAGAGCCAUGACUGCAUCUGUUGUUUCAAGGCCAGUUUUAUUAACCGCCUAUGUCAUAGAGGCGUUUUUUUUGGAGGGAUUUGAAGAAUGCCGGCGGCAUCAAGAAACGGACUUGAUGGUUGACGCCUGUUUUUAAAGUUAGAGACGUCGCGACCCUCGCACUUGUGGAGUCGUUCUUGACUUUUACUUUGGUCGCUUGAUGUUUCUCUCGUCUUCCCGUUCGCUCUU cwc27_yeast Peptidyl-prolyl isomerase CWC27 CWC27 Complexed with CEF1 protein 27 Rotamase CWC27 CYP7 YPL064C protein protein yeast Saccharomyces cerevisiae Baker's yeast MSSNIEPQTTAKCILYTTKGNIAIELWAKECPETCKRFLSMLSDGTFTNGEFKELKPTQWLMFNANSTGEYRTVAEEKNPRIRFNRDGLLGWDRRRNTWFITVLADSKHVLNDCNVFGKIVGKSIYIFREILGGEIEASSRDNDVKRFMYPAVLKDVEITIPFFEDIFGSKRRLEDNEKKEQEPAKKLVKSAKVKMVYEDEQEDDDGDVQKLKPRKRMILPAWIKDDSRSEGIKLDASLDQPQEALIREKTELHDNVDEATTKETESQENIKEEPMDKRERETLAMLSKFQERIKNKNILK 131A4138F6C993B8 smd1_yeast Small nuclear ribonucleoprotein Sm D1 YGR074W SMD1 snRNP core protein D1 protein protein yeast Saccharomyces cerevisiae Baker's yeast MKLVNFLKKLRNEQVTIELKNGTTVWGTLQSVSPQMNAILTDVKLTLPQPRLNKLNSNGIAMASLYLTGGQQPTASDNIASLQYINIRGNTIRQIILPDSLNLDSLLVDQKQLNSLRRSGQIANDPSKKRRRDFGAPANKRPRRGL 9929F21EB9218447 9929F21EB9218447 spp2_yeast Pre-mRNA-splicing factor SPP2 SPP2 Spliceosome maturation protein SPP2 Suppressor of PRP protein 2 YOR148C protein protein yeast Saccharomyces cerevisiae Baker's yeast MSKFSLKLGSKTLKKNISKKTKKKNSLQKANLFDWDDAETASLSHKPQSKIKIQSIDKFDLDEESSSKKKLVIKLSENADTKKNDAPLVEYVTEKEYNEVPVEEFGDALLRGMGWESDSEQDSKGDKTQSRNKDVSNVSQIHPDGLGIGAKLNKAINVEEASFMPVVKIDKITGTKVDDDKKNKS 3120C3234D178FCD cwc15_yeast Pre-mRNA-splicing factor CWC15 CWC15 Complexed with CEF1 protein 15 YDR163W YD8358.17 protein protein yeast Saccharomyces cerevisiae Baker's yeast MTTSHRPQLEARSGAKAAAYTPTGIEHARLLPGHTTLKYRKFKEEENLRANCAQEDRSNDKSLEEAVMNEEKQDVVGSGNLQETRSEKDQKDSLQELLVTQKNKVEDKAELEGNEQLKGGNSSRRSWRKGTAFGRHKVTKETNIKEHATKKSASGYINDMTKSEYHQEFLHKHVR 6F8D838C169F0FF1 lsm4_yeast U6 snRNA-associated Sm-like protein LSm4 LSM4 SDB23 USS1 YER112W protein protein yeast Saccharomyces cerevisiae Baker's yeast MLPLYLLTNAKGQQMQIELKNGEIIQGILTNVDNWMNLTLSNVTEYSEESAINSEDNAESSKAVKLNEIYIRGTFIKFIKLQDNIIDKVKQQINSNNNSNSNGPGHKRYYNNRDSNNNRGNYNRRNNNNGNSNRRPYSQNRQYNNSNSSNINNSINSINSNNQNMNNGLGGSVQHHFNSSSPQKVEF 69CAC1F01D5BFA98 69CAC1F01D5BFA98 snru6_yeast small nuclear RNA U6 Yeast snrna small nuclear rna snRNA snrna yeast Saccharomyces cerevisiae Baker's yeast GUUCGCGAAGUAACCCUUCGUGGACAUUUGGUCAAUUUGAAACAAUACAGAGAUGAUCAGCAGUUCCCCUGCAUAAGGAUGAACCGUUUUACAAAGAGAUUUAUUUCGUUUU snr14_u4_yeast SNR14 snrna small nuclear rna snRNA snrna yeast Saccharomyces cerevisiae Baker's yeast AUCCUUAUGCACGGGAAAUACGCAUAUCAGUGAGGAUUCGUCCGAGAUUGUGUUUUUGCUGGUUGAAAUUUAAUUAUAAACCAGACCGUCUCCUCAUGGUCAAUUCGGUGUUCGCUUUUGAAUACUUCAAGACUAUGUAGGGAAUUUUUGGAAUACCUUU snu66_yeast 66 kDa U4/U6.U5 small nuclear ribonucleoprotein component SNU66 05667 YOR308C protein protein yeast Saccharomyces cerevisiae Baker's yeast MNKTENLSIEETNEIREKLGMKPIPVFQEKNTDHKESLSIEETNELRASLGLKLIPPQQNFNSSPPNVHNTSKIDELREKITKFQKKANAPLRMAHLLEETNVNDDSSWLENMDAIPSSHESKRSSTLPRKGATKEDENIDLHNVQVSYNIEALSPKKDTILTLKESSIFDDTDSTEVLENVKAAEENADREKLRLRQMNKDRRQKKKILNVSSLDIEEEEEGEKHSITTTHLIIGAEQGVMKAPNTISAKPPTGKVKVNFDSANNMSDEDGGDFKPLKIKKRKIKDPRSTKARKSKITDKMEIVKLVDEDESLSWMEEEQPVTIINPRTSSNNELKGPEDLAREIEKARDEEKRRTESILKMREISNSIVVDEKVTFLNTLDTSLSERSATENKVKVHGEGEKNIGDVTNGHTKEGSGNNTLTEAVNNEPNYEGDAENAPNFFSGLASTLGYLRKKSVFTTGDVDLKPGKDVNNSESLRRDVRNKEHTGTGTYTKDKLHGLEQFTSSDSSNANTHSKRQDHYDPDIKLVYRDEKGNRLTTKEAYKKLSQKFHGTKSNKKKRAKMKSRIEARKNTPENGSLFEFDDN 154BC3873DD6B0FA 154BC3873DD6B0FA prp9_yeast Pre-mRNA-splicing factor PRP9 PRP9 D2773 YDL030W protein protein yeast Saccharomyces cerevisiae Baker's yeast MNLLETRRSLLEEMEIIENAIAERIQRNPELYYHYIQESSKVFPDTKLPRSSLIAENKIYKFKKVKRKRKQIILQQHEINIFLRDYQEKQQTFNKINRPEETQEDDKDLPNFERKLQQLEKELKNEDENFELDINSKKDKYALFSSSSDPSRRTNILSDRARDLDLNEIFTRDEQYGEYMELEQFHSLWLNVIKRGDCSLLQFLDILELFLDDEKYLLTPPMDRKNDRYMAFLLKLSKYVETFFFKSYALLDAAAVENLIKSDFEHSYCRGSLRSEAKGIYCPFCSRWFKTSSVFESHLVGKIHKKNESKRRNFVYSEYKLHRYLKYLNDEFSRTRSFVERKLAFTANERMAEMDILTQKYEAPAYDSTEKEGAEQVDGEQRDGQLQEEHLSGKSFDMPLGPDGLPMPYWLYKLHGLDREYRCEICSNKVYNGRRTFERHFNEERHIYHLRCLGIEPSSVFKGITKIKEAQELWKNMQGQSQLTSIAAVPPKPNPSQLKVPTELELEEEDEEGNVMSKKVYDELKKQGLV 9020885E620488F3 9020885E620488F3 sp382_yeast Pre-mRNA-splicing factor SPP382 NTR1 YLR424W SPP382 CCF8 Suppressor of PRP38 protein 2 Nineteen complex-related protein 1 CLF1 complex factor 8 protein protein yeast Saccharomyces cerevisiae Baker's yeast MEDSDSNTDKKFFFKKRRIDSYNYSDEEDNNSSMNSDMTYTNDALKTSSGNAPTISKLTKTYGIGAKLLSSMGYVAGKGLGKDGSGITTPIETQSRPMHNAGLGMFSNTNSSNYHSENEDYLSSEDEVVEGIEQVKFNKTSTEVLGEALLNDSGDMTIVRTLRELRLAGVQLPESILKELDPLNAVPKPKKDVVVEILQELLGIEKSLEAIRQRTSPLEVQVKEYYGQERLLSELEVTLRDESKHVSLYDKIGAILKLSDDELIDRLTSCLLRKELLIEFDLDHLEKPNDILDELTQIIELLAYRMDTTSKFLNRTQTTIFKVIYPKLKKFWEGFDMTKSKIDSAITLLLDFQQVLSFIGCKEHIMEEFVYPKLLQELDNWELHDEVDHVSPRIWVLDFMVLIDDKIKDTIVDKIEAKFFAYCKNWYHRESFCITNSDIIFIKELICERRYYKILCKEFLPKFLDELWERHNDPIYELEDWKEKQEWKEKDSGFFYFMKKLRSYTHYFHPKQYELMMRGTFNNINKILYQWHLYSTVEDLHKSKWWLNWLMNTVFEHSLPTEIELSEIRKSYNIFAMSHRYHLDKSTLDEDFDLRQGLRNLMETQVIDDISQSEQEPTYTVQNIPLGKVSSSFKDVVEDYCLEKGYLISKIPNRYTQLPYGRDQDCIVPLFEIRNGKKKMEVALKHDILWVEDSSGTFKPIYLWALDL 9986B547B9582338 9986B547B9582338 lsm7_yeast U6 snRNA-associated Sm-like protein LSm7 LSM7 N1202 N1780 YNL147W protein protein yeast Saccharomyces cerevisiae Baker's yeast MHQQHSKSENKPQQQRKKFEGPKREAILDLAKYKDSKIRVKLMGGKLVIGVLKGYDQLMNLVLDDTVEYMSNPDDENNTELISKNARKLGLTVIRGTILVSLSSAEGSDVLYMQK EA1D019FC5D1B5C5 EA1D019FC5D1B5C5 snu71_yeast U1 small nuclear ribonucleoprotein component SNU71 YGR013W SNU71 protein protein yeast Saccharomyces cerevisiae Baker's yeast MRDIVFVSPQLYLSSQEGWKSDSAKSGFIPILKNDLQRFQDSLKHIVDARNSLSETLLNSNDDGSIHNSDQNTGLNKDKEASIADNNSANKCATSSSRYQELKQFLPISLDQQIHTVSLQGVSSSFSRGQIESLLDHCLNLALTETQSNSALKVEAWSSFSSFLDTQDIFIRFSKVDEDEAFVNTLNYCKALFAFIRKLHEDFKIELHLDLNTKEYVEDRTGTIPSVKPEKASEFYSVFKNIEDQTDERNSKKEQLDDSSTQYKVDTNTLSDLPSDALDQLCKDIIEFRTKVVSIEKEKKMKSTYEESRRQRHQMQKVFDQIRKNHSGAKGSANTEEEDTNMEDEDEEDDTEDDLALEKRKEERDLEESNRRYEDMLHQLHSNTEPKIKSIRADIMSAENYEEHLEKNRSLYLKELLHLANDVHYDHHRSFKEQEERRDEEDRAKNGNAKELAPIQLSDGKAISAGKAAAITLPEGTVKSENYNADKNVSESSEHVKIKFDFKKAIDHSVESSSEDEGYRESELPPTKPSERSAAEDRLPFTADELNIRLTNLKESRYVDELVREFLGVYEDELVEYILENIRVNQSKQALLNELRETFDEDGETIADRLWSRKEFRLGT 2659AAA62C4993D5 2659AAA62C4993D5 sn114_yeast Pre-mRNA-splicing factor SNU114 GIN10 YKL173W YKL637 SNU114 Growth inhibitory protein 10 114 kDa U5 small nuclear ribonucleoprotein component protein protein yeast Saccharomyces cerevisiae Baker's yeast MEGDDLFDEFGNLIGVDPFDSDEEESVLDEQEQYQTNTFEGSGNNNEIESRQLTSLGSKKELGISLEHPYGKEVEVLMETKNTQSPQTPLVEPVTERTKLQEHTIFTQLKKNIPKTRYNRDYMLSMANIPERIINVGVIGPLHSGKTSLMDLLVIDSHKRIPDMSKNVELGWKPLRYLDNLKQEIDRGLSIKLNGSTLLCTDLESKSRMINFLDAPGHVNFMDETAVALAASDLVLIVIDVVEGVTFVVEQLIKQSIKNNVAMCFVINKLDRLILDLKLPPMDAYLKLNHIIANINSFTKGNVFSPIDNNIIFASTKLGFTFTIKEFVSYYYAHSIPSSKIDDFTTRLWGSVYYHKGNFRTKPFENVEKYPTFVEFILIPLYKIFSYALSMEKDKLKNLLRSNFRVNLSQEALQYDPQPFLKHVLQLIFRQQTGLVDAITRCYQPFELFDNKTAHLSIPGKSTPEGTLWAHVLKTVDYGGAEWSLVRIYSGLLKRGDTVRILDTSQSESRQKRQLHDISKTETSNEDEDEDDETPSCEVEEIGLLGGRYVYPVHEAHKGQIVLIKGISSAYIKSATLYSVKSKEDMKQLKFFKPLDYITEAVFKIVLQPLLPRELPKLLDALNKISKYYPGVIIKVEESGEHVILGNGELYMDCLLYDLRASYAKIEIKISDPLTVFSESCSNESFASIPVSNSISRLGEENLPGLSISVAAEPMDSKMIQDLSRNTLGKGQNCLDIDGIMDNPRKLSKILRTEYGWDSLASRNVWSFYNGNVLINDTLPDEISPELLSKYKEQIIQGFYWAVKEGPLAEEPIYGVQYKLLSISVPSDVNIDVMKSQIIPLMKKACYVGLLTAIPILLEPIYEVDITVHAPLLPIVEELMKKRRGSRIYKTIKVAGTPLLEVRGQVPVIESAGFETDLRLSTNGLGMCQLYFWHKIWRKVPGDVLDKDAFIPKLKPAPINSLSRDFVMKTRRRKGISTGGFMSNDGPTLEKYISAELYAQLRENGLVP 5CE30CEFF154D013 5CE30CEFF154D013 cus1_yeast Cold sensitive U2 snRNA suppressor 1 YM9408.02C YMR240C CUS1 protein protein yeast Saccharomyces cerevisiae Baker's yeast MARTKSRKRSGNNQNKNASVVNNKAEIAAMIDARRLEQKKKGGVTNSKGKTNKVVDAKLEKEFKDVLQRFQVQENDTPKEITKDEKNNHVVIVEKNPVMNRKHTAEDELEDTPSDGIEEHLSARKRRKTEKPSLSQLKSQVPYPQIIEWYDCDARYPGLLASIKCTKNVIPVPSHWQSKKEYLSGRSLLGKRPFELPDIIKKTNIEQMRSTLPQSGLDGQDEKSLKEASRARVQPKMGALDLDYKKLHDVFFKIGANWKPDHLLCFGDVYYENRNLFEETNWKRMVDHKRPGRISQELRAIMNLPEGQLPPWCMKMKDIGLPTGYPDLKIAGLNWDITNLKGDVYGKIIPNHHSRSKKQGRNYFGALISFETPEFENSKEDTQANAENGRQDDKIDDEVEHKLDHFQEDISEVTSAEEKLERNEEESEKQLYTVLK 0204B3A666AF7336 0204B3A666AF7336 prp6_yeast Pre-mRNA-splicing factor 6 PRP6 RNA6 YBR055C YBR0508 protein protein yeast Saccharomyces cerevisiae Baker's yeast MERPSFLDQEPPAGYVPGIGRGATGFSTKEKQVVSNDDKGRRIPKRYRENLNNHLQSQPKDDEDDEAANVFKTLELKLAQKKKKRANEKDDDNSVDSSNVKRQFADLKESLAAVTESEWMDIPDATDFTRRNKRNRIQEQLNRKTYAAPDSLIPGNVDLNKLTEEREKLLQSQIDENLAQLTKNASNPIQVNKPNAATDALSYLKDLENDRVNSLSDATLEDLQKMRTILKSYRKADPTNPQGWIASARLEEKARKFSVAKKIIENGCQECPRSSDIWLENIRLHESDVHYCKTLVATAINFNPTSPLLWFKAIDLESTTVNKYRVVRKALQEIPRDEGLWKLAVSFEADKAQVIKMLEKATQFIPQSMDLLTAYTNLQSYHNAKMTLNSFRKILPQEPEIWIISTLLEERNNPDIPVDKLVSLLKEGLLELSKNGYKATLSAWLKRAEALNDAPNSNLTCQAIVYAILEWLRESGEYESELNNVDQILEKMPHSKVQIAVLKKLIQWDPCDTVLWSRLKMATESYHKIEELLAFFQELLFQTKNSDDIRANMREKSPGLLMMYVSEYWKAQKGDTRQTLVLIDQIIDFAPHNLDLRFFKIKLLGRSLQLDELRDFFQQTFSSLEDFKISGTERLYYKYVNFLRYQDLNEEAIKFLNERCLKSFPICHKFFLQLGQIYHSMGNIEMSRETYLSGTRLVPNCPLLWVSLSKIDEIDLKNPVRARSILDRGLLKNPDDVLFYIAKIQMEIRLGNLDQAELLVTQALQKFPSNALLWVEQIKLFKHGNKSSLKKTIFQDALRRTQNDHRVLLEIGVSFYAEAQYETSLKWLERALKKCSRYGDTWVWLFRTYARLGKDTVDLYNMFDQCEPTYGPEWIAASKNVKMQYCTPREILLRLMNDK 3E87F8AF63EAAC41 3E87F8AF63EAAC41 prp8_yeast Pre-mRNA-splicing factor 8 PRP8 DBF3 DNA39 RNA8 SLT21 USA2 YHR165C protein protein yeast Saccharomyces cerevisiae Baker's yeast MSGLPPPPPGFEEDSDLALPPPPPPPPGYEIEELDNPMVPSSVNEDTFLPPPPPPPSNFEINAEEIVDFTLPPPPPPPGLDELETKAEKKVELHGKRKLDIGKDTFVTRKSRKRAKKMTKKAKRSNLYTPKAEMPPEHLRKIINTHSDMASKMYNTDKKAFLGALKYLPHAILKLLENMPHPWEQAKEVKVLYHTSGAITFVNETPRVIEPVYTAQWSATWIAMRREKRDRTHFKRMRFPPFDDDEPPLSYEQHIENIEPLDPINLPLDSQDDEYVKDWLYDSRPLEEDSKKVNGTSYKKWSFDLPEMSNLYRLSTPLRDEVTDKNYYYLFDKKSFFNGKALNNAIPGGPKFEPLYPREEEEDYNEFNSIDRVIFRVPIRSEYKVAFPHLYNSRPRSVRIPWYNNPVSCIIQNDEEYDTPALFFDPSLNPIPHFIDNNSSLNVSNTKENGDFTLPEDFAPLLAEEEELILPNTKDAMSLYHSPFPFNRTKGKMVRAQDVALAKKWFLQHPDEEYPVKVKVSYQKLLKNYVLNELHPTLPTNHNKTKLLKSLKNTKYFQQTTIDWVEAGLQLCRQGHNMLNLLIHRKGLTYLHLDYNFNLKPTKTLTTKERKKSRLGNSFHLMRELLKMMKLIVDTHVQFRLGNVDAFQLADGIHYILNHIGQLTGIYRYKYKVMHQIRACKDLKHIIYYKFNKNLGKGPGCGFWQPAWRVWLNFLRGTIPLLERYIGNLITRQFEGRSNEIVKTTTKQRLDAYYDLELRNSVMDDILEMMPESIRQKKARTILQHLSEAWRCWKANIPWDVPGMPAPIKKIIERYIKSKADAWVSAAHYNRERIKRGAHVEKTMVKKNLGRLTRLWIKNEQERQRQIQKNGPEITPEEATTIFSVMVEWLESRSFSPIPFPPLTYKNDTKILVLALEDLKDVYASKVRLNASEREELALIEEAYDNPHDTLNRIKKYLLTQRVFKPVDITMMENYQNISPVYSVDPLEKITDAYLDQYLWYEADQRKLFPNWIKPSDSEIPPLLVYKWTQGINNLSEIWDVSRGQSAVLLETTLGEMAEKIDFTLLNRLLRLIVDPNIADYITAKNNVVINFKDMSHVNKYGLIRGLKFASFIFQYYGLVIDLLLLGQERATDLAGPANNPNEFMQFKSKEVEKAHPIRLYTRYLDRIYMLFHFEEDEGEELTDEYLAENPDPNFENSIGYNNRKCWPKDSRMRLIRQDVNLGRAVFWEIQSRVPTSLTSIKWENAFVSVYSKNNPNLLFSMCGFEVRILPRQRMEEVVSNDEGVWDLVDERTKQRTAKAYLKVSEEEIKKFDSRIRGILMASGSTTFTKVAAKWNTSLISLFTYFREAIVATEPLLDILVKGETRIQNRVKLGLNSKMPTRFPPAVFYTPKELGGLGMISASHILIPASDLSWSKQTDTGITHFRAGMTHEDEKLIPTIFRYITTWENEFLDSQRVWAEYATKRQEAIQQNRRLAFEELEGSWDRGIPRISTLFQRDRHTLAYDRGHRIRREFKQYSLERNSPFWWTNSHHDGKLWNLNAYRTDVIQALGGIETILEHTLFKGTGFNSWEGLFWEKASGFEDSMQFKKLTHAQRTGLSQIPNRRFTLWWSPTINRANVYVGFLVQLDLTGIFLHGKIPTLKISLIQIFRAHLWQKIHESIVFDICQILDGELDVLQIESVTKETVHPRKSYKMNSSAADITMESVHEWEVSKPSLLHETNDSFKGLITNKMWFDVQLRYGDYDSHDISRYVRAKFLDYTTDNVSMYPSPTGVMIGIDLAYNMYDAYGNWFNGLKPLIQNSMRTIMKANPALYVLRERIRKGLQIYQSSVQEPFLNSSNYAELFNNDIKLFVDDTNVYRVTVHKTFEGNVATKAINGCIFTLNPKTGHLFLKIIHTSVWAGQKRLSQLAKWKTAEEVSALVRSLPKEEQPKQIIVTRKAMLDPLEVHMLDFPNIAIRPTELRLPFSAAMSIDKLSDVVMKATEPQMVLFNIYDDWLDRISSYTAFSRLTLLLRALKTNEESAKMILLSDPTITIKSYHLWPSFTDEQWITIESQMRDLILTEYGRKYNVNISALTQTEIKDIILGQNIKAPSVKRQKMAELEAARSEKQNDEEAAGASTVMKTKTINAQGEEIVVVASADYESQTFSSKNEWRKSAIANTLLYLRLKNIYVSADDFVEEQNVYVLPKNLLKKFIEISDVKIQVAAFIYGMSAKDHPKVKEIKTVVLVPQLGHVGSVQISNIPDIGDLPDTEGLELLGWIHTQTEELKFMAASEVATHSKLFADKKRDCIDISIFSTPGSVSLSAYNLTDEGYQWGEENKDIMNVLSEGFEPTFSTHAQLLLSDRITGNFIIPSGNVWNYTFMGTAFNQEGDYNFKYGIPLEFYNEMHRPVHFLQFSELAGDEELEAEQIDVFS 8F4F6F89D34D3508 8F4F6F89D34D3508 smd3_yeast Small nuclear ribonucleoprotein Sm D3 SMD3 YLR147C L9634.6 snRNP core protein D3 protein protein yeast Saccharomyces cerevisiae Baker's yeast MTMNGIPVKLLNEAQGHIVSLELTTGATYRGKLVESEDSMNVQLRDVIATEPQGAVTHMDQIFVRGSQIKFIVVPDLLKNAPLFKKNSSRPMPPIRGPKRR BB02A56C5AD70CF2 BB02A56C5AD70CF2 prp22_yeast Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22 PRP22 YER013W protein protein yeast Saccharomyces cerevisiae Baker's yeast MSDISKLIGAIVGSDDPVIIEFVLNIINKSGNLQEFIRNIQKLDAGISYEDSIKMYNAFLGKQEEEKVRNKVKSSPLSQKINQVLKDDVNLDDPVVTEFVLSILNKSKSITEFQEQLNLMQSGLDNETIFKIYQIASPPVMKEEVSVLPSTKIPAKIEAKIEEEVQKIESLDPSPVLHKVYEGKVRNITTFGCFVQIFGTRMKNCDGLVHISEMSDQRTLDPHDVVRQGQHIFVEVIKIQNNGKISLSMKNIDQHSGEIRKRNTESVEDRGRSNDAHTSRNMKNKIKRRALTSPERWEIRQLIASGAASIDDYPELKDEIPINTSYLTAKRDDGSIVNGNTEKVDSKLEEQQRDETDEIDVELNTDDGPKFLKDQQVKGAKKYEMPKITKVPRGFMNRSAINGSNAIRDHREEKLRKKREIEQQIRKQQSFDDPTKNKKDSRNEIQMLKNQLIVTEWEKNRMNESISYGKRTSLPISAQRQTLPVYAMRSELIQAVRDNQFLVIVGETGSGKTTQITQYLDEEGFSNYGMIGCTQPRRVAAVSVAKRVAEEVGCKVGHDVGYTIRFEDVTGPDTRIKYMTDGMLQREALLDPEMSKYSVIMLDEAHERTVATDVLFALLKKAAIKRPELKVIVTSATLNSAKFSEYFLNCPIINIPGKTFPVEVLYSQTPQMDYIEAALDCVIDIHINEGPGDILVFLTGQEEIDSCCEILYDRVKTLGDSIGELLILPVYSALPSEIQSKIFEPTPKGSRKVVFATNIAETSITIDGIYYVVDPGFAKINIYNARAGIEQLIVSPISQAQANQRKGRAGRTGPGKCYRLYTESAFYNEMLENTVPEIQRQNLSHTILMLKAMGINDLLKFDFMDPPPKNLMLNALTELYHLQSLDDEGKLTNLGKEMSLFPMDPTLSRSLLSSVDNQCSDEIVTIISMLSVQNVFYRPKDRQLEADSKKAKFHHPYGDHLTLLNVYTRWQQANYSEQYCKTNFLHFRHLKRARDVKSQISMIFKKIGLKLISCHSDPDLIRKTFVSGFFMNAAKRDSQVGYKTINGGTEVGIHPSSSLYGKEYEYVMYHSIVLTSREYMSQVTSIEPQWLLEVAPHFYKAGDAESQSRKKAKIIPLHNKFAKDQNSWRLSSIRQSRERALGIKR D92DBD620531B9A7 D92DBD620531B9A7 ru1a_yeast U1 small nuclear ribonucleoprotein A MUD1 YBR119W YBR0915 Mutant U1 die protein 1 protein protein yeast Saccharomyces cerevisiae Baker's yeast MSALYFQNLPSRPANKENYTRLLLKHINPNNKYAINPSLPLPHNKLQISSQPLMLLDDQMGLLEVSISRSSKMTNQAFLTFVTQEEADRFLEKYTTTALKVQGRKVRMGKARTNSLLGLSIEMQKKKGNDETYNLDIKKVLKARKLKRKLRSDDICAKKFRLKRQIRRLKHKLRSRKVEEAEIDRIVKEFETRRLENMKSQQENLKQSQKPLKRAKVSNTMENPPNKVLLIQNLPSGTTEQLLSQILGNEALVEIRLVSVRNLAFVEYETVADATKIKNQLGSTYKLQNNDVTIGFAK 42256530BF1C5379 ist3_yeast U2 snRNP component IST3 IST3 SNU17 YIR005W YIB5W U2 snRNP protein SNU17 Increased sodium tolerance protein 3 protein protein yeast Saccharomyces cerevisiae Baker's yeast MNKIQQINDKELQSGILSPHQSWHNEYKDNAYIYIGNLNRELTEGDILTVFSEYGVPVDVILSRDENTGESQGFAYLKYEDQRSTILAVDNLNGFKIGGRALKIDHTFYRPKRSLQKYYEAVKEELDRDIVSKNNAEKLILAKKDQPN 9D51C3043AB823D2 9D51C3043AB823D2 clf1_yeast Pre-mRNA-splicing factor CLF1 CLF1 NTC77 YLR117C SYF3 L2952 Crooked neck-like factor 1 PRP19-associated complex protein 77 Synthetic lethal with CDC40 protein 3 protein protein yeast Saccharomyces cerevisiae Baker's yeast MDTLEPTAVDTHVSAEQILRDVYKKGQKARGSTNIDILDLEELREYQRRKRTEYEGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARNLMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQKNWNGVREIYSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWPSNQLLKAGLLDFEKQFGDINSIEETISYKRKMEYETILSNNAYDYDTWWLYLDLISESFPKQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWMRYICYVELELENSLLEEELFQRLIDDIIPHKHFTFSKIWLMYAKFLIRHDDVPKARKILGKAIGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGELEENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLELNQYSPQSWIEFAMYQTSTPTEQQLLDLAKLQSENVDEDIEFEITDENKLEARKVFEEAIVFFKEKDDKQGRLSILEALKDYEETYGTELDQETVKKRFPKVIKKVRLQNGVEEEFVDYIFPDDIDDDKPKPSKFLELAKKWKQEQAL AE7D5EC5B3979E00 AE7D5EC5B3979E00 prp42_yeast U1 small nuclear ribonucleoprotein component PRP42 PRP42 MUD16 SNU65 YD8419.02 YDR235W Pre-mRNA-processing factor 42 65 kDa snRNP protein protein protein yeast Saccharomyces cerevisiae Baker's yeast MDKYTALIHDENFSTLTLNVSRYPKSLAYWEKLLNYIVKASAPICKSTEPQLLKLIRCTYSSMLNEFPYLENYYIDFALLEYKLGNVSMSHKIFQRGLQAFNQRSLLLWTSYLKFCNNVISHQKQLFKKYETAEEYVGLHFFSGEFWDLYLEQISSRCTSSKKYWNVLRKILEIPLHSFSKFYALWLQRIDDIMDLKQLSQLTSKDELLKKLKIDINYSGRKGPYLQDAKKKLKKITKEMYMVVQYQVLEIYSIFESKIYINYYTSPETLVSSDEIETWIKYLDYTITLQTDSLTHLNFQRALLPLAHYDLVWIKYSKWLINSKNDLLGAKNVLLMGLKFSLKKTEIIKLLYSVICKLNEYVLLRNLLEKIESSYSDNVENVDDFEIFWDYLQFKTFCQNSLYSSRYSDSQSNGLLNKELFDKVWKRLSCKEKKSGQEILLNNLVQFYSKDTVEFVEKNIFQKIIEFGWEYYLQNGMFWNCYCRLIYFDTSRSYLDKRQYIVRKIWPQIDKKFAQSVLPSLTEFCESYFPEEMDTLEEMFTEEP 7F6790FFD0ECEB80 snr19_u1_yeast SNR19 snrna small nuclear rna snRNA snrna yeast Saccharomyces cerevisiae Baker's yeast AUACUUACCUUAAGAUAUCAGAGGAGAUCAAGAAGUCCUACUGAUCAAACAUGCGCUUCCAAUAGUAGAAGGACGUUAAGCAUUUAUCAUUGAACUAUAAUUGUUCAUUGAAGUCAUUGAUGCAAACUCCUUGGUCACACACACAUACGGCGCGGAAGGCGUGUUUGCUGACGUUUCCAUUCCCUUGUUUCAAUCAUUGGUUAAUCCCUUGAUUCCUUUGGGGAUUUUUGGGUUAAACUGAUUUUUGGGGCCCUUUGUUUCUUCUGCCUGGAGAAGUUUGACACCAAAUUCAAAUUGGUGUUAGGGGAGCUGGGGCCUUUCAAAAGAGAGCUUUGUAGAGGCAUUCUUUUUGACUACUUUUCUCUAGCGUGCCAUUUUAGUUUUUGACGGCAGAUUCGAAUGAACUUAAGUUUAUGAUGAAGGUAUGGCUGUUGAGAUUAUUUGGUCGGGAUUGUAGUUUGAAGAUGUGCUCUUUUGAGCAGUCUCAACUUUGCUCGUUCCCGUUAUGGGAAAAAUUUUGGAAGGUCUUGGUAGGAACGGGUGGAUCUUAUAAUUUUUGAUUUAUUUU prp46_yeast Pre-mRNA-splicing factor PRP46 CWC1 PRP nineteen-associated complex protein 50 PRP19-associated complex protein 50 P2594 YPL151C PRP46 NTC50 Pre-mRNA-processing protein 46 Complexed with CEF1 protein 1 protein protein yeast Saccharomyces cerevisiae Baker's yeast MDGNDHKVENLGDVDKFYSRIRWNNQFSYMATLPPHLQSEMEGQKSLLMRYDTYRKESSSFSGEGKKVTLQHVPTDFSEASQAVISKKDHDTHASAFVNKIFQPEVAEELIVNRYEKLLSQRPEWHAPWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDVAVSDRHPYLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLDLIATAGRDSVIKLWDMRTRIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTMKVLTHHKRSVRATALHPKEFSVASACTDDIRSWGLAEGSLLTNFESEKTGIINTLSINQDDVLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEGERSVLCSTFDKTGLRLITGEADKSIKIWKQDETATKESEPGLAWNPNLSAKRF 0E888F566A5414BD 0E888F566A5414BD sp381_yeast Pre-mRNA-splicing factor SPP381 YBR152W YBR1202 SPP381 Suppressor of PRP38-1 mutation protein protein yeast Saccharomyces cerevisiae Baker's yeast MSFRHFKRRLDTSSADESSSADEEHPDQNVSLTEKSASLSHSDLGGEILNGTGKNRTPNDGQESNESDGSPESDESPESEESSDNSDSSDSDDMRPLPRPLFMKKKANNLQKATKIDQPWNAQDDARVLQTKKENMIKNIDKANQVAKNYETMKLRLNTNYSTNEELIKQCLLLDDNDEVDSEKERQKWFERQNERKQKHRRIQLAKQRESEEYEAKRFEAMQKGKDGNTKYDVILDKEKEKLDHKKQRSAEKVEKSHNNNRYKITRTKNVEFGDLGKNSRDYEETEYSVI B65D0F00DE860A83 B65D0F00DE860A83 bud31_yeast Pre-mRNA-splicing factor BUD31 BUD31 Bud site selection protein 31 CWC14 Complexed with CEF1 protein 14 YCR63W YCR903 YCR063W protein protein yeast Saccharomyces cerevisiae Baker's yeast MPRIKTRRSKPAPDGFEKIKPTLTDFEIQLRDAQKDKSSKLAAKSNEQLWEIMQLHHQRSRYIYTLYYKRKAISKDLYDWLIKEKYADKLLIAKWRKTGYEKLCCLRCIQKNETNNGSTCICRVPRAQLEEEARKKGTQVSFHQCVHCGCRGCASTD 70A8B15F8DA6F85D 70A8B15F8DA6F85D yju2_yeast Splicing factor YJU2 YKL095W YKL442 YJU2 CWC16 protein protein yeast Saccharomyces cerevisiae Baker's yeast MSERKAINKYYPPDYNPLEAEKLSRKMAKKLKTMNKSHASIRLMTPFSMRCLECNEYIPKSRKFNGKKELLKEKYLDSIKIYRLTISCPRCANSIAFRTDPGNSDYVMEVGGVRNYVPQKPNDDLNAKTAVESIDETLQRLVREKEMEQNEKMGIKEQADDKMDLLEKRLAKIQQEQEDDEELENLRKKNLEMSQRAEMINRSKHAQQEKAVTTDDLDNLVDQVFDNHRQRTNKPGNNNDEKRTPLFNPTSTKGKIQKKSSVRTNPLGIVIKRGKSLK B57F3A173A2113FD B57F3A173A2113FD cwc23_yeast Pre-mRNA-splicing factor CWC23 YGL128C G2861 CWC23 Complexed with CEF1 protein 23 protein protein yeast Saccharomyces cerevisiae Baker's yeast MPGHELEDVINQRLNLYDVLELPTPLDVHTIYDDLPQIKRKYRTLALKYHPDKHPDNPSIIHKFHLLSTATNILTNADVRPHYDRWLIEFLRKTNDIERNKLIQKLEESESSTIPTTTPHPDLLQIQRHGELLRKLKHFNLPYGDWKHLNTQDQENASQHPYYDCSTLRIVLDNFLQSNNKSNCLSHLRNQVFITLSANEIYDIYFSERNNYSKDDSIIIYTVFDTPITAQHVFRNWSSGNLIPTVKDISPLIPLHYYSDFNLETELNDDIARLVSNEPILLD AA1D0894328CAEA5 AA1D0894328CAEA5 prp43_yeast Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43 PRP43 Helicase JA1 YGL120C protein protein yeast Saccharomyces cerevisiae Baker's yeast MGSKRRFSSEHPDPVETSIPEQAAEIAEELSKQHPLPSEEPLVHHDAGEFKGLQRHHTSAEEAQKLEDGKINPFTGREFTPKYVDILKIRRELPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFVLFDEMPHLENTQVACTQPRRVAAMSVAQRVAEEMDVKLGEEVGYSIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKRRPDLKIIIMSATLDAEKFQRYFNDAPLLAVPGRTYPVELYYTPEFQRDYLDSAIRTVLQIHATEEAGDILLFLTGEDEIEDAVRKISLEGDQLVREEGCGPLSVYPLYGSLPPHQQQRIFEPAPESHNGRPGRKVVISTNIAETSLTIDGIVYVVDPGFSKQKVYNPRIRVESLLVSPISKASAQQRAGRAGRTRPGKCFRLYTEEAFQKELIEQSYPEILRSNLSSTVLELKKLGIDDLVHFDFMDPPAPETMMRALEELNYLACLDDEGNLTPLGRLASQFPLDPMLAVMLIGSFEFQCSQEILTIVAMLSVPNVFIRPTKDKKRADDAKNIFAHPDGDHITLLNVYHAFKSDEAYEYGIHKWCRDHYLNYRSLSAADNIRSQLERLMNRYNLELNTTDYESPKYFDNIRKALASGFFMQVAKKRSGAKGYITVKDNQDVLIHPSTVLGHDAEWVIYNEFVLTSKNYIRTVTSVRPEWLIEIAPAYYDLSNFQKGDVKLSLERIKEKVDRLNELKQGKNKKKSKHSKK DA8A085EC50FF430 DA8A085EC50FF430 sn309_yeast Pre-mRNA-splicing factor SNT309 YPR101W SNT309 NTC25 Synergistic to PRP19 mutation protein 309 PRP19-associated complex protein 25 protein protein yeast Saccharomyces cerevisiae Baker's yeast MDGLSFVDKGKIPDGYKNEIDQLVKKEFANIKREPVHPEIRGILAKRKGADNSVSTLTNALYTEYLKQRNNKKRRTPDFNDDDDTLFLEEYRRKYPRIDTSRYIPNESSEVSLLGIVDSYLKHQEIVLDTLLPQTVSNQWRINNDYIRQTCTIVEEMNIQQRKQINDLEIYRKRL B781CA65BC9A1918 B781CA65BC9A1918 prp40_yeast Pre-mRNA-processing protein PRP40 YKL165 YKL012W PRP40 protein protein yeast Saccharomyces cerevisiae Baker's yeast MSIWKEAKDASGRIYYYNTLTKKSTWEKPKELISQEELLLRENGWKAAKTADGKVYYYNPTTRETSWTIPAFEKKVEPIAEQKHDTVSHAQVNGNRIALTAGEKQEPGRTINEEESQYANNSKLLNVRRRTKEEAEKEFITMLKENQVDSTWSFSRIISELGTRDPRYWMVDDDPLWKKEMFEKYLSNRSADQLLKEHNETSKFKEAFQKMLQNNSHIKYYTRWPTAKRLIADEPIYKHSVVNEKTKRQTFQDYIDTLIDTQKESKKKLKTQALKELREYLNGIITTSSSETFITWQQLLNHYVFDKSKRYMANRHFKVLTHEDVLNEYLKIVNTIENDLQNKLNELRLRNYTRDRIARDNFKSLLREVPIKIKANTRWSDIYPHIKSDPRFLHMLGRNGSSCLDLFLDFVDEQRMYIFAQRSIAQQTLIDQNFEWNDADSDEITKQNIEKVLENDRKFDKVDKEDISLIVDGLIKQRNEKIQQKLQNERRILEQKKHYFWLLLQRTYTKTGKPKPSTWDLASKELGESLEYKALGDEDNIRRQIFEDFKPESSAPTAESATANLTLTASKKRHLTPAVELDY BA1C1C91D532524C BA1C1C91D532524C ru2a_yeast U2 small nuclear ribonucleoprotein A' YPL213W LEA1 Looks exceptionally like U2A protein 1 protein protein yeast Saccharomyces cerevisiae Baker's yeast MKFTPSIVIDAPQYYVDHFNGKYNVDKCVILRDLQLETDSESMPSSLKHLTKPTHILDLTNNDLIMIPDLSRRDDIHTLLLGRNNIVEVDGRLLPMNVQNLTLSNNSIRRFEDLQRLRRAPRTLKNLTLIGNQVCHLANYREHVLRLVPHLETLDFQNVTAEERKSAMSFPRQADGDTLGPVNTAIRDNGSRDKTMEIMNLVVSKMTVERRNELKKQLAEATSLEEIARLEKLLSGGV 0E92A1922BFEDC25 cef1_yeast Pre-mRNA-splicing factor CEF1 CEF1 YMR213W YM8261.07 NTC85 PRP nineteen-associated complex protein 85 PRP19-associated complex protein 85 protein protein yeast Saccharomyces cerevisiae Baker's yeast MPPVPIYVKGGVWTNVEDQILKAAVQKYGTHQWSKVASLLQKKTARQSELRWNEYLNPKLNFTEFSKEEDAQLLDLARELPNQWRTIADMMARPAQVCVERYNRLLESEDSGGAALSTGVTDLKAGDINPNAETQMARPDNGDLEDEEKEMLAEARARLLNTQGKKATRKIRERMLEESKRIAELQKRRELKQAGINVAIKKPKKKYGTDIDYNEDIVYEQAPMPGIYDTSTEDRQIKKKFEQFERKVNRKGLDGNKDKPSKKNKDKKRKHDENEHVEKAALGESTTLTDEYKKPKLILSAPGTKQGKVTYKKKLESKRQKLIEAQATGTVLTPKELLPHDSGQEDNERSNIKSGKQLKSRIRKFLVQMFASLPSPKNDFEIVLSEDEKEEDAEIAEYEKEFENERAMNEEDNFIEPPSQNDAPRVSLVAVPLAYSTLPIPEFKNNPQSAIDNKYNLLVANAINKEPHMVPEDTVDFLKEVESRMQHITQGRTSMKIQFKTAMPPTEVLLESIQSKVESIEQLQRKLQHVQPLEQQNNEMCSTLCHHSLPALIEGQRKYYADYYAYRQEIRSLEGRRKRLQAMLNSSSSI A4C417A8B330EA9C A4C417A8B330EA9C prp19_yeast Pre-mRNA-processing factor 19 PRP19 PSO4 RING-type E3 ubiquitin transferase PRP19 YLL036C protein protein yeast Saccharomyces cerevisiae Baker's yeast MLCAISGKVPRRPVLSPKSRTIFEKSLLEQYVKDTGNDPITNEPLSIEEIVEIVPSAQQASLTESTNSATLKANYSIPNLLTSLQNEWDAIMLENFKLRSTLDSLTKKLSTVMYERDAAKLVAAQLLMEKNEDSKDLPKSSQQAVAITREEFLQGLLQSSRDFVARGKLKAPKWPILKNLELLQAQNYSRNIKTFPYKELNKSMYYDKWVCMCRCEDGALHFTQLKDSKTITTITTPNPRTGGEHPAIISRGPCNRLLLLYPGNQITILDSKTNKVLREIEVDSANEIIYMYGHNEVNTEYFIWADNRGTIGFQSYEDDSQYIVHSAKSDVEYSSGVLHKDSLLLALYSPDGILDVYNLSSPDQASSRFPVDEEAKIKEVKFADNGYWMVVECDQTVVCFDLRKDVGTLAYPTYTIPEFKTGTVTYDIDDSGKNMIAYSNESNSLTIYKFDKKTKNWTKDEESALCLQSDTADFTDMDVVCGDGGIAAILKTNDSFNIVALTP A44D8C7DD6F64185 A44D8C7DD6F64185 prp3_yeast U4/U6 small nuclear ribonucleoprotein PRP3 PRP3 RNA3 YDR473C D8035.16 Pre-mRNA-splicing factor 3 protein protein yeast Saccharomyces cerevisiae Baker's yeast MPPRNTYEKGNPKRQNSPYYKPSFLRREETTNDEEKFQGHGLKTELHSALKSSNLNLIRRTYQTGENPYLSDPHDRGSSSRFNRRYERGLKFYQKGEISKRIAQERTLQKQQEEEELKRKLKQEEDEKDKRKLIESGDLPNLELHEDKFLLDLSKFKIYYDNNHGYEWWDTAYLDEKGELMEKYDMNGTSPAEEKLAEDIDEVDDDDDDEHPSIRYVAHPLPEKINEAKVSIKAYLTQHERKRLRRNRRKMAREAREIKIKLGLLPKPEPKVKLSNMMSVFENDQNITDPTAWEKVVKDQVDLRKRKHLEENERRHEDAIKRRKEAVNMNVEKPTVYHCKVFQFKNLQNPKIRFKLKMNSKELSLKGLCLRIRDDGPGIIIVVGNEKSCKFYENLVMKRIKWNEDFELHTNTGDIKMDMHNNSISKTWEGYLQDCKFKGWFMKVCNDQDSLLRTLGQFDSEHFYSPVQT E977FD9F708BDD91 E977FD9F708BDD91 brr2_yeast Pre-mRNA-splicing helicase BRR2 BRR2 RSS1 SNU246 YER172C SYGP-ORF66 Protein Snu246 protein protein yeast Saccharomyces cerevisiae Baker's yeast MTEHETKDKAKKIREIYRYDEMSNKVLKVDKRFMNTSQNPQRDAEISQPKSMSGRISAKDMGQGLCNNINKGLKENDVAVEKTGKSASLKKIQQHNTILNSSSDFRLHYYPKDPSNVETYEQILQWVTEVLGNDIPHDLIIGTADIFIRQLKENEENEDGNIEERKEKIQHELGINIDSLKFNELVKLMKNITDYETHPDNSNKQAVAILADDEKSDEEEVTEMSNNANVLGGEINDNEDDDEEYDYNDVEVNSKKKNKRALPNIENDIIKLSDSKTSNIESVPIYSIDEFFLQRKLRSELGYKDTSVIQDLSEKILNDIETLEHNPVALEQKLVDLLKFENISLAEFILKNRSTIFWGIRLAKSTENEIPNLIEKMVAKGLNDLVEQYKFRETTHSKRELDSGDDQPQSSEAKRTKFSNPAIPPVIDLEKIKFDESSKLMTVTKVSLPEGSFKRVKPQYDEIHIPAPSKPVIDYELKEITSLPDWCQEAFPSSETTSLNPIQSKVFHAAFEGDSNMLICAPTGSGKTNIALLTVLKALSHHYNPKTKKLNLSAFKIVYIAPLKALVQEQVREFQRRLAFLGIKVAELTGDSRLSRKQIDETQVLVSTPEKWDITTRNSNNLAIVELVRLLIIDEIHLLHDDRGPVLESIVARTFWASKYGQEYPRIIGLSATLPNYEDVGRFLRVPKEGLFYFDSSFRPCPLSQQFCGIKERNSLKKLKAMNDACYEKVLESINEGNQIIVFVHSRKETSRTATWLKNKFAEENITHKLTKNDAGSKQILKTEAANVLDPSLRKLIESGIGTHHAGLTRSDRSLSEDLFADGLLQVLVCTATLAWGVNLPAHTVIIKGTDVYSPEKGSWEQLSPQDVLQMLGRAGRPRYDTFGEGIIITDQSNVQYYLSVLNQQLPIESQFVSKLVDNLNAEVVAGNIKCRNDAVNWLAYTYLYVRMLASPMLYKVPDISSDGQLKKFRESLVHSALCILKEQELVLYDAENDVIEATDLGNIASSFYINHASMDVYNRELDEHTTQIDLFRIFSMSEEFKYVSVRYEEKRELKQLLEKAPIPIREDIDDPLAKVNVLLQSYFSQLKFEGFALNSDIVFIHQNAGRLLRAMFEICLKRGWGHPTRMLLNLCKSATTKMWPTNCPLRQFKTCPVEVIKRLEASTVPWGDYLQLETPAEVGRAIRSEKYGKQVYDLLKRFPKMSVTCNAQPITRSVMRFNIEIIADWIWDMNVHGSLEPFLLMLEDTDGDSILYYDVLFITPDIVGHEFTLSFTYELKQHNQNNLPPNFFLTLISENWWHSEFEIPVSFNGFKLPKKFPPPTPLLENISISTSELGNDDFSEVFEFKTFNKIQSQVFESLYNSNDSVFVGSGKGTGKTAMAELALLNHWRQNKGRAVYINPSGEKIDFLLSDWNKRFSHLAGGKIINKLGNDPSLNLKLLAKSHVLLATPVQFELLSRRWRQRKNIQSLELMIYDDAHEISQGVYGAVYETLISRMIFIATQLEKKIRFVCLSNCLANARDFGEWAGMTKSNIYNFSPSERIEPLEINIQSFKDVEHISFNFSMLQMAFEASAAAAGNRNSSSVFLPSRKDCMEVASAFMKFSKAIEWDMLNVEEEQIVPYIEKLTDGHLRAPLKHGVGILYKGMASNDERIVKRLYEYGAVSVLLISKDCSAFACKTDEVIILGTNLYDGAEHKYMPYTINELLEMVGLASGNDSMAGKVLILTSHNMKAYYKKFLIEPLPTESYLQYIIHDTLNNEIANSIIQSKQDCVDWFTYSYFYRRIHVNPSYYGVRDTSPHGISVFLSNLVETCLNDLVESSFIEIDDTEAEVTAEVNGGDDEATEIISTLSNGLIASHYGVSFFTIQSFVSSLSNTSTLKNMLYVLSTAVEFESVPLRKGDRALLVKLSKRLPLRFPEHTSSGSVSFKVFLLLQAYFSRLELPVDFQNDLKDILEKVVPLINVVVDILSANGYLNATTAMDLAQMLIQGVWDVDNPLRQIPHFNNKILEKCKEINVETVYDIMALEDEERDEILTLTDSQLAQVAAFVNNYPNVELTYSLNNSDSLISGVKQKITIQLTRDVEPENLQVTSEKYPFDKLESWWLVLGEVSKKELYAIKKVTLNKETQQYELEFDTPTSGKHNLTIWCVCDSYLDADKELSFEINVK DFAF7E3B7168D944 DFAF7E3B7168D944 snu23_yeast 23 kDa U4/U6.U5 small nuclear ribonucleoprotein component SNU23 D2378 YDL098C protein protein yeast Saccharomyces cerevisiae Baker's yeast MSNFGRRTWDREEYAEQARSGYDDRSLKATLTPIELQALKSKYTNYDHLIKGSLKDLNKRKLTANTESLSSFKRGKKFGFYCDICNLTFKDTLQYIDHLNHKVHAIKFENLFDEPLIIDIRDNDDVPQEEFELCYHNLIKDFVEVRSMETQSKRKRLLDTDVEKAKKVATKPSIESESKVSQMMGFSNFATSKK 4F1C0288149B91FB 4F1C0288149B91FB pml1_yeast Pre-mRNA leakage protein 1 L1591 YLR016C PML1 protein protein yeast Saccharomyces cerevisiae Baker's yeast MFHRRKRPYNTRNYGHDDKKFKSQYIDIMPDFSPSGLLELESNNKEGIALKHVEPQDAISPDNYMDMLGLEARDRTMYELVIYRKNDKDKGPWKRYDLNGRSCYLVGRELGHSLDTDLDDRTEIVVADIGIPEETSSKQHCVIQFRNVRGILKCYVMDLDSSNGTCLNNVVIPGARYIELRSGDVLTLSEFEEDNDYELIFMNV DA39B4465EFFD378 DA39B4465EFFD378 cwc22_yeast Pre-mRNA-splicing factor CWC22 YGR278W CWC22 Complexed with CEF1 protein 22 protein protein yeast Saccharomyces cerevisiae Baker's yeast MSTATIQDEDIKFQRENWEMIRSHVSPIISNLTMDNLQESHRDLFQVNILIGRNIICKNVVDFTLNKQNGRLIPALSALIALLNSDIPDIGETLAKELMLMFVQQFNRKDYVSCGNILQCLSILFLYDVIHEIVILQILLLLLEKNSLRLVIAVMKICGWKLALVSKKTHDMIWEKLRYILQTQELSSTLRESLETLFEIRQKDYKSGSQGLFILDPTSYTVHTHSYIVSDEDEANKELGNFEKCENFNELTMAFDTLRQKLLINNTSDTNEGSNSQLQIYDMTSTNDVEFKKKIYLVLKSSLSGDEAAHKLLKLKIANNLKKSVVDIIIKSSLQESTFSKFYSILSERMITFHRSWQTAYNETFEQNYTQDIEDYETDQLRILGKFWGHLISYEFLPMDCLKIIKLTEEESCPQGRIFIKFLFQELVNELGLDELQLRLNSSKLDGMFPLEGDAEHIRYSINFFTAIGLGLLTEDMRSRLTIIQEVEDAEEEEKKLREEEELEKLRKKARESQPTQGPKIHESRLFLQKDTRENSRSRSPFTVETRKRARSRTPPRGSRNHRNRSRTPPARRQRHR 773E33C71E4A29D0 773E33C71E4A29D0 lsm8_yeast U6 snRNA-associated Sm-like protein LSm8 LSM8 J1464 YJR83.16 YJR022W protein protein yeast Saccharomyces cerevisiae Baker's yeast MSATLKDYLNKRVVIIKVDGECLIASLNGFDKNTNLFITNVFNRISKEFICKAQLLRGSEIALVGLIDAENDDSLAPIDEKKVPMLKDTKNKIENEHVIWEKVYESKTK B6E37F585B6292EA B6E37F585B6292EA cwc26_yeast Pre-mRNA-splicing factor CWC26 YGL174W G1642 BUD13 SLC7 Complexed with CEF1 protein 26 Bud site selection protein 13 Synthetic lethal with CLF1 protein 7 CWC26 protein protein yeast Saccharomyces cerevisiae Baker's yeast MALHQYLSETYGPTKPKNKTKKKKKESKSDANSDKTSLIVKERLSTLQQEQEKSGVASFSKFDKQKSKNIWKNLETNELSHAITHPSASSITGNESKNDLKEIRAQEPLVTVADKSKTRKTIYRDAQGHKIQEDSKIDDSSFSRSKYEDEKAAEREQYLKNLNMGDVQKLGINVDAHDKKKNQTASSLTIEDPAITFTHDKERTVKTSLLGRKLYDKPAPENRFAIMPGSRWDGVHRSNGFEEKWFAKQNEINEKKVQSYTLQEDY 1584B390121325CD 1584B390121325CD prp39_yeast Pre-mRNA-processing factor 39 YM9827.06 YML046W PRP39 protein protein yeast Saccharomyces cerevisiae Baker's yeast MPDETNFTIEDIEPRPDALRGLDTQFLQDNTALVQAYRGLDWSDISSLTQMVDVIEQTVVKYGNPNDSIKLALETILWQILRKYPLLFGFWKRFATIEYQLFGLKKSIAVLATSVKWFPTSLELWCDYLNVLCVNNPNETDFIRNNFEIAKDLIGKQFLSHPFWDKFIEFEVGQKNWHNVQRIYEYIIEVPLHQYARFFTSYKKFLNEKNLKTTRNIDIVLRKTQTTVNEIWQFESKIKQPFFNLGQVLNDDLENWSRYLKFVTDPSKSLDKEFVMSVFDRCLIPCLYHENTWMMYIKWLTKKNISDEVVVDIYQKANTFLPLDFKTLRYDFLRFLKRKYRSNNTLFNNIFNETVSRYLKIWPNDILLMTEYLCMLKRHSFKNSLDQSPKEILEKQTSFTKILETSITNYINNQIDAKVHLQTLINDKNLSIVVVELIKTTWLVLKNNMQTRKYFNLYQKNILIKNSVPFWLTYYKFEKSNVNFTKLNKFIRELGVEIYLPTTVMNDILTDYKTFYLTHSNIVTYESSIIDSNTFDPILYPELKMSNPKYDPVLNTTANVDWHKKTEWKEAGHIGITTERPQISNSIIECNSGTLIQKPISLPNFRNLEKINQVKINDLYTEEFLKEGK 67480ED01347B6AB syf1_yeast Pre-mRNA-splicing factor SYF1 SYF1 NTC90 Synthetic lethal with CDC40 protein 1 PRP19-associated complex protein 90 YDR416W protein protein yeast Saccharomyces cerevisiae Baker's yeast MSAYIAMKGVITNVDENIRNDEDVAFEYEIQKTPQNILTWKRYIEYWKEEGRTDKQIRWLYERFCSQFVTDTSIWEDYIRWESTKEVVETSRIFWLFQRCLKSCVRDCDRICLSYLELAIEQYDLAMIRHALASSLMKMEREMHRKVWDPVIKFVEEKVLPLTQLDSTQEDEEESTDEAELINVLLVKGFTKGGFISEEISENGSRGDIWSSHILERYLKVAPQQKRNESLATLALTRDNITIKSVYEKYLPQDENSGKYLPSSELPFELNFNYLASLEKLGLDNQYEEFMRQMNGIYPDKWLFLILSLAKYYISRGRLDSCGDLLKKSLQQTLRYSDFDRIYNFYLLFEQECSQFILGKLKENDSKFFNQKDWTEKLQAHMATFESLINLYDIYLNDVALRQDSNLVETWMKRVSLQKSAAEKCNVYSEAILKIDPRKVGTPGSFGRLWCSYGDLYWRSNAISTARELWTQSLKVPYPYIEDLEEIYLNWADRELDKEGVERAFSILEDALHVPTNPEILLEKYKNGHRKIPAQTVLFNSLRIWSKYIDYLEAYCPKDANSSDKIFNKTKMAYNTVIDLRLITPAMAENFALFLQNHYEVMESFQVYEKTIPLFPPEIQYELWIEYLEVATSHQLSSLSPEHIRFLFEKALKNLCSNGIDCKTIFIAYSVFEERISGLISKSIEILRRGAVIGTVSVSTHLESRLQLWRMCISKAESTLGPSVTRELYQECIQILPNSKAVEFVIKFSDFESSIGETIRAREILAYGAKLLPPSRNTELWDSFEIFELKHGDKETYKDMLKMKKVLESNMLIDSASVSHEEGNINFVAAATSHAPNSHTLTQSTSSYSINPDEIELDI ED4368A624A40E7C ED4368A624A40E7C snr7s_u5_yeast small nuclear RNA U5 Yeast snrna small nuclear rna snRNA snrna yeast Saccharomyces cerevisiae Baker's yeast AAGCAGCUUUACAGAUCAAUGGCGGAGGGAGGUCAACAUCAAGAACUGUGGGCCUUUUAUUGCCUAUAGAACUUAUAACGAACAUGGUUCUUGCCUUUUACCAGAACCAUCCGGGUGUUGUCUCCAUAGAAACAGGUAAAGCUGUCCGUUACUGUGGGCUUGCCAUAUUUUUUGGAACU ruxf_yeast Small nuclear ribonucleoprotein F SMX3 YPR182W P9705.4 Sm protein F protein protein yeast Saccharomyces cerevisiae Baker's yeast MSESSDISAMQPVNPKPFLKGLVNHRVGVKLKFNSTEYRGTLVSTDNYFNLQLNEAEEFVAGVSHGTLGEIFIRCNNVLYIRELPN 1640D3237597B2D8 1640D3237597B2D8 prp21_yeast Pre-mRNA-splicing factor PRP21 PRP21 SPP91 YJL203W J0322 protein protein yeast Saccharomyces cerevisiae Baker's yeast MEPEDTQLKEDIKTTVNYIKQHGVEFENKLLEDERFSFIKKDDPLHEYYTKLMNEPTDTVSGEDNDRKSEREIARPPDFLFSQYDTGISRRDMEVIKLTARYYAKDKSIVEQMISKDGEARLNFMNSSHPLHKTFTDFVAQYKRVYSFTGQEIKKSKRTILDNCFERTQYWEFEKDKDREHDKLVELCKIQFAAIPWDKFTQVAKFSIPEDTEIFEGSLDLEQMRLRRVQTGIKLFDSIKPTNEEEKIVSDQGKQKGGDSKGKKRKIRAVGETRLKKSKK 2E9DBA6F06759B3F 2E9DBA6F06759B3F prp2_yeast Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2 PRP2 RNA2 YNR011C N2048 Pre-mRNA-processing protein 2 protein protein yeast Saccharomyces cerevisiae Baker's yeast MSSITSETGKRRVKRTYEVTRQNDNAVRIEPSSLGEEEDKEAKDKNSALQLKRSRYDPNKVFSNTNQGPEKNNLKGEQLGSQKKSSKYDEKITSNNELTTKKGLLGDSENETKYASSNSKFNVEVTHKIKNAKEIDKINRQRMWEEQQLRNAMAGQSDHPDDITLEGSDKYDYVFDTDAMIDYTNEEDDLLPEEKLQYEARLAQALETEEKRILTIQEARKLLPVHQYKDELLQEIKKNQVLIIMGETGSGKTTQLPQYLVEDGFTDQGKLQIAITQPRRVAATSVAARVADEMNVVLGKEVGYQIRFEDKTTPNKTVLKYMTDGMLLREFLTDSKLSKYSCIMIDEAHERTLATDILIGLLKDILPQRPTLKLLISSATMNAKKFSEFFDNCPIFNVPGRRYPVDIHYTLQPEANYIHAAITTIFQIHTTQSLPGDILVFLTGQEEIERTKTKLEEIMSKLGSRTKQMIITPIYANLPQEQQLKIFQPTPENCRKVVLATNIAETSLTIDGIRYVIDPGFVKENSYVPSTGMTQLLTVPCSRASVDQRAGRAGRVGPGKCFRIFTKWSYLHELELMPKPEITRTNLSNTVLLLLSLGVTDLIKFPLMDKPSIPTLRKSLENLYILGALNSKGTITRLGKMMCEFPCEPEFAKVLYTAATHEQCQGVLEECLTIVSMLHETPSLFIGQKRDAAASVLSEVESDHILYLEIFNQWRNSKFSRSWCQDHKIQFKTMLRVRNIRNQLFRCSEKVGLVEKNDQARMKIGNIAGYINARITRCFISGFPMNIVQLGPTGYQTMGRSSGGLNVSVHPTSILFVNHKEKAQRPSKYVLYQQLMLTSKEFIRDCLVIPKEEWLIDMVPQIFKDLIDDKTNRGRR 7EB3E1EE93215F57 7EB3E1EE93215F57 cwc24_yeast Pre-mRNA-splicing factor CWC24 YLR323C L8543.3 Complexed with CEF1 protein 24 CWC24 protein protein yeast Saccharomyces cerevisiae Baker's yeast MFRKRLVNKSSSDEKNQKKRQKINFSEEKLVASDEEKGSSDLMSLAKSGNSRTLQLSHENEGKLQKKGEDLDKYTLTVNDDSTKEDLLNFERKELAEKAKKRRPSDDNELVLNMSGKNKRLTKQINQPTNIRTTVLMDFQPDVCKDYKQTGYCGYGDSCKFLHSRDDFKTGWKLNQEWNADKEDSKAVTLDLEKIPFKCTLCKEDYKSPVVTNCGHYFCGSCFAKDMKKGTKCFICHKETHGSAKVASDLQKMLNKRKS 4371454CCB6F13D1 4371454CCB6F13D1 prp17_yeast Pre-mRNA-processing factor 17 CDC40 PRP17 SLU4 XRS2 YDR364C D9481.11 Cell division control protein 40 protein protein yeast Saccharomyces cerevisiae Baker's yeast MGLVDGYDTSSDSDLNFDEGKSVHEKKNGNLHEDTSYEPSSNNIHKRKSHFTKSELKRRRKTRKGDGPWGSWSSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 40AED5DB35319147 40AED5DB35319147 slt11_yeast Pre-mRNA-splicing factor SLT11 ECM2 SLT11 YBR065C YBR0614 Synthetic lethality with U2 protein 11 Extracellular mutant protein 2 protein protein yeast Saccharomyces cerevisiae Baker's yeast MNDEINEPPPNICEQCLGDEANIRMTKIPQGSECKICTLPFTLYHFKTSKRSNNIIKTLICVRCATQRNICQCCMLDSRWHIPIQLRDHLISLVNEENVMTEEAKNDMMKRFLSLKNVKLGGAQITSDPSEADNIVDKLKNILLRATSDGPSTPLIKNTTALYKNEKGANEVKNLEKYASVDISHILKKLPLNESFLKNPSTKSFFLYNIDASIPEWKITDTVSQLLGIKKWKDGNSLSLIVNHKAKCGGLRFQSSELGERFVSKISETLVTPKGLKRGVLLIDRFRIFIIPWSSGFSAASFGTNTAENIKLSLSLNKLIQLELGLSFPTKSTDNAKNDKKKTSKKVHKDRSKKSKPRANKLTI BF21E687817A42B4 BF21E687817A42B4 hsh49_yeast Protein HSH49 O6142 YOR319W HSH49 protein protein yeast Saccharomyces cerevisiae Baker's yeast MNYSADSGNTVYVGNIDPRITKEQLYELFIQINPVLRIKYPKDKVLQAYQGYAFIEFYNQGDAQYAIKIMNNTVRLYDRLIKVRQVTNSTGTTNLPSNISKDMILPIAKLFIKNLADSIDSDQLVKIFNKFGKLIREPEIFYLSNGKLKCAYVYFEDFEKADLAIKSLNNQLVANNRITVDYAFKENGKGNAKYGDDVDRLLNKEALKHNMLK F6FC44083094B176 F6FC44083094B176 cwc21_yeast Pre-mRNA-splicing factor CWC21 YDR482C Complexed with CEF1 protein 21 CWC21 protein protein yeast Saccharomyces cerevisiae Baker's yeast MSYNGIGLKSAKGSSTSGHVQRSLASNNRRRPQGSQQQRQQRQNAIKKASHDKASRPLAVQKQIETHMEKREIEVQVSELRDRLEEEETLSEEQIDKKCEALRAKLTNEWQEQQRMSSLYTPRKARLTEEQHRHE 9723E1C0A393508B 9723E1C0A393508B dib1_yeast Spliceosomal protein DIB1 DIB1 CDH1 SNU16 YPR082C P9513.12 protein protein yeast Saccharomyces cerevisiae Baker's yeast MASVLLPQLRTGWHVDQAIVTETKRLVVIRFGRKNDRQCMIMDELLSSIAERVRNFAVIYLCDIDEVSDFDEMYELTDPMTVMFFYHNKHMMCDFGTGNNNKLNFIVDDKQEMIDILETIFRGARKNKGLVVSPYDYNHKRVS B8C11278571C57E5 B8C11278571C57E5 prp18_yeast Pre-mRNA-splicing factor 18 PRP18 YGR006W protein protein yeast Saccharomyces cerevisiae Baker's yeast MDLDLASILKGEISKKKKELANSKGVQPPCTEKFQPHESANIDETPRQVEQESTDEENLSDNQSDDIRTTISKLENRPERIQEAIAQDKTISVIIDPSQIGSTEGKPLLSMKCNLYIHEILSRWKASLEAYHPELFLDTKKALFPLLLQLRRNQLAPDLLISLATVLYHLQQPKEINLAVQSYMKLSIGNVAWPIGVTSVGIHARSAHSKIQGGRNAANIMIDERTRLWITSIKRLITFEEWYTSNHDSLA B50D9B9A99D9711B rds3_yeast Pre-mRNA-splicing factor RDS3 Regulator of drug sensitivity 3 RDS3 YPR094W P9513.2 protein protein yeast Saccharomyces cerevisiae Baker's yeast MSRHQFDLIMCLKQPGVQTGLLCEKCDGKCPICDSYVRPKRKVRVCENCSFGKQAKNCIICNLNVGVNDAFYCWECCRLGKDKDGCPRILNLGSNRLDRHFEKKKKV F0E4737CA4FE8D24 spliceosome b-1 1 18 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 8 unspecified role unspecified role bait bait tag MS2 tag binding to MBP tag tag certain certain sequence position certain certain certain sequence position certain the tag is MS2 sequence that binds to MBP protein used for purification label 32p radiolabel 32p radiolabel P32 32P 32P P32 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 75 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 3 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 10 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 60 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 83 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 62 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 54 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 81 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 38 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 25 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 41 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 17 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 44 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 63 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 4 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 72 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 11 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 47 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 51 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 64 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 26 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 70 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 76 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 29 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 15 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 27 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 32 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 42 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 71 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 5 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 65 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 73 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 6 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 22 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 52 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 67 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 7 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 39 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 43 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 61 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 24 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 46 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 28 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 66 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 9 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 35 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 21 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 12 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 13 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 55 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 49 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 45 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 19 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 2 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 36 northern blot northern blot northen de novo protein sequence de novo protein sequencing by mass spectrometry de novo protein sequence unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 30 northern blot northern blot northen de novo protein sequence de novo protein sequencing by mass spectrometry de novo protein sequence unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 74 northern blot northern blot northen de novo protein sequence de novo protein sequencing by mass spectrometry de novo protein sequence unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 37 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 53 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast association association Fig 3, Table 1 The spiceosome was affinity purified with the actin mRNA and separated on glycerol gradient. To isolate B complex 0.05mM ATP was added to stall the splicing reaction. spliceosome b act-1 1 18 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 8 unspecified role unspecified role bait bait deletion mutation mutation certain certain sequence position certain certain certain sequence position certain tag MS2 tag that binds MBP tag tag certain certain sequence position certain certain certain sequence position certain the tag is MS2 sequence that binds to MBP protein used for purification label 32p radiolabel 32p radiolabel P32 32P 32P P32 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 74 northern blot northern blot northen de novo protein sequence de novo protein sequencing by mass spectrometry de novo protein sequence unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 36 northern blot northern blot northen de novo protein sequence de novo protein sequencing by mass spectrometry de novo protein sequence unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 30 northern blot northern blot northen de novo protein sequence de novo protein sequencing by mass spectrometry de novo protein sequence unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 4 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 75 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 60 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 85 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 62 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 54 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 31 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 81 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 25 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 33 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 77 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 17 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 44 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 63 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 13 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 78 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 11 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 47 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 51 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 68 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 64 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 26 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 76 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 69 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 29 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 27 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 32 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 42 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 71 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 5 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 82 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 73 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 79 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 34 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 14 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 7 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 39 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 43 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 57 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 61 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 16 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 50 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 46 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 28 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 66 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 21 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 56 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 80 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 2 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast association association Table 1, Suppl. Fig 3B The spliceosome was affinity purified with the actin mRNA and separated on glycerol gradient. To isolate B act complex 2mM ATP was added and a deleted mutant of actin mRNA was used to stall the splicing reaction. spliceosoma c-1 1 18 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 8 unspecified role unspecified role bait bait label 32p radiolabel 32p radiolabel P32 32P 32P P32 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined tag MS2 tag that binds MBP tag tag certain certain sequence position certain certain certain sequence position certain the tag is MS2 sequence that binds to MBP protein used for purification deletion mutation mutation certain certain sequence position certain certain certain sequence position certain 30 northern blot northern blot northen de novo protein sequence de novo protein sequencing by mass spectrometry de novo protein sequence unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 74 northern blot northern blot northen de novo protein sequence de novo protein sequencing by mass spectrometry de novo protein sequence unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 75 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 60 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 62 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 54 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 31 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 81 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 25 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 33 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 77 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 23 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 17 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 44 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 63 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 4 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 40 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 78 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 11 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 47 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 51 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 68 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 64 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 26 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 76 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 69 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 29 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 27 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 32 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 84 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 71 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 58 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 59 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 5 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 82 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 73 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 79 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 34 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 20 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 14 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 7 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 39 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 43 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 57 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 16 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 50 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 46 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 66 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 21 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 48 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 56 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 13 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 80 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 45 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 2 unspecified role unspecified role prey prey yeast Saccharomyces cerevisiae Baker's yeast 36 unspecified role unspecified role prey prey association association Table 1, Suppl Fig4 The spiceosome was affinity purified with the actin mRNA and separated on glycerol gradient. To isolate C complex 2mM ATP was added and a deletion mutant of actin premRNA was used