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        <shortLabel>IntAct</shortLabel>
        <fullName>European Bioinformatics Institute</fullName>
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        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/</attribute>
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        <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
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        <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
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    </source>
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        <names>
          <fullName>Cloning and expression of a divergent integrin subunit beta 8.</fullName>
        </names>
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            <attribute name="publication title" nameAc="MI:1091">Cloning and expression of a divergent integrin subunit beta 8.</attribute>
            <attribute name="journal" nameAc="MI:0885">J. Biol. Chem. (0021-9258)</attribute>
            <attribute name="publication year" nameAc="MI:0886">1991</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Moyle M., Napier MA., McLean JW.</attribute>
            <attribute name="exp-modification" nameAc="MI:0627">Immunoprecipitations were carried out using protein G-Sepharose 4FF. Molecular weight of prey protein compared to band produced by coimmunoprecipitation with anti-beta8 antibody.</attribute>
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        <hostOrganismList>
          <hostOrganism ncbiTaxId="9606">
            <names>
              <shortLabel>human-293</shortLabel>
              <fullName>Homo sapiens transformed primary embryonal kidney cells</fullName>
              <alias type="synonym" typeAc="MI:1041">Human</alias>
            </names>
            <cellType>
              <names>
                <shortLabel>293</shortLabel>
                <fullName>Transformed human primary embryonal kidney cells.</fullName>
              </names>
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              <attributeList>
                <attribute name="comment" nameAc="MI:0612">The Cell type named 293 is synonymous with HEK-293.</attribute>
              </attributeList>
            </cellType>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>coip</shortLabel>
            <fullName>coimmunoprecipitation</fullName>
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        </interactionDetectionMethod>
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          <names>
            <shortLabel>weight autoradiogra</shortLabel>
            <fullName>molecular weight estimation by autoradiography</fullName>
            <alias type="synonym" typeAc="MI:1041">weight autoradiogra</alias>
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          <attribute name="author-list" nameAc="MI:0636">Moyle M., Napier MA., McLean JW.</attribute>
          <attribute name="exp-modification" nameAc="MI:0627">Immunoprecipitations were carried out using protein G-Sepharose 4FF. Molecular weight of prey protein compared to band produced by coimmunoprecipitation with anti-beta8 antibody.</attribute>
          <attribute name="accepted">Accepted 2009-OCT-18 by ORCHARD.</attribute>
          <attribute name="journal" nameAc="MI:0885">J. Biol. Chem. (0021-9258)</attribute>
          <attribute name="publication year" nameAc="MI:0886">1991</attribute>
          <attribute name="reviewer">orchard</attribute>
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          <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
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    </experimentList>
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          <shortLabel>itav_human</shortLabel>
          <fullName>Integrin alpha-V</fullName>
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          <alias type="gene name synonym" typeAc="MI:0302">VNRA</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Vitronectin receptor subunit alpha</alias>
          <alias type="gene name synonym" typeAc="MI:0302">MSK8</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Vitronectin receptor</alias>
          <alias type="gene name synonym" typeAc="MI:0302">VTNR</alias>
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            <shortLabel>protein</shortLabel>
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          </names>
        </organism>
        <sequence>MAFPPRRRLRLGPRGLPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDMEINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHTLGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTTNVTWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRPPQEEQEREQLQPHENGEGNSET</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P06756 original sequence version: 136</attribute>
          <attribute name="remark-internal">DIP protein P06756 original sequence version: 145</attribute>
          <attribute name="remark-internal">DIP protein P06756 original sequence version: 174</attribute>
          <attribute name="remark-internal">DIP protein P06756-1 original sequence version: 182</attribute>
          <attribute name="remark-internal">DIP protein P06756 original sequence version: 149</attribute>
          <attribute name="crc64">364EE25C5303A2D7</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>itb8_human</shortLabel>
          <fullName>Integrin beta-8</fullName>
          <alias type="gene name" typeAc="MI:0301">ITGB8</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P26012" version="SP_90" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B4DHD4" version="SP_141" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A4D133" version="SP_95" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000222573" version="SP_202" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2436381" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_002205.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011513698.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_016867667.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_016867668.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_016867669.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_016867670.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_016867671.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_016867672.1"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000105855" version="SP_202" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000222573" version="SP_202" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001570" version="SP_202"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001573" version="SP_202"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005178" version="SP_202"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" version="SP_202"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005925" version="SP_202"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006955" version="SP_202"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007155" version="SP_202"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007179" version="SP_202"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007229" version="SP_202"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008305" version="SP_202"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009615" version="SP_202"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009986" version="SP_202"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010628" version="SP_202"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010629" version="SP_202"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016477" version="SP_202"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0033627" version="SP_202"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0034686" version="SP_202"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0038023" version="SP_202"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045766" version="SP_202"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051216" version="SP_202"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0060022" version="SP_202"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0060674" version="SP_202"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0061520" version="SP_202"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070062" version="SP_202"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1901388" version="SP_202"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1990430" version="SP_202"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000742" version="SP_202"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002369" version="SP_202"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013111" version="SP_202"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR015442" version="SP_202"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR015812" version="SP_202"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016201" version="SP_202"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR032695" version="SP_202"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR033760" version="SP_202"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036465" version="SP_202"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="P26012" version="SP_202"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6DJP" version="SP_202"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6OM1" version="SP_202"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6OM2" version="SP_202"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6UJA" version="SP_202"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6UJB" version="SP_202"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6UJC" version="SP_202"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2129379" version="SP_202"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-216083" version="SP_202"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MCGSALAFFTAAFVCLQNDRRGPASFLWAAWVFSLVLGLGQGEDNRCASSNAASCARCLALGPECGWCVQEDFISGGSRSERCDIVSNLISKGCSVDSIEYPSVHVIIPTENEINTQVTPGEVSIQLRPGAEANFMLKVHPLKKYPVDLYYLVDVSASMHNNIEKLNSVGNDLSRKMAFFSRDFRLGFGSYVDKTVSPYISIHPERIHNQCSDYNLDCMPPHGYIHVLSLTENITEFEKAVHRQKISGNIDTPEGGFDAMLQAAVCESHIGWRKEAKRLLLVMTDQTSHLALDSKLAGIVVPNDGNCHLKNNVYVKSTTMEHPSLGQLSEKLIDNNINVIFAVQGKQFHWYKDLLPLLPGTIAGEIESKAANLNNLVVEAYQKLISEVKVQVENQVQGIYFNITAICPDGSRKPGMEGCRNVTSNDEVLFNVTVTMKKCDVTGGKNYAIIKPIGFNETAKIHIHRNCSCQCEDNRGPKGKCVDETFLDSKCFQCDENKCHFDEDQFSSESCKSHKDQPVCSGRGVCVCGKCSCHKIKLGKVYGKYCEKDDFSCPYHHGNLCAGHGECEAGRCQCFSGWEGDRCQCPSAAAQHCVNSKGQVCSGRGTCVCGRCECTDPRSIGRFCEHCPTCYTACKENWNCMQCLHPHNLSQAILDQCKTSCALMEQQHYVDQTSECFSSPSYLRIFFIIFIVTFLIGLLKVLIIRQVILQWNSNKIKSSSDYRVSASKKDKLILQSVCTRAVTYRREKPEEIKMDISKLNAHETFRCNF</sequence>
        <attributeList>
          <attribute name="crc64">F7E3994F92B12A65</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4" imexId="IM-20373-1">
        <names>
          <shortLabel>intav-intb8</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-2436404" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-20373-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="6">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">7</attribute>
          <attribute name="source-text">The anti-&amp; antiserum precipitated two polypeptides from detergent extracts of ORtransfected cells that migrated at -160 and -95 kDa under nonreducing conditions</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>