MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it Auto-activation mechanism of the Mycobacterium tuberculosis PknB receptor Ser/Thr kinase. Auto-activation mechanism of the Mycobacterium tuberculosis PknB receptor Ser/Thr kinase. EMBO J. (0261-4189) 2008 imex curation Mieczkowski C., Iavarone AT., Alber T. Only protein-protein interactions in vitro In vitro protein kinase assay protein kinase assay predetermined predetermined participant predetermined Mieczkowski C., Iavarone AT., Alber T. EMBO J. (0261-4189) 2008 Only protein-protein interactions imex curation pknb_myctu Serine/threonine-protein kinase PknB pknB MTCY10H4.14c Rv0014c protein protein myctu Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) MTTPSHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARHEGLSADLDAVVLKALAKNPENRYQTAAEMRADLVRVHNGEPPEAPKVLTDAERTSLLSSAAGNLSGPRTDPLPRQDLDDTDRDRSIGSVGRWVAVVAVLAVLTVVVTIAINTFGGITRDVQVPDVRGQSSADAIATLQNRGFKIRTLQKPDSTIPPDHVIGTDPAANTSVSAGDEITVNVSTGPEQREIPDVSTLTYAEAVKKLTAAGFGRFKQANSPSTPELVGKVIGTNPPANQTSAITNVVIIIVGSGPATKDIPDVAGQTVDVAQKNLNVYGFTKFSQASVDSPRPAGEVTGTNPPAGTTVPVDSVIELQVSKGNQFVMPDLSGMFWVDAEPRLRALGWTGMLDKGADVDAGGSQHNRVVYQNPPAGTGVNRDGIITLRFGQ 6C27EEBE9D5A453B 6C27EEBE9D5A453B pknb-1 1 pknB 2 predetermined predetermined participant predetermined predetermined predetermined participant predetermined self self neutral component neutral component purified purified P9WI81:p.Ala225Leu mutation increasing interaction mutation increasing mutation increasing interaction mutation increasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain A L Tue Jul 12 10:06:44 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'mutation increasing' Wed May 02 16:47:49 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ala225leu' Tue Jun 30 18:10:51 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ala225Leu' binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain phosphorylation phosphorylation reaction phosphorylation true F2 mint pknb-pknb 1 pknB 2 predetermined predetermined participant predetermined predetermined predetermined participant predetermined enzyme enzyme neutral component neutral component purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P9WI81:p.Val229Asp mutation increasing interaction mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain V D Tue Jul 12 10:13:04 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'mutation increasing' Wed May 02 17:17:57 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'val229asp' Tue Jun 30 18:47:37 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val229Asp' pknB 2 weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra predetermined predetermined participant predetermined enzyme target enzyme target substrate substrate neutral component neutral component purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain phosphorylation phosphorylation reaction phosphorylation F6 mint pknb-1 1 pknB 2 predetermined predetermined participant predetermined predetermined predetermined participant predetermined self self neutral component neutral component purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P9WI81:p.Val229Asp mutation increasing interaction mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain V D Tue Jul 12 10:52:53 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'mutation increasing' Wed May 02 19:11:54 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'val229asp' Tue Jun 30 16:29:23 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val229Asp' P9WI81:p.Val222Asp mutation decreasing interaction mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain V D Tue Jul 12 10:52:48 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'mutation decreasing' Wed May 02 18:15:07 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'val222asp' Tue Jun 30 18:38:33 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val222Asp' phosphorylation phosphorylation reaction phosphorylation true F2 mint pknb-1 1 pknB 2 predetermined predetermined participant predetermined predetermined predetermined participant predetermined self self neutral component neutral component purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P9WI81:p.Ala225Glu mutation decreasing interaction mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain A E Tue Jul 12 10:12:45 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'mutation decreasing' Wed May 02 16:19:05 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ala225glu' Tue Jun 30 17:17:02 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ala225Glu' P9WI81:p.Val229Asp mutation increasing interaction mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain V D Tue Jul 12 10:54:02 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'mutation increasing' Wed May 02 17:30:28 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'val229asp' Tue Jun 30 15:55:21 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val229Asp' phosphorylation phosphorylation reaction phosphorylation true F2 mint pknb-1 1 pknB 2 predetermined predetermined participant predetermined predetermined predetermined participant predetermined self self neutral component neutral component purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P9WI81:p.Ala225Glu mutation decreasing interaction mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain A E Tue Jul 12 10:14:38 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'mutation decreasing' Wed May 02 20:02:16 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ala225glu' Tue Jun 30 19:22:09 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ala225Glu' phosphorylation phosphorylation reaction phosphorylation true F2 mint pknb-1 1 pknB 2 predetermined predetermined participant predetermined predetermined predetermined participant predetermined self self neutral component neutral component purified purified P9WI81:p.Leu33Asp mutation decreasing interaction mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain L D Tue Jul 12 10:14:33 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'mutation decreasing' Wed May 02 16:16:15 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu33asp' Tue Jun 30 19:22:05 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu33Asp' binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P9WI81:p.Val222Asp mutation increasing interaction mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain V D Tue Jul 12 10:10:11 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'mutation increasing' Wed May 02 17:40:04 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'val222asp' Tue Jun 30 17:04:21 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val222Asp' phosphorylation phosphorylation reaction phosphorylation true F2 mint pknb-1 1 pknB 2 predetermined predetermined participant predetermined predetermined predetermined participant predetermined self self neutral component neutral component purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain phosphorylated phosphorylated residue phosres phosphorylated residue PhosRes Phospho Phosphorylation Phosphorylation (O of Serine, Threonine, Tyrosine and Aspartate, N epsilon of Lysine) modified residue ms mass detection of residue modification modified residue ms certain certain sequence position certain certain certain sequence position certain resulting-ptm phosphorylated phosphorylated residue phosres phosphorylated residue PhosRes Phospho Phosphorylation Phosphorylation (O of Serine, Threonine, Tyrosine and Aspartate, N epsilon of Lysine) modified residue ms mass detection of residue modification modified residue ms certain certain sequence position certain certain certain sequence position certain resulting-ptm phosphorylated phosphorylated residue phosres phosphorylated residue PhosRes Phospho Phosphorylation Phosphorylation (O of Serine, Threonine, Tyrosine and Aspartate, N epsilon of Lysine) modified residue ms mass detection of residue modification modified residue ms certain certain sequence position certain certain certain sequence position certain resulting-ptm phosphorylated phosphorylated residue phosres phosphorylated residue PhosRes Phospho Phosphorylation Phosphorylation (O of Serine, Threonine, Tyrosine and Aspartate, N epsilon of Lysine) modified residue ms mass detection of residue modification modified residue ms certain certain sequence position certain certain certain sequence position certain resulting-ptm phosphorylation phosphorylation reaction phosphorylation true F3 mint pknb-pknb-1 1 pknB 2 predetermined predetermined participant predetermined predetermined predetermined participant predetermined enzyme enzyme neutral component neutral component purified purified P9WI81:p.Val229Asp mutation increasing interaction mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain V D Tue Jul 12 10:12:24 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'mutation increasing' Wed May 02 15:26:36 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'val229asp' Tue Jun 30 17:09:10 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val229Asp' binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain pknB 2 weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra predetermined predetermined participant predetermined enzyme target enzyme target substrate substrate neutral component neutral component purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P9WI81:p.Val229Asp mutation decreasing interaction mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain V D Tue Jul 12 10:12:20 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'mutation decreasing' Wed May 02 18:30:37 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'val229asp' Tue Jun 30 19:36:05 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val229Asp' phosphorylation phosphorylation reaction phosphorylation F6 mint pknb-2 1 pknB 2 predetermined predetermined participant predetermined predetermined predetermined participant predetermined self self neutral component neutral component purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P9WI81:p.Val229Asp mutation increasing interaction mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain V D Tue Jul 12 10:12:08 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'mutation increasing' Wed May 02 16:19:53 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'val229asp' Tue Jun 30 15:40:46 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val229Asp' phosphorylation phosphorylation reaction phosphorylation true F2 mint