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  <entry>
    <source releaseDate="2022-02-04">
      <names>
        <shortLabel>MINT</shortLabel>
        <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
        <alias type="synonym" typeAc="MI:1041">MINT</alias>
      </names>
      <bibref>
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      </bibref>
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      </xref>
      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it/mint</attribute>
        <attribute name="url" nameAc="MI:0614">url&amp;gt;http://mint.bio.uniroma2.it/mint/</attribute>
        <attribute name="url" nameAc="MI:0614">https://mint.bio.uniroma2.it</attribute>
        <attribute name="id-validation-regexp" nameAc="MI:0628">MINT-[0-9]+</attribute>
        <attribute name="search-url" nameAc="MI:0615">https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac}</attribute>
        <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>The PP1-R6 protein phosphatase holoenzyme is involved in the glucose-induced dephosphorylation and inactivation of AMP-activated protein kinase, a key regulator of insulin secretion, in MIN6 beta cells.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="20724523" refType="primary-reference" refTypeAc="MI:0358"/>
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            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8174959" refType="identity" refTypeAc="MI:0356"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">The PP1-R6 protein phosphatase holoenzyme is involved in the glucose-induced dephosphorylation and inactivation of AMP-activated protein kinase, a key regulator of insulin secretion, in MIN6 beta cells.</attribute>
            <attribute name="journal" nameAc="MI:0885">FASEB J. (0892-6638)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2010</attribute>
            <attribute name="author-list" nameAc="MI:0636">Garcia-Haro L., Garcia-Gimeno MA., Neumann D., Beullens M., Bollen M., Sanz P.</attribute>
            <attribute name="partial coverage" nameAc="MI:0958">partial coverage</attribute>
            <attribute name="rapid curation" nameAc="MI:0961">rapid curation</attribute>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="mint" dbAc="MI:0471" id="MINT-8203998" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="pubmed" dbAc="MI:0446" id="20724523" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="10090">
            <names>
              <shortLabel>mouse</shortLabel>
              <fullName>Mus musculus</fullName>
              <alias type="synonym" typeAc="MI:1041">Mouse</alias>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>anti tag coip</shortLabel>
            <fullName>anti tag coimmunoprecipitation</fullName>
            <alias type="synonym" typeAc="MI:1041">anti tag coip</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0007" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-90" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="7708014" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Garcia-Haro L., Garcia-Gimeno MA., Neumann D., Beullens M., Bollen M., Sanz P.</attribute>
          <attribute name="accepted">Accepted 2013-AUG-29 by ORCHARD</attribute>
          <attribute name="journal" nameAc="MI:0885">FASEB J. (0892-6638)</attribute>
          <attribute name="publication year" nameAc="MI:0886">2010</attribute>
          <attribute name="partial coverage" nameAc="MI:0958">partial coverage</attribute>
          <attribute name="rapid curation" nameAc="MI:0961">rapid curation</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>aakb1_mouse</shortLabel>
          <fullName>5'-AMP-activated protein kinase subunit beta-1</fullName>
          <alias type="gene name" typeAc="MI:0301">Prkab1</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q9R078" version="SP_69" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q91YN6" version="SP_69" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000031486" version="SP_169" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000107630" version="SP_169" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2366248" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_114075.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_006530264.1"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSG00000029513" version="SP_169" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000031486" version="SP_169" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000111999" version="SP_169" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004672" version="SP_169"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004679" version="SP_169"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="SP_169"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" version="SP_169"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" version="SP_169"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006468" version="SP_169"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006633" version="SP_169"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007165" version="SP_169"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010628" version="SP_169"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0019901" version="SP_169"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031588" version="SP_169"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0032991" version="SP_169"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0035878" version="SP_169"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0050790" version="SP_169"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0080090" version="SP_169"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0120162" version="SP_169"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR006828" version="SP_169"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013783" version="SP_169"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR014756" version="SP_169"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR032640" version="SP_169"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR037256" version="SP_169"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR039160" version="SP_169"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="Q9R078" version="SP_169"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-1632852" version="SP_169"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-380972" version="SP_169"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-5628897" version="SP_169"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-6804756" version="SP_169"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10090">
          <names>
            <shortLabel>mouse</shortLabel>
            <fullName>Mus musculus</fullName>
            <alias type="synonym" typeAc="MI:1041">Mouse</alias>
          </names>
        </organism>
        <sequence>MGNTSSERAALERQAGHKTPRRDSSGGAKDGDRPKILMDSPEDADIFHSEEIKAPEKEEFLAWQHDLEANDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSQNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYMSKPEERFKAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI</sequence>
        <attributeList>
          <attribute name="crc64">6B520A95A0A844E5</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>ppr3d_human</shortLabel>
          <fullName>Protein phosphatase 1 regulatory subunit 3D</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">Protein phosphatase 1 regulatory subunit 6</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Protein phosphatase 1-binding subunit R6</alias>
          <alias type="gene name" typeAc="MI:0301">PPP1R3D</alias>
          <alias type="gene name synonym" typeAc="MI:0302">PPP1R6</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="O95685" version="SP_44" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6DK02" version="SP_44" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000360035" version="SP_155" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1045661" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_006233.1"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000132825" version="SP_155" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000370996" version="SP_155" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000164" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004722" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005977" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005979" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005981" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008157" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042587" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043231" version="SP_155"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2001069" version="SP_155"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR005036" version="SP_155"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR017434" version="SP_155"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR038175" version="SP_155"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="O95685" version="SP_155"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MSRGPSSAVLPSALGSRKLGPRSLSCLSDLDGGVALEPRACRPPGSPGRAPPPTPAPSGCDPRLRPIILRRARSLPSSPERRQKAAGAPGAACRPGCSQKLRVRFADALGLELAQVKVFNAGDDPSVPLHVLSRLAINSDLCCSSQDLEFTLHCLVPDFPPPVEAADFGERLQRQLVCLERVTCSDLGISGTVRVCNVAFEKQVAVRYTFSGWRSTHEAVARWRGPAGPEGTEDVFTFGFPVPPFLLELGSRVHFAVRYQVAGAEYWDNNDHRDYSLTCRNHALHMPRGECEESWIHFI</sequence>
        <attributeList>
          <attribute name="crc64">DB848FB1CF55E49E</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4">
        <names>
          <shortLabel>ppp1r3d-prkab1</shortLabel>
        </names>
        <xref>
          <primaryRef db="mint" dbAc="MI:0471" id="MINT-8204001" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8175079" refType="identity" refTypeAc="MI:0356"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <names>
              <alias type="author assigned name" typeAc="MI:0345">PPP1R6</alias>
            </names>
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-8204003" refType="identity" refTypeAc="MI:0356"/>
            </xref>
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="6">
            <names>
              <alias type="author assigned name" typeAc="MI:0345">AMPKbeta-1</alias>
            </names>
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-8204004" refType="identity" refTypeAc="MI:0356"/>
            </xref>
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">f6b</attribute>
          <attribute name="comment" nameAc="MI:0612">homomint</attribute>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>