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  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>MINT</shortLabel>
        <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
        <alias type="synonym" typeAc="MI:1041">MINT</alias>
      </names>
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      </xref>
      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it/mint</attribute>
        <attribute name="url" nameAc="MI:0614">url&amp;gt;http://mint.bio.uniroma2.it/mint/</attribute>
        <attribute name="url" nameAc="MI:0614">https://mint.bio.uniroma2.it</attribute>
        <attribute name="id-validation-regexp" nameAc="MI:0628">MINT-[0-9]+</attribute>
        <attribute name="search-url" nameAc="MI:0615">https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac}</attribute>
        <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint.</fullName>
        </names>
        <bibref>
          <xref>
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          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint.</attribute>
            <attribute name="journal" nameAc="MI:0885">EMBO Rep. (1469-221X)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2008</attribute>
            <attribute name="curation depth" nameAc="MI:0955">rapid curation</attribute>
            <attribute name="rapid curation" nameAc="MI:0961"/>
            <attribute name="author-list" nameAc="MI:0636">Nakada S., Chen GI., Gingras AC., Durocher D.</attribute>
            <attribute name="remark-internal">suggested by santonico</attribute>
            <attribute name="author-announcement">30-Sept-2013: Contacted by IntAct-Help.</attribute>
            <attribute name="partial coverage" nameAc="MI:0958">partial coverage</attribute>
            <attribute name="rapid curation" nameAc="MI:0961">rapid curation</attribute>
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        </bibref>
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        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="-1">
            <names>
              <shortLabel>in vitro</shortLabel>
              <fullName>In vitro</fullName>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>phosphatase assay</shortLabel>
            <fullName>phosphatase assay</fullName>
          </names>
          <xref>
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        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
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          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Nakada S., Chen GI., Gingras AC., Durocher D.</attribute>
          <attribute name="remark-internal">suggested by santonico</attribute>
          <attribute name="accepted">Accepted 2013-SEP-25 by MARTA</attribute>
          <attribute name="author-announcement">30-Sept-2013: Contacted by IntAct-Help.</attribute>
          <attribute name="journal" nameAc="MI:0885">EMBO Rep. (1469-221X)</attribute>
          <attribute name="publication year" nameAc="MI:0886">2008</attribute>
          <attribute name="partial coverage" nameAc="MI:0958">partial coverage</attribute>
          <attribute name="curation depth" nameAc="MI:0955">rapid curation</attribute>
          <attribute name="rapid curation" nameAc="MI:0961">rapid curation</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>pp2aa_human</shortLabel>
          <fullName>Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform</fullName>
          <alias type="gene name" typeAc="MI:0301">PPP2CA</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Replication protein C</alias>
        </names>
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          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_002706.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-29395N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
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            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P67775 original sequence version: 112</attribute>
          <attribute name="remark-internal">DIP protein P67775-1 original sequence version: 98</attribute>
          <attribute name="remark-internal">DIP protein P67775 original sequence version: 29</attribute>
          <attribute name="remark-internal">DIP protein P67775 original sequence version: 102</attribute>
          <attribute name="remark-internal">DIP protein P67775 original sequence version: 65</attribute>
          <attribute name="remark-internal">DIP protein P67775 original sequence version: 67</attribute>
          <attribute name="remark-internal">DIP protein P67775-1 original sequence version: 114</attribute>
          <attribute name="remark-internal">DIP protein P67775 original sequence version: 113</attribute>
          <attribute name="remark-internal">DIP protein P67775-1 original sequence version: 122</attribute>
          <attribute name="crc64">C602291F78F34555</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>h2ax_human</shortLabel>
          <fullName>Histone H2AX</fullName>
          <alias type="gene name" typeAc="MI:0301">H2AX</alias>
          <alias type="gene name synonym" typeAc="MI:0302">H2AFX</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Histone H2A.X</alias>
        </names>
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          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-110329" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-110330" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-110331" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1221632" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-171306" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1912408" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-201722" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-212300" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2299718" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2559580" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2559582" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2559586" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-3214858" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-427359" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-427389" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-427413" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5250924" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5334118" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5578749" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5617472" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5625886" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5693565" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5693571" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5693607" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-606279" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-69473" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-73728" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-73772" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8936459" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8939236" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9018519" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-912446" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9616222" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9670095" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9710421" version="SP_217"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-977225" version="SP_217"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005813" version="SP_217"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006302" version="SP_217"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006334" version="SP_217"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006342" version="SP_217"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006974" version="SP_217"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007283" version="SP_217"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010212" version="SP_217"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016607" version="SP_217"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0019899" version="SP_217"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0021987" version="SP_217"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0035861" version="SP_217"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042393" version="SP_217"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045739" version="SP_217"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0046982" version="SP_217"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051321" version="SP_217"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070062" version="SP_217"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071480" version="SP_217"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0090398" version="SP_217"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0090734" version="SP_217"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002119" version="SP_217"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR007125" version="SP_217"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR009072" version="SP_217"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR032454" version="SP_217"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR032458" version="SP_217"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="P16104" version="SP_217"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1YDP" version="SP_217"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2AZM" version="SP_217"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2D31" version="SP_217"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2DYP" version="SP_217"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3SHV" version="SP_217"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3SQD" version="SP_217"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3SZM" version="SP_217"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3U3Z" version="SP_217"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6K1I" version="SP_217"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6K1J" version="SP_217"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6K1K" version="SP_217"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MSGRGKTGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGHYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKKTSATVGPKAPSGGKKATQASQEY</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P16104 original sequence version: 114</attribute>
          <attribute name="remark-internal">DIP protein P16104 original sequence version: 110</attribute>
          <attribute name="remark-internal">DIP protein P16104 original sequence version: 117</attribute>
          <attribute name="remark-internal">DIP protein P16104 original sequence version: 133</attribute>
          <attribute name="remark-internal">DIP protein P16104 original sequence version: 140</attribute>
          <attribute name="remark-internal">DIP protein P16104 original sequence version: 113</attribute>
          <attribute name="remark-internal">DIP protein P16104 original sequence version: 99</attribute>
          <attribute name="crc64">D4683775C2E6C3A9</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4">
        <names>
          <shortLabel>h2afx-ppp2ca</shortLabel>
        </names>
        <xref>
          <primaryRef db="mint" dbAc="MI:0471" id="MINT-8209928" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8061550" refType="identity" refTypeAc="MI:0356"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-8209931" refType="identity" refTypeAc="MI:0356"/>
            </xref>
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>enzyme target</shortLabel>
                <fullName>enzyme target</fullName>
                <alias type="go synonym" typeAc="MI:0303">substrate</alias>
                <alias type="synonym" typeAc="MI:1041">substrate</alias>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0502" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-64" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>purified</shortLabel>
                  <fullName>purified</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
          </participant>
          <participant id="6">
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-8209930" refType="identity" refTypeAc="MI:0356"/>
            </xref>
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>enzyme</shortLabel>
                <fullName>enzyme</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0501" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-46" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>dephosphorylation</shortLabel>
            <fullName>dephosphorylation reaction</fullName>
            <alias type="synonym" typeAc="MI:1041">dephosphorylation</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0203" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49880" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="resid" dbAc="MI:0248" id="AA0033" refType="see-also" refTypeAc="MI:0361"/>
            <secondaryRef db="resid" dbAc="MI:0248" id="AA0034" refType="see-also" refTypeAc="MI:0361"/>
            <secondaryRef db="resid" dbAc="MI:0248" id="AA0035" refType="see-also" refTypeAc="MI:0361"/>
            <secondaryRef db="resid" dbAc="MI:0248" id="AA0036" refType="see-also" refTypeAc="MI:0361"/>
            <secondaryRef db="resid" dbAc="MI:0248" id="AA0037" refType="see-also" refTypeAc="MI:0361"/>
            <secondaryRef db="resid" dbAc="MI:0248" id="AA0038" refType="see-also" refTypeAc="MI:0361"/>
            <secondaryRef db="resid" dbAc="MI:0248" id="AA0039" refType="see-also" refTypeAc="MI:0361"/>
            <secondaryRef db="resid" dbAc="MI:0248" id="AA0222" refType="see-also" refTypeAc="MI:0361"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="go" dbAc="MI:0448" id="GO:0016311" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">F1B</attribute>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>