UniProt UniProt http://www.uniprot.org Structural basis of fatty acid substrate binding to cyclooxygenase-2. Structural basis of fatty acid substrate binding to cyclooxygenase-2. J. Biol. Chem. (0021-9258) 2010 mimix curation Vecchio A.J., Simmons D.M., Malkowski M.G. malkowski@hwi.buffalo.edu 14-Mar-2012: Contacted by JYOTI. in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Vecchio A.J., Simmons D.M., Malkowski M.G. malkowski@hwi.buffalo.edu Accepted 2012-JAN-18 by ORCHARD J. Biol. Chem. (0021-9258) 2010 mimix curation pgh2_mouse Prostaglandin G/H synthase 2 Ptgs2 Cox-2 Cox2 Pghs-b Tis10 Gripghs TIS10 protein Macrophage activation-associated marker protein P71/73 PES-2 Cyclooxygenase-2 Prostaglandin-endoperoxide synthase 2 Prostaglandin H2 synthase 2 PHS II Glucocorticoid-regulated inflammatory cyclooxygenase protein protein mouse Mus musculus Mouse MLFRAVLLCAALGLSQAANPCCSNPCQNRGECMSTGFDQYKCDCTRTGFYGENCTTPEFLTRIKLLLKPTPNTVHYILTHFKGVWNIVNNIPFLRSLIMKYVLTSRSYLIDSPPTYNVHYGYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPGFTRGLGHGVDLNHIYGETLDRQHKLRLFKDGKLKYQVIGGEVYPPTVKDTQVEMIYPPHIPENLQFAVGQEVFGLVPGLMMYATIWLREHNRVCDILKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQNRIASEFNTLYHWHPLLPDTFNIEDQEYSFKQFLYNNSILLEHGLTQFVESFTRQIAGRVAGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKALYSDIDVMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEVGFKIINTASIQSLICNNVKGCPFTSFNVQDPQPTKTATINASASHSRLDDINPTVLIKRRSTEL not sure if the protein origin is right determined, my suggestion is based on fig.1c and 1d description DIP protein Q05769 original sequence version: 98 DFE1658295C92064 ptgs2 1 2 unspecified role unspecified role neutral component neutral component spofr-sf_21 Spodoptera frugiperda insect cells sf_21 Insect cells derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae. full name: IPLB-SF-21-AE cells are susceptible to Baculovirus infection. direct interaction direct interaction 0.171 R factor for 3Hs5 0.21 free R factor for 3Hs5 0.179 R factor for 3Hs6 0.223 free R factor for 3Hs6 0.184 R factor for 3Hs7 0.234 free R factor for 3Hs7 0.182 R factor for 3krk 0.228 free R factor for 3krk 2.1 A for 3hs5 2.4 A for 3hs6 2.65 A for 3hs7 2.4 A for 3krk