MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes. Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes. Blood (0006-4971) 2006 mimix curation Grabbe A., Wienands J. SH3 suggested by mcarducci mimix curation in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Grabbe A., Wienands J. SH3 suggested by mcarducci Blood (0006-4971) 2006 mimix curation mimix curation Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes. Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes. Blood (0006-4971) 2006 mimix curation Grabbe A., Wienands J. SH3 suggested by mcarducci mimix curation in vitro In vitro pull down pull down predetermined predetermined participant predetermined Grabbe A., Wienands J. SH3 suggested by mcarducci Blood (0006-4971) 2006 mimix curation mimix curation Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes. Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes. Blood (0006-4971) 2006 mimix curation Grabbe A., Wienands J. SH3 suggested by mcarducci mimix curation chick Gallus gallus (Chicken) Chicken anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Grabbe A., Wienands J. SH3 suggested by mcarducci Blood (0006-4971) 2006 mimix curation mimix curation blnk_human B-cell linker protein BASH SLP65 B-cell adapter containing a SH2 domain protein B-cell adapter containing a Src homology 2 domain protein Cytoplasmic adapter protein Src homology 2 domain-containing leukocyte protein of 65 kDa BLNK protein protein human Homo sapiens Human MDKLNKITVPASQKLRQLQKMVHDIKNNEGGIMNKIKKLKVKAPPSVPRRDYASESPADEEEQWSDDFDSDYENPDEHSDSEMYVMPAEENADDSYEPPPVEQETRPVHPALPFARGEYIDNRSSQRHSPPFSKTLPSKPSWPSEKARLTSTLPALTALQKPQVPPKPKGLLEDEADYVVPVEDNDENYIHPTESSSPPPEKAPMVNRSTKPNSSTPASPPGTASGRNSGAWETKSPPPAAPSPLPRAGKKPTTPLKTTPVASQQNASSVCEEKPIPAERHRGSSHRQEAVQSPVFPPAQKQIHQKPIPLPRFTEGGNPTVDGPLPSFSSNSTISEQEAGVLCKPWYAGACDRKSAEEALHRSNKDGSFLIRKSSGHDSKQPYTLVVFFNKRVYNIPVRFIEATKQYALGRKKNGEEYFGSVAEIIRNHQHSPLVLIDSQNNTKDSTRLKYAVKVS 95F1D5485D03D397 q8uux6_chick VAV3 RCJMB04_7l6 protein protein chick Gallus gallus (Chicken) Chicken MEPWKQCGQWLISCKVLPPNHRVTWETAQVFDLAQTLRDGVLLCQLLNNLRSHSINLKEINLRPQMSQFLCLKNIRTFLSACCEIFGMKKSELFEAFDLFDVRDFGKVIETLSKLSRTPIAIGTGIRPFPTEESVDDEDVYKCLPDLIDETGVDEDEELYDCVYGEDEGGEVYEDLMKDEAAQQPKHTENDVRSCCLAEIKQTEEKYTETLESIEKFFMVPLKRFMSASEFETVFINIPDLVKIHRSLTQDISDSIINKNDQNLYQIFINYKERLVIYGQYCSQVETAISCLDNISKTKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPMEKANLKLALDAMKDLAQYVNEVKRDNETLREIRQFQLSIENLNHSLLQYGRPQGDGEIRITTLDKRARQDRHIFLFDLAVIVCKRRGDNYEMKEIIDLQKYKITNNPTTDKENKKWSYGFYLIHIQGQNGLEVYCKTKDLKKKWLEQFQMALSNIRPDYADTSFHEFKMHTFSRVTSCKVCQMLLRGTFYQGYLCSKCGAGAHKECLGRLDNCGRANSGEHGNLKHEKRTNGIRRNSRHVDPGLPRMQVIRNYKGIPQPTPQDGPPLHIQIGDTIELITGDVHSLFWQGRNLTTGELGFFPSDAVKPSPCVPKPVDYSSQLWFAGAMERLQAESELINRVNSTYLVRHRTKESGEYAISIKYNNEVKHIKIFTRDGYFHITENRKFINLMELVDYYKHHSLKEGFRSLDTTLQFPYKESENSVGQRGNRAGGNLLSPKVIGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE mint C47EE949D873821B grb2_human Growth factor receptor-bound protein 2 GRB2 ASH Adapter protein GRB2 SH2/SH3 adapter GRB2 Protein Ash protein protein human Homo sapiens Human MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV 83A4B0BA1B248DC4 plcg2 plcg2 protein protein chick Gallus gallus (Chicken) Chicken mint grb2_mouse Growth factor receptor-bound protein 2 Grb2 Adapter protein GRB2 SH2/SH3 adapter GRB2 protein protein mouse Mus musculus Mouse MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQMPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV 97F4A4FE4B248DDF blnk_chick B-cell linker protein BLNK BASH Cytoplasmic adapter protein B-cell adapter SH2 domain-containing protein Src homology 2 domain-containing leukocyte protein of 65 kDa protein protein chick Gallus gallus (Chicken) Chicken MDKLNKLAVPAGEKFRKLQKMVHDIKKNESGIINKFKKFQNEQVALICKTGKDTWDRLKKKPPPSLPRRDYASEHADNEEEQWSDDFDSDYENPDGHSDSEMYVVPSEENPDDSYEPPPSEQEKKKIPSSFPISRGEYADNRTSHHQLPPINKPLPSTPSSALPRPKKPSLPSPAAKPKLPLKPRECSDDEDNYIVPVDNDDDNYIEPTESSTPPPAKPPVNRFMKPPAKSALPTPPKPSLASDMQEVYEVPEEEEELSPPPVTRFTKPLPATRAQNAEHSHMHSMTRESPKLDASRNILPLPRNRLHPKTDHEANNNDENHSFSNTQESKFPPGAAPSPLPRALKKTSNAVNPAKPCLPSRDTFTVNEDKPTAADRRRGSSHEFPLPPLPSGTPKSSLQKPLVLPKVPEAPSRALGTSPHSSISSISSTADQDAGVHSKAWYAATCDRKTAEDALYRSNKDGSFLIRKSSGQDSRQPYTLVVFYNRRVYNIPIRFIESTRQYALGREKCGEERFDSVAEIVENHQHTSLVLIDSQNNTKDSTKLKYIVRVS mint May function as a central linker protein that bridges kinases associated with the B-cell receptor (BCR) with a multitude of signaling pathways, regulating biological outcomes of B-cell function and development. Plays an important role in BCR-mediated PLCG1 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition (By similarity). Plays a critical role in B-cell development in the bursa FB232179BE38D072 blnk-grb2 1 SLP65 4 unspecified role unspecified role bait bait GRB2 6 unspecified role unspecified role prey prey binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction f1c homomint domino mint blnk-grb2-1 1 GRB2 6 unspecified role unspecified role prey prey SLP65 4 unspecified role unspecified role bait bait direct interaction direct interaction f1c homomint mint plcg2-blnk 3 slp65 9 unspecified role unspecified role prey prey plc gamma2 7 unspecified role unspecified role bait bait physical association physical association f2b mint vav3-blnk 3 vav3 5 unspecified role unspecified role bait bait slp65 9 unspecified role unspecified role prey prey physical association physical association f2b homomint mint grb2-blnk-5 2 SLP65 4 unspecified role unspecified role prey prey Grb2 6 unspecified role unspecified role bait bait binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain gst tagged gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association f1b homomint domino mint blnk-grb2-2 2 SLP65 4 unspecified role unspecified role bait bait binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain biotin tagged biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Grb2 8 unspecified role unspecified role prey prey physical association physical association f1d homomint domino mint