UniProt UniProt http://www.uniprot.org VANGL2 mutations in human cranial neural-tube defects. VANGL2 mutations in human cranial neural-tube defects. N. Engl. J. Med. (0028-4793) 2010 mimix curation Lei Y.P., Zhang T., Li H., Wu B.L., Jin L., Wang H.Y. Origin of Dvl constructs according pmid 15456783 (P Gros and E Torban). wanghy@fudan.edu.cn 17-Jun-2013: Contacted by IntAct-Help. yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined Lei Y.P., Zhang T., Li H., Wu B.L., Jin L., Wang H.Y. Origin of Dvl constructs according pmid 15456783 (P Gros and E Torban). wanghy@fudan.edu.cn Accepted 2013-JUN-04 by MGT 17-Jun-2013: Contacted by IntAct-Help. N. Engl. J. Med. (0028-4793) 2010 mimix curation dvl2_mouse Segment polarity protein dishevelled homolog DVL-2 Dvl2 DSH homolog 2 protein protein mouse Mus musculus Mouse MAGSSAGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLVSSDTPQPEVAPPAHESRTELVPPPPPLPPLPPERTSGIGDSRPPSFHPNVSSSHENLEPETETESVVSLRRDRPRRRDSSEHGAGGHRPGGPSRLERHLAGYESSSTLMTSELESTSLGDSDEDDTMSRFSSSTEQSSASRLLKRHRRRRKQRPPRMERTSSFSSVTDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPRNEPIQPIDPAAWVSHSAALTGAFPAYPGSSSMSTITSGSSLPDGCEGRGLSVHMDMASVTKAMAAPESGLEVRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGDLSGGCESYLVNLSLNDNDGSSGASDQDTLAPLPGATPWPLLPTFSYQYPAPHPYSPQPPPYHELSSYTYGGGSASSQHSEGSRSSGSTRSDGGAGRTGRPEERAPESKSGSGSESELSSRGGSLRRGGEPGGTGDGGPPPSRGSTGAPPNLRALPGLHPYGAPSGMALPYNPMMVVMMPPPPPPVSTAVQPPGAPPVRDLGSVPPELTASRQSFHMAMGNPSEFFVDVM DIP protein Q60838 original sequence version: 132 DIP protein Q60838 original sequence version: 63 DIP protein Q60838 original sequence version: 125 DIP protein Q60838 original sequence version: 69 DIP protein Q60838 original sequence version: 91 928A527143BBBBB0 dvl3_mouse Segment polarity protein dishevelled homolog DVL-3 Dvl3 DSH homolog 3 protein protein mouse Mus musculus Mouse MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGSHPEPAPFCADNPSELPPSMERTGGIGDSRPPSFHPHASGGSQENLDNDTETDSLVSAQRERPRRRDGPEHAARLNGTTKGERRREPGGYDSSSTLMSSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTGTFPAYGMSPSLSTITSTSSSITSSIPDTERLDDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNMANLSLHDHDGSSGASDQDTLAPLPHPGAAPWPMAFPYQYPPPPHPYNPHPGFPELGYSYGGGSASSQHSEGSRSSGSNRSGSDRRKEKDPKAGDSKSGGSGSESDHTTRSSLRGPRERAPSERSGPAASEHSHRSHHSLTSSLRSHHTHPSYGPPGVPPLYGPPMLMMTPPPAAMGPPGAPPGRDLASVPPELTASRQSFRMAMGNPSEFFVDVM 552A5BE4BEA801F0 vang2_human Vang-like protein 2 Van Gogh-like protein 2 Strabismus 1 Loop-tail protein 1 homolog VANGL2 KIAA1215 STB1 protein protein human Homo sapiens Human MDTESQYSGYSYKSGHSRSSRKHRDRRDRHRSKSRDGGRGDKSVTIQAPGEPLLDNESTRGDERDDNWGETTTVVTGTSEHSISHDDLTRIAKDMEDSVPLDCSRHLGVAAGATLALLSFLTPLAFLLLPPLLWREELEPCGTACEGLFISVAFKLLILLLGSWALFFRRPKASLPRVFVLRALLMVLVFLLVVSYWLFYGVRILDARERSYQGVVQFAVSLVDALLFVHYLAVVLLELRQLQPQFTLKVVRSTDGASRFYNVGHLSIQRVAVWILEKYYHDFPVYNPALLNLPKSVLAKKVSGFKVYSLGEENSTNNSTGQSRAVIAAAARRRDNSHNEYYYEEAEHERRVRKRRARLVVAVEEAFTHIKRLQEEEQKNPREVMDPREAAQAIFASMARAMQKYLRTTKQQPYHTMESILQHLEFCITHDMTPKAFLERYLAAGPTIQYHKERWLAKQWTLVSEEPVTNGLKDGIVFLLKRQDFSLVVSTKKVPFFKLSEEFVDPKSHKFVMRLQSETSV 0E1FFE4ACC102560 dvl1_mouse Segment polarity protein dishevelled homolog DVL-1 Dvl1 Dvl DSH homolog 1 protein protein mouse Mus musculus Mouse MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVKEEIFDDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRPPSFHPNVASSRDGMDNETGTESMVSHRRERARRRNRDEAARTNGHPRGDRRRDLGLPPDSASTVLSSELESSSFIDSDEEDNTSRLSSSTEQSTSSRLVRKHKCRRRKQRLRQTDRASSFSSITDSTMSLNIITVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPRSYFTIPRADPVRPIDPAAWLSHTAALTGALPRYGTSPCSSAITRTSSSSLTSSVPGAPQLEEAPLTVKSDMSAIVRVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFKERREARKYASSMLKHGFLRHTVNKITFSEQCYYVFGDLCSNLASLNLNSGSSGASDQDTLAPLPHPSVPWPLGQGYPYQYPGPPPCFPPAYQDPGFSCGSGSAGSQQSEGSKSSGSTRSSHRTPGREERRATGAGGSGSESDHTVPSGSGSTGWWERPVSQLSRGSSPRSQASAVAPGLPPLHPLTKAYAVVGGPPGGPPVRELAAVPPELTGSRQSFQKAMGNPCEFFVDIM DIP protein P51141 original sequence version: 147 FA21ACAC48FF71E0 vangl2-dvl1-3 1 5 unspecified role unspecified role prey prey 4 unspecified role unspecified role bait bait Q9ULK5:p.Arg353Cys mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain R C Wed May 02 17:41:09 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg353cys' Tue Jun 30 17:39:43 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg353Cys' Q9ULK5:p.Asp255Glu mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain D E Wed May 02 18:28:32 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp255glu' Tue Jun 30 18:34:17 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp255Glu' Q9ULK5:p.Ser464Asn mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain S N Wed May 02 17:48:51 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ser464asn' Tue Jun 30 19:28:21 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ser464Asn' Q9ULK5:p.Phe437Ser mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain F S Wed May 02 19:12:12 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'phe437ser' Tue Jun 30 18:42:58 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Phe437Ser' physical association physical association 1B vangl2-dvl2-3 1 2 unspecified role unspecified role prey prey 4 unspecified role unspecified role bait bait Q9ULK5:p.Arg353Cys mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain R C Wed May 02 19:24:36 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg353cys' Tue Jun 30 20:00:19 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg353Cys' Q9ULK5:p.Ser464Asn mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain S N Wed May 02 16:37:57 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ser464asn' Tue Jun 30 17:46:08 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ser464Asn' Q9ULK5:p.Phe437Ser mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain F S Wed May 02 19:22:09 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'phe437ser' Tue Jun 30 16:34:31 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Phe437Ser' Q9ULK5:p.Asp255Glu mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain D E Wed May 02 17:06:05 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp255glu' Tue Jun 30 18:56:56 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp255Glu' physical association physical association 1B vangl2-dvl3-2 1 3 unspecified role unspecified role prey prey 4 unspecified role unspecified role bait bait Q9ULK5:p.Phe437Ser mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain F S Wed May 02 17:20:58 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'phe437ser' Tue Jun 30 15:55:27 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Phe437Ser' Q9ULK5:p.Arg353Cys mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain R C Wed May 02 17:38:55 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg353cys' Tue Jun 30 17:52:26 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg353Cys' Q9ULK5:p.Ser464Asn mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain S N Wed May 02 16:57:12 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ser464asn' Tue Jun 30 18:11:07 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ser464Asn' Q9ULK5:p.Asp255Glu mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain D E Wed May 02 16:32:01 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp255glu' Tue Jun 30 18:28:52 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp255Glu' physical association physical association 1B