IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Novel role of signal transducer and activator of transcription 3 as a progesterone receptor coactivator in breast cancer. Novel role of signal transducer and activator of transcription 3 as a progesterone receptor coactivator in breast cancer. Steroids (0039-128X) 2011 imex curation Proietti C.J., Beguelin W., Flaque M.C., Cayrol F., Rivas M.A., Tkach M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer RE-CH-IP experiment patriciaelizalde@ibyme.conicet.uba.ar, cproietti@ibyme.conicet.uba.ar 19-Sept-2012: Contacted by IntAct-Help. Only protein-protein interactions human-t47d human breast cancer tumour cell line-epithelial cells t47d Epithelial cells derived from human breast tumour ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Proietti C.J., Beguelin W., Flaque M.C., Cayrol F., Rivas M.A., Tkach M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer I gave up trying to find a sequence for MMTV - LTR region from ref 42 - cannot see subsequent refs from here. As a reference I entered NCBI whole viral genome result from NCBI Blast results. RE-CH-IP experiment RE-CH-IP experiment patriciaelizalde@ibyme.conicet.uba.ar, cproietti@ibyme.conicet.uba.ar Accepted 2012-AUG-09 by ORCHARD 19-Sept-2012: Contacted by IntAct-Help. Steroids (0039-128X) 2011 Only protein-protein interactions imex curation Novel role of signal transducer and activator of transcription 3 as a progesterone receptor coactivator in breast cancer. Novel role of signal transducer and activator of transcription 3 as a progesterone receptor coactivator in breast cancer. Steroids (0039-128X) 2011 imex curation Proietti C.J., Beguelin W., Flaque M.C., Cayrol F., Rivas M.A., Tkach M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer RE-CH-IP experiment patriciaelizalde@ibyme.conicet.uba.ar, cproietti@ibyme.conicet.uba.ar 19-Sept-2012: Contacted by IntAct-Help. Only protein-protein interactions mouse-c4hd Mouse C4HD - ER+and PR+ progestin (MPA) induced mammary adenocarcinoma cell line c4hd C4HD Mouse ER+and PR+ progestin (MPA) induced mammary adenocarcinoma cell line ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Proietti C.J., Beguelin W., Flaque M.C., Cayrol F., Rivas M.A., Tkach M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer RE-CH-IP experiment patriciaelizalde@ibyme.conicet.uba.ar, cproietti@ibyme.conicet.uba.ar Accepted 2012-AUG-09 by ORCHARD 19-Sept-2012: Contacted by IntAct-Help. Steroids (0039-128X) 2011 Only protein-protein interactions imex curation Novel role of signal transducer and activator of transcription 3 as a progesterone receptor coactivator in breast cancer. Novel role of signal transducer and activator of transcription 3 as a progesterone receptor coactivator in breast cancer. Steroids (0039-128X) 2011 imex curation Proietti C.J., Beguelin W., Flaque M.C., Cayrol F., Rivas M.A., Tkach M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer RE-CH-IP experiment patriciaelizalde@ibyme.conicet.uba.ar, cproietti@ibyme.conicet.uba.ar 19-Sept-2012: Contacted by IntAct-Help. Only protein-protein interactions mouse-c4hd Mouse C4HD - ER+and PR+ progestin (MPA) induced mammary adenocarcinoma cell line c4hd C4HD Mouse ER+and PR+ progestin (MPA) induced mammary adenocarcinoma cell line anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Proietti C.J., Beguelin W., Flaque M.C., Cayrol F., Rivas M.A., Tkach M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer RE-CH-IP experiment patriciaelizalde@ibyme.conicet.uba.ar, cproietti@ibyme.conicet.uba.ar Accepted 2012-AUG-09 by ORCHARD 19-Sept-2012: Contacted by IntAct-Help. Steroids (0039-128X) 2011 Only protein-protein interactions imex curation Novel role of signal transducer and activator of transcription 3 as a progesterone receptor coactivator in breast cancer. Novel role of signal transducer and activator of transcription 3 as a progesterone receptor coactivator in breast cancer. Steroids (0039-128X) 2011 imex curation Proietti C.J., Beguelin W., Flaque M.C., Cayrol F., Rivas M.A., Tkach M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer RE-CH-IP experiment patriciaelizalde@ibyme.conicet.uba.ar, cproietti@ibyme.conicet.uba.ar 19-Sept-2012: Contacted by IntAct-Help. Only protein-protein interactions mouse-c4hd Mouse C4HD - ER+and PR+ progestin (MPA) induced mammary adenocarcinoma cell line c4hd C4HD Mouse ER+and PR+ progestin (MPA) induced mammary adenocarcinoma cell line ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Proietti C.J., Beguelin W., Flaque M.C., Cayrol F., Rivas M.A., Tkach M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer RE-CH-IP experiment patriciaelizalde@ibyme.conicet.uba.ar, cproietti@ibyme.conicet.uba.ar Accepted 2012-AUG-09 by ORCHARD 19-Sept-2012: Contacted by IntAct-Help. Steroids (0039-128X) 2011 Only protein-protein interactions imex curation Novel role of signal transducer and activator of transcription 3 as a progesterone receptor coactivator in breast cancer. Novel role of signal transducer and activator of transcription 3 as a progesterone receptor coactivator in breast cancer. Steroids (0039-128X) 2011 imex curation Proietti C.J., Beguelin W., Flaque M.C., Cayrol F., Rivas M.A., Tkach M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer RE-CH-IP experiment patriciaelizalde@ibyme.conicet.uba.ar, cproietti@ibyme.conicet.uba.ar 19-Sept-2012: Contacted by IntAct-Help. Only protein-protein interactions mouse-c4hd Mouse C4HD - ER+and PR+ progestin (MPA) induced mammary adenocarcinoma cell line c4hd C4HD Mouse ER+and PR+ progestin (MPA) induced mammary adenocarcinoma cell line confocal microscopy confocal microscopy immunostaining immunostaining Proietti C.J., Beguelin W., Flaque M.C., Cayrol F., Rivas M.A., Tkach M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer RE-CH-IP experiment patriciaelizalde@ibyme.conicet.uba.ar, cproietti@ibyme.conicet.uba.ar Accepted 2012-AUG-09 by ORCHARD 19-Sept-2012: Contacted by IntAct-Help. Steroids (0039-128X) 2011 Only protein-protein interactions imex curation Novel role of signal transducer and activator of transcription 3 as a progesterone receptor coactivator in breast cancer. Novel role of signal transducer and activator of transcription 3 as a progesterone receptor coactivator in breast cancer. Steroids (0039-128X) 2011 imex curation Proietti C.J., Beguelin W., Flaque M.C., Cayrol F., Rivas M.A., Tkach M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer RE-CH-IP experiment patriciaelizalde@ibyme.conicet.uba.ar, cproietti@ibyme.conicet.uba.ar 19-Sept-2012: Contacted by IntAct-Help. Only protein-protein interactions human-t47d human breast cancer tumour cell line-epithelial cells t47d Epithelial cells derived from human breast tumour ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Proietti C.J., Beguelin W., Flaque M.C., Cayrol F., Rivas M.A., Tkach M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer I gave up trying to find a sequence for MMTV - LTR region from ref 42 - cannot see refs from here. As a reference I entered NCBI whole viral genome result from NCBI Blast results. RE-CH-IP experiment patriciaelizalde@ibyme.conicet.uba.ar, cproietti@ibyme.conicet.uba.ar Accepted 2012-AUG-09 by ORCHARD 19-Sept-2012: Contacted by IntAct-Help. Steroids (0039-128X) 2011 Only protein-protein interactions imex curation Novel role of signal transducer and activator of transcription 3 as a progesterone receptor coactivator in breast cancer. Novel role of signal transducer and activator of transcription 3 as a progesterone receptor coactivator in breast cancer. Steroids (0039-128X) 2011 imex curation Proietti C.J., Beguelin W., Flaque M.C., Cayrol F., Rivas M.A., Tkach M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer RE-CH-IP experiment patriciaelizalde@ibyme.conicet.uba.ar, cproietti@ibyme.conicet.uba.ar 19-Sept-2012: Contacted by IntAct-Help. Only protein-protein interactions human-t47d human breast cancer tumour cell line-epithelial cells t47d Epithelial cells derived from human breast tumour anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Proietti C.J., Beguelin W., Flaque M.C., Cayrol F., Rivas M.A., Tkach M., Charreau E.H., Schillaci R., Elizalde P.V. Cancer - Interactions investigated in the context of cancer RE-CH-IP experiment patriciaelizalde@ibyme.conicet.uba.ar, cproietti@ibyme.conicet.uba.ar Accepted 2012-AUG-09 by ORCHARD 19-Sept-2012: Contacted by IntAct-Help. Steroids (0039-128X) 2011 Only protein-protein interactions imex curation b2cl1_mouse_gene Mouse Bcl2l1/BCL-X gene gene gene mouse Mus musculus Mouse prgr_human Progesterone receptor PGR NR3C3 Nuclear receptor subfamily 3 group C member 3 protein protein human Homo sapiens Human MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLFPRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLAPSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAAAHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGKPRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTVMDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPDCAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLGPPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPCKAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK DIP protein P06401 original sequence version: 196 DIP protein P06401-1 original sequence version: 186 DIP protein P06401-1 original sequence version: 192 80452E54FF3A0454 sp1_human Transcription factor Sp1 SP1 TSFP1 protein protein human Homo sapiens Human MSDQDHSMDEMTAVVKIEKGVGGNNGGNGNGGGAFSQARSSSTGSSSSTGGGGQESQPSPLALLAATCSRIESPNENSNNSQGPSQSGGTGELDLTATQLSQGANGWQIISSSSGATPTSKEQSGSSTNGSNGSESSKNRTVSGGQYVVAAAPNLQNQQVLTGLPGVMPNIQYQVIPQFQTVDGQQLQFAATGAQVQQDGSGQIQIIPGANQQIITNRGSGGNIIAAMPNLLQQAVPLQGLANNVLSGQTQYVTNVPVALNGNITLLPVNSVSAATLTPSSQAVTISSSGSQESGSQPVTSGTTISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTTSGSSGTNSQGQTPQRVSGLQGSDALNIQQNQTSGGSLQAGQQKEGEQNQQTQQQQILIQPQLVQGGQALQALQAAPLSGQTFTTQAISQETLQNLQLQAVPNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNPQAQTITLAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLSSMPGLQTINLSALGTSGIQVHPIQGLPLAIANAPGDHGAQLGLHGAGGDGIHDDTAGGEEGENSPDAQPQAGRRTRREACTCPYCKDSEGRGSGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCTWSYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTHQNKKGGPGVALSVGTLPLDSGAGSEGSGTATPSALITTNMVAMEAICPEGIARLANSGINVMQVADLQSINISGNGF DIP protein P08047 original sequence version: 185 DIP protein P08047 original sequence version: 187 DIP protein P08047 original sequence version: 181 DIP protein P08047 original sequence version: 162 DIP protein P08047 original sequence version: 161 43893DBF6518B9EA prgr_mouse Progesterone receptor Pgr Nr3c3 Pr Nuclear receptor subfamily 3 group C member 3 protein protein mouse Mus musculus Mouse MTELQAKDPQVLHTSGASPSPPHIGSPLLARLDSGPFQGSQHSDVSSVVSPIPISLDGLLFPRSCRGPELPDGKTGDQQSLSDVEGAFSGVEATHREGGRNSRAPEKDSRLLDSVLDSLLTPSGTEQSHASPPACEAITSWCLFGPELPEDPRSVPATKGLLSPLMSRPEIKAGDSSGTGAGQKVLPKGLSPPRQLLLPTSGSAHWPGAGVKPSPQPAAGEVEEDSGLETEGSAAPLLKSKPRALEGTGSGGGVAANAASAAPGGVTLVPKEDSRFSAPRVSLEQDSPIAPGRSPLATTVVDFIHVPILPLNHALLAARTRQLLEGDSYDGGATAQGPFAPPRGSPSAPSPPVPCGDFPDCTYPLEGDPKEDVFPLYGDFQTPGLKIKEEEEGADAAVRSPRPYLSAGASSSTFPDFPLAPAPQRAPSSRPGEAAVAGGPSSAAVSPASSSGSALECILYKAEGAPPTQGSFAPLPCKPPAAGSCLLPRDSLPAAPATAAAPAIYQPLGLNGLPQLGYQAAVLKDSLPQVYPPYLNYLRPDSEASQSPQYGFDSLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVMRTLDGVALPQSVGLPNESQALGQRITFSPNQEIQLVPPLINLLMSIEPDVVYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKELSFYSLCLTMWQIPQEFVKLQVTHEEFLCMKVLLLLNTIPLEGLRSQSQFEEMRSSYIRELIKAIGLRQKGVVPSSQRFYQLTKLLDSLHDLVKQLHLYCLNTFIQSRTLAVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK E26DDDE9529996A7 stat3_human Signal transducer and activator of transcription 3 Acute-phase response factor STAT3 APRF protein protein human Homo sapiens Human MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM 6C00632211C8012D DIP protein P40763 original sequence version: 157 DIP protein P40763-1 original sequence version: 147 DIP protein P40763-1 original sequence version: 135 DIP protein P40763-1 original sequence version: 157 DIP protein P40763 original sequence version: 165 DIP protein P40763 original sequence version: 182 DIP protein P40763 original sequence version: 135 6C00632211C8012D stat3_mouse Signal transducer and activator of transcription 3 Acute-phase response factor Stat3 Aprf protein protein mouse Mus musculus Mouse MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMDLTSECATSPM DIP protein P42227 original sequence version: 169 DIP protein P42227 original sequence version: 162 DIP protein P42227 original sequence version: 164 DIP protein P42227 original sequence version: 141 6C00626711C8012D cdkn1a_human_gene Human CDKN1A gene gene gene human Homo sapiens Human mmtv_promoter MMTV- Mouse Mammary Tumour Virus Promoter dna deoxyribonucleic acid DNA deoxyribonucleic acid dna DNA deoxyribonucleic acid mmtvc Mouse mammary tumor virus (strain C3H) pgr-b2cl1 4 8 unspecified role unspecified role prey prey promoter_xp4_region (with 2 progesterone response elements) binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 11 unspecified role unspecified role bait bait association association Fig 1 A/B MPA - Medroxyprogesterone acetate - a synthetic variant of human progesterone. pgr-stat3 4 13 unspecified role unspecified role bait bait 8 unspecified role unspecified role prey prey promoter_xp4_region (with 2 progesterone response elements) binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association Fig 1 A/B MPA - Medroxyprogesterone acetate - a synthetic variant of human progesterone. pgr-b2cl1-1 6 15 unspecified role unspecified role prey prey hormone response elements binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 9 unspecified role unspecified role bait bait association association Fig 1 C/D MPA - Medroxyprogesterone acetate - a synthetic variant of human progesterone. stat3-b2cl1 2 13 unspecified role unspecified role bait bait 11 unspecified role unspecified role prey prey 8 unspecified role unspecified role prey prey promoter_xp4_region (with 2 progesterone response elements) binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association Fig 1 E/F MPA - Medroxyprogesterone acetate - a synthetic variant of human progesterone. stat3-mmtv 1 12 unspecified role unspecified role bait bait 9 unspecified role unspecified role prey prey 15 unspecified role unspecified role prey prey hormone response elements binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association Fig 1 G/H MPA stat3-pgr 7 9 unspecified role unspecified role prey prey p_ser294 opser O-phospho-L-serine (2S)-2-amino-3-(phosphonooxy)propanoic acid 2-amino-3-hydroxypropanoic acid 3-phosphate 2-azanyl-3-(phosphonooxy)propanoic acid ACT_SITE Phosphoserine intermediate MOD_RES Phosphoserine O-phospho-L-serine O-phosphonoserine O-phosphorylated L-serine O3-phosphoserine serine phosphate ester OPSer Phospho Phospho Seryl Phosphorylation phosphorylations certain certain sequence position certain certain certain sequence position certain 12 unspecified role unspecified role bait bait p_tyr705 optyr O4'-phospho-L-tyrosine (2S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid 2-azanyl-3-(4-phosphonooxyphenyl)propanoic acid MOD_RES Phosphotyrosine O4-phosphotyrosine tyrosine phosphate 2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-phosphate O4'-phospho-L-tyrosine O4'-phosphorylated L-tyrosine OPTyr Phospho Phospho Tyrosinyl Phosphorylation phosphorylationy certain certain sequence position certain certain certain sequence position certain physical association physical association Fig 2A MPA pgr-mmtv 6 15 unspecified role unspecified role prey prey hormone response elements binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 12 unspecified role unspecified role bait bait association association Fig 1 C/D MPA - Medroxyprogesterone acetate - a synthetic variant of human progesterone. stat3-b2cl1-1 3 11 unspecified role unspecified role prey prey p_294ser opser O-phospho-L-serine (2S)-2-amino-3-(phosphonooxy)propanoic acid 2-amino-3-hydroxypropanoic acid 3-phosphate 2-azanyl-3-(phosphonooxy)propanoic acid ACT_SITE Phosphoserine intermediate MOD_RES Phosphoserine O-phospho-L-serine O-phosphonoserine O-phosphorylated L-serine O3-phosphoserine serine phosphate ester OPSer Phospho Phospho Seryl Phosphorylation phosphorylations certain certain sequence position certain certain certain sequence position certain 13 unspecified role unspecified role bait bait p_tyr705 optyr O4'-phospho-L-tyrosine (2S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid 2-azanyl-3-(4-phosphonooxyphenyl)propanoic acid MOD_RES Phosphotyrosine O4-phosphotyrosine tyrosine phosphate 2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-phosphate O4'-phospho-L-tyrosine O4'-phosphorylated L-tyrosine OPTyr Phospho Phospho Tyrosinyl Phosphorylation phosphorylationy certain certain sequence position certain certain certain sequence position certain physical association physical association Fig 2A MPA pgr-stat3-1 5 13 unspecified role unspecified role neutral component neutral component 11 unspecified role unspecified role neutral component neutral component colocalization colocalization Fig 2B MPA sp1-pgr 7 10 unspecified role unspecified role bait bait 12 unspecified role unspecified role prey prey 9 unspecified role unspecified role prey prey association association Fig 6A MPA - Medroxyprogesterone acetate - a synthetic variant of human progesterone. RU486 (Mifepristone) -a progesterone receptor antagonist. pgr-cdkn1a 6 9 unspecified role unspecified role bait bait 14 unspecified role unspecified role prey prey sp1_response_element binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association Fig 6B MPA sp1-cdkn1a-1 6 14 unspecified role unspecified role prey prey sp1_response_element binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 10 unspecified role unspecified role bait bait association association Fig 6B MPA sp1-cdkn1a-2 6 14 unspecified role unspecified role prey prey sp1_response_element binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 12 unspecified role unspecified role bait bait association association Fig 6B MPA stat3-cdkn1a 1 14 unspecified role unspecified role prey prey sp1_response_element binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 10 unspecified role unspecified role prey prey 12 unspecified role unspecified role bait bait association association Fig 6D-1 MPA stat3-cdkn1a-1 1 14 unspecified role unspecified role prey prey sp1_response_element binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 10 unspecified role unspecified role prey prey 9 unspecified role unspecified role bait bait association association Fig 6D-2 MPA