Molecular Connections Molecular Connections Pvt. Ltd. 2/2, Kariappa Road, Basavanagudi, Bangalore -560 004 www.molecularconnections.com Multiple paxillin binding sites regulate FAK function. Multiple paxillin binding sites regulate FAK function. J Mol Signal 2008 imex curation Scheswohl DM., Harrell JR., Rajfur Z., Gao G., Campbell SL., Schaller MD. crispy4@med.unc.edu 13-Sept-2010: Contacted by JYOTI. orchard Only protein-protein interactions Curation by: Molecular Connections Pvt. Ltd in vitro In vitro pull down pull down western blot western blot Immuno blot Immuno blot Scheswohl DM., Harrell JR., Rajfur Z., Gao G., Campbell SL., Schaller MD. crispy4@med.unc.edu. crispy4@med.unc.edu Accepted 2010-AUG-29 by ORCHARD. J Mol Signal 2008 orchard Only protein-protein interactions imex curation Curation by: Molecular Connections Pvt. Ltd paxi_chick Paxillin PXN protein protein chick Gallus gallus (Chicken) Chicken MDDLDALLADLESTTSHISKRPVFLTEETPYSYPTGNHTYQEIAVPPPVPPPPSSEALNGTVIDPLDQWQPSVSRYGHQQPQSQSPIYSSSAKSSSASVPRDGLSSPSPRASEEEHVYSFPNKQKSAEPSPTMTSTSLGSNLSELDRLLLELNAVQHNPPSGFSADEVSRSPSLPNVTGPHYVIPESSSSAGGKAAPPTKEKPKRNGGRGIEDVRPSVESLLDELESSVPSPVPAITVSQGEVSSPQRVNASQQQTRISASSATRELDELMASLSDFKFMAQGKAGGSSSPPSTTPKPGSQLDTMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGVFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFINGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMGKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLFC 6450270D90B2DE84 fak1_chick Focal adhesion kinase 1 PTK2 FAK FAK1 pp125FAK Protein-tyrosine kinase 2 Focal adhesion kinase-related nonkinase p125FAK protein protein chick Gallus gallus (Chicken) Chicken MAAAYLDPNLNHTPSSSAKTHLGTGMERSPGAMERVLKVFHYFENSSEPTTWASIIRHGDATDVRGIIQKIVDCHKVKNVACYGLRLSHLQSEEVHWLHLDMGVSNVREKFELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKNDYMLEIADQVDQEIALKLGCLEIRRSYGEMRGNALEKKSNYEVLEKDVGLRRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGANPTHLADFNQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGATQSFIIRPQKEGERALPSIPKLANNEKQGVRSHTVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKLQQEERMRMESRRQVTVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQPNHYQVSGYSGSHGIPAMAGSIYPGQASLLDQTDSWNHRPQEVSAWQPNMEDSGTLDVRGMGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLVMKPDVRLSRGSIEREDGGLQGPAGNQHIYQPVGKPDHAAPPKKPPRPGAPHLGSLASLNSPVDSYNEGVKIKPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDESLPVLPASTHREIEMAQKLLNSDLAELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMISQSRPH 8051154219B953B9 paxi_fak-1 1 3 unspecified role unspecified role prey prey Q00944:p.[Glu949Ala;Lys956Ala;Arg963Ala] E949A/K956A/R963A mutation mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain K A certain certain sequence position certain certain certain sequence position certain R A certain certain sequence position certain certain certain sequence position certain E A Thu Dec 08 14:36:10 GMT 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'E949A,K956A,R963A' Wed May 02 15:03:10 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'glu949ala,lys956ala,arg963ala' Tue Jun 30 16:50:44 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Glu949Ala;Lys956Ala;Arg963Ala]' Q00944:p.Ile937Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain I A Wed May 02 15:19:34 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ile937ala' Tue Jun 30 17:21:45 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ile937Ala' chick-embryo Gallus gallus chick embryo embryo Embryo Defined as the development stage prior to the initiation of tissue differentiation. 2 unspecified role unspecified role bait bait P49024:p.Asp146Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain D A Wed May 02 14:48:21 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp146ala' Tue Jun 30 18:55:24 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp146Ala' P49024:p.[Asp146Ala;Asp268Ala] mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain D A certain certain sequence position certain certain certain sequence position certain D A Fri Jul 22 11:07:58 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'asp268ala,asp146ala' Wed May 02 15:55:12 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp146ala,asp268ala' Tue Jun 30 16:43:28 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Asp146Ala;Asp268Ala]' n-term gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined ecoli Escherichia coli (strain K12) direct interaction direct interaction fig 1