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        <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
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          <fullName>Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation.</fullName>
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          </names>
        </organism>
        <sequence>MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLEAP</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P27361 original sequence version: 171</attribute>
          <attribute name="remark-internal">DIP protein P27361 original sequence version: 101</attribute>
          <attribute name="remark-internal">DIP protein P27361 original sequence version: 124</attribute>
          <attribute name="remark-internal">DIP protein P27361 original sequence version: 129</attribute>
          <attribute name="remark-internal">DIP protein P27361 original sequence version: 143</attribute>
          <attribute name="crc64">E6020CE413EC41F7</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>dus1_human</shortLabel>
          <fullName>Dual specificity protein phosphatase 1</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">Mitogen-activated protein kinase phosphatase 1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Protein-tyrosine phosphatase CL100</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Dual specificity protein phosphatase hVH1</alias>
          <alias type="gene name" typeAc="MI:0301">DUSP1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">CL100</alias>
          <alias type="gene name synonym" typeAc="MI:0302">MKP1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">PTPN10</alias>
          <alias type="gene name synonym" typeAc="MI:0302">VH1</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P28562" version="SP_78" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000239223" version="SP_200" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q2V508" version="SP_78" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="D3DQL9" version="SP_108" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-975493" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000120129" version="SP_200" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000239223" version="SP_200" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000188" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001706" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004721" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004722" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004725" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006470" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007049" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007162" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008138" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008330" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009416" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0017017" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0019838" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0032355" version="SP_200"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR020422" version="SP_200"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR029021" version="SP_200"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036873" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0032526" version="SP_200"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="P28562" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6APX" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6D65" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0032870" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0033574" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0035335" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0035556" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6D66" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0035970" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6D67" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042542" version="SP_200"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-112409" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043065" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043066" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043407" version="SP_200"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5675221" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043409" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051019" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051384" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051447" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051591" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051592" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051726" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070262" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070373" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0090027" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0090266" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0106306" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0106307" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1903753" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1990869" version="SP_200"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000279" version="SP_200"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000340" version="SP_200"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000387" version="SP_200"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001763" version="SP_200"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003595" version="SP_200"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008343" version="SP_200"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016130" version="SP_200"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_004408.1"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAMGLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFFLKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSPITTSPSC</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P28562 original sequence version: null</attribute>
          <attribute name="crc64">11BD1D39A9FCD51F</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4">
        <names>
          <shortLabel>dusp1-mapk3-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="mint" dbAc="MI:0471" id="MINT-8238422" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7164842" refType="identity" refTypeAc="MI:0356"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-8238425" refType="identity" refTypeAc="MI:0356"/>
            </xref>
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>enzyme</shortLabel>
                <fullName>enzyme</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0501" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-46" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="6">
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-8238424" refType="identity" refTypeAc="MI:0356"/>
            </xref>
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>enzyme target</shortLabel>
                <fullName>enzyme target</fullName>
                <alias type="go synonym" typeAc="MI:0303">substrate</alias>
                <alias type="synonym" typeAc="MI:1041">substrate</alias>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0502" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-64" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>phosphorylation</shortLabel>
            <fullName>phosphorylation reaction</fullName>
            <alias type="synonym" typeAc="MI:1041">phosphorylation</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0217" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49922" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="resid" dbAc="MI:0248" id="AA0033" refType="see-also" refTypeAc="MI:0361"/>
            <secondaryRef db="resid" dbAc="MI:0248" id="AA0034" refType="see-also" refTypeAc="MI:0361"/>
            <secondaryRef db="resid" dbAc="MI:0248" id="AA0035" refType="see-also" refTypeAc="MI:0361"/>
            <secondaryRef db="resid" dbAc="MI:0248" id="AA0036" refType="see-also" refTypeAc="MI:0361"/>
            <secondaryRef db="resid" dbAc="MI:0248" id="AA0037" refType="see-also" refTypeAc="MI:0361"/>
            <secondaryRef db="resid" dbAc="MI:0248" id="AA0038" refType="see-also" refTypeAc="MI:0361"/>
            <secondaryRef db="resid" dbAc="MI:0248" id="AA0039" refType="see-also" refTypeAc="MI:0361"/>
            <secondaryRef db="resid" dbAc="MI:0248" id="AA0222" refType="see-also" refTypeAc="MI:0361"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="go" dbAc="MI:0448" id="GO:0016310" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">F3A</attribute>
          <attribute name="comment" nameAc="MI:0612">homomint</attribute>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>