UniProt UniProt http://www.uniprot.org Full-length human glutaminase in complex with an allosteric inhibitor. Full-length human glutaminase in complex with an allosteric inhibitor. Biochemistry (0006-2960) 2011 mimix curation DeLaBarre B., Gross S., Fang C., Gao Y., Jha A., Jiang F., Song J J., Wei W., Hurov J.B. byron.delabarre@agios.com 20-Jun-2012: Contacted by JYOTI. in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined DeLaBarre B., Gross S., Fang C., Gao Y., Jha A., Jiang F., Song J J., Wei W., Hurov J.B. byron.delabarre@agios.com Accepted 2012-APR-19 by ORCHARD Biochemistry (0006-2960) 2011 mimix curation glsk_human Glutaminase kidney isoform, mitochondrial GLS GLS1 KIAA0838 L-glutamine amidohydrolase K-glutaminase protein protein human Homo sapiens Human MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGGGGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEGKELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQTVHKNLDGLL DIP protein O94925 original sequence version: 113 4E5E63505E84E0B7 gls-1 1 2 unspecified role unspecified role neutral component neutral component region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm direct interaction direct interaction fig 2 R = 0.2 Rworking = 0.19 Rfree = 0.25 for 3uo9 Rworking = 0.23 Rfree = 0.26 for 3unw 2.3 Å for 3uo9 2.56 A for 3unw