InnateDB InnateDB A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. Nat. Immunol. (1529-2908) 2010 imex curation Au-Yeung BB., Levin SE., Zhang C., Hsu LY., Cheng DA., Killeen N., Shokat KM., Weiss A. Thymocytes were taken from Zap70(AS) transgenic mice. aweiss@medicine.ucsf.edu jyoti Only protein-protein interactions Curated by: InnateDB - a knowledge resource for innate immunity mouse-thymus Mus musculus thymus thymus anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Au-Yeung BB., Levin SE., Zhang C., Hsu LY., Cheng DA., Killeen N., Shokat KM., Weiss A. Thymocytes were taken from Zap70(AS) transgenic mice. aweiss@medicine.ucsf.edu Accepted 2011-APR-05 by ORCHARD Nat. Immunol. (1529-2908) 2010 jyoti Only protein-protein interactions imex curation Curated by: InnateDB - a knowledge resource for innate immunity zap70_mouse Tyrosine-protein kinase ZAP-70 Zap70 Srk Zap-70 Syk-related tyrosine kinase 70 kDa zeta-chain associated protein protein protein mouse Mus musculus Mouse MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYAIAGGKAHCGPAELCQFYSQDPDGLPCNLRKPCNRPPGLEPQPGVFDCLRDAMVRDYVRQTWKLEGDALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGQQTDGKFLLRPRKEQGTYALSLVYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYRLKEVCPNSSASAAVAAPTLPAHPSTFTQPQRRVDTLNSDGYTPEPARLASSTDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRENLLVADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADKDEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLLGKKEEIPVSNVAELLHQVAMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEAFSYGQKPYKKMKGPEVLDFIKQGKRMECPPECPPEMYALMSDCWIYKWEDRPDFLTVEQRMRNYYYSLASRAEGPPQCEQVAEAACG 9E0D18B240B28392 crk_mouse Adapter molecule crk Crk Crko Proto-oncogene c-Crk p38 protein protein mouse Mus musculus Mouse MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVARSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPDEDFS 5491896FC7A89065 crk-zap70 1 2 unspecified role unspecified role prey prey P43404:p.Glu414Ala mutation mutation certain certain sequence position certain certain certain sequence position certain E A Wed May 02 15:44:45 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'glu414ala' Tue Jun 30 17:10:32 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Glu414Ala' 3 unspecified role unspecified role bait bait physical association physical association Fig. 6C CD3 mAb crosslinking, 2 mins.