HPIDb Host Pathogen Interaction database http://www.agbase.msstate.edu/hpi/main.html Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart. Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart. Science (0036-8075) 1999 imex curation Brown C.B., Boyer A.S., Runyan R.B., Barnett J.V. joey.barnett@mcmail.vanderbilt.edu 8-May-2012: Contacted by IntAct-Help. Immunoprecipitation with antisera to extracellular domain of TBRIII and crosslinking with I125-TGFB1 Only protein-protein interactions imex curation chick-embryonic_fibroblast Chick embryonic fibroblasts embryonic_fibroblast Embryonic fibroblast Fibroblasts taken from an embryonic as opposed to a foetal or adult source. Foetus is defined as the stage at which tissue diferentiation is initiated. Tissue taken from an embryonic as opposed to a foetal or adult source. Embryo is defined as the development stage prior to organ formation. affinity techniques affinity technology affinity techniques weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Brown C.B., Boyer A.S., Runyan R.B., Barnett J.V. joey.barnett@mcmail.vanderbilt.edu Accepted 2013-APR-30 by ORCHARD 8-May-2012: Contacted by IntAct-Help. Immunoprecipitation with antisera to extracellular domain of TBRIII and crosslinking with I125-TGFB1 Science (0036-8075) 1999 imex curation q90998_chick TGFBR3 protein protein chick Gallus gallus (Chicken) Chicken MSSSCVTPVFALMILCFADAGPVPRSECVLSPVNSSHPVHALLESFTVLSGCASRGTTGLPQEVHVLNLRNPDEGLDHHEREVTLHLTPISSVHIHQKPLVFLLNSPLPLVWKLKTERLAPGIRRVFFVSSGSIVWFEKGNFSLSAETEEKNFPERNEHLLQWAQKEYGAVTSFTELKISRNIYIKVGEDQVFPPTCNIEKNFLSLNYLAGYLQPKRAEGCLMSNLVQEREVHIIELITPNSNPYSAFQVDIIVDIKPSQPGAKLERNVVLILKCKKSVNWVIKSHDVQGKLEVITSNSIGFGKETERSMTMSKSVIPDIPSSHESLIKWAYEHKYSPVTSYTKAPVANRFHLQLEHTEEMNDEEDHSLPPELTELLHGAKNPALSDGLTFPFHINRGGHETGGEGIFPSRDSVDTLINHDFEHSLSKHKEPEEVQGSADVALSIKCDDKVMTVAVEKDSLQASGYTRTELSLLDHSCKARMNGTHFILESLPNKCGTRTSYILDKIVYFNSIVIQLSSPAEGSSFDDDDMESGDNGFPGDADEGDVTFSNWPEIAFNCTLHQPEKDFFNPAMFWPPEPHITNVTFNMELYKTDLFLAPSQGLFSVAENGPIYVEVSVTKADISLGFAIQTCFVSPFSNPDRMSDYTIIENICPKDESVKFYSTEKLNFPIAHAQKDKKRFSFVFKPIFNISLLFLHCELTLCTNIDKDTQRLPKCVPPDEACTSLNVDMILAMMHNKKTFTKPLVITHEGKPEDSSLPKSNVRQPSVFYGLDTLTVVGIAFAAFVIGALLTGALWFIYSHTGEAAGRRQVPTSPPASENSSAAHSIGSTQSTPCSSSSAT BFDEA3FCCBFFFB72 tgfb1_human Transforming growth factor beta-1 proprotein TGFB1 TGFB protein protein human Homo sapiens Human MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS DIP protein P01137 original sequence version: 149 DIP protein P01137 original sequence version: 185 DIP protein P01137 original sequence version: 160 75391614250288FE tgfb1-tgfbr3 1 TBRIII 2 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level I125-TGF-B1 3 unspecified role unspecified role neutral component neutral component engineered engineered i125-tgfb1 125i radiolabel 125i radiolabel I125 125I 125I I125 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association true replication-based confidence replication-based confidence replication score 3 1C Binding of TBRIII and TGFB1 reduces as concentration of antiserum against extracellular domain of TBRIII increases