MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it Identification of ICAD-derived peptides capable of inhibiting caspase-activated DNase. Identification of ICAD-derived peptides capable of inhibiting caspase-activated DNase. FEBS J. (1742-464X) 2012 Kutscher D., Pingoud A., Jeltsch A., Meiss G. in vitro In vitro peptide array peptide array predetermined predetermined participant predetermined Kutscher D., Pingoud A., Jeltsch A., Meiss G. FEBS J. (1742-464X) 2012 dffa_mouse DNA fragmentation factor subunit alpha Dffa Icad DNA fragmentation factor 45 kDa subunit Inhibitor of CAD protein protein mouse Mus musculus Mouse MELSRGASAPDPDDVRPLKPCLLRRNHSRDQHGVAASSLEELRSKACELLAIDKSLTPITLVLAEDGTIVDDDDYFLCLPSNTKFVALACNEKWIYNDSDGGTAWVSQESFEADEPDSRAGVKWKNVARQLKEDLSSIILLSEEDLQALIDIPCAELAQELCQSCATVQGLQSTLQQVLDQREEARQSKQLLELYLQALEKEGNILSNQKESKAALSEELDAVDTGVGREMASEVLLRSQILTTLKEKPAPELSLSSQDLESVSKEDPKALAVALSWDIRKAETVQQACTTELALRLQQVQSLHSLRNLSARRSPLPGEPQRPKRAKRDSS 4EA9314DD470040F dffb_mouse DNA fragmentation factor subunit beta Dffb Cad DNA fragmentation factor 40 kDa subunit Caspase-activated deoxyribonuclease protein protein mouse Mus musculus Mouse MCAVLRQPKCVKLRALHSACKFGVAARSCQELLRKGCVRFQLPMPGSRLCLYEDGTEVTDDCFPGLPNDAELLLLTAGETWHGYVSDITRFLSVFNEPHAGVIQAARQLLSDEQAPLRQKLLADLLHHVSQNITAETREQDPSWFEGLESRFRNKSGYLRYSCESRIRGYLREVSAYTSMVDEAAQEEYLRVLGSMCQKLKSVQYNGSYFDRGAEASSRLCTPEGWFSCQGPFDLESCLSKHSINPYGNRESRILFSTWNLDHIIEKKRTVVPTLAEAIQDGREVNWEYFYSLLFTAENLKLVHIACHKKTTHKLECDRSRIYRPQTGSRRKQPARKKRPARKR mint Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology homomint E854B413EA139DE1 dffa_human DNA fragmentation factor subunit alpha DNA fragmentation factor 45 kDa subunit Inhibitor of CAD DFFA DFF1 DFF45 H13 protein protein human Homo sapiens Human MEVTGDAGVPESGEIRTLKPCLLRRNYSREQHGVAASCLEDLRSKACDILAIDKSLTPVTLVLAEDGTIVDDDDYFLCLPSNTKFVALASNEKWAYNNSDGGTAWISQESFDVDETDSGAGLKWKNVARQLKEDLSSIILLSEEDLQMLVDAPCSDLAQELRQSCATVQRLQHTLQQVLDQREEVRQSKQLLQLYLQALEKEGSLLSKQEESKAAFGEEVDAVDTGISRETSSDVALASHILTALREKQAPELSLSSQDLELVTKEDPKALAVALNWDIKKTETVQEACERELALRLQQTQSLHSLRSISASKASPPGDLQNPKRARQDPT 8656FE45DB003DF3 dffa-dffb-2 1 CAD 3 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role prey prey purified purified ICAD 2 peptide synthesis peptide synthesis predetermined predetermined participant predetermined unspecified role unspecified role bait bait purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction homomint mint t1 f1a The ICAD SPOT-membrane (Figure 1A), consisted of 53 spots arranged in three rows (A, B and C), starting with the very N-terminal peptide of the ICAD sequence at spot A1 and ending with the very C-terminal peptide of ICAD at spot C11. The ICAD SPOT-membrane showed mainly six clusters of positive signals representing putative sites of interaction distributed over all three domains of ICAD (spots: A8-A10, A17-A18, B1-B2, B8-B11, B14-B16 and C7-C11). Very strong interaction signals were seen at spots A10, A18, B1, B2, and B10 (Table 1, Figure 1A) dffa-dffb-3 1 CAD 3 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role prey prey purified purified ICAD 2 peptide synthesis peptide synthesis predetermined predetermined participant predetermined unspecified role unspecified role bait bait purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction homomint mint t1 f1a The ICAD SPOT-membrane (Figure 1A), consisted of 53 spots arranged in three rows (A, B and C), starting with the very N-terminal peptide of the ICAD sequence at spot A1 and ending with the very C-terminal peptide of ICAD at spot C11. The ICAD SPOT-membrane showed mainly six clusters of positive signals representing putative sites of interaction distributed over all three domains of ICAD (spots: A8-A10, A17-A18, B1-B2, B8-B11, B14-B16 and C7-C11). Very strong interaction signals were seen at spots A10, A18, B1, B2, and B10 (Table 1, Figure 1A) dffa-dffb-4 1 CAD 3 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role prey prey purified purified ICAD 2 peptide synthesis peptide synthesis predetermined predetermined participant predetermined unspecified role unspecified role bait bait purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction homomint mint t1 f1a The ICAD SPOT-membrane (Figure 1A), consisted of 53 spots arranged in three rows (A, B and C), starting with the very N-terminal peptide of the ICAD sequence at spot A1 and ending with the very C-terminal peptide of ICAD at spot C11. The ICAD SPOT-membrane showed mainly six clusters of positive signals representing putative sites of interaction distributed over all three domains of ICAD (spots: A8-A10, A17-A18, B1-B2, B8-B11, B14-B16 and C7-C11). Very strong interaction signals were seen at spots A10, A18, B1, B2, and B10 (Table 1, Figure 1A) dffa-dffb-5 1 CAD 3 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role prey prey purified purified ICAD 2 peptide synthesis peptide synthesis predetermined predetermined participant predetermined unspecified role unspecified role bait bait purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction homomint mint t1 f1a The ICAD SPOT-membrane (Figure 1A), consisted of 53 spots arranged in three rows (A, B and C), starting with the very N-terminal peptide of the ICAD sequence at spot A1 and ending with the very C-terminal peptide of ICAD at spot C11. The ICAD SPOT-membrane showed mainly six clusters of positive signals representing putative sites of interaction distributed over all three domains of ICAD (spots: A8-A10, A17-A18, B1-B2, B8-B11, B14-B16 and C7-C11). Very strong interaction signals were seen at spots A10, A18, B1, B2, and B10 (Table 1, Figure 1A) dffa-dffb-6 1 CAD 3 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role prey prey purified purified ICAD 2 peptide synthesis peptide synthesis predetermined predetermined participant predetermined unspecified role unspecified role bait bait purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction homomint mint t1 f1a The ICAD SPOT-membrane (Figure 1A), consisted of 53 spots arranged in three rows (A, B and C), starting with the very N-terminal peptide of the ICAD sequence at spot A1 and ending with the very C-terminal peptide of ICAD at spot C11. The ICAD SPOT-membrane showed mainly six clusters of positive signals representing putative sites of interaction distributed over all three domains of ICAD (spots: A8-A10, A17-A18, B1-B2, B8-B11, B14-B16 and C7-C11). Very strong interaction signals were seen at spots A10, A18, B1, B2, and B10 (Table 1, Figure 1A) dffb-dffa-1 1 CAD 3 peptide synthesis peptide synthesis predetermined predetermined participant predetermined unspecified role unspecified role bait bait purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ICAD 4 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role prey prey purified purified direct interaction direct interaction homomint mint The CAD SPOT-membrane (Figure 1B), consisted of 55 spots distributed over three rows (E, F and G), starting with the very N-terminal peptide of the CAD sequence at spot E1 and ending with the very C-terminal peptide of CAD at spot G13. The CAD SPOT-membrane showed seven clusters of interaction sites distributed over all three domains of CAD (spots: E1-E6, E16-E20, F3-F6, F11-F13, F17-F20, G1 and G3 as well as G7-G13). The strongest interaction signal was seen at spot E18 (Figure 1B, Table 2). Other strong interaction signals were detected at E3, E6, E16, E20, F5, F12, F19 and G10 (Figure 1B, Table 2). Peptides t2 f1B dffb-dffa-2 1 CAD 3 peptide synthesis peptide synthesis predetermined predetermined participant predetermined unspecified role unspecified role bait bait purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ICAD 4 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role prey prey purified purified direct interaction direct interaction homomint mint The CAD SPOT-membrane (Figure 1B), consisted of 55 spots distributed over three rows (E, F and G), starting with the very N-terminal peptide of the CAD sequence at spot E1 and ending with the very C-terminal peptide of CAD at spot G13. The CAD SPOT-membrane showed seven clusters of interaction sites distributed over all three domains of CAD (spots: E1-E6, E16-E20, F3-F6, F11-F13, F17-F20, G1 and G3 as well as G7-G13). The strongest interaction signal was seen at spot E18 (Figure 1B, Table 2). Other strong interaction signals were detected at E3, E6, E16, E20, F5, F12, F19 and G10 (Figure 1B, Table 2). Peptides t2 f1B dffb-dffa-3 1 CAD 3 peptide synthesis peptide synthesis predetermined predetermined participant predetermined unspecified role unspecified role bait bait purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ICAD 4 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role prey prey purified purified direct interaction direct interaction homomint mint The CAD SPOT-membrane (Figure 1B), consisted of 55 spots distributed over three rows (E, F and G), starting with the very N-terminal peptide of the CAD sequence at spot E1 and ending with the very C-terminal peptide of CAD at spot G13. The CAD SPOT-membrane showed seven clusters of interaction sites distributed over all three domains of CAD (spots: E1-E6, E16-E20, F3-F6, F11-F13, F17-F20, G1 and G3 as well as G7-G13). The strongest interaction signal was seen at spot E18 (Figure 1B, Table 2). Other strong interaction signals were detected at E3, E6, E16, E20, F5, F12, F19 and G10 (Figure 1B, Table 2). Peptides t2 f1B dffb-dffa-4 1 CAD 3 peptide synthesis peptide synthesis predetermined predetermined participant predetermined unspecified role unspecified role bait bait purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ICAD 4 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role prey prey purified purified direct interaction direct interaction homomint mint The CAD SPOT-membrane (Figure 1B), consisted of 55 spots distributed over three rows (E, F and G), starting with the very N-terminal peptide of the CAD sequence at spot E1 and ending with the very C-terminal peptide of CAD at spot G13. The CAD SPOT-membrane showed seven clusters of interaction sites distributed over all three domains of CAD (spots: E1-E6, E16-E20, F3-F6, F11-F13, F17-F20, G1 and G3 as well as G7-G13). The strongest interaction signal was seen at spot E18 (Figure 1B, Table 2). Other strong interaction signals were detected at E3, E6, E16, E20, F5, F12, F19 and G10 (Figure 1B, Table 2). Peptides t2 f1B dffb-dffa-5 1 CAD 3 peptide synthesis peptide synthesis predetermined predetermined participant predetermined unspecified role unspecified role bait bait purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ICAD 4 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role prey prey purified purified direct interaction direct interaction homomint mint The CAD SPOT-membrane (Figure 1B), consisted of 55 spots distributed over three rows (E, F and G), starting with the very N-terminal peptide of the CAD sequence at spot E1 and ending with the very C-terminal peptide of CAD at spot G13. The CAD SPOT-membrane showed seven clusters of interaction sites distributed over all three domains of CAD (spots: E1-E6, E16-E20, F3-F6, F11-F13, F17-F20, G1 and G3 as well as G7-G13). The strongest interaction signal was seen at spot E18 (Figure 1B, Table 2). Other strong interaction signals were detected at E3, E6, E16, E20, F5, F12, F19 and G10 (Figure 1B, Table 2). Peptides t2 f1B dffb-dffa-6 1 CAD 3 peptide synthesis peptide synthesis predetermined predetermined participant predetermined unspecified role unspecified role bait bait purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ICAD 4 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role prey prey purified purified direct interaction direct interaction homomint mint The CAD SPOT-membrane (Figure 1B), consisted of 55 spots distributed over three rows (E, F and G), starting with the very N-terminal peptide of the CAD sequence at spot E1 and ending with the very C-terminal peptide of CAD at spot G13. The CAD SPOT-membrane showed seven clusters of interaction sites distributed over all three domains of CAD (spots: E1-E6, E16-E20, F3-F6, F11-F13, F17-F20, G1 and G3 as well as G7-G13). The strongest interaction signal was seen at spot E18 (Figure 1B, Table 2). Other strong interaction signals were detected at E3, E6, E16, E20, F5, F12, F19 and G10 (Figure 1B, Table 2). Peptides t2 f1B dffb-dffa-7 1 CAD 3 peptide synthesis peptide synthesis predetermined predetermined participant predetermined unspecified role unspecified role bait bait purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ICAD 4 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role prey prey purified purified direct interaction direct interaction homomint mint The CAD SPOT-membrane (Figure 1B), consisted of 55 spots distributed over three rows (E, F and G), starting with the very N-terminal peptide of the CAD sequence at spot E1 and ending with the very C-terminal peptide of CAD at spot G13. The CAD SPOT-membrane showed seven clusters of interaction sites distributed over all three domains of CAD (spots: E1-E6, E16-E20, F3-F6, F11-F13, F17-F20, G1 and G3 as well as G7-G13). The strongest interaction signal was seen at spot E18 (Figure 1B, Table 2). Other strong interaction signals were detected at E3, E6, E16, E20, F5, F12, F19 and G10 (Figure 1B, Table 2). Peptides t2 f1B dffb-dffa-8 1 CAD 3 peptide synthesis peptide synthesis predetermined predetermined participant predetermined unspecified role unspecified role bait bait purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ICAD 4 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role prey prey purified purified direct interaction direct interaction homomint mint The CAD SPOT-membrane (Figure 1B), consisted of 55 spots distributed over three rows (E, F and G), starting with the very N-terminal peptide of the CAD sequence at spot E1 and ending with the very C-terminal peptide of CAD at spot G13. The CAD SPOT-membrane showed seven clusters of interaction sites distributed over all three domains of CAD (spots: E1-E6, E16-E20, F3-F6, F11-F13, F17-F20, G1 and G3 as well as G7-G13). The strongest interaction signal was seen at spot E18 (Figure 1B, Table 2). Other strong interaction signals were detected at E3, E6, E16, E20, F5, F12, F19 and G10 (Figure 1B, Table 2). Peptides t2 f1B dffa-dffb-7 1 CAD 3 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role prey prey purified purified ICAD 2 peptide synthesis peptide synthesis predetermined predetermined participant predetermined unspecified role unspecified role bait bait purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction homomint mint t1 f1a The ICAD SPOT-membrane (Figure 1A), consisted of 53 spots arranged in three rows (A, B and C), starting with the very N-terminal peptide of the ICAD sequence at spot A1 and ending with the very C-terminal peptide of ICAD at spot C11. The ICAD SPOT-membrane showed mainly six clusters of positive signals representing putative sites of interaction distributed over all three domains of ICAD (spots: A8-A10, A17-A18, B1-B2, B8-B11, B14-B16 and C7-C11). Very strong interaction signals were seen at spots A10, A18, B1, B2, and B10 (Table 1, Figure 1A)