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  <entry>
    <source releaseDate="2022-02-04">
      <names>
        <shortLabel>MINT</shortLabel>
        <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
        <alias type="synonym" typeAc="MI:1041">MINT</alias>
      </names>
      <bibref>
        <xref>
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      </bibref>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0471" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="mint" dbAc="MI:0471" id="MINT-80017" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579228" refType="identity" refTypeAc="MI:0356"/>
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      </xref>
      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it/mint</attribute>
        <attribute name="url" nameAc="MI:0614">url&amp;gt;http://mint.bio.uniroma2.it/mint/</attribute>
        <attribute name="url" nameAc="MI:0614">https://mint.bio.uniroma2.it</attribute>
        <attribute name="id-validation-regexp" nameAc="MI:0628">MINT-[0-9]+</attribute>
        <attribute name="search-url" nameAc="MI:0615">https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac}</attribute>
        <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Pten coordinates retinal neurogenesis by regulating Notch signalling.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="22258620" refType="primary-reference" refTypeAc="MI:0358"/>
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            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7650901" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-17560" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Pten coordinates retinal neurogenesis by regulating Notch signalling.</attribute>
            <attribute name="journal" nameAc="MI:0885">EMBO J. (0261-4189)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2012</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Jo HS., Kang KH., Joe CO., Kim JW.</attribute>
            <attribute name="imex-exported"/>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="mint" dbAc="MI:0471" id="MINT-8375658" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-17560" refType="imex-primary" refTypeAc="MI:0662"/>
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          <secondaryRef db="doi" dbAc="MI:0574" id="10.1038/emboj.2011.443" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="10090">
            <names>
              <shortLabel>mouse-retina</shortLabel>
              <fullName>Mus musculus retina</fullName>
            </names>
            <tissue>
              <names>
                <shortLabel>retina</shortLabel>
                <fullName>retinal tissue</fullName>
              </names>
              <xref>
                <primaryRef db="intact" dbAc="MI:0469" id="IA:0541" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="brenda" dbAc="MI:0864" id="BTO:0001175" refType="identity" refTypeAc="MI:0356"/>
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              </xref>
            </tissue>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>anti bait coip</shortLabel>
            <fullName>anti bait coimmunoprecipitation</fullName>
            <alias type="synonym" typeAc="MI:1041">anti bait coip</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0006" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-976" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="7708014" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>western blot</shortLabel>
            <fullName>western blot</fullName>
            <alias type="go synonym" typeAc="MI:0303">Immuno blot</alias>
            <alias type="synonym" typeAc="MI:1041">Immuno blot</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
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          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Jo HS., Kang KH., Joe CO., Kim JW.</attribute>
          <attribute name="journal" nameAc="MI:0885">EMBO J. (0261-4189)</attribute>
          <attribute name="publication year" nameAc="MI:0886">2012</attribute>
          <attribute name="imex-exported"/>
          <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
          <attribute name="imex curation" nameAc="MI:0959"/>
          <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>maml1_mouse</shortLabel>
          <fullName>Mastermind-like protein 1</fullName>
          <alias type="gene name" typeAc="MI:0301">Maml1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Kiaa0200</alias>
        </names>
        <xref>
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          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000059210" version="SP_139" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q8BIU5" version="SP_80" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q505D8" version="SP_80" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6PDK3" version="SP_80" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q5SUC2" version="SP_80" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6ZQG5" version="SP_80" refType="secondary-ac" refTypeAc="MI:0360"/>
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          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSG00000050567" version="SP_139" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000059458" version="SP_139" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0002193" version="SP_139"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016607" version="SP_139"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0019901" version="SP_139"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042605" version="SP_139"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043231" version="SP_139"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051149" version="SP_139"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0060928" version="SP_139"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR019082" version="SP_139"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-2122947" version="SP_139"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-350054" version="SP_139"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-8941856" version="SP_139"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007221" version="SP_139"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010831" version="SP_139"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_780543.2"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10090">
          <names>
            <shortLabel>mouse</shortLabel>
            <fullName>Mus musculus</fullName>
            <alias type="synonym" typeAc="MI:1041">Mouse</alias>
          </names>
        </organism>
        <sequence>MVLPTCPMAEFALPRHSAVMERLRRRIELCRRHHSTCEARYEAVSPERLELERQHTFALHQRCIQAKAKRAGKHRQPPAAATAPVAAPAPASAPAAARLDAADGPEHGRPVAHLHDTVKRSLDSAASPQNGDQPNGYGDLFPGHKKTRREAPLGVSVSANGLPPASPLGQPDKPSGGDTLQTAGKHSLGLDPINKKCLADSGIHLNGGSNSSEPFPLSLSKELKQEPVDDLPCMIAGAGGSVAQSNLMPDLNLNEQEWKELIEELNRSVPDEDMKDLFTEDFEEKKDPEPPGSATQTPLAQDINIKTEFSPAAFEQEQLGSPQVRAGSAGQTFLGASSAPVGTDSPSLGSSQTLFHTTSQPGVDNSSPNLMPASAQAQSAQRALTSVVLPSQGPGGASELSSAHQLQQIAAKQKREQMLQNPQQAAPAPGPGQLATWQQAGPSHSPLDVPYPMEKPASPSGYKQDFTNSKLLMMPGVNKSSPRPGGPYLQPSHSNLLSHQSPSNLNQNPVNNQGSVLDYGNTKPLSHYKADCGQGGPGSGQNKPALMAYLPQQLPHLSNEQNSLFLMKPKSGNMPFRSLVPPGQEQNPSSVPVAAPAASVGTQPTVSVASTHNSSPYLSSQQQAAVMKQHQLLLDQQKQREQQQQQLQQQQFLQRQHLLAEQEKQQFQRHLTRPPPQYQDPTQSTFPQQVGQFTGPSAAVPGMNNLGPSNSSCPRVFPQPGTLMSMGPGHAPVSSLPSSSGQQDRGVAQFTGSQSLPQNSLYGMASGLAQIVAQPPPQATSTHAHIPRQTNVGQNASTSAAYGQNSLGSASLSQQHSKGTLPPGLTKPQVPRVSAAMGSQNASWQHQGMPNLSSQTSGNSSVNPFTAAPSFHIQQAHLKLAGQQFSQAMPSRPMAPLSSAGAAGPMLPPVSAQQRNSAPASAPPQAAPQQGLPGLSPSGPELGAFGQSPTSQMSGRPGLHCAQAYPVRTMGQELPFAYSGQPGSSGLSSVAGHTDLIDSLLKNRTSEEWINELDDLLGSQ</sequence>
        <attributeList>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
          <attribute name="crc64">637132736ECD3A78</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>suh_mouse</shortLabel>
          <fullName>Recombining binding protein suppressor of hairless</fullName>
          <alias type="gene name" typeAc="MI:0301">Rbpj</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Igkjrb1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Igkrsbp</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Rbpsuh</alias>
          <alias type="gene name synonym" typeAc="MI:0302">J kappa-recombination signal-binding protein</alias>
          <alias type="gene name synonym" typeAc="MI:0302">RBP-J kappa</alias>
        </names>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000138" version="SP_209"/>
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          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR014756" version="SP_209"/>
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          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR037095" version="SP_209"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR038007" version="SP_209"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR040159" version="SP_209"/>
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          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3IAG" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4J2X" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5EG6" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6DKS" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6WQU" version="SP_209"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-2122947" version="SP_209"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-350054" version="SP_209"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-8941856" version="SP_209"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10090">
          <names>
            <shortLabel>mouse</shortLabel>
            <fullName>Mus musculus</fullName>
            <alias type="synonym" typeAc="MI:1041">Mouse</alias>
          </names>
        </organism>
        <sequence>MPSGFPQSPRTSPRARPKTRITGALPMDYSEGLSAEERPAHAPSAGKFGERPPPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGSGWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFYIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEQNKEMINDGASWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGVIYSTSLTFTYTPEPGPRPHCSAAGAILRANSSQVPSNESNTNSEGNYTNASTNSTSVTSSTATVVS</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P31266 original sequence version: 143</attribute>
          <attribute name="remark-internal">DIP protein P31266 original sequence version: 89</attribute>
          <attribute name="remark-internal">DIP protein P31266-1 original sequence version: 141</attribute>
          <attribute name="crc64">8BF517CC24099E03</attribute>
        </attributeList>
      </interactor>
      <interactor id="4">
        <names>
          <shortLabel>notc1_mouse</shortLabel>
          <fullName>Neurogenic locus notch homolog protein 1</fullName>
          <alias type="gene name" typeAc="MI:0301">Notch1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Motch</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Motch A</alias>
          <alias type="gene name synonym" typeAc="MI:0302">p300</alias>
          <alias type="gene name synonym" typeAc="MI:0302">mT14</alias>
        </names>
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          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q61905" version="SP_92" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q99JC2" version="SP_92" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9QW58" version="SP_92" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9R0X7" version="SP_92" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q3TZW2" version="SP_141" refType="secondary-ac" refTypeAc="MI:0360"/>
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          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000028288" version="SP_230" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1392707" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_032740.3"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-214N"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSG00000026923" version="SP_230" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000028288" version="SP_230" refType="transcript"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0060982" version="SP_230"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0061314" version="SP_230"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0061344" version="SP_230"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0061384" version="SP_230"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0061419" version="SP_230"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0062043" version="SP_230"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070168" version="SP_230"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070374" version="SP_230"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070986" version="SP_230"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071372" version="SP_230"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071944" version="SP_230"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0072017" version="SP_230"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0072044" version="SP_230"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0072144" version="SP_230"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0090051" version="SP_230"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0090090" version="SP_230"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0097150" version="SP_230"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0120163" version="SP_230"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1901189" version="SP_230"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1901201" version="SP_230"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1902263" version="SP_230"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1902339" version="SP_230"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1903849" version="SP_230"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000048" version="SP_230"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000737" version="SP_230"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000811" version="SP_230"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000974" version="SP_230"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2001027" version="SP_230"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000152" version="SP_230"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000742" version="SP_230"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000800" version="SP_230"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001881" version="SP_230"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002110" version="SP_230"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008297" version="SP_230"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR009030" version="SP_230"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR010660" version="SP_230"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011656" version="SP_230"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013032" version="SP_230"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018097" version="SP_230"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR020683" version="SP_230"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR022362" version="SP_230"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR024600" version="SP_230"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR035993" version="SP_230"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036770" version="SP_230"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1YMP" version="SP_230"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2QC9" version="SP_230"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2RQZ" version="SP_230"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2RR0" version="SP_230"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2RR2" version="SP_230"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3P3N" version="SP_230"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3P3P" version="SP_230"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5KY0" version="SP_230"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5KY4" version="SP_230"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5KY8" version="SP_230"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5KY9" version="SP_230"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-1912420" version="SP_230"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-2122947" version="SP_230"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-2122948" version="SP_230"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-350054" version="SP_230"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-8941856" version="SP_230"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10090">
          <names>
            <shortLabel>mouse</shortLabel>
            <fullName>Mus musculus</fullName>
            <alias type="synonym" typeAc="MI:1041">Mouse</alias>
          </names>
        </organism>
        <sequence>MPRLLTPLLCLTLLPALAARGLRCSQPSGTCLNGGRCEVANGTEACVCSGAFVGQRCQDSNPCLSTPCKNAGTCHVVDHGGTVDYACSCPLGFSGPLCLTPLDNACLANPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFESSYICRCPPGFHGPTCRQDVNECSQNPGLCRHGGTCHNEIGSYRCACRATHTGPHCELPYVPCSPSPCQNGGTCRPTGDTTHECACLPGFAGQNCEENVDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFQGATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECALGANPCEHAGKCLNTLGSFECQCLQGYTGPRCEIDVNECISNPCQNDATCLDQIGEFQCICMPGYEGVYCEINTDECASSPCLHNGHCMDKINEFQCQCPKGFNGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCQPGYTGHHCETNINECHSQPCRHGGTCQDRDNSYLCLCLKGTTGPNCEINLDDCASNPCDSGTCLDKIDGYECACEPGYTGSMCNVNIDECAGSPCHNGGTCEDGIAGFTCRCPEGYHDPTCLSEVNECNSNPCIHGACRDGLNGYKCDCAPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCPLPYTGATCEVVLAPCATSPCKNSGVCKESEDYESFSCVCPTGWQGQTCEVDINECVKSPCRHGASCQNTNGSYRCLCQAGYTGRNCESDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFQGAFCEEDINECASNPCQNGANCTDCVDSYTCTCPVGFNGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQYDVNECDSRPCLHGGTCQDSYGTYKCTCPQGYTGLNCQNLVRWCDSAPCKNGGRCWQTNTQYHCECRSGWTGVNCDVLSVSCEVAAQKRGIDVTLLCQHGGLCVDEGDKHYCHCQAGYTGSYCEDEVDECSPNPCQNGATCTDYLGGFSCKCVAGYHGSNCSEEINECLSQPCQNGGTCIDLTNSYKCSCPRGTQGVHCEINVDDCHPPLDPASRSPKCFNNGTCVDQVGGYTCTCPPGFVGERCEGDVNECLSNPCDPRGTQNCVQRVNDFHCECRAGHTGRRCESVINGCRGKPCKNGGVCAVASNTARGFICRCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGSFTGPECQFPASSPCVGSNPCYNQGTCEPTSENPFYRCLCPAKFNGLLCHILDYSFTGGAGRDIPPPQIEEACELPECQVDAGNKVCNLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYFSDGHCDSQCNSAGCLFDGFDCQLTEGQCNPLYDQYCKDHFSDGHCDQGCNSAECEWDGLDCAEHVPERLAAGTLVLVVLLPPDQLRNNSFHFLRELSHVLHTNVVFKRDAQGQQMIFPYYGHEEELRKHPIKRSTVGWATSSLLPGTSGGRQRRELDPMDIRGSIVYLEIDNRQCVQSSSQCFQSATDVAAFLGALASLGSLNIPYKIEAVKSEPVEPPLPSQLHLMYVAAAAFVLLFFVGCGVLLSRKRRRQHGQLWFPEGFKVSEASKKKRREPLGEDSVGLKPLKNASDGALMDDNQNEWGDEDLETKKFRFEEPVVLPDLSDQTDHRQWTQQHLDAADLRMSAMAPTPPQGEVDADCMDVNVRGPDGFTPLMIASCSGGGLETGNSEEEEDAPAVISDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILLRNRATDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVDAAVVLLKNGANKDMQNNKEETPLFLAAREGSYETAKVLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLLDEYNLVRSPQLHGTALGGTPTLSPTLCSPNGYLGNLKSATQGKKARKPSTKGLACGSKEAKDLKARRKKSQDGKGCLLDSSSMLSPVDSLESPHGYLSDVASPPLLPSPFQQSPSMPLSHLPGMPDTHLGISHLNVAAKPEMAALAGGSRLAFEPPPPRLSHLPVASSASTVLSTNGTGAMNFTVGAPASLNGQCEWLPRLQNGMVPSQYNPLRPGVTPGTLSTQAAGLQHSMMGPLHSSLSTNTLSPIIYQGLPNTRLATQPHLVQTQQVQPQNLQLQPQNLQPPSQPHLSVSSAANGHLGRSFLSGEPSQADVQPLGPSSLPVHTILPQESQALPTSLPSSMVPPMTTTQFLTPPSQHSYSSSPVDNTPSHQLQVPEHPFLTPSPESPDQWSSSSPHSNISDWSEGISSPPTTMPSQITHIPEAFK</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein Q01705 original sequence version: 161</attribute>
          <attribute name="remark-internal">DIP protein Q01705 original sequence version: 102</attribute>
          <attribute name="remark-internal">DIP protein Q01705-1 original sequence version: 137</attribute>
          <attribute name="remark-internal">DIP protein Q01705-1 original sequence version: 126</attribute>
          <attribute name="remark-internal">DIP protein Q01705 original sequence version: 169</attribute>
          <attribute name="crc64">97C91F69BABF02BF</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="5" imexId="IM-17560-1">
        <names>
          <shortLabel>notch1-maml1</shortLabel>
        </names>
        <xref>
          <primaryRef db="mint" dbAc="MI:0471" id="MINT-8375662" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7650919" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-17560-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="6">
            <names>
              <alias type="author assigned name" typeAc="MI:0345">MAML1</alias>
            </names>
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-8375740" refType="identity" refTypeAc="MI:0356"/>
            </xref>
            <interactorRef>2</interactorRef>
            <participantIdentificationMethodList>
              <participantIdentificationMethod>
                <names>
                  <shortLabel>western blot</shortLabel>
                  <fullName>western blot</fullName>
                  <alias type="go synonym" typeAc="MI:0303">Immuno blot</alias>
                  <alias type="synonym" typeAc="MI:1041">Immuno blot</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </participantIdentificationMethod>
              <participantIdentificationMethod>
                <names>
                  <shortLabel>predetermined</shortLabel>
                  <fullName>predetermined participant</fullName>
                  <alias type="synonym" typeAc="MI:1041">predetermined</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </participantIdentificationMethod>
            </participantIdentificationMethodList>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>living cell</shortLabel>
                  <fullName>living cell</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0349" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537765" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
              <experimentalPreparation>
                <names>
                  <shortLabel>physiological level</shortLabel>
                  <fullName>physiological level</fullName>
                  <alias type="go synonym" typeAc="MI:0303">endogenous level</alias>
                  <alias type="go synonym" typeAc="MI:0303">endogenous</alias>
                  <alias type="synonym" typeAc="MI:1041">endogenous</alias>
                  <alias type="synonym" typeAc="MI:1041">endogenous level</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
          </participant>
          <participant id="7">
            <names>
              <alias type="author assigned name" typeAc="MI:0345">CBF1</alias>
            </names>
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-8375665" refType="identity" refTypeAc="MI:0356"/>
            </xref>
            <interactorRef>3</interactorRef>
            <participantIdentificationMethodList>
              <participantIdentificationMethod>
                <names>
                  <shortLabel>western blot</shortLabel>
                  <fullName>western blot</fullName>
                  <alias type="go synonym" typeAc="MI:0303">Immuno blot</alias>
                  <alias type="synonym" typeAc="MI:1041">Immuno blot</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </participantIdentificationMethod>
              <participantIdentificationMethod>
                <names>
                  <shortLabel>predetermined</shortLabel>
                  <fullName>predetermined participant</fullName>
                  <alias type="synonym" typeAc="MI:1041">predetermined</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </participantIdentificationMethod>
            </participantIdentificationMethodList>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>living cell</shortLabel>
                  <fullName>living cell</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0349" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537765" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
              <experimentalPreparation>
                <names>
                  <shortLabel>physiological level</shortLabel>
                  <fullName>physiological level</fullName>
                  <alias type="go synonym" typeAc="MI:0303">endogenous level</alias>
                  <alias type="go synonym" typeAc="MI:0303">endogenous</alias>
                  <alias type="synonym" typeAc="MI:1041">endogenous</alias>
                  <alias type="synonym" typeAc="MI:1041">endogenous level</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
          </participant>
          <participant id="8">
            <names>
              <alias type="author assigned name" typeAc="MI:0345">NICD</alias>
            </names>
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-8375664" refType="identity" refTypeAc="MI:0356"/>
            </xref>
            <interactorRef>4</interactorRef>
            <participantIdentificationMethodList>
              <participantIdentificationMethod>
                <names>
                  <shortLabel>western blot</shortLabel>
                  <fullName>western blot</fullName>
                  <alias type="go synonym" typeAc="MI:0303">Immuno blot</alias>
                  <alias type="synonym" typeAc="MI:1041">Immuno blot</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </participantIdentificationMethod>
              <participantIdentificationMethod>
                <names>
                  <shortLabel>predetermined</shortLabel>
                  <fullName>predetermined participant</fullName>
                  <alias type="synonym" typeAc="MI:1041">predetermined</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </participantIdentificationMethod>
            </participantIdentificationMethodList>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>living cell</shortLabel>
                  <fullName>living cell</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0349" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537765" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
              <experimentalPreparation>
                <names>
                  <shortLabel>physiological level</shortLabel>
                  <fullName>physiological level</fullName>
                  <alias type="go synonym" typeAc="MI:0303">endogenous level</alias>
                  <alias type="go synonym" typeAc="MI:0303">endogenous</alias>
                  <alias type="synonym" typeAc="MI:1041">endogenous</alias>
                  <alias type="synonym" typeAc="MI:1041">endogenous level</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>association</shortLabel>
            <fullName>association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0914" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813191" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
          <attribute name="figure legend" nameAc="MI:0599">F5D</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>