UniProt UniProt http://www.uniprot.org c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2. c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2. J. Biol. Chem. (0021-9258) 2005 mimix curation Jacob C., Cottrell G.S., Gehringer D., Schmidlin F., Grady E.F., Bunnett N.W. cololcal exp w endosome markers not annotated nigelb@itsa.ucsf.edu 26-Sep-2011: Contacted by JYOTI. mgt rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip anti tag western anti tag western blot anti tag western Jacob C., Cottrell G.S., Gehringer D., Schmidlin F., Grady E.F., Bunnett N.W. cololcal exp w endosome markers not annotated nigelb@itsa.ucsf.edu Accepted 2011-JUL-26 by MGT 26-Sep-2011: Contacted by JYOTI. J. Biol. Chem. (0021-9258) 2005 mgt mimix curation c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2. c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2. J. Biol. Chem. (0021-9258) 2005 mimix curation Jacob C., Cottrell G.S., Gehringer D., Schmidlin F., Grady E.F., Bunnett N.W. cololcal exp w endosome markers not annotated nigelb@itsa.ucsf.edu 26-Sep-2011: Contacted by JYOTI. mgt rat Rattus norvegicus (Rat) Rat anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Jacob C., Cottrell G.S., Gehringer D., Schmidlin F., Grady E.F., Bunnett N.W. cololcal exp w endosome markers not annotated nigelb@itsa.ucsf.edu Accepted 2011-JUL-26 by MGT 26-Sep-2011: Contacted by JYOTI. J. Biol. Chem. (0021-9258) 2005 mgt mimix curation c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2. c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2. J. Biol. Chem. (0021-9258) 2005 mimix curation Jacob C., Cottrell G.S., Gehringer D., Schmidlin F., Grady E.F., Bunnett N.W. cololcal exp w endosome markers not annotated nigelb@itsa.ucsf.edu 26-Sep-2011: Contacted by JYOTI. mgt rat Rattus norvegicus (Rat) Rat confocal microscopy confocal microscopy immunostaining immunostaining Jacob C., Cottrell G.S., Gehringer D., Schmidlin F., Grady E.F., Bunnett N.W. cololcal exp w endosome markers not annotated nigelb@itsa.ucsf.edu Accepted 2011-JUL-26 by MGT 26-Sep-2011: Contacted by JYOTI. J. Biol. Chem. (0021-9258) 2005 mgt mimix curation par2_human Proteinase-activated receptor 2 F2RL1 GPR11 PAR2 Coagulation factor II receptor-like 1 G-protein coupled receptor 11 Thrombin receptor-like 1 protein protein human Homo sapiens Human MRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY DIP protein P55085 original sequence version: 142 F1A4E1D5AB9B362B cbl_human E3 ubiquitin-protein ligase CBL Signal transduction protein CBL Proto-oncogene c-Cbl Casitas B-lineage lymphoma proto-oncogene RING finger protein 55 CBL CBL2 RNF55 RING-type E3 ubiquitin transferase CBL protein protein human Homo sapiens Human MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLLRQGAEGAPSPNYDDDDDERADDTLFMMKELAGAKVERPPSPFSMAPQASLPPVPPRLDLLPQRVCVPSSASALGTASKAASGSLHKDKPLPVPPTLRDLPPPPPPDRPYSVGAESRPQRRPLPCTPGDCPSRDKLPPVPSSRLGDSWLPRPIPKVPVSAPSSSDPWTGRELTNRHSLPFSLPSQMEPRPDVPRLGSTFSLDTSMSMNSSPLVGPECDHPKIKPSSSANAIYSLAARPLPVPKLPPGEQCEGEEDTEYMTPSSRPLRPLDTSQSSRACDCDQQIDSCTYEAMYNIQSQAPSITESSTFGEGNLAAAHANTGPEESENEDDGYDVPKPPVPAVLARRTLSDISNASSSFGWLSLDGDPTTNVTEGSQVPERPPKPFPRRINSERKAGSCQQGSGPAASAATASPQLSSEIENLMSQGYSYQDIQKALVIAQNNIEMAKNILREFVSISSPAHVAT DIP protein P22681 original sequence version: 173 DIP protein P22681 original sequence version: 128 DIP protein P22681 original sequence version: 145 DIP protein P22681 original sequence version: 150 DIP protein P22681 original sequence version: 191 DIP protein P22681 original sequence version: 91 DIP protein P22681 original sequence version: 139 1AA6BF67377322CA cbl-f2rl1 3 5 unspecified role unspecified role neutral component neutral component 4 unspecified role unspecified role neutral component neutral component colocalization colocalization 7 cbl-f2rl1-1 1 5 unspecified role unspecified role bait bait 4 unspecified role unspecified role prey prey physical association physical association 8a f2rl1-cbl 2 4 unspecified role unspecified role bait bait 5 unspecified role unspecified role prey prey physical association physical association 8b and 8 e/f Observed upon activation of F2RL1/PAR-2 and dependent on proto-oncogene tyrosine-protein kinase Src which phosphorylates CBL.