MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it Conformational switch of angiotensin II type 1 receptor underlying mechanical stress-induced activation. Conformational switch of angiotensin II type 1 receptor underlying mechanical stress-induced activation. EMBO Rep. (1469-221X) 2008 imex curation Yasuda N., Miura S., Akazawa H., Tanaka T., Qin Y., Kiya Y., Imaizumi S., Fujino M., Ito K., Zou Y., Fukuhara S., Kunimoto S., Fukuzaki K., Sato T., Ge J., Mochizuki N., Nakaya H., Saku K., Komuro I. 2009-01-08 Only protein-protein interactions in vitro In vitro saturation binding saturation binding predetermined predetermined participant predetermined Yasuda N., Miura S., Akazawa H., Tanaka T., Qin Y., Kiya Y., Imaizumi S., Fujino M., Ito K., Zou Y., Fukuhara S., Kunimoto S., Fukuzaki K., Sato T., Ge J., Mochizuki N., Nakaya H., Saku K., Komuro I. EMBO Rep. (1469-221X) 2008 2009-01-08 Only protein-protein interactions imex curation angt_human Angiotensinogen Serpin A8 AGT SERPINA8 protein protein human Homo sapiens Human MRKRAPQSEMAPAGVSLRATILCLLAWAGLAAGDRVYIHPFHLVIHNESTCEQLAKANAGKPKDPTFIPAPIQAKTSPVDEKALQDQLVLVAAKLDTEDKLRAAMVGMLANFLGFRIYGMHSELWGVVHGATVLSPTAVFGTLASLYLGALDHTADRLQAILGVPWKDKNCTSRLDAHKVLSALQAVQGLLVAQGRADSQAQLLLSTVVGVFTAPGLHLKQPFVQGLALYTPVVLPRSLDFTELDVAAEKIDRFMQAVTGWKTGCSLMGASVDSTLAFNTYVHFQGKMKGFSLLAEPQEFWVDNSTSVSVPMLSGMGTFQHWSDIQDNFSVTQVPFTESACLLLIQPHYASDLDKVEGLTFQQNSLNWMKKLSPRTIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQKLSNDRIRVGEVLNSIFFELEADEREPTESTQQLNKPEVLEVTLNRPFLFAVYDQSATALHFLGRVANPLSTA DIP protein P01019 original sequence version: 136 5026C2DFB2DD236E agtra_rat Type-1A angiotensin II receptor Angiotensin II type-1A receptor Agtr1 Agtr1a At1a protein protein rat Rattus norvegicus (Rat) Rat MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVCAFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKISDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSSAKKPASCFEVE 200EAE56DB4DA678 agt-agtr1 1 angiotensin II 2 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain range MINT-6177809: original sequence: 34-41 : LLAWAGLAAGDRVYIHPFHLVIHNEST At1 receptor 3 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component subcellular prep subcellular preparation subcellular prep over-expressed over expressed level over-expressed physical association physical association st1 kd 0.7 nanomolar homomint mint agt-agtr1-1 1 At1 receptor 3 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component subcellular prep subcellular preparation subcellular prep over-expressed over expressed level over-expressed undefined mutation mutation decreasing interaction mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain Wed Jul 06 16:20:53 BST 2016 Sequence change details about this feature cannot be ascertained or do not fit with the current version of the referenced protein, so they have been deleted as a result of our quality control procedures. The original label was 'mutation decreasing' Cys76;289Ala range MINT-6177830: original sequence: 76-76 : FLLNLALADLCFLLTLPLWA range MINT-6177831: original sequence: 289-289 : IVDTAMPITICIAYFNNCLN angiotensin II 2 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain range MINT-6177821: original sequence: 34-41 : LLAWAGLAAGDRVYIHPFHLVIHNEST physical association physical association st1 kd 1.8 nanomolar homomint mint agt-agtr1-2 1 At1 receptor 3 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component subcellular prep subcellular preparation subcellular prep over-expressed over expressed level over-expressed undefined mutation mutation decreasing interaction mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain Wed Jul 06 16:21:00 BST 2016 Sequence change details about this feature cannot be ascertained or do not fit with the current version of the referenced protein, so they have been deleted as a result of our quality control procedures. The original label was 'mutation decreasing' Cys76;296Ala range MINT-6177842: original sequence: 76-76 : FLLNLALADLCFLLTLPLWA range MINT-6177841: original sequence: 296-296 : ITICIAYFNNCLNPLFYGFL angiotensin II 2 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain range MINT-6177837: original sequence: 34-41 : LLAWAGLAAGDRVYIHPFHLVIHNEST physical association physical association st1 kd 2.6 nanomolar homomint mint agt-agtr1-3 1 At1 receptor 3 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component subcellular prep subcellular preparation subcellular prep over-expressed over expressed level over-expressed undefined mutation mutation decreasing interaction mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain Wed Jul 06 16:25:11 BST 2016 Sequence change details about this feature cannot be ascertained or do not fit with the current version of the referenced protein, so they have been deleted as a result of our quality control procedures. The original label was 'mutation decreasing' Cys76;296;289Ala range MINT-6177857: original sequence: 296-296 : ITICIAYFNNCLNPLFYGFL range MINT-6177858: original sequence: 76-76 : FLLNLALADLCFLLTLPLWA range MINT-6177862: original sequence: 289-289 : IVDTAMPITICIAYFNNCLN angiotensin II 2 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain range MINT-6177853: original sequence: 34-41 : LLAWAGLAAGDRVYIHPFHLVIHNEST physical association physical association st1 kd 2.6 nanomolar homomint mint agt-agtr1-4 1 angiotensin II 2 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain range MINT-6177868: original sequence: 34-41 : LLAWAGLAAGDRVYIHPFHLVIHNEST At1 receptor 3 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component subcellular prep subcellular preparation subcellular prep over-expressed over expressed level over-expressed undefined mutation mutation decreasing interaction mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain Wed Jul 06 16:26:34 BST 2016 Sequence change details about this feature cannot be ascertained or do not fit with the current version of the referenced protein, so they have been deleted as a result of our quality control procedures. The original label was 'mutation decreasing' Cys289;76Ala range MINT-6177873: original sequence: 76-76 : FLLNLALADLCFLLTLPLWA range MINT-6177874: original sequence: 289-289 : IVDTAMPITICIAYFNNCLN P25095:p.Asn295Cys mutation decreasing interaction mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain N C Tue Jul 12 10:24:15 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'mutation decreasing' Wed May 02 17:06:41 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asn295cys' Tue Jun 30 16:19:15 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asn295Cys' range MINT-6177901: original sequence: 295-295 : PITICIAYFNNCLNPLFYGF physical association physical association st1 kd 1.3 nanomolar homomint mint agt-agtr1-5 1 angiotensin II 2 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain range MINT-6177881: original sequence: 34-41 : LLAWAGLAAGDRVYIHPFHLVIHNEST At1 receptor 3 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component subcellular prep subcellular preparation subcellular prep over-expressed over expressed level over-expressed P25095:p.Asn294Cys mutation increasing interaction mutation increasing mutation increasing interaction mutation increasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain N C Tue Jul 12 10:10:33 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'mutation increasing' Wed May 02 16:31:53 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asn294cys' Tue Jun 30 20:09:42 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asn294Cys' range MINT-6177895: original sequence: 294-294 : MPITICIAYFNNCLNPLFYG undefined mutation mutation decreasing interaction mutation increasing mutation increasing interaction mutation increasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain Wed Jul 06 16:31:28 BST 2016 Sequence change details about this feature cannot be ascertained or do not fit with the current version of the referenced protein, so they have been deleted as a result of our quality control procedures. The original label was 'mutation decreasing' Cys289;76Ala range MINT-6177886: original sequence: 289-289 : IVDTAMPITICIAYFNNCLN range MINT-6177885: original sequence: 76-76 : FLLNLALADLCFLLTLPLWA physical association physical association st1 kd 0.5 nanomolar homomint mint agt-agtr1-6 1 angiotensin II 2 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain range MINT-6177909: original sequence: 34-41 : LLAWAGLAAGDRVYIHPFHLVIHNEST At1 receptor 3 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component subcellular prep subcellular preparation subcellular prep over-expressed over expressed level over-expressed P25095:p.Cys149Ala mutation decreasing interaction mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain C A Tue Jul 12 10:51:50 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'mutation decreasing' Wed May 02 18:39:11 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'cys149ala' Tue Jun 30 18:37:12 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Cys149Ala' range MINT-6177915: original sequence: 149-149 : RRTMLVAKVTCIIIWLMAGL physical association physical association st1 kd 0.5 nanomolar homomint mint agt-agtr1-7 1 angiotensin II 2 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain range MINT-6177926: original sequence: 34-41 : LLAWAGLAAGDRVYIHPFHLVIHNEST At1 receptor 3 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component subcellular prep subcellular preparation subcellular prep over-expressed over expressed level over-expressed P25095:p.Gln257Ala mutation decreasing interaction mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Q A Tue Jul 12 10:11:16 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'mutation decreasing' Wed May 02 18:46:43 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln257ala' Tue Jun 30 18:34:16 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gln257Ala' range MINT-6177930: original sequence: 257-257 : LFFFFSWVPHQIFTFLDVLI physical association physical association kd 1.2 nanomolar st2 homomint mint agt-agtr1-8 1 angiotensin II 2 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain range MINT-6177941: original sequence: 34-41 : LLAWAGLAAGDRVYIHPFHLVIHNEST At1 receptor 3 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component subcellular prep subcellular preparation subcellular prep over-expressed over expressed level over-expressed P25095:p.Thr287Ala mutation decreasing interaction mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain T A Tue Jul 12 10:09:37 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'mutation decreasing' Wed May 02 15:37:31 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'thr287ala' Tue Jun 30 19:03:52 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Thr287Ala' range MINT-6177945: original sequence: 287-287 : SDIVDTAMPITICIAYFNNC physical association physical association kd 1.3 nanomolar st2 homomint mint agt-agtr1-9 1 At1 receptor 3 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component subcellular prep subcellular preparation subcellular prep over-expressed over expressed level over-expressed P25095:p.Tyr292Ala mutation decreasing interaction mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Y A Tue Jul 12 10:55:44 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'mutation decreasing' Wed May 02 20:14:59 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr292ala' Tue Jun 30 15:35:19 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr292Ala' range MINT-6177962: original sequence: 292-292 : TAMPITICIAYFNNCLNPLF angiotensin II 2 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain range MINT-6177958: original sequence: 34-41 : LLAWAGLAAGDRVYIHPFHLVIHNEST physical association physical association st2 kd 1.5 nanomolar homomint mint