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    <source releaseDate="2022-02-04">
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        <shortLabel>MINT</shortLabel>
        <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
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        <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
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        <names>
          <fullName>RKIP inhibits NF-kappaB in cancer cells by regulating upstream signaling components of the IkappaB kinase complex.</fullName>
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            <attribute name="publication title" nameAc="MI:1091">RKIP inhibits NF-kappaB in cancer cells by regulating upstream signaling components of the IkappaB kinase complex.</attribute>
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            <attribute name="publication year" nameAc="MI:0886">2010</attribute>
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            <names>
              <shortLabel>human-293ilr</shortLabel>
              <fullName>Homo sapiens</fullName>
            </names>
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                <shortLabel>293ilr</shortLabel>
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          <names>
            <shortLabel>anti bait coip</shortLabel>
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            <shortLabel>western blot</shortLabel>
            <fullName>western blot</fullName>
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          <shortLabel>traf6_human</shortLabel>
          <fullName>TNF receptor-associated factor 6</fullName>
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          <alias type="gene name synonym" typeAc="MI:0302">RNF85</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Interleukin-1 signal transducer</alias>
          <alias type="gene name synonym" typeAc="MI:0302">RING finger protein 85</alias>
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          </names>
        </organism>
        <sequence>MSLLNCENSCGSSQSESDCCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILKDCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPIPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSVIPDSGYISEVRNFQETIHQLEGRLVRQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein Q9Y4K3 original sequence version: 154</attribute>
          <attribute name="remark-internal">DIP protein Q9Y4K3 original sequence version: 91</attribute>
          <attribute name="remark-internal">DIP protein Q9Y4K3 original sequence version: 114</attribute>
          <attribute name="remark-internal">DIP protein Q9Y4K3 original sequence version: 118</attribute>
          <attribute name="remark-internal">DIP protein Q9Y4K3 original sequence version: 140</attribute>
          <attribute name="remark-internal">DIP protein Q9Y4K3 original sequence version: 159</attribute>
          <attribute name="remark-internal">DIP protein Q9Y4K3 original sequence version: 132</attribute>
          <attribute name="remark-internal">DIP protein Q9Y4K3 original sequence version: 158</attribute>
          <attribute name="remark-internal">DIP protein Q9Y4K3 original sequence version: 171</attribute>
          <attribute name="remark-internal">DIP protein Q9Y4K3 original sequence version: 117</attribute>
          <attribute name="remark-internal">DIP protein Q9Y4K3 original sequence version: 113</attribute>
          <attribute name="crc64">5AB9C255CCFEE749</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>pebp1_human</shortLabel>
          <fullName>Phosphatidylethanolamine-binding protein 1</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">Prostatic-binding protein</alias>
          <alias type="gene name synonym" typeAc="MI:0302">HCNPpp</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Neuropolypeptide h3</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Raf kinase inhibitor protein</alias>
          <alias type="gene name" typeAc="MI:0301">PEBP1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">PEBP</alias>
          <alias type="gene name synonym" typeAc="MI:0302">PBP</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P30086" version="SP_82" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B2R4S1" version="SP_105" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000261313" version="SP_214" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-716384" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_002558.1"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000089220" version="SP_214" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000261313" version="SP_214" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003723" version="SP_214"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004867" version="SP_214"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005524" version="SP_214"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="SP_214"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" version="SP_214"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008429" version="SP_214"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0019899" version="SP_214"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0019901" version="SP_214"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043409" version="SP_214"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070062" version="SP_214"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001858" version="SP_214"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008914" version="SP_214"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR035810" version="SP_214"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036610" version="SP_214"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="P30086" version="SP_214"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1BD9" version="SP_214"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1BEH" version="SP_214"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2L7W" version="SP_214"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2QYQ" version="SP_214"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5674135" version="SP_214"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5675221" version="SP_214"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6802946" version="SP_214"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6802948" version="SP_214"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6802952" version="SP_214"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6802955" version="SP_214"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9649948" version="SP_214"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-44269N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MPVDLSKWSGPLSLQEVDEQPQHPLHVTYAGAAVDELGKVLTPTQVKNRPTSISWDGLDSGKLYTLVLTDPDAPSRKDPKYREWHHFLVVNMKGNDISSGTVLSDYVGSGPPKGTGLHRYVWLVYEQDRPLKCDEPILSNRSGDHRGKFKVASFRKKYELRAPVAGTCYQAEWDDYVPKLYEQLSGK</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P30086 original sequence version: 136</attribute>
          <attribute name="crc64">F1E9F17E2CD11C36</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4" imexId="IM-15454-1">
        <names>
          <shortLabel>traf6-pebp1</shortLabel>
        </names>
        <xref>
          <primaryRef db="mint" dbAc="MI:0471" id="MINT-7386121" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7695195" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-15454-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <names>
              <alias type="author assigned name" typeAc="MI:0345">RKIP</alias>
            </names>
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-7386124" refType="identity" refTypeAc="MI:0356"/>
            </xref>
            <interactorRef>3</interactorRef>
            <participantIdentificationMethodList>
              <participantIdentificationMethod>
                <names>
                  <shortLabel>western blot</shortLabel>
                  <fullName>western blot</fullName>
                  <alias type="go synonym" typeAc="MI:0303">Immuno blot</alias>
                  <alias type="synonym" typeAc="MI:1041">Immuno blot</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </participantIdentificationMethod>
              <participantIdentificationMethod>
                <names>
                  <shortLabel>predetermined</shortLabel>
                  <fullName>predetermined participant</fullName>
                  <alias type="synonym" typeAc="MI:1041">predetermined</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </participantIdentificationMethod>
            </participantIdentificationMethodList>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>living cell</shortLabel>
                  <fullName>living cell</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0349" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537765" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
              <experimentalPreparation>
                <names>
                  <shortLabel>physiological level</shortLabel>
                  <fullName>physiological level</fullName>
                  <alias type="go synonym" typeAc="MI:0303">endogenous level</alias>
                  <alias type="go synonym" typeAc="MI:0303">endogenous</alias>
                  <alias type="synonym" typeAc="MI:1041">endogenous</alias>
                  <alias type="synonym" typeAc="MI:1041">endogenous level</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
          </participant>
          <participant id="6">
            <names>
              <alias type="author assigned name" typeAc="MI:0345">TRAF6</alias>
            </names>
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-7386123" refType="identity" refTypeAc="MI:0356"/>
            </xref>
            <interactorRef>2</interactorRef>
            <participantIdentificationMethodList>
              <participantIdentificationMethod>
                <names>
                  <shortLabel>western blot</shortLabel>
                  <fullName>western blot</fullName>
                  <alias type="go synonym" typeAc="MI:0303">Immuno blot</alias>
                  <alias type="synonym" typeAc="MI:1041">Immuno blot</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </participantIdentificationMethod>
              <participantIdentificationMethod>
                <names>
                  <shortLabel>predetermined</shortLabel>
                  <fullName>predetermined participant</fullName>
                  <alias type="synonym" typeAc="MI:1041">predetermined</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </participantIdentificationMethod>
            </participantIdentificationMethodList>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>living cell</shortLabel>
                  <fullName>living cell</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0349" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537765" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
              <experimentalPreparation>
                <names>
                  <shortLabel>physiological level</shortLabel>
                  <fullName>physiological level</fullName>
                  <alias type="go synonym" typeAc="MI:0303">endogenous level</alias>
                  <alias type="go synonym" typeAc="MI:0303">endogenous</alias>
                  <alias type="synonym" typeAc="MI:1041">endogenous</alias>
                  <alias type="synonym" typeAc="MI:1041">endogenous level</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">f2b</attribute>
          <attribute name="comment" nameAc="MI:0612">homomint</attribute>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>