NTNU NTNU, Norwegian University of Science and Technology www.ntnu.no/home Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription. Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription. Nucleic Acids Res. (0305-1048) 2005 imex curation Christensen J., Cloos P., Toftegaard U., Klinkenberg D., Bracken A.P., Trinh E., Heeran M., Di Stefano L., Helin K. kristian.helin@bric.dk 03-Dec-2015: Contacted by IntAct-Help. human-u2-os Human U2-OS osteosarcoma cell line u2-os U2-OS osteocaroma cell line Not in CAPRI and no primary literature reference ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Christensen J., Cloos P., Toftegaard U., Klinkenberg D., Bracken A.P., Trinh E., Heeran M., Di Stefano L., Helin K. kristian.helin@bric.dk Accepted 2015-NOV-19 AT 10:36 GMT AT 10:36 GMT by ORCHARD Nucleic Acids Res. (0305-1048) 2005 imex curation e2f1_human_gene Human transcription factor E2F1 gene gene human Homo sapiens Human ccna2_human_gene Human CCNA2 gene gene gene human Homo sapiens Human e2f7_human Transcription factor E2F7 E2F7 protein protein human Homo sapiens Human MEVNCLTLKDLISPRQPRLDFAVEDGENAQKENIFVDRSRMAPKTPIKNEPIDLSKQKKFTPERNPITPVKFVDRQQAEPWTPTANLKMLISAASPDIRDREKKKGLFRPIENKDDAFTDSLQLDVVGDSAVDEFEKQRPSRKQKSLGLLCQKFLARYPSYPLSTEKTTISLDEVAVSLGVERRRIYDIVNVLESLHLVSRVAKNQYGWHGRHSLPKTLRNLQRLGEEQKYEEQMAYLQQKELDLIDYKFGERKKDGDPDSQEQQLLDFSEPDCPSSSANSRKDKSLRIMSQKFVMLFLVSKTKIVTLDVAAKILIEESQDAPDHSKFKTKVRRLYDIANVLTSLALIKKVHVTEERGRKPAFKWIGPVDFSSSDEELVDVSASVLPELKRETYGQIQVCAKQKLARHGSFNTVQASERIQRKVNSEPSSPYREEQGSGGYSLEIGSLAAVYRQKIEDNSQGKAFASKRVVPPSSSLDPVAPFPVLSVDPEYCVNPLAHPVFSVAQTDLQAFSMQNGLNGQVDVSLASAASAVESLKPALLAGQPLVYVPSASLFMLYGSLQEGPASGSGSERDDRSSEAPATVELSSAPSAQKRLCEERKPQEEDEPATKRQSREYEDGPLSLVMPKKPSDSTDLASPKTMGNRASIPLKDIHVNGQLPAAEEISGKATANSLVSSEWGNPSRNTDVEKPSKENESTKEPSLLQYLCVQSPAGLNGFNVLLSGSQTPPTVGPSSGQLPSFSVPCMVLPSPPLGPFPVLYSPAMPGPVSSTLGALPNTGPVNFSLPGLGSIAQLLVGPTAVVNPKSSTLPSADPQLQSQPSLNLSPVMSRSHSVVQQPESPVYVGHPVSVVKLHQSPVPVTPKSIQRTHRETFFKTPGSLGDPVLKRRERNQSRNTSSAQRRLEIPSGGAD 748FEC8F24EAC5D8 e2f4_human Transcription factor E2F4 E2F4 protein protein human Homo sapiens Human MAEAGPQAPPPPGTPSRHEKSLGLLTTKFVSLLQEAKDGVLDLKLAADTLAVRQKRRIYDITNVLEGIGLIEKKSKNSIQWKGVGPGCNTREIADKLIELKAEIEELQQREQELDQHKVWVQQSIRNVTEDVQNSCLAYVTHEDICRCFAGDTLLAIRAPSGTSLEVPIPEGLNGQKKYQIHLKSVSGPIEVLLVNKEAWSSPPVAVPVPPPEDLLQSPSAVSTPPPLPKPALAQSQEASRPNSPQLTPTAVPGSAEVQGMAGPAAEITVSGGPGTDSKDSGELSSLPLGPTTLDTRPLQSSALLDSSSSSSSSSSSSSNSNSSSSSGPNPSTSFEPIKADPTGVLELPKELSEIFDPTRECMSSELLEELMSSEVFAPLLRLSPPPGDHDYIYNLDESEGVCDLFDVPVLNL DIP protein Q16254 original sequence version: 146 DIP protein Q16254 original sequence version: 114 BAAC95DE1B7E0832 e2f8_human_gene E2F transcription factor 8 gene gene human Homo sapiens Human e2f1_human Transcription factor E2F1 Retinoblastoma-associated protein 1 Retinoblastoma-binding protein 3 PBR3 E2F1 RBBP3 pRB-binding protein E2F-1 protein protein human Homo sapiens Human MALAGAPAGGPCAPALEALLGAGALRLLDSSQIVIISAAQDASAPPAPTGPAAPAAGPCDPDLLLFATPQAPRPTPSAPRPALGRPPVKRRLDLETDHQYLAESSGPARGRGRHPGKGVKSPGEKSRYETSLNLTTKRFLELLSHSADGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLIAKKSKNHIQWLGSHTTVGVGGRLEGLTQDLRQLQESEQQLDHLMNICTTQLRLLSEDTDSQRLAYVTCQDLRSIADPAEQMVMVIKAPPETQLQAVDSSENFQISLKSKQGPIDVFLCPEETVGGISPGKTPSQEVTSEEENRATDSATIVSPPPSSPPSSLTTDPSQSLLSLEQEPLLSRMGSLRAPVDEDRLSPLVAADSLLEHVREDFSGLLPEEFISLSPPHEALDYHFGLEEGEGIRDLFDCDFGDLTPLDF DIP protein Q01094 original sequence version: 173 DIP protein Q01094 original sequence version: 168 DIP protein Q01094 original sequence version: 149 DIP protein Q01094 original sequence version: 130 DIP protein Q01094 original sequence version: 125 DIP protein Q01094 original sequence version: 153 DIP protein Q01094 original sequence version: 180 003B3F654F0C60DF e2f1-e2f8-1 1 6 unspecified role unspecified role prey prey 7 unspecified role unspecified role bait bait association association Q01094 increase expression at RNA level of ENSG00000129173 Fig 4B e2f4-e2f8 1 e2f8 6 unspecified role unspecified role prey prey e2f4 5 unspecified role unspecified role bait bait association association Fig 4B e2f7-e2f8-2 1 e2f7 4 unspecified role unspecified role bait bait E2F8 6 unspecified role unspecified role prey prey association association Fig 4B e2f1-e2f1-1 1 7 unspecified role unspecified role bait bait 2 unspecified role unspecified role prey prey association association Fig 4B e2f4-e2f1 1 5 unspecified role unspecified role bait bait 2 unspecified role unspecified role prey prey association association Fig 4B e2f7-e2f1 1 4 unspecified role unspecified role bait bait 2 unspecified role unspecified role prey prey association association Fig 4B e2f1-ccna2 1 7 unspecified role unspecified role bait bait 3 unspecified role unspecified role prey prey association association Fig 4B e2f4-ccna2 1 5 unspecified role unspecified role bait bait 3 unspecified role unspecified role prey prey association association Fig 4B