MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain. Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain. FEBS Lett. (0014-5793) 2014 imex curation Lubula M.Y., Eckenroth B.E., Carlson S., Poplawski A., Chruszcz M., Glass K.C. karen.glass@acphs.edu 20-Oct-2014: Contacted by IntAct-Help. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined karen.glass@acphs.edu Accepted 2014-SEP-18 by LUANA 2014 imex curation Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain. Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain. FEBS Lett. (0014-5793) 2014 imex curation Lubula M.Y., Eckenroth B.E., Carlson S., Poplawski A., Chruszcz M., Glass K.C. karen.glass@acphs.edu 20-Oct-2014: Contacted by IntAct-Help. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined karen.glass@acphs.edu Accepted 2014-SEP-18 by LUANA 2014 imex curation h4_human Histone H4 H4-16 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4 HIST2H4A HIST2H4B HIST4H4 protein protein human Homo sapiens Human MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG DIP protein P62805 original sequence version: 68 DIP protein P62805 original sequence version: 111 DIP protein P62805 original sequence version: 94 DIP protein P62805 original sequence version: 97 DIP protein P62805 original sequence version: 116 DIP protein P62805 original sequence version: 105 DIP protein P62805 original sequence version: 120 DIP protein P62805 original sequence version: 144 DIP protein P62805 original sequence version: 150 DIP protein P62805 original sequence version: 154 DIP protein P62805 original sequence version: 156 DIP protein P62805 original sequence version: 112 DIP protein P62805 original sequence version: 121 DIP protein P62805 original sequence version: 123 DIP protein P62805 original sequence version: 126 DIP protein P62805 original sequence version: 132 DIP protein P62805 original sequence version: 136 DIP protein P62805 original sequence version: 119 A9E5DFD3F8B97598 h2a1_human Histone H2A type 1 H2AC11 H2AC13 H2AC15 H2AC16 H2AC17 H2AFC H2AFD H2AFI H2AFN H2AFP HIST1H2AG HIST1H2AI HIST1H2AK HIST1H2AL HIST1H2AM Histone H2A/ptl protein protein human Homo sapiens Human MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHHKAKGK DIP protein P0C0S8 original sequence version: 65 48DD539793FE8256 brpf1_human Peregrin BRPF1 BR140 Bromodomain and PHD finger-containing protein 1 Protein Br140 protein protein human Homo sapiens Human MGVDFDVKTFCHNLRATKPPYECPVETCRKVYKSYSGIEYHLYHYDHDNPPPPQQTPLRKHKKKGRQSRPANKQSPSPSEVSQSPGREVMSYAQAQRMVEVDLHGRVHRISIFDNLDVVSEDEEAPEEAPENGSNKENTETPAATPKSGKHKNKEKRKDSNHHHHHNVSASTTPKLPEVVYRELEQDTPDAPPRPTSYYRYIEKSAEELDEEVEYDMDEEDYIWLDIMNERRKTEGVSPIPQEIFEYLMDRLEKESYFESHNKGDPNALVDEDAVCCICNDGECQNSNVILFCDMCNLAVHQECYGVPYIPEGQWLCRRCLQSPSRAVDCALCPNKGGAFKQTDDGRWAHVVCALWIPEVCFANTVFLEPIDSIEHIPPARWKLTCYICKQRGSGACIQCHKANCYTAFHVTCAQQAGLYMKMEPVRETGANGTSFSVRKTAYCDIHTPPGSARRLPALSHSEGEEDEDEEEDEGKGWSSEKVKKAKAKSRIKMKKARKILAEKRAAAPVVSVPCIPPHRLSKITNRLTIQRKSQFMQRLHSYWTLKRQSRNGVPLLRRLQTHLQSQRNCDQVGRDSEDKNWALKEQLKSWQRLRHDLERARLLVELIRKREKLKRETIKVQQIAMEMQLTPFLILLRKTLEQLQEKDTGNIFSEPVPLSEVPDYLDHIKKPMDFFTMKQNLEAYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVRLREQGGAVLRQARRQAEKMGIDFETGMHIPHSLAGDEATHHTEDAAEEERLVLLENQKHLPVEEQLKLLLERLDEVNASKQSVGRSRRAKMIKKEMTALRRKLAHQRETGRDGPERHGPSSRGSLTPHPAACDKDGQTDSAAEESSSQETSKGLGPNMSSTPAHEVGRRTSVLFSKKNPKTAGPPKRPGRPPKNRESQMTPSHGGSPVGPPQLPIMSSLRQRKRGRSPRPSSSSDSDSDKSTEDPPMDLPANGFSGGNQPVKKSFLVYRNDCSLPRSSSDSESSSSSSSSAASDRTSTTPSKQGRGKPSFSRGTFPEDSSEDTSGTENEAYSVGTGRGVGHSMVRKSLGRGAGWLSEDEDSPLDALDLVWAKCRGYPSYPALIIDPKMPREGMFHHGVPIPVPPLEVLKLGEQMTQEAREHLYLVLFFDNKRTWQWLPRTKLVPLGVNQDLDKEKMLEGRKSNIRKSVQIAYHRALQHRSKVQGEQSSETSDSD 618F359F21F4CBF7 brpf1-hist1h4a 1 H4K12ac 3 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified naclys12 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain BRPF1 5 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction t1 f2b f2d brpf1-hist1h4a-1 1 H2AK5ac 4 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified naclys5 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain BRPF1 5 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction T1 f1c f1d f2a f2c brpf1-hist1h2ag 2 BRPF1 5 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain H2AK5ac 4 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified naclys5 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction f3a sf1a brpf1-hist1h2ag-1 2 H2AK5ac 4 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified naclys5 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain BRPF1 5 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P55201:p.Ala709Ser mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain A S Wed May 02 15:14:27 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ala709ser' Tue Jun 30 18:32:58 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ala709Ser' direct interaction direct interaction f3a sf1g brpf1-hist1h2ag-2 2 BRPF1 5 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified P55201:p.Glu661Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain E A Wed May 02 16:38:27 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'glu661ala' Tue Jun 30 20:01:58 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Glu661Ala' range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain H2AK5ac 4 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified naclys5 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction f3a sf1d brpf1-hist1h2ag-3 2 BRPF1 5 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P55201:p.Ile713Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain I A Wed May 02 18:19:31 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ile713ala' Tue Jun 30 16:13:21 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ile713Ala' H2AK5ac 4 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain naclys5 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction f3a sf1f brpf1-hist1h2ag-4 2 H2AK5ac 4 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified naclys5 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain BRPF1 5 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P55201:p.Cys704Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain C A Wed May 02 16:00:39 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'cys704ala' Tue Jun 30 17:55:09 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Cys704Ala' direct interaction direct interaction f3a sf1e brpf1-hist1h2ag-5 2 BRPF1 5 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P55201:p.Phe714Ala mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain F A Wed May 02 18:57:08 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'phe714ala' Tue Jun 30 15:57:56 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Phe714Ala' H2AK5ac 4 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain naclys5 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction f3a sf1c brpf1-hist1h2ag-6 2 H2AK5ac 4 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain naclys5 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain BRPF1 5 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P55201:p.Asn708Ala mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain N A Wed May 02 16:11:17 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asn708ala' Tue Jun 30 17:02:47 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asn708Ala' direct interaction direct interaction f3a sf1b brpf1-hist1h4a-2 2 H4K12ac 3 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain naclys12 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain BRPF1 5 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction f3b f3c sf2a sf3a No binding was observed between BRPF1 and H4(4-17) unmodified peptide. brpf1-hist1h4a-3 2 H4K12ac 3 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified naclys12 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain BRPF1 5 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P55201:p.Ala709Ser mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain A S Wed May 02 14:25:30 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ala709ser' Tue Jun 30 18:30:04 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ala709Ser' direct interaction direct interaction f3b f3c sf2g sf3g No binding was observed between BRPF1 and H4(4-17) unmodified peptide. brpf1-hist1h4a-4 2 BRPF1 5 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified P55201:p.Glu661Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain E A Wed May 02 15:03:49 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'glu661ala' Tue Jun 30 18:39:12 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Glu661Ala' range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain H4K12ac 3 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified naclys12 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction f3b f3c sf2d sf3d No binding was observed between BRPF1 and H4(4-17) unmodified peptide. brpf1-hist1h4a-5 2 H4K12ac 3 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain naclys12 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain BRPF1 5 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified P55201:p.Ile713Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain I A Wed May 02 17:50:33 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ile713ala' Tue Jun 30 15:36:19 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ile713Ala' range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction f3b f3c sf2f sf3f No binding was observed between BRPF1 and H4(4-17) unmodified peptide. brpf1-hist1h4a-6 2 BRPF1 5 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P55201:p.Cys704Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain C A Wed May 02 16:34:04 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'cys704ala' Tue Jun 30 18:37:45 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Cys704Ala' H4K12ac 3 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified naclys12 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction f3b f3c sf2e sf3e No binding was observed between BRPF1 and H4(4-17) unmodified peptide. brpf1-hist1h4a-7 2 H4K12ac 3 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain naclys12 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain BRPF1 5 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P55201:p.Phe714Ala mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain F A Wed May 02 16:10:09 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'phe714ala' Tue Jun 30 20:13:34 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Phe714Ala' direct interaction direct interaction f3b f3c sf2c sf3c No binding was observed between BRPF1 and H4(4-17) unmodified peptide. brpf1-hist1h4a-8 2 BRPF1 5 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified P55201:p.Asn708Ala mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain N A Wed May 02 17:13:54 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asn708ala' Tue Jun 30 18:51:42 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asn708Ala' range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain H4K12ac 3 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified naclys12 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction f3b f3c sf2b sf3b No binding was observed between BRPF1 and H4(4-17) unmodified peptide.