UniProt UniProt http://www.uniprot.org Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus. Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus. Hum. Mol. Genet. (0964-6906) 2004 imex curation Li N., Nakamura K., Jiang Y., Tsurui H., Matsuoka S., Abe M., Ohtsuji M., Nishimura H., Kato K., Kawai T., Atsumi T., Koike T., Shirai T., Ueno H., Hirose S. sacchi@med.juntendo.ac.jp 16-Apr-2013: Contacted by IntAct-Help. Only protein-protein interactions chlae-cos_7 Cercopithecus aethiops simian cells transformed with SV40 Grivet cos_7 cercopithecus aethiops, by transformation with SV40 anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Li N., Nakamura K., Jiang Y., Tsurui H., Matsuoka S., Abe M., Ohtsuji M., Nishimura H., Kato K., Kawai T., Atsumi T., Koike T., Shirai T., Ueno H., Hirose S. sacchi@med.juntendo.ac.jp Accepted 2013-APR-05 by ORCHARD 16-Apr-2013: Contacted by IntAct-Help. Hum. Mol. Genet. (0964-6906) 2004 Only protein-protein interactions imex curation p85a_chlae_protein Green monkey Major Phosphatidylinositol 3-kinase regulatory subunit alpha protein protein chlae Chlorocebus aethiops Cercopithecus aethiops Grivet Green monkey similar to human P27986 UniProt entry ltk_human Leukocyte tyrosine kinase receptor LTK TYK1 Protein tyrosine kinase 1 protein protein human Homo sapiens Human MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLNSPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYLISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCLGESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYLRPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGCSEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELFLQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHKPPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWLSSGLKPLKSRGLQPQNLWNPTYRS 0617F378AA04298E pik3r1-ltk 1 2 unspecified role unspecified role bait bait 3 unspecified role unspecified role prey prey nucl transfection nucleic acid transfection nucl transfection P29376:p.Gly750Glu mutation increasing mutation increasing interaction mutation increasing certain certain sequence position certain certain certain sequence position certain G E Wed May 02 15:09:41 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly750glu' Tue Jun 30 17:40:25 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly750Glu' P29376:p.Glu763Lys mutation increasing mutation increasing interaction mutation increasing certain certain sequence position certain certain certain sequence position certain E K Wed May 02 20:01:36 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'glu763lys' Tue Jun 30 19:23:25 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Glu763Lys' may possibly contribute to susceptibility to systemic lupus erythematosus (SLE) physical association physical association 4c