UniProt UniProt http://www.uniprot.org The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity. The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity. FEBS Lett. (0014-5793) 2000 imex curation Mancini A., Koch A., Stefan M., Niemann H., Tamura T. Experiments/interactions involving phosphatidylinositol 3-kinase 85 kDa regulatory subunit (fig 2A and 4) omitted as protein identity is ambiguous and protein cannot be mapped to UniProt. Interactions involving Grb10 (fig 4) omitted as protein source and identity cannot be established. tamura.teruko@mh-hannover.de 22-Jan-2015: Contacted by IntAct-Help. Only protein-protein interactions yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined Mancini A., Koch A., Stefan M., Niemann H., Tamura T. Experiments/interactions involving phosphatidylinositol 3-kinase 85 kDa regulatory subunit (fig 2A and 4) omitted as protein identity is ambiguous and protein cannot be mapped to UniProt. Interactions involving Grb10 (fig 4) omitted as protein source and identity cannot be established. tamura.teruko@mh-hannover.de Accepted 2015-JAN-15 by ORCHARD 10-11-day mouse embryo cDNA FEBS Lett. (0014-5793) 2000 imex curation The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity. The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity. FEBS Lett. (0014-5793) 2000 imex curation Mancini A., Koch A., Stefan M., Niemann H., Tamura T. Experiments/interactions involving phosphatidylinositol 3-kinase 85 kDa regulatory subunit (fig 2A and 4) omitted as protein identity is ambiguous and protein cannot be mapped to UniProt. Interactions involving Grb10 (fig 4) omitted as protein source and identity cannot be established. tamura.teruko@mh-hannover.de 22-Jan-2015: Contacted by IntAct-Help. Only protein-protein interactions in vitro In vitro pull down pull down weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Mancini A., Koch A., Stefan M., Niemann H., Tamura T. Experiments/interactions involving phosphatidylinositol 3-kinase 85 kDa regulatory subunit (fig 2A and 4) omitted as protein identity is ambiguous and protein cannot be mapped to UniProt. Interactions involving Grb10 (fig 4) omitted as protein source and identity cannot be established. tamura.teruko@mh-hannover.de Accepted 2015-JAN-15 by ORCHARD FEBS Lett. (0014-5793) 2000 imex curation The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity. The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity. FEBS Lett. (0014-5793) 2000 imex curation Mancini A., Koch A., Stefan M., Niemann H., Tamura T. Experiments/interactions involving phosphatidylinositol 3-kinase 85 kDa regulatory subunit (fig 2A and 4) omitted as protein identity is ambiguous and protein cannot be mapped to UniProt. Interactions involving Grb10 (fig 4) omitted as protein source and identity cannot be established. tamura.teruko@mh-hannover.de 22-Jan-2015: Contacted by IntAct-Help. Only protein-protein interactions yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid nucleotide sequence nucleotide sequence identification sequence cloning sequence cloning nucleotide sequence Mancini A., Koch A., Stefan M., Niemann H., Tamura T. Experiments/interactions involving phosphatidylinositol 3-kinase 85 kDa regulatory subunit (fig 2A and 4) omitted as protein identity is ambiguous and protein cannot be mapped to UniProt. Interactions involving Grb10 (fig 4) omitted as protein source and identity cannot be established. tamura.teruko@mh-hannover.de Accepted 2015-JAN-15 by ORCHARD 10-11-day mouse embryo cDNA FEBS Lett. (0014-5793) 2000 imex curation The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity. The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity. FEBS Lett. (0014-5793) 2000 imex curation Mancini A., Koch A., Stefan M., Niemann H., Tamura T. Experiments/interactions involving phosphatidylinositol 3-kinase 85 kDa regulatory subunit (fig 2A and 4) omitted as protein identity is ambiguous and protein cannot be mapped to UniProt. Interactions involving Grb10 (fig 4) omitted as protein source and identity cannot be established. tamura.teruko@mh-hannover.de 22-Jan-2015: Contacted by IntAct-Help. Only protein-protein interactions in vitro In vitro pull down pull down western blot western blot Immuno blot Immuno blot Mancini A., Koch A., Stefan M., Niemann H., Tamura T. Experiments/interactions involving phosphatidylinositol 3-kinase 85 kDa regulatory subunit (fig 2A and 4) omitted as protein identity is ambiguous and protein cannot be mapped to UniProt. Interactions involving Grb10 (fig 4) omitted as protein source and identity cannot be established. tamura.teruko@mh-hannover.de Accepted 2015-JAN-15 by ORCHARD FEBS Lett. (0014-5793) 2000 imex curation mpdz_mouse Multiple PDZ domain protein Mpdz Mupp1 Multi-PDZ domain protein 1 protein protein mouse Mus musculus Mouse MLETIDKNRALQAAERLQSKLKERGDVANEDKLSLLKSVLQSPLFSQILNLQTSLQQLKDQVNIATLATAAADHAHTPQFSSAVISNLQSESLLLSPNHGNLEALPGPGAPAVMDGKPTCDELDQLIKNMAQGRHVEIFELLKPPCGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQVLDQTITHQQAISILQKAKDTVQLVIARGSLPPVSSPRISRSPSAASTISAHSNPMHWQHVETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAVEETPASSSLGITLSSSTSSTSEMRVDASTQKNDESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVRLTLMRKGASQEAELTSRGDTAKDVDLPAENCEKDEESLSLKRNTSILPIEEEGFPLLSAELEEAEDVQQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGINLLGENHQDVVNILKELPIDVTMVCCRRTVPPIALSEMDSLDINDLELTEKPHIDLGEFIGSSETEDPMLAMSDVDQNAEEIQTPLAMWEAGGQSIELEKGSRGLGFSILDYQDPIDPANTVIVIRSLVPGGIAEKDGRLFPGDRLMFVNDINLENSTLEEAVEALKGAPSGMVRIGVAKPLPLSPEEGYVSAKEDAFLCSPHACKESGLSDKALFRADLALIDTPDAESIAESRFESQFSPDNDSVYSTQASIFSLHDGTCSDGMNYGPSLPSSPPKDVTSSSEVVLGLHLSLEELYTQNLLQRQHAGSPPTDMRPAPTSGFPISDYTTTNAVEQKYECANPVAWPHSQLPSSLSTSELAPALPAVAQKYLTDQSSLASDAESVNLQSMSQEAFERTVTIAKGSSSLGMTVSANKDGLGVIVRSIIHGGAISRDGRIAVGDCILSINEESTISLTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFRVSFGQQAGGIMALDIFSSYTGRDIPELPEREEGEGEESELQNAAYSSWSQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIIEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLPHSLYPKYSFSSTNPFADSLQLTTDQAPSQSESETEKPALCNVPPSSPSVFSEMGSDCAQPSATAVSEDEDKEDEFGYSWKNIQERYGSLTGQLHVIELEKGQSGLGLSLAGNKDRTRMSVFIVGIDPTGAAGRDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNADAVNQMAVCPGIAADSPSSTSDSPQNKEVEPCSTTSASAADLSSLTDVYQLELPKDQGGLGIAICEEDTINGVMIESLTEHGGAAKDGRLKPGDHILAVDDEVVAGCPVEKFISLLKTAKATVKLTVRAENPACPAVPSSAVTVSGERKDNSQTPAVPAPDLEPIPSTSRSSTPAVFASDPATCPIIPGCETTIEISKGQTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEDVCDTFTIELQKRPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRHATQEAVAALLKCSLGAVTLEVGRVKAAPFHSERRPSQSSQVSESSLSSFTPPLSGINTSESLESNSKKNALASEIQGLRTVEIKKGPADSLGLSIAGGVGSPLGDVPIFIAMMHPNGVAAQTQKLRVGDRIVTICGTSTDGMTHTQAVNLMKNASGSIEVQVVAGGDVSVVTGHQQELANPCLAFTGLTSSSIFPDDLGPPQSKTITLDRGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAAAEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVLS DIP protein Q8VBX6 original sequence version: 55 mint Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses 26EA94B814214B69 kit_human Mast/stem cell growth factor receptor Kit Tyrosine-protein kinase Kit KIT Proto-oncogene c-Kit SCFR Piebald trait protein p145 c-kit v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog protein protein human Homo sapiens Human MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV DIP protein P10721 original sequence version: 149 81B0CD76817F3454 kit-mpdz-1 3 5 unspecified role unspecified role prey prey pdz_10 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 6 unspecified role unspecified role bait bait region sufficient to bind sufficient binding region sufficient to bind range range certain certain sequence position certain physical association physical association 1A mpdz-kit 2 5 unspecified role unspecified role prey prey in vitro translated in vitro translated protein in vitro translated region 35s radiolabel 35s radiolabel 35S s35 radiolabelled S35 s35 radiolabelled 35S S35 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined region sufficient to bind sufficient binding region sufficient to bind range range certain certain sequence position certain 6 unspecified role unspecified role bait bait val976del required to bind necessary binding region required to bind certain certain sequence position certain certain certain sequence position certain region gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) physical association physical association 2B mpdz-kit-1 4 5 unspecified role unspecified role bait bait region gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined pdz_10 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) 6 unspecified role unspecified role prey prey human-m07e Homo sapiens hematopoietic cells m07e human hematopoietic cells physical association physical association 3 kit-mpdz-2 1 5 unspecified role unspecified role prey prey pdz_10 sufficient to bind sufficient binding region sufficient to bind range range range range 6 unspecified role unspecified role bait bait region sufficient to bind sufficient binding region sufficient to bind range range certain certain sequence position certain val976del required to bind necessary binding region required to bind certain certain sequence position certain certain certain sequence position certain P10721:p.Lys623Met mutation increasing mutation increasing interaction mutation increasing certain certain sequence position certain certain certain sequence position certain K M kinase negative mutant Wed May 02 15:29:42 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys623met' Tue Jun 30 16:55:36 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys623Met' P10721:p.Asp816Val mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain D V In mast cell leukemia and mastocytosis. UniProt FTId: VAR_004109 Wed May 02 14:37:19 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp816val' Tue Jun 30 15:58:19 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp816Val' 29 27 physical association physical association 2A