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  <entry>
    <source releaseDate="2022-02-04">
      <names>
        <shortLabel>MINT</shortLabel>
        <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
        <alias type="synonym" typeAc="MI:1041">MINT</alias>
      </names>
      <bibref>
        <xref>
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        </xref>
      </bibref>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0471" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="mint" dbAc="MI:0471" id="MINT-80017" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579228" refType="identity" refTypeAc="MI:0356"/>
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      </xref>
      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it/mint</attribute>
        <attribute name="url" nameAc="MI:0614">url&amp;gt;http://mint.bio.uniroma2.it/mint/</attribute>
        <attribute name="url" nameAc="MI:0614">https://mint.bio.uniroma2.it</attribute>
        <attribute name="id-validation-regexp" nameAc="MI:0628">MINT-[0-9]+</attribute>
        <attribute name="search-url" nameAc="MI:0615">https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac}</attribute>
        <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Inhibition effect of enteropeptidase on RANKL-RANK signalling by cleavage of RANK</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="23954298" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-21638" refType="secondary-ac" refTypeAc="MI:0360"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6914827" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-21010" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Inhibition effect of enteropeptidase on RANKL-RANK signalling by cleavage of RANK</attribute>
            <attribute name="journal" nameAc="MI:0885">FEBS Lett. (0014-5793)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2013</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Zhao Y., Jin M., Ma J., Zhang S., Li W., Chen Y., Zhou Y., Tao H., Liu Y., Wang L., Han H., Niu G., Tao H., Liu C., Gao B.</attribute>
            <attribute name="contact-email" nameAc="MI:0634">bgao2004@gmail.com lcz0220@163.com</attribute>
            <attribute name="author-announcement">28-Oct_2013: Contacted by IntAct-Help.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="pubmed" dbAc="MI:0446" id="23954298" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-21010" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="-1">
            <names>
              <shortLabel>in vitro</shortLabel>
              <fullName>In vitro</fullName>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>cleavage</shortLabel>
            <fullName>cleavage assay</fullName>
            <alias type="synonym" typeAc="MI:1041">cleavage</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0990" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-5527371" refType="identity" refTypeAc="MI:0356"/>
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          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>western blot</shortLabel>
            <fullName>western blot</fullName>
            <alias type="go synonym" typeAc="MI:0303">Immuno blot</alias>
            <alias type="synonym" typeAc="MI:1041">Immuno blot</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Zhao Y., Jin M., Ma J., Zhang S., Li W., Chen Y., Zhou Y., Tao H., Liu Y., Wang L., Han H., Niu G., Tao H., Liu C., Gao B.</attribute>
          <attribute name="contact-email" nameAc="MI:0634">bgao2004@gmail.com lcz0220@163.com</attribute>
          <attribute name="accepted">Accepted 2013-AUG-04 by MARTA</attribute>
          <attribute name="author-announcement">28-Oct_2013: Contacted by IntAct-Help.</attribute>
          <attribute name="journal" nameAc="MI:0885">FEBS Lett. (0014-5793)</attribute>
          <attribute name="publication year" nameAc="MI:0886">2013</attribute>
          <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
          <attribute name="imex curation" nameAc="MI:0959"/>
          <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>tnr11_human</shortLabel>
          <fullName>Tumor necrosis factor receptor superfamily member 11A</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">Receptor activator of NF-KB</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Osteoclast differentiation factor receptor</alias>
          <alias type="gene name" typeAc="MI:0301">TNFRSF11A</alias>
          <alias type="gene name synonym" typeAc="MI:0302">RANK</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q9Y6Q6" version="SP_61" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000465500" version="SP_182" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="I4EC39" version="SP_117" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="I4EC36" version="SP_126" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="I4EC38" version="SP_126" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="I7JE63" version="SP_126" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="N0GVH0" version="SP_126" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q59EP9" version="SP_126" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-525675" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001257878.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001257879.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001265197.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_003830.1"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0072674" version="SP_182"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001368" version="SP_182"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR022323" version="SP_182"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR022361" version="SP_182"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR034040" version="SP_182"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR041648" version="SP_182"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="Q9Y6Q6" version="SP_182"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1LB5" version="SP_182"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5668541" version="SP_182"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" version="SP_182"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008284" version="SP_182"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0034097" version="SP_182"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0034612" version="SP_182"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0038023" version="SP_182"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043507" version="SP_182"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051092" version="SP_182"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0060086" version="SP_182"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0060749" version="SP_182"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070555" version="SP_182"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071812" version="SP_182"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071847" version="SP_182"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001257880.1"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MAPRARRRRPLFALLLLCALLARLQVALQIAPPCTSEKHYEHLGRCCNKCEPGKYMSSKCTTTSDSVCLPCGPDEYLDSWNEEDKCLLHKVCDTGKALVAVVAGNSTTPRRCACTAGYHWSQDCECCRRNTECAPGLGAQHPLQLNKDTVCKPCLAGYFSDAFSSTDKCRPWTNCTFLGKRVEHHGTEKSDAVCSSSLPARKPPNEPHVYLPGLIILLLFASVALVAAIIFGVCYRKKGKALTANLWHWINEACGRLSGDKESSGDSCVSTHTANFGQQGACEGVLLLTLEEKTFPEDMCYPDQGGVCQGTCVGGGPYAQGEDARMLSLVSKTEIEEDSFRQMPTEDEYMDRPSQPTDQLLFLTEPGSKSTPPFSEPLEVGENDSLSQCFTGTQSTVGSESCNCTEPLCRTDWTPMSSENYLQKEVDSGHCPHWAASPSPNWADVCTGCRNPPGEDCEPLVGSPKRGPLPQCAYGMGLPPEEEASRTEARDQPEDGADGRLPSSARAGAGSGSSPGGQSPASGNVTGNSNSTFISSGQVMNFKGDIIVVYVSQTSQEGAAAAAEPMGRPVQEETLARRDSFAGNGPRFPDPCGGPEGLREPEKASRPVQEQGGAKA</sequence>
        <attributeList>
          <attribute name="crc64">E3DE9A7A08196F81</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>tnr11_mouse</shortLabel>
          <fullName>Tumor necrosis factor receptor superfamily member 11A</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">Receptor activator of NF-KB</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Osteoclast differentiation factor receptor</alias>
          <alias type="gene name" typeAc="MI:0301">Tnfrsf11a</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Rank</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="O35305" version="SP_60" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q8VCT7" version="SP_60" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000027559" version="SP_157" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-647362" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_033425.3"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-48710N"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSG00000026321" version="SP_157" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000027559" version="SP_157" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001503" version="SP_157"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0002250" version="SP_157"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004888" version="SP_157"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" version="SP_157"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" version="SP_157"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009314" version="SP_157"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009897" version="SP_157"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016021" version="SP_157"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0019955" version="SP_157"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051091" version="SP_157"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051092" version="SP_157"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0060086" version="SP_157"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0060749" version="SP_157"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070555" version="SP_157"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071812" version="SP_157"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071847" version="SP_157"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071848" version="SP_157"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0072674" version="SP_157"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001368" version="SP_157"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR022323" version="SP_157"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR022361" version="SP_157"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR034040" version="SP_157"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR041648" version="SP_157"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3ME2" version="SP_157"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3ME4" version="SP_157"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3QBQ" version="SP_157"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4GIQ" version="SP_157"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5BNQ" version="SP_157"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-5668541" version="SP_157"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-5676594" version="SP_157"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10090">
          <names>
            <shortLabel>mouse</shortLabel>
            <fullName>Mus musculus</fullName>
            <alias type="synonym" typeAc="MI:1041">Mouse</alias>
          </names>
        </organism>
        <sequence>MAPRARRRRQLPAPLLALCVLLVPLQVTLQVTPPCTQERHYEHLGRCCSRCEPGKYLSSKCTPTSDSVCLPCGPDEYLDTWNEEDKCLLHKVCDAGKALVAVDPGNHTAPRRCACTAGYHWNSDCECCRRNTECAPGFGAQHPLQLNKDTVCTPCLLGFFSDVFSSTDKCKPWTNCTLLGKLEAHQGTTESDVVCSSSMTLRRPPKEAQAYLPSLIVLLLFISVVVVAAIIFGVYYRKGGKALTANLWNWVNDACSSLSGNKESSGDRCAGSHSATSSQQEVCEGILLMTREEKMVPEDGAGVCGPVCAAGGPWAEVRDSRTFTLVSEVETQGDLSRKIPTEDEYTDRPSQPSTGSLLLIQQGSKSIPPFQEPLEVGENDSLSQCFTGTESTVDSEGCDFTEPPSRTDSMPVSPEKHLTKEIEGDSCLPWVVSSNSTDGYTGSGNTPGEDHEPFPGSLKCGPLPQCAYSMGFPSEAAASMAEAGVRPQDRADERGASGSGSSPSDQPPASGNVTGNSNSTFISSGQVMNFKGDIIVVYVSQTSQEGPGSAEPESEPVGRPVQEETLAHRDSFAGTAPRFPDVCATGAGLQEQGAPRQKDGTSRPVQEQGGAQTSLHTQGSGQCAE</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein O35305 original sequence version: 82</attribute>
          <attribute name="remark-internal">DIP protein O35305 original sequence version: 91</attribute>
          <attribute name="remark-internal">DIP protein O35305 original sequence version: 102</attribute>
          <attribute name="crc64">F8C1872E99511D8E</attribute>
        </attributeList>
      </interactor>
      <interactor id="4">
        <names>
          <shortLabel>entk_human</shortLabel>
          <fullName>Enteropeptidase</fullName>
          <alias type="gene name" typeAc="MI:0301">TMPRSS15</alias>
          <alias type="gene name synonym" typeAc="MI:0302">ENTK</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Enterokinase</alias>
          <alias type="gene name synonym" typeAc="MI:0302">PRSS7</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Serine protease 7</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Transmembrane protease serine 15</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P98073" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000284885" version="SP_208" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q2NKL7" version="SP_145" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6914845" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000154646" version="SP_208" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000284885" version="SP_208" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004252" version="SP_208"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005044" version="SP_208"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005903" version="SP_208"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016020" version="SP_208"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016021" version="SP_208"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000082" version="SP_208"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000859" version="SP_208"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000998" version="SP_208"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001190" version="SP_208"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001254" version="SP_208"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001314" version="SP_208"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002172" version="SP_208"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR009003" version="SP_208"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011163" version="SP_208"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013320" version="SP_208"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR017448" version="SP_208"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018114" version="SP_208"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR023415" version="SP_208"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR033116" version="SP_208"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR035914" version="SP_208"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036055" version="SP_208"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036364" version="SP_208"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036772" version="SP_208"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR043504" version="SP_208"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4DGJ" version="SP_208"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6ZOV" version="SP_208"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_002763.2"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MGSKRGISSRHHSLSSYEIMFAALFAILVVLCAGLIAVSCLTIKESQRGAALGQSHEARATFKITSGVTYNPNLQDKLSVDFKVLAFDLQQMIDEIFLSSNLKNEYKNSRVLQFENGSIIVVFDLFFAQWVSDENVKEELIQGLEANKSSQLVTFHIDLNSVDILDKLTTTSHLATPGNVSIECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDEDNKMCATVCDGRFLLTGSSGSFQATHYPKPSETSVVCQWIIRVNQGLSIKLSFDDFNTYYTDILDIYEGVGSSKILRASIWETNPGTIRIFSNQVTATFLIESDESDYVGFNATYTAFNSSELNNYEKINCNFEDGFCFWVQDLNDDNEWERIQGSTFSPFTGPNFDHTFGNASGFYISTPTGPGGRQERVGLLSLPLDPTLEPACLSFWYHMYGENVHKLSINISNDQNMEKTVFQKEGNYGDNWNYGQVTLNETVKFKVAFNAFKNKILSDIALDDISLTYGICNGSLYPEPTLVPTPPPELPTDCGGPFELWEPNTTFSSTNFPNSYPNLAFCVWILNAQKGKNIQLHFQEFDLENINDVVEIRDGEEADSLLLAVYTGPGPVKDVFSTTNRMTVLLITNDVLARGGFKANFTTGYHLGIPEPCKADHFQCKNGECVPLVNLCDGHLHCEDGSDEADCVRFFNGTTNNNGLVRFRIQSIWHTACAENWTTQISNDVCQLLGLGSGNSSKPIFPTDGGPFVKLNTAPDGHLILTPSQQCLQDSLIRLQCNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQSFLH</sequence>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="5" imexId="IM-21010-1">
        <names>
          <shortLabel>ep-tnfrsf11a-2</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-6914842" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-21010-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="6">
            <names>
              <alias type="author assigned name" typeAc="MI:0345">EP</alias>
            </names>
            <xref>
              <primaryRef db="uniprot" dbAc="MI:1097" id="P98073" refType="primary-reference" refTypeAc="MI:0358"/>
            </xref>
            <interactorRef>4</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>enzyme</shortLabel>
                <fullName>enzyme</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0501" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-46" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>purified</shortLabel>
                  <fullName>purified</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
          </participant>
          <participant id="7">
            <names>
              <alias type="author assigned name" typeAc="MI:0345">mRANK</alias>
            </names>
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>enzyme target</shortLabel>
                <fullName>enzyme target</fullName>
                <alias type="go synonym" typeAc="MI:0303">substrate</alias>
                <alias type="synonym" typeAc="MI:1041">substrate</alias>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0502" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-64" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>purified</shortLabel>
                  <fullName>purified</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>cleavage</shortLabel>
            <fullName>cleavage reaction</fullName>
            <alias type="synonym" typeAc="MI:1041">cleavage</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0194" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49853" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">f2a f2d f2e f2f f2g</attribute>
        </attributeList>
      </interaction>
      <interaction id="8" imexId="IM-21010-2">
        <names>
          <shortLabel>ep-tnfrsf11a-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-6914852" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-21010-2" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="9">
            <names>
              <alias type="author assigned name" typeAc="MI:0345">EP</alias>
            </names>
            <xref>
              <primaryRef db="uniprot" dbAc="MI:1097" id="P98073" refType="primary-reference" refTypeAc="MI:0358"/>
            </xref>
            <interactorRef>4</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>enzyme</shortLabel>
                <fullName>enzyme</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0501" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-46" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>purified</shortLabel>
                  <fullName>purified</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
          </participant>
          <participant id="10">
            <names>
              <alias type="author assigned name" typeAc="MI:0345">hRANK</alias>
            </names>
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>enzyme target</shortLabel>
                <fullName>enzyme target</fullName>
                <alias type="go synonym" typeAc="MI:0303">substrate</alias>
                <alias type="synonym" typeAc="MI:1041">substrate</alias>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0502" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-64" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>purified</shortLabel>
                  <fullName>purified</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>cleavage</shortLabel>
            <fullName>cleavage reaction</fullName>
            <alias type="synonym" typeAc="MI:1041">cleavage</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0194" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49853" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">f2b</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>