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  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>MINT</shortLabel>
        <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
        <alias type="synonym" typeAc="MI:1041">MINT</alias>
      </names>
      <bibref>
        <xref>
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      </bibref>
      <xref>
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      <attributeList>
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        <attribute name="search-url" nameAc="MI:0615">https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac}</attribute>
        <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="9524113" refType="primary-reference" refTypeAc="MI:0358"/>
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          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins.</attribute>
            <attribute name="journal" nameAc="MI:0885">EMBO J. (0261-4189)</attribute>
            <attribute name="publication year" nameAc="MI:0886">1998</attribute>
            <attribute name="author-list" nameAc="MI:0636">Ku NO., Liao J., Omary MB.</attribute>
            <attribute name="rapid curation" nameAc="MI:0961">rapid curation</attribute>
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        </bibref>
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        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="-3">
            <names>
              <shortLabel>unknown</shortLabel>
              <fullName>Unknown</fullName>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>coip</shortLabel>
            <fullName>coimmunoprecipitation</fullName>
            <alias type="go synonym" typeAc="MI:0303">co-immunoprecipitation</alias>
            <alias type="go synonym" typeAc="MI:0303">CoIp</alias>
            <alias type="go synonym" typeAc="MI:0303">immunoprecipitation</alias>
            <alias type="go synonym" typeAc="MI:0303">Co-IP</alias>
            <alias type="synonym" typeAc="MI:1041">co-immunoprecipitation</alias>
            <alias type="synonym" typeAc="MI:1041">CoIp</alias>
            <alias type="synonym" typeAc="MI:1041">immunoprecipitation</alias>
            <alias type="synonym" typeAc="MI:1041">Co-IP</alias>
            <alias type="synonym" typeAc="MI:1041">coip</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0019" refType="identity" refTypeAc="MI:0356"/>
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            <secondaryRef db="pubmed" dbAc="MI:0446" id="7708014" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Ku NO., Liao J., Omary MB.</attribute>
          <attribute name="journal" nameAc="MI:0885">EMBO J. (0261-4189)</attribute>
          <attribute name="publication year" nameAc="MI:0886">1998</attribute>
          <attribute name="rapid curation" nameAc="MI:0961">rapid curation</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>k1c18_human</shortLabel>
          <fullName>Keratin, type I cytoskeletal 18</fullName>
          <alias type="gene name" typeAc="MI:0301">KRT18</alias>
          <alias type="gene name synonym" typeAc="MI:0302">CYK18</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Keratin-18</alias>
          <alias type="orf name" typeAc="MI:0306">PIG46</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Cytokeratin-18</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Cell proliferation-inducing gene 46 protein</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P05783" version="SP_102" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q53G38" version="SP_102" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q5U0N8" version="SP_102" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9BW26" version="SP_102" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000373487" version="SP_231" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000373489" version="SP_231" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-297888" refType="identity" refTypeAc="MI:0356"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005815" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005882" version="SP_231"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043066" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045095" version="SP_231"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0098641" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1902488" version="SP_231"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002957" version="SP_231"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018039" version="SP_231"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR027695" version="SP_231"/>
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          <secondaryRef db="mint" dbAc="MI:0471" id="P05783" version="SP_231"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6805567" version="SP_231"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6809371" version="SP_231"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000111057" version="SP_231" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000388835" version="SP_231" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000388837" version="SP_231" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003723" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005198" version="SP_231"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_000215.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_954657.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-633N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MSFTTRSTFSTNYRSLGSVQAPSYGARPVSSAASVYAGAGGSGSRISVSRSTSFRGGMGSGGLATGIAGGLAGMGGIQNEKETMQSLNDRLASYLDRVRSLETENRRLESKIREHLEKKGPQVRDWSHYFKIIEDLRAQIFANTVDNARIVLQIDNARLAADDFRVKYETELAMRQSVENDIHGLRKVIDDTNITRLQLETEIEALKEELLFMKKNHEEEVKGLQAQIASSGLTVEVDAPKSQDLAKIMADIRAQYDELARKNREELDKYWSQQIEESTTVVTTQSAEVGAAETTLTELRRTVQSLEIDLDSMRNLKASLENSLREVEARYALQMEQLNGILLHLESELAQTRAEGQRQAQEYEALLNIKVKLEAEIATYRRLLEDGEDFNLGDALDSSNSMQTIQKTTTRRIVDGKVVSETNDTKVLRH</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P05783 original sequence version: 186</attribute>
          <attribute name="remark-internal">DIP protein P05783 original sequence version: 175</attribute>
          <attribute name="crc64">1E5604C6BCC7A17A</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>1433z_mouse</shortLabel>
          <fullName>14-3-3 protein zeta/delta</fullName>
          <alias type="gene name" typeAc="MI:0301">Ywhaz</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Protein kinase C inhibitor protein 1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">SEZ-2</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P63101" version="SP_47" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P35215" version="SP_47" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P70197" version="SP_47" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P97286" version="SP_47" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q3TSF1" version="SP_47" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q5EBQ1" version="SP_47" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000022894" version="SP_176" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000105990" version="SP_176" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000105991" version="SP_176" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-354751" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001240734.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001240735.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_035870.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011243654.1"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSG00000022285" version="SP_176" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000110361" version="SP_176" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000110362" version="SP_176" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001525" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0002553" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003016" version="SP_176"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000022894" version="SP_176" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005739" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006468" version="SP_176"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010941" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0014069" version="SP_176"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0035148" version="SP_176"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0090128" version="SP_176"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0098686" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0098978" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0140297" version="SP_176"/>
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          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR023409" version="SP_176"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR023410" version="SP_176"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036815" version="SP_176"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="P63101" version="SP_176"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-111447" version="SP_176"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-3769402" version="SP_176"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-392517" version="SP_176"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-430116" version="SP_176"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-450604" version="SP_176"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-512988" version="SP_176"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-5625740" version="SP_176"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-5628897" version="SP_176"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-75035" version="SP_176"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-9013700" version="SP_176"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-9614399" version="SP_176"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-31894N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10090">
          <names>
            <shortLabel>mouse</shortLabel>
            <fullName>Mus musculus</fullName>
            <alias type="synonym" typeAc="MI:1041">Mouse</alias>
          </names>
        </organism>
        <sequence>MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQPESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P63101 original sequence version: 72</attribute>
          <attribute name="crc64">2164DF3793B45B7A</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4">
        <names>
          <shortLabel>krt18-ywhaz-4</shortLabel>
        </names>
        <xref>
          <primaryRef db="mint" dbAc="MI:0471" id="MINT-8005255" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8686577" refType="identity" refTypeAc="MI:0356"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <names>
              <alias type="author assigned name" typeAc="MI:0345">1433Z_MOUSE</alias>
            </names>
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-8005256" refType="identity" refTypeAc="MI:0356"/>
              <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P63101" refType="original identifier" refTypeAc="MI:0869"/>
            </xref>
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="6">
            <names>
              <alias type="author assigned name" typeAc="MI:0345">K1C18_HUMAN</alias>
            </names>
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-8005259" refType="identity" refTypeAc="MI:0356"/>
              <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P05783" refType="original identifier" refTypeAc="MI:0869"/>
            </xref>
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>association</shortLabel>
            <fullName>association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0914" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813191" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="comment" nameAc="MI:0612">domino</attribute>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>