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  <entry>
    <source releaseDate="2022-02-04">
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        <shortLabel>UniProt</shortLabel>
        <fullName>UniProt</fullName>
      </names>
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        <names>
          <fullName>Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT).</fullName>
        </names>
        <bibref>
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          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT).</attribute>
            <attribute name="journal" nameAc="MI:0885">J. Biol. Chem. (0021-9258)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2005</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Prunier C., Howe P.H.</attribute>
            <attribute name="contact-email" nameAc="MI:0634">howep@ccf.org</attribute>
            <attribute name="author-announcement">11-Oct-2012: Contacted by IntAct-Help.</attribute>
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        <hostOrganismList>
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            <names>
              <shortLabel>mouse-nmumg</shortLabel>
              <fullName>Mus musculus NMuMG mammary gland epithelial cells</fullName>
            </names>
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                <shortLabel>nmumg</shortLabel>
                <fullName>NMuMG mammary gland epithelial cells</fullName>
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        <interactionDetectionMethod>
          <names>
            <shortLabel>anti bait coip</shortLabel>
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            <shortLabel>western blot</shortLabel>
            <fullName>western blot</fullName>
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            <alias type="synonym" typeAc="MI:1041">Immuno blot</alias>
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          <attribute name="author-list" nameAc="MI:0636">Prunier C., Howe P.H.</attribute>
          <attribute name="contact-email" nameAc="MI:0634">howep@ccf.org</attribute>
          <attribute name="accepted">Accepted 2012-OCT-01 by ORCHARD</attribute>
          <attribute name="author-announcement">11-Oct-2012: Contacted by IntAct-Help.</attribute>
          <attribute name="journal" nameAc="MI:0885">J. Biol. Chem. (0021-9258)</attribute>
          <attribute name="publication year" nameAc="MI:0886">2005</attribute>
          <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
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          <alias type="gene name synonym" typeAc="MI:0302">VLA-4 subunit beta</alias>
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          </names>
        </organism>
        <sequence>MNLQLVSWIGLISLICSVFGQTDKNRCLKANAKSCGECIQAGPNCGWCTNTTFLQEGMPTSARCDDLEALKKKGCQPSDIENPRGSQTIKKNKNVTNRSKGMAEKLRPEDITQIQPQQLLLKLRSGEPQKFTLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTDRGEFFNELVGQQRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLENNVYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSGNSSNVIQLIIDAYNSLSSEVILENSKLPDGVTINYKSYCKNGVNGTGENGRKCSNISIGDEVQFEISITANKCPNKESETIKIKPLGFTEEVEVVLQFICKCNCQSHGIPASPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCRCRVCECYPNYTGSACDCSLDTGPCLASNGQICNGRGICECGACKCTDPKFQGPTCETCQTCLGVCAEHKECVQCRAFNKGEKKDTCAQECSHFNLTKVESREKLPQPVQVDPVTHCKEKDIDDCWFYFTYSVNGNNEAIVHVVETPDCPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P09055 original sequence version: 100</attribute>
          <attribute name="crc64">26788F7F0A168B56</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>dab2_mouse</shortLabel>
          <fullName>Disabled homolog 2</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">Mitogen-responsive phosphoprotein</alias>
          <alias type="gene name" typeAc="MI:0301">Dab2</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Doc2</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Adaptor molecule disabled-2</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Differentially expressed in ovarian carcinoma 2</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P98078" version="SP_69" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q3U3K1" version="SP_69" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q91W56" version="SP_69" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q923E1" version="SP_69" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1391846" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001008702.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001032994.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_075607.2"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="P98078"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011243626.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_017171913.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-39422N"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000122" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000904" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001650" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001701" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001921" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001934" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0002092" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005178" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005546" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005905" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006898" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006915" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007257" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007588" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008022" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010718" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010862" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010977" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0015031" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016055" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016324" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030099" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030132" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030136" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030276" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030308" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030335" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030511" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030665" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0032091" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0032349" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0032436" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0032968" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0035026" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0035091" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0035612" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0035615" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0038024" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043066" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043231" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045785" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045807" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045944" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0046332" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0048268" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0048471" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0048545" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0050680" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0050750" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0060391" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0060766" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070373" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071364" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071425" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071560" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0090090" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1900026" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1903077" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000096" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000298" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000370" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000643" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000860" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2001046" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2001237" version="SP_186"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR006020" version="SP_186"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011993" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1M7E" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1P3R" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-190873" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-196025" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-8856825" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-8856828" version="SP_186"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10090">
          <names>
            <shortLabel>mouse</shortLabel>
            <fullName>Mus musculus</fullName>
            <alias type="synonym" typeAc="MI:1041">Mouse</alias>
          </names>
        </organism>
        <sequence>MSNEVETSTTNGQPDQQAAPKAPSKKEKKKGSEKTDEYLLARFKGDGVKYKAKLIGIDDVPDARGDKMSQDSMMKLKGMAAAGRSQGQHKQRIWVNISLSGIKIIDEKTGVIEHEHPVNKISFIARDVTDNRAFGYVCGGEGQHQFFAIKTGQQAEPLVVDLKDLFQVIYNVKKKEEDKKKVEEANKAEENGSEALMTLDDQANKLKLGVDQMDLFGDMSTPPDLNSPTESKDILLVDLNSEIDTNQNSLRENPFLTNGVTSCSLPRPKPQASFLPENAFSANLNFFPTPNPDPFRDDPFAQPDQSAPSSFDSLTSPDQKKASLSSSSTPQSKGPLNGDTDYFGQQFDQLSNRTGKPEAQGGPWPYPSSQTQQAVRTQNGVSEREQNGFHIKSSPNPFVGSPPKGLSVPNGVKQDLESSVQSSAHDSIAIIPPPQSTKPGRGRRTAKSSANDLLASDIFASEPPGQMSPTGQPAVPQSNFLDLFKGNAPAPVGPLVGLGTVPVTPPQAGPWTPVVYSPSTTVVPGAIISGQPPSFRQPLVFGTTPAVQVWNQSPSFATPASPPPPTVWCPTTSVAPNAWSSTSPLGNPFQSNNIFPPPTMSTQSSPQPMMSSVLATPPQPPPRNGPLKDIPSDAFTGLDPLGDKEVKEVKEMFKDFQLRQPPLVPSRKGETPPSGTSSAFSSYFNNKVGIPQEHVDHDDFDANQLLNKINEPPKPAPRQGVLLGTKSADNSLENPFSKGFSSSNPSVVSQPASSDPHRSPFGNPFA</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P98078 original sequence version: 127</attribute>
          <attribute name="crc64">856C946BD43C4B07</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4" imexId="IM-17870-1">
        <names>
          <shortLabel>itgb1-dab2</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-6306812" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-17870-1" refType="imex-primary" refTypeAc="MI:0662"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016020" refType="component" refTypeAc="MI:0354"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="6">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">6B</attribute>
          <attribute name="agonist" nameAc="MI:0625">TGFbeta</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>