IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Natural intracellular peptides can modulate the interactions of mouse brain proteins and thimet oligopeptidase with 14-3-3ε and calmodulin. Natural intracellular peptides can modulate the interactions of mouse brain proteins and thimet oligopeptidase with 14-3-3ε and calmodulin. Proteomics (1615-9853) 2012 imex curation Russo L.C., Asega A.F., Castro L.M., Negraes P.D., Cruz L., Gozzo F.C., Ulrich H., Camargo A.C., Rioli V., Ferro E.S. eferro@usp.br 15-Nov-2012: Contacted by pporras. Only protein-protein interactions in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Russo L.C., Asega A.F., Castro L.M., Negraes P.D., Cruz L., Gozzo F.C., Ulrich H., Camargo A.C., Rioli V., Ferro E.S. eferro@usp.br Accepted 2012-OCT-31 by MGT 15-Nov-2012: Contacted by pporras. Proteomics (1615-9853) 2012 Only protein-protein interactions imex curation calm_rat Calmodulin Calm1 Calm Cam Cam1 Calm2 Cam2 Camb Calm3 Cam3 Camc CaMII protein protein rat Rattus norvegicus (Rat) Rat MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK DIP protein P62161 original sequence version: 125 DIP protein P62161 original sequence version: 51 DIP protein P62161 original sequence version: 55 DIP protein P62161 original sequence version: 59 DIP protein P62161 original sequence version: 80 DIP protein P62161 original sequence version: 81 DIP protein P62161 original sequence version: 132 DIP protein P62161 original sequence version: 96 6B4BC3FCDE10727B thop1_rat Thimet oligopeptidase Thop1 Endo-oligopeptidase A Endopeptidase 24.15 PZ-peptidase Soluble metallo-endopeptidase protein protein rat Rattus norvegicus (Rat) Rat MKPPAACAGDVVDTVSPCSTVNHLRWDLSAQQIRALTTQLIEQTKCVYDRVGAQDFEDVSYESTLKALADVEVTYTVQRNILDFPQHVSPNKDIRAASTEADKKLSEFDVEMSMRQDVYQRVVWLQEKIPKDSLKPEAARYLERLIKLGRRNGLHLPQDTQEKIKNIKKRLSLLCIDFNKNLNEDTTFLPFTREELGGLPEDFLNSLEKTEDGKLKVTLKYPHYFPLLKKCHVPETRRLLEEAFNCRCKEENCAILKELVSLRAQKSNLLGFRTHADYVLEMNMAKTSQTVATFLDELARKLKPLGEQERAVILELKEAECAKRGLPFDGRIHAWDMRYYMNQVEETRYRVDQNLLKEYFPMQVVTRGLLAIYQELLGLTFTLEEGAAAWHEDVRLYSVRDAASGEEIGKFYLDLYPREGKYGHAACFGLQPGCLRQDGSRQLAIAAMVANFTKPTPDVPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEKEPLMRMSQHYRTGGEAPEDLLEKLIKSRQANAGLFNLRQIVLAKVDQVLHTQTDVDPAEEYARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLSPKVGMDYRTSILRPGGSEDASTMLKQFLGRDPKQDAFLLSKGLQVEGCEPPAC A0B399AF61B60F81 1433e_rat 14-3-3 protein epsilon Ywhae Mitochondrial import stimulation factor L subunit protein protein rat Rattus norvegicus (Rat) Rat MDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDGEEQNKEALQDVEDENQ DIP protein P62260 original sequence version: 67 07817CCBD1F75B26 ywhae-thop1 1 3 unspecified role unspecified role prey prey purified purified P24155:p.His473Ala mutation mutation certain certain sequence position certain certain certain sequence position certain H A Wed May 02 14:45:58 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'his473ala' Tue Jun 30 20:22:24 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.His473Ala' This mutation inactivates the catalytic activity of thop1. ecoli Escherichia coli (strain K12) 4 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction table 2 Peptide VFD-7 (VFDVELL) disrupts the interactions in a concentration-dependent manner. Peptides AVA-9 (AVAIKAMAK) and SAM-12 (SAMTEEAAVAIK) disrupt the interaction at concentrations of 10 and 1 microM, respectively. calm-thop1 1 2 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) 3 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction fig 4a Peptide VFD-7 (VFDVELL) disrupts the interactions in a concentration-dependent manner. calm1-thop1 1 3 unspecified role unspecified role prey prey purified purified P24155:p.His473Ala mutation mutation certain certain sequence position certain certain certain sequence position certain H A Wed May 02 16:31:29 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'his473ala' Tue Jun 30 17:24:01 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.His473Ala' This mutation inactivates the catalytic activity of thop1. ecoli Escherichia coli (strain K12) 2 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction table 2 Peptide VFD-7 (VFDVELL) disrupts the interactions in a concentration-dependent manner. Peptide AVA-9 (AVAIKAMAK) disrupts the interaction at concentration of 10 microM.