IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Casein kinase II and calcineurin modulate TRPP function and ciliary localization. Casein kinase II and calcineurin modulate TRPP function and ciliary localization. Mol. Biol. Cell (1059-1524) 2006 imex curation Hu J., Bae YK., Knobel KM., Barr MM. The current UniProt amino acid numbers for the LOV-1 PLAT domain have been added, as there has been a significant sequence change since this paper was written. Interactions involving CK2 have not been included, as the identity of the catalytic subunit(s) is not identified on the suppliers web site. mmbarr@pharmacy.wisc.edu 06-Jun-2011: Contacted by JYOTI. orchard Only protein-protein interactions yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid nucleotide sequence nucleotide sequence identification sequence cloning sequence cloning nucleotide sequence Hu J., Bae YK., Knobel KM., Barr MM. The current UniProt amino acid numbers for the LOV-1 PLAT domain have been added, as there has been a significant sequence change since this paper was written. Interactions involving CK2 have not been included, as the identity of the catalytic subunit(s) is not identified on the suppliers web site. mmbarr@pharmacy.wisc.edu Accepted 2011-APR-28 by ORCHARD 06-Jun-2011: Contacted by JYOTI. cDNA library derived from mix-staged him-5 animals. Mol. Biol. Cell (1059-1524) 2006 orchard Only protein-protein interactions imex curation Casein kinase II and calcineurin modulate TRPP function and ciliary localization. Casein kinase II and calcineurin modulate TRPP function and ciliary localization. Mol. Biol. Cell (1059-1524) 2006 imex curation Hu J., Bae YK., Knobel KM., Barr MM. The current UniProt amino acid numbers for the LOV-1 PLAT domain have been added, as there has been a significant sequence change since this paper was written. Interactions involving CK2 have not been included, as the identity of the catalytic subunit(s) is not identified on the suppliers web site. mmbarr@pharmacy.wisc.edu 06-Jun-2011: Contacted by JYOTI. orchard Only protein-protein interactions in vitro In vitro pull down pull down weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Hu J., Bae YK., Knobel KM., Barr MM. The current UniProt amino acid numbers for the LOV-1 PLAT domain have been added, as there has been a significant sequence change since this paper was written. Interactions involving CK2 have not been included, as the identity of the catalytic subunit(s) is not identified on the suppliers web site. mmbarr@pharmacy.wisc.edu Accepted 2011-APR-28 by ORCHARD 06-Jun-2011: Contacted by JYOTI. Mol. Biol. Cell (1059-1524) 2006 orchard Only protein-protein interactions imex curation Casein kinase II and calcineurin modulate TRPP function and ciliary localization. Casein kinase II and calcineurin modulate TRPP function and ciliary localization. Mol. Biol. Cell (1059-1524) 2006 imex curation Hu J., Bae YK., Knobel KM., Barr MM. The current UniProt amino acid numbers for the LOV-1 PLAT domain have been added, as there has been a significant sequence change since this paper was written. Interactions involving CK2 have not been included, as the identity of the catalytic subunit(s) is not identified on the suppliers web site. mmbarr@pharmacy.wisc.edu 06-Jun-2011: Contacted by JYOTI. orchard Only protein-protein interactions caeel Caenorhabditis elegans confocal microscopy confocal microscopy tag fluorescence tag visualisation by fluorescence tag fluorescence Hu J., Bae YK., Knobel KM., Barr MM. I wanted to enter "Caeel" as Host Organism - but a (?) bug will not allow this - will need altering. The current UniProt amino acid numbers for the LOV-1 PLAT domain have been added, as there has been a significant sequence change since this paper was written. Interactions involving CK2 have not been included, as the identity of the catalytic subunit(s) is not identified on the suppliers web site. mmbarr@pharmacy.wisc.edu Accepted 2011-APR-28 by ORCHARD 06-Jun-2011: Contacted by JYOTI. Mol. Biol. Cell (1059-1524) 2006 orchard Only protein-protein interactions imex curation csk2b_caeel Casein kinase II subunit beta kin-10 kin-5 T01G9.6 protein protein caeel Caenorhabditis elegans MSSSEEVSWITWFCGLRGNEFFCEVDEEYIQDRFNLTGLNEQVPKYRQALDMILDLEPDDIEDNATNTDLVEQAAEMLYGLIHARYILTNRGISQMVEKWRDHDFGVCPRVYCENQPMLPIGLSDVPGEAMVKLYCPRCNDVFVPRSSRHQHTDGSYFGTGFPHMLFFVHPDLRPRRPVTQFVPKLYGFKIHPVAYGGQEGNSGGNTANNVAAAQNNTTPAGQQSGGQFNNYGL 634E76B78761AD74 pp2b_caeel Serine/threonine-protein phosphatase 2B catalytic subunit tax-6 Abnormal chemotaxis protein 6 Calmodulin-dependent calcineurin subunit A cna-1 C02F4.2 protein protein caeel Caenorhabditis elegans MASTSAGQNSAAKPDTTNTTTTASNNNRERERDLKQFTERFVKTVQFPVSERLTVDQVYDRRTGKPRHEVLRDHFIKEGRIEEEAAIRVIQECSSLFRNEKTMLEIEAPVTVCGDIHGQFYDLMKLFEVGGSPATTKYLFLGDYVDRGYFSIECVLYLWALKICYPTTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDVCMESFDALPLAALMNQQFLCVHGGLSPEIHTLEDIRRIDRFKEPPAFGPMCDLLWSDPLEDFGNERNSEQFSHNSVRGCSYFYSYAACCDFLQHNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLITIFSAPNYLDVYNNKAAILKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVHILNICSDDELMAECDDTFEGGVGSARKEVIRHKIRAIGKMARAFSVLRHESESVLQLKGLNAGGKLPQGALSEGRTGLNAAYRIEQSVAAESGCDSGHLIQSFEEARRLDKINERMPPTMATPPAQSPSQSPIPSRQTTPQPPQNGPSNS 60983B8A0C504883 pkd1_human Polycystin-1 PKD1 Autosomal dominant polycystic kidney disease 1 protein protein protein human Homo sapiens Human MPPAAPARLALALGLGLWLGALAGGPGRGCGPCEPPCLCGPAPGAACRVNCSGRGLRTLGPALRIPADATALDVSHNLLRALDVGLLANLSALAELDISNNKISTLEEGIFANLFNLSEINLSGNPFECDCGLAWLPRWAEEQQVRVVQPEAATCAGPGSLAGQPLLGIPLLDSGCGEEYVACLPDNSSGTVAAVSFSAAHEGLLQPEACSAFCFSTGQGLAALSEQGWCLCGAAQPSSASFACLSLCSGPPPPPAPTCRGPTLLQHVFPASPGATLVGPHGPLASGQLAAFHIAAPLPVTATRWDFGDGSAEVDAAGPAASHRYVLPGRYHVTAVLALGAGSALLGTDVQVEAAPAALELVCPSSVQSDESLDLSIQNRGGSGLEAAYSIVALGEEPARAVHPLCPSDTEIFPGNGHCYRLVVEKAAWLQAQEQCQAWAGAALAMVDSPAVQRFLVSRVTRSLDVWIGFSTVQGVEVGPAPQGEAFSLESCQNWLPGEPHPATAEHCVRLGPTGWCNTDLCSAPHSYVCELQPGGPVQDAENLLVGAPSGDLQGPLTPLAQQDGLSAPHEPVEVMVFPGLRLSREAFLTTAEFGTQELRRPAQLRLQVYRLLSTAGTPENGSEPESRSPDNRTQLAPACMPGGRWCPGANICLPLDASCHPQACANGCTSGPGLPGAPYALWREFLFSVPAGPPAQYSVTLHGQDVLMLPGDLVGLQHDAGPGALLHCSPAPGHPGPRAPYLSANASSWLPHLPAQLEGTWACPACALRLLAATEQLTVLLGLRPNPGLRLPGRYEVRAEVGNGVSRHNLSCSFDVVSPVAGLRVIYPAPRDGRLYVPTNGSALVLQVDSGANATATARWPGGSVSARFENVCPALVATFVPGCPWETNDTLFSVVALPWLSEGEHVVDVVVENSASRANLSLRVTAEEPICGLRATPSPEARVLQGVLVRYSPVVEAGSDMVFRWTINDKQSLTFQNVVFNVIYQSAAVFKLSLTASNHVSNVTVNYNVTVERMNRMQGLQVSTVPAVLSPNATLALTAGVLVDSAVEVAFLWTFGDGEQALHQFQPPYNESFPVPDPSVAQVLVEHNVMHTYAAPGEYLLTVLASNAFENLTQQVPVSVRASLPSVAVGVSDGVLVAGRPVTFYPHPLPSPGGVLYTWDFGDGSPVLTQSQPAANHTYASRGTYHVRLEVNNTVSGAAAQADVRVFEELRGLSVDMSLAVEQGAPVVVSAAVQTGDNITWTFDMGDGTVLSGPEATVEHVYLRAQNCTVTVGAASPAGHLARSLHVLVFVLEVLRVEPAACIPTQPDARLTAYVTGNPAHYLFDWTFGDGSSNTTVRGCPTVTHNFTRSGTFPLALVLSSRVNRAHYFTSICVEPEVGNVTLQPERQFVQLGDEAWLVACAWPPFPYRYTWDFGTEEAAPTRARGPEVTFIYRDPGSYLVTVTASNNISAANDSALVEVQEPVLVTSIKVNGSLGLELQQPYLFSAVGRGRPASYLWDLGDGGWLEGPEVTHAYNSTGDFTVRVAGWNEVSRSEAWLNVTVKRRVRGLVVNASRTVVPLNGSVSFSTSLEAGSDVRYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIVTAENEVGSAQDSIFVYVLQLIEGLQVVGGGRYFPTNHTVQLQAVVRDGTNVSYSWTAWRDRGPALAGSGKGFSLTVLEAGTYHVQLRATNMLGSAWADCTMDFVEPVGWLMVAASPNPAAVNTSVTLSAELAGGSGVVYTWSLEEGLSWETSEPFTTHSFPTPGLHLVTMTAGNPLGSANATVEVDVQVPVSGLSIRASEPGGSFVAAGSSVPFWGQLATGTNVSWCWAVPGGSSKRGPHVTMVFPDAGTFSIRLNASNAVSWVSATYNLTAEEPIVGLVLWASSKVVAPGQLVHFQILLAAGSAVTFRLQVGGANPEVLPGPRFSHSFPRVGDHVVSVRGKNHVSWAQAQVRIVVLEAVSGLQVPNCCEPGIATGTERNFTARVQRGSRVAYAWYFSLQKVQGDSLVILSGRDVTYTPVAAGLLEIQVRAFNALGSENRTLVLEVQDAVQYVALQSGPCFTNRSAQFEAATSPSPRRVAYHWDFGDGSPGQDTDEPRAEHSYLRPGDYRVQVNASNLVSFFVAQATVTVQVLACREPEVDVVLPLQVLMRRSQRNYLEAHVDLRDCVTYQTEYRWEVYRTASCQRPGRPARVALPGVDVSRPRLVLPRLALPVGHYCFVFVVSFGDTPLTQSIQANVTVAPERLVPIIEGGSYRVWSDTRDLVLDGSESYDPNLEDGDQTPLSFHWACVASTQREAGGCALNFGPRGSSTVTIPRERLAAGVEYTFSLTVWKAGRKEEATNQTVLIRSGRVPIVSLECVSCKAQAVYEVSRSSYVYLEGRCLNCSSGSKRGRWAARTFSNKTLVLDETTTSTGSAGMRLVLRRGVLRDGEGYTFTLTVLGRSGEEEGCASIRLSPNRPPLGGSCRLFPLGAVHALTTKVHFECTGWHDAEDAGAPLVYALLLRRCRQGHCEEFCVYKGSLSSYGAVLPPGFRPHFEVGLAVVVQDQLGAAVVALNRSLAITLPEPNGSATGLTVWLHGLTASVLPGLLRQADPQHVIEYSLALVTVLNEYERALDVAAEPKHERQHRAQIRKNITETLVSLRVHTVDDIQQIAAALAQCMGPSRELVCRSCLKQTLHKLEAMMLILQAETTAGTVTPTAIGDSILNITGDLIHLASSDVRAPQPSELGAESPSRMVASQAYNLTSALMRILMRSRVLNEEPLTLAGEEIVAQGKRSDPRSLLCYGGAPGPGCHFSIPEAFSGALANLSDVVQLIFLVDSNPFPFGYISNYTVSTKVASMAFQTQAGAQIPIERLASERAITVKVPNNSDWAARGHRSSANSANSVVVQPQASVGAVVTLDSSNPAAGLHLQLNYTLLDGHYLSEEPEPYLAVYLHSEPRPNEHNCSASRRIRPESLQGADHRPYTFFISPGSRDPAGSYHLNLSSHFRWSALQVSVGLYTSLCQYFSEEDMVWRTEGLLPLEETSPRQAVCLTRHLTAFGASLFVPPSHVRFVFPEPTADVNYIVMLTCAVCLVTYMVMAAILHKLDQLDASRGRAIPFCGQRGRFKYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDRAFHRNSLDIFRIATPHSLGSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGLVEKEVLAASDAALLRFRRLLVAELQRGFFDKHIWLSIWDRPPRSRFTRIQRATCCVLLICLFLGANAVWYGAVGDSAYSTGHVSRLSPLSVDTVAVGLVSSVVVYPVYLAILFLFRMSRSKVAGSPSPTPAGQQVLDIDSCLDSSVLDSSFLTFSGLHAEQAFVGQMKSDLFLDDSKSLVCWPSGEGTLSWPDLLSDPSIVGSNLRQLARGQAGHGLGPEEDGFSLASPYSPAKSFSASDEDLIQQVLAEGVSSPAPTQDTHMETDLLSSLSSTPGEKTETLALQRLGELGPPSPGLNWEQPQAARLSRTGLVEGLRKRLLPAWCASLAHGLSLLLVAVAVAVSGWVGASFPPGVSVAWLLSSSASFLASFLGWEPLKVLLEALYFSLVAKRLHPDEDDTLVESPAVTPVSARVPRVRPPHGFALFLAKEEARKVKRLHGMLRSLLVYMLFLLVTLLASYGDASCHGHAYRLQSAIKQELHSRAFLAITRSEELWPWMAHVLLPYVHGNQSSPELGPPRLRQVRLQEALYPDPPGPRVHTCSAAGGFSTSDYDVGWESPHNGSGTWAYSAPDLLGAWSWGSCAVYDSGGYVQELGLSLEESRDRLRFLQLHNWLDNRSRAVFLELTRYSPAVGLHAAVTLRLEFPAAGRALAALSVRPFALRRLSAGLSLPLLTSVCLLLFAVHFAVAEARTWHREGRWRVLRLGAWARWLLVALTAATALVRLAQLGAADRQWTRFVRGRPRRFTSFDQVAQLSSAARGLAASLLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELLGVTLGLVVLGVAYAQLAILLVSSCVDSLWSVAQALLVLCPGTGLSTLCPAESWHLSPLLCVGLWALRLWGALRLGAVILRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGLSKVKEFRHKVRFEGMEPLPSRSSRGSKVSPDVPPPSAGSDASHPSTSSSQLDGLSVSLGRLGTRCEPEPSRLQAVFEALLTQFDRLNQATEDVYQLEQQLHSLQGRRSSRAPAGSSRGPSPGLRPALPSRLARASRGVDLATGPSRTPLRAKNKVHPSST DIP protein P98161 original sequence version: 176 AEDAC48F3F0A853C csk2a_caeel Casein kinase II subunit alpha B0205.7 kin-3 protein protein caeel Caenorhabditis elegans MPPIPSRARVYAEVNPSRPREYWDYEAHMIEWGQIDDYQLVRKLGRGKYSEVFEGFKMSTDEKVVVKILKPVKKKKIKREIKILENLRGGTNIITLLDVVKDPISRTPALIFEHVNNSDFKQLYQTLSDYDIRYYLYELLKALDFCHSQGIMHRDVKPHNVMIDAEKRELRLIDWGLAEFYHPRQDYNVRVASRYFKGPELLVDYQCYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTDELYEYIARYHIDLDPRFNDILGRHSRKRWERFIHAENQHLVTPEALDFLDKLLRYDHAERLTAQEAMGHEYFRPVVEAHARANGTEQADGQGASNSASSQSSDAKIDGA B98DF039F6B566FA pkd1_caeel Location of vulva defective 1 lov-1 pkd-1 Polycystin-1 Polycystic kidney disease 1 protein homolog ZK945.9/ZK945.10 protein protein caeel Caenorhabditis elegans MKKSNFFVLLLLAISAIQIDGLHYQLLDGIATFRLDNDDTTIGGVPRNSQGVVKIKLSCGLNRLSVENKVTEVSSLELIHNCIQTETRLVGLFLNSTWITLNEVNDDDEISIAVEAKYEVCYDDGIDRCDGSLWWLQVGGNEMALLGYREKCESGEINEEYARRMCKRPYRSEKSTAISDSQGVYYDGQVLKGVRAKQFSMRTSGSPTLRRMKRDAGDNTCDYTIESTSTSTTTPTTTTVTSTVTSTTTVPTSTSTVTTAMSTSTSTPSTSTTIESTSTTFTSTASTSTSSTSTTQQSSSTITSSPSSTTLSTSIPTTTTPEITSTLSSLPDNAICSYLDETTTSTTFTTTMLTSTTTEEPSTSTTTTEVTSTSSTVTTTEPTTTLTTSTASTSTTEPSTSTVTTSPSTSPVTSTVTSSSSSSTTVTTPTSTESTSTSPSSTVTTSTTAPSTSTTGPSSSSSTPSSTASSSVSSTASSTQSSTSTQQSSTTTKSETTTSSDGTNPDFYFVEKATTTFYDSTSVNLTLNSGLGIIGYQTSIECTSPTSSNYVSTTKDGACFTKSVSMPRLGGTYPASTFVGPGNYTFRATMTTDDKKVYYTYANVYIQEYSSTTIESESSTSAVASSTSSTPSTPSSTLSTSTVTEPSSTRSSDSTTTSAGSTTTLQESTTTSEESTTDSSTTTISDTSTTSSSPSSTTADSTSTLSVDQFDFILDSGLSWNETRHNEDSINIVPLPTNAITPTERSQTFECRNVSTEPFLIIKESTCLNYSNTVLNATYSSNIPIQPIETFLVGIGTYEFRINMTDLTTMQVVSHIFTLNVVADSTSTSEVTSTTSTGSSSESSAISTTSGIESTSTLEASTTDASQDSSTSTSDSGTTSDSTTIDSSNSTPSTSDSSGLSQTPSDSSSASDSMRTTTVDPDASTETPYDFVLENLTWNETVYYSENPFYITPIPNKEPGALTTAMTCQCRNDSSQPFVLLKESNCLTEFGKNGAYSASVSFNPMTSFVPATGTYEFLINVTNRASGESASHIFTMNVVLPTTTTETPPTTVSSSDDAGGKTGGTGATGGTGGTGSGGSATTLSTGDAVRSTTSGSGSGQSSTGSGAGGSGTTASGSGSGGSSGTGSDGVNSGKTTALNGDGTGSGTATTPGSHLGDGGSTSGSGSDSNGSSGVSTKSSSGSDTSGSSDSSGANGAFSATAQPSTRTTKTRSSLATVSPISAAEQAIIDAQKADVMNQLAGIMDGSASNNSLNTSSSLLNQISSLPAADLVEVAQSLLSNTLKIPGVGNMSSVDVLKTLQDNIATTNSELADEMAKVITKLANVNMTSAQSLNSVLSSLDLALKGSTVYTLGVSSTKSKDGTYAVIFGYVIASGYTLVSPRCTLSIYGSTIYLTGDTRASYKQLDGDTVTADTMLAAAIGIQGMFATNGRTVQVEQDKIDDKRSLVSGNIMATMSGVGDVQSGEYSYNDMYVTAWNVTYDNSTVGSTSQKNTSFSFNIPVSEVQYILLIESGTMIKLHSTQNIVSRGLVVTASYGGVTYTITCTNGTGKFVEVDTDNAIFSYNADSFTVVASDGSSASTVKKLIQMPIVIENVNLALFNQTTSPLVFSNAGSYSMRMVLSPQDIGIPAVSALSQTVSISTLSPTASYTKDDLQSLIKEQTLVTVSGTLFFSKASSIDVSGYSFFVDSTALYLSNSVTTLVISSPTYNIVSLALGGYGIQITAGTYTSGSQTHTVTLMEFSDTQKMRIDGGLIIRNGTNGYVIQNGQVSTEGDVSGTKIDIVPQSLMNQESQQQIETILSNTQDFLTNNGMTMTDAEINDTSNSLLSIAGSLTSALKIALDNPLSSDLAANLKYATDNYDSLYNVLPSDPDNIVYVEEMTSEEWAAYVTKMFQKNIAKNLANQLASTLDTLENTLAARAIATGNLPYDYSNSVDGTGMVIVIDDASNIVGKTQNCEEWAFKLPSPASTLNTAEITDKTLIQVGLVCYATNPRTYVDNFDMLITSGALEAHIKDENQIIIPITGTTAPIYVNGRGSEDDAVLTLMQQGDFASYQILDLHAFRTTNWNNSLQVEIIASQDYEIPNNDDTYMFSSFQSLPGPLESNHEWIFDLNTLNKTSNYFVTAGNLINNTGLFFIGIGKRNSSTNTGNSSDIVNYGQYDSMQWSFARSVPMDYQVAAVSKGCYFYQKTSDVFNSEGMYPSDGQGMQFVNCSTDHLTMFSVGAFNPTIDADFSYNYNVNEIEKNVKVMIAAVFMLVVYGCLTINAIICQRKDASRGRLRFLKDNEPHDGYMYVIAVETGYRMFATTDSTICFNLSGNEGDQIFRSFRSEEDGNWEFPFSWGTTDRFVMTTAFPLGELEYMRLWLDDAGLDHRESWYCNRIIVKDLQTQDIYYFPFNNWLGTKNGDGETERLARVEYKRRFLDESMSMHMLAQTISWFAMFTGGGNRLRDRVSRQDYSVSIIFSLVVVSMISITILKSDNSIISDSKSVSEFTFTIKDIAFGVGFGVLITFLNSLHILLCTKCRSHSEHYYYKKRKREDPEFKDNSGSWPMFMAGMARTIIVFPVLMGLIYISGAGMSLMDDLANSFYIRFLISLILWAVVFEPIKGLIWAFLILKTRKSHKIINKLEEALLRAKPAETFLRNPYGKIEKGLGTEIADVTKLRDTENRKMRDEQLFITIRDMLCFFASLYIMVMLTYYCKDRHGYWYQLEMSTILNINQKNYGDNTFMSIQHADDFWDWARESLATALLASWYDGNPAYGMRAYMNDKVSRSMGIGTIRQVRTKKSAECTMFKQFQGYINDCGEELTSKNEEKTLYMQAGWTELESENGTDASDEYTYKTSEELSTETVSGLLYSYSGGGYTISMSGTQAEIITLFNKLDSERWIDDHTRAVIIEFSAYNAQINYFSVVQLLVEIPKSGIYLPNSWVESVRLIKSEGSDGTVVKYYEMLYIFFSVLIFVKEIVFYLYGRYKVITTMKPTRNPFKIVYQLALGNFSPWNFMDLIVGALAVASVLAYTIRQRTTNRAMEDFNANNGNSYINLTEQRNWEIVFSYCLAGAVFFTSCKMIRILRFNRRIGVLAATLDNALGAIVSFGIAFLFFSMTFNSVLYAVLGNKMGGYRSLMATFQTALAGMLGKLDVTSIQPISQFAFVVIMLYMIAGSKLVLQLYVTIIMFEFEEIRNDSEKQTNDYEIIDHIKYKTKRRLGLLEPKDFAPVSIADTQKDFRLFHSAVAKVNLLHHRATRMLQTQGQYQNQTVINYTLSYDPVSAIHETGPKRFQKWRLNDVEKD 1E2E5320857CED2F pkd2_caeel Polycystin-2 Y73F8A.1 pdk-2 pkd-2 Polycystic kidney disease 2 protein homolog protein protein caeel Caenorhabditis elegans MNYGAADERWANPPQPVAAAEHGPSFDHSMVSEEYEHDKKKNPAQKEGISFSQALLASGHEKSDGKIKLTARSFMEVGGYAVFLIVLVYVAFAQNSIQSYYYSKVMSDLFVASTGASGAPAFGSCTSMDNIWDWLSQVLIPGIYWTETSNSTDNENMIYYENRLLGEPRIRMLKVTNDSCTVMKSFQREIKECFANYEEKLEDKTMVGDGSVDAFIYATAKELENLKTVGTIASYGGGGFVQRLPVAGSTEAQSAIATLKANRWIDRGSRAIIVDFALYNANINLFCVVKLLFELPASGGVITTPKLMTYDLLTYQTSGGTRMMIFEGIFCGFILYFIFEELFAIGRHRLHYLTQFWNLVDVVLLGFSVATIILSVNRTKTGVNRVNSVIENGLTNAPFDDVTSSENSYLNIKACVVFVAWVKVFKFISVNKTMSQLSSTLTRSAKDIGGFAVMFAVFFFAFAQFGYLCFGTQIADYSNLYNSAFALLRLILGDFNFSALESCNRFFGPAFFIAYVFFVSFILLNMFLAIINDSYVEVKAELARKKDGEGILDWFMNKVRGLTKRGKRPDAPGEDATYEDYKLMLYRAGYAEKDINEAFTRFNVTSMTEHVPEKVAEDIADEVARMTEQKRNYMENHRDYANLNRRVDQMQESVFSIVDRIEGVNATLQTIEKQRVQQQDGGNLMDLSALLTNQVRNRESAARRPTITSIADKKEE lov_1-kin_10 2 8 unspecified role unspecified role bait bait region gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined plat_domain sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) 4 unspecified role unspecified role prey prey region 35s radiolabel 35s radiolabel 35S s35 radiolabelled S35 s35 radiolabelled 35S S35 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined in vitro In vitro physical association physical association Fig 1B The PLAT domain of lov1 has been remapped to the updated sequence. lov_1-kin_10-1 1 8 unspecified role unspecified role bait bait plat_domain sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 4 unspecified role unspecified role prey prey ck2_beta-domain required to bind necessary binding region required to bind certain certain sequence position certain certain certain sequence position certain physical association physical association Fig 1C pkd1-kin_10 1 6 unspecified role unspecified role bait bait plat_domain sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 4 unspecified role unspecified role prey prey ck2_beta-domain required to bind necessary binding region required to bind certain certain sequence position certain certain certain sequence position certain physical association physical association Fig 1C pkd2-tax_6 3 5 unspecified role unspecified role neutral component neutral component ds_red2 fluorescent prot tag fluorescent protein tag fluorescent prot tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 9 unspecified role unspecified role neutral component neutral component region gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined colocalization colocalization Fig 5A In the male, tax-6 expression was observed in the CEM, HOB, and ray RnB neurons, with expression noticeably absent from ray 6. GO terms do not seem to have reached C elegans, so no possible Xrefs can be added - comment instaed. kin_3-pkd2 3 7 unspecified role unspecified role neutral component neutral component region gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 9 unspecified role unspecified role neutral component neutral component ds_red2 fluorescent prot tag fluorescent protein tag fluorescent prot tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined colocalization colocalization Fig S1 kin-3 and kin-10 are coexpressed with lov-1 and pkd-2 in the male-specific CEM head neurons and ray RnB and hook HOB tail neurons. GO terms do not seem to have reached C elegans, so no possible Xrefs can be added - comment instaed. kin_10-pkd2 3 9 unspecified role unspecified role neutral component neutral component ds_red2 fluorescent prot tag fluorescent protein tag fluorescent prot tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 4 unspecified role unspecified role neutral component neutral component region gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined colocalization colocalization Fig S1 kin-3 and kin-10 are coexpressed with lov-1 and pkd-2 in the male-specific CEM head neurons and ray RnB and hook HOB tail neurons. GO terms do not seem to have reached C elegans, so no possible Xrefs can be added - comment instaed.