MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it XTsh3 is an essential enhancing factor of canonical Wnt signaling in Xenopus axial determination. XTsh3 is an essential enhancing factor of canonical Wnt signaling in Xenopus axial determination. EMBO J. (0261-4189) 2007 imex curation Onai T., Matsuo-Takasaki M., Inomata H., Aramaki T., Matsumura M., Yakura R., Sasai N., Sasai Y. Only protein-protein interactions xenla-animal_cap Xenopus laevis animal cap animal_cap Animal cap Xenopus laevis animal cap cells are cells situated around the animal (pigmented) pole of a blastula or very early gastrula-stage embryo. This tissue is fated to become cement gland/neurectoderm on the dorsal side of the embryo and epidermis on the ventral side. Animal caps are composed of pluripotent cells that can be induced to form endodermal, mesodermal, or ectodermal cell types. XAO:0000036. anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Onai T., Matsuo-Takasaki M., Inomata H., Aramaki T., Matsumura M., Yakura R., Sasai N., Sasai Y. EMBO J. (0261-4189) 2007 Only protein-protein interactions imex curation XTsh3 is an essential enhancing factor of canonical Wnt signaling in Xenopus axial determination. XTsh3 is an essential enhancing factor of canonical Wnt signaling in Xenopus axial determination. EMBO J. (0261-4189) 2007 imex curation Onai T., Matsuo-Takasaki M., Inomata H., Aramaki T., Matsumura M., Yakura R., Sasai N., Sasai Y. Only protein-protein interactions in vitro In vitro anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Onai T., Matsuo-Takasaki M., Inomata H., Aramaki T., Matsumura M., Yakura R., Sasai N., Sasai Y. EMBO J. (0261-4189) 2007 Only protein-protein interactions imex curation XTsh3 is an essential enhancing factor of canonical Wnt signaling in Xenopus axial determination. XTsh3 is an essential enhancing factor of canonical Wnt signaling in Xenopus axial determination. EMBO J. (0261-4189) 2007 imex curation Onai T., Matsuo-Takasaki M., Inomata H., Aramaki T., Matsumura M., Yakura R., Sasai N., Sasai Y. Only protein-protein interactions xenla-embryo Xenopus laevis embryo embryo Embryo Defined as the development stage prior to the initiation of tissue differentiation. anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Onai T., Matsuo-Takasaki M., Inomata H., Aramaki T., Matsumura M., Yakura R., Sasai N., Sasai Y. EMBO J. (0261-4189) 2007 Only protein-protein interactions imex curation ctnb1_xenla Catenin beta-1 ctnnb1 Beta-catenin protein protein xenla Xenopus laevis (African clawed frog) African clawed frog MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEDEDVDTNQVLYEWEQGFSQSFTQDQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDSAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYSYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDSSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSIGGTQQQFVEGVRMEEIVEGCTGALHILARDIHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCDVAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMPWNEAADLGLDIGAQGEPLGYRQDDSSYRSFHAAGYGQDAMGMDSMMDHDMGGHHPGADYPVDGLPDLSHAQDLMDGLPPGDSNQLAWFDTDL DIP protein P26233 original sequence version: 86 DIP protein P26233 original sequence version: 53 DIP protein P26233 original sequence version: 70 mint Binds to the cytoplasmic domain of the cell-cell adhesion molecule E-cadherin, and perhaps to other (membrane) proteins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Essential component of the vertebrate Wnt-signaling pathway and is required for formation of the embryonic axis 3ECD27232239F799 a0snq7_xenla tshz3.L tshz3 protein protein xenla Xenopus laevis (African clawed frog) African clawed frog MDSDSHVSETSDRMGDFESCSIKNEEESKESLAPLEDSNVSDSLEQMKAVYNNFLSNSYWSSLSLNLHQSTSEKNNASSSSSSSSSSSCGSGSFDWHQTAIAKTLQQVSQSRVLPEPSLFSTVQLYRQSSKLYGSIFTGASKFRCKDCSAVYDTLVELTVHMNETGHYRDDNHETDNKNPKRWSKPRKRSLLEMEGKEDAQKVLKCMYCGHSFESLQDLSVHMIKTKHYQKVPLKEPVTPVAAKIVPASRKKLSLELELSNSPDSTGGTQKATNPDVNDALQKNSNPYITPNNRYGHQNGASYAWHFEARKSQILKCMECGSSHDTLQELTTHMMVTGHFIKVTNSALKKGKSVLEAPATPTSLIDEKVQSVPLAATTFTPPLNNSSCLSPKLNVEIKKEVDKGISDDKIKDKDKTNEEEDKFDVSSKYHYLTENDLEESPKGGLDILKSLENTVTSAINKAQNGTPSWGGYPSIHAAYQLPNMMKLSLGSSGKATPLKPMYGSSELISPTKNQPIMSPPSSQTSPVPKTNFHAMEELVKKVTEKVAKVEEKMKEPEGKFSPIKRTTPSPSGSEISETLKGDVSNEVTFKSQQNSPIPQKDSRKDSPSVEPVENGKDHAKSIIGSLSSSTAIITDHPPEQPFVNPLSALQSVMNIHLGKAAKPSLPALDPMSMLFKMSNSLAEKAAVATPPIQAKKIDHLDRYFYHVNNDQPIDLTKGKSDKNCSLASALLSSTSTSTASSSSTVTTAKTSAVVSFMSNSPLRENALSDISDMLKNLTESHTSKSSTPTSISEKSDIEGTTIEEPEENTPAQKRKGRQSNWNPQHLLILQAQFAASLRQTSEGKYVMSDLSPQERMHISRFTGLSMTTISHWLANVKYQLRRTGGTKFLKNLDTGHPVFFCNDCASQIRTPSTYISHLESHLGFRIRDLSKLSSEQISNQIAQTKSPSEKMVASSPEEENGTSYQCKLCNRTFASKHAVKLHLSKTHGKSPEDHLLYVTELEKQ mint F8FC6F2DFB48C354 t7l1a_xenla Transcription factor 7-like 1-A tcf7l1-a tcf3 tcf3a HMG box transcription factor 3-A protein protein xenla Xenopus laevis (African clawed frog) African clawed frog MPQLNSGGGDELGANDELIRFKDEGEQEEKSPGEGSAEGDLADVKSSLVNESENHSSDSDSEVERRPPPREAFEKHRDYLTEALRRQQDAAFFKGPPYAGYPFLMIPDLGGHYLPNGALSPSARTYLQMKWPLLDSPSTAGLKDARSPSPAHLSNKVPVVQHPHHMHPLTPLITYSNEHFSPGTPPGHLSPEIDPKTGIPRPPHPSELSPYYPLSPGAVGQIPHPLGWLVPPQGQPMYSIPPGGFRHPYPALAMNASMSSLVSSRFSPHMVPPPHHSLHTSGIPHPAIVSPIVKQEPSSGNISPNLHTKSNMIVKKEEEKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHSLSREEQAKYYELARKERQLHSQLYPSWSARDNYGKRKKRKREKQSPEMETHTKTKKMCVQHLPADKSCDSPASSHGSMLDSPATPSAALASPAAPAATHSEQAQPLSLTTKPEARAQLSLSHSAAFLASKSPSSSSFSGHLSSPVGSPLLSRPIPLTSSILSPSGVFPSALQALPLLQAQPLSLVTKSSD 90B24D134AE4EBDD ctnnb1-tshz3 1 Tsh3 5 anti tag western anti tag western blot anti tag western predetermined predetermined participant predetermined unspecified role unspecified role prey prey over-expressed over expressed level over-expressed living cell living cell ha tagged ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined beta catenin 4 anti tag western anti tag western blot anti tag western predetermined predetermined participant predetermined unspecified role unspecified role bait bait over-expressed over expressed level over-expressed living cell living cell myc tagged myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association F6A EMBO-Journal mint tcf7l1_a-tshz3 1 Tsh3 5 anti tag western anti tag western blot anti tag western predetermined predetermined participant predetermined unspecified role unspecified role prey prey over-expressed over expressed level over-expressed living cell living cell ha tagged ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined tcf3 6 anti tag western anti tag western blot anti tag western predetermined predetermined participant predetermined unspecified role unspecified role bait bait over-expressed over expressed level over-expressed living cell living cell flag tagged flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association EMBO-Journal F6F mint ctnnb1-tshz3-1 2 beta catenin 4 anti tag western anti tag western blot anti tag western predetermined predetermined participant predetermined unspecified role unspecified role bait bait in vitro translated in vitro translated protein in vitro translated myc tagged myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Tsh3 5 anti tag western anti tag western blot anti tag western predetermined predetermined participant predetermined unspecified role unspecified role prey prey in vitro translated in vitro translated protein in vitro translated ha tagged ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined binding site binding region binding-associated region binding region deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain range MINT-4790939: original sequence: 1-399 : MDSDSHVSETSDRMGDFESCSIKNEEESKESLAPLEDSNVSDSLEQMKAVYNNFLSNSYWSSLSLNLHQSTSEKNNASSSSSSSSSSSCGSGSFDWHQTAIAKTLQQVSQSRVLPEPSLFSTVQLYRQSSKLYGSIFTGASKFRCKDCSAVYDTLVELTVHMNETGHYRDDNHETDNKNPKRWSKPRKRSLLEMEGKEDAQKVLKCMYCGHSFESLQDLSVHMIKTKHYQKVPLKEPVTPVAAKIVPASRKKLSLELELSNSPDSTGGTQKATNPDVNDALQKNSNPYITPNNRYGHQNGASYAWHFEARKSQILKCMECGSSHDTLQELTTHMMVTGHFIKVTNSALKKGKSVLEAPATPTSLIDEKVQSVPLAATTFTPPLNNSSCLSPKLNVEIK physical association physical association F6B F6D EMBO-Journal mint tcf7l1_a-tshz3-1 2 Tsh3 5 anti tag western anti tag western blot anti tag western predetermined predetermined participant predetermined unspecified role unspecified role prey prey in vitro translated in vitro translated protein in vitro translated binding site binding region binding-associated region binding region deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain range MINT-4791018: original sequence: 400-1004 : EVDKGISDDKIKDKDKTNEEEDKFDVSSKYHYLTENDLEESPKGGLDILKSLENTVTSAINKAQNGTPSWGGYPSIHAAYQLPNMMKLSLGSSGKATPLKPMYGSSELISPTKNQPIMSPPSSQTSPVPKTNFHAMEELVKKVTEKVAKVEEKMKEPEGKFSPIKRTTPSPSGSEISETLKGDVSNEVTFKSQQNSPIPQKDSRKDSPSVEPVENGKDHAKSIIGSLSSSTAIITDHPPEQPFVNPLSALQSVMNIHLGKAAKPSLPALDPMSMLFKMSNSLAEKAAVATPPIQAKKIDHLDRYFYHVNNDQPIDLTKGKSDKNCSLASALLSSTSTSTASSSSTVTTAKTSAVVSFMSNSPLRENALSDISDMLKNLTESHTSKSSTPTSISEKSDIEGTTIEEPEENTPAQKRKGRQSNWNPQHLLILQAQFAASLRQTSEGKYVMSDLSPQERMHISRFTGLSMTTISHWLANVKYQLRRTGGTKFLKNLDTGHPVFFCNDCASQIRTPSTYISHLESHLGFRIRDLSKLSSEQISNQIAQTKSPSEKMVASSPEEENGTSYQCKLCNRTFASKHAVKLHLSKTHGKSPEDHLLYVTELEK ha tagged ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined tcf3 6 anti tag western anti tag western blot anti tag western predetermined predetermined participant predetermined unspecified role unspecified role bait bait in vitro translated in vitro translated protein in vitro translated flag tagged flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association EMBO-Journal F6G F6H mint ctnnb1-tcf7l1_a 2 beta catenin 4 anti tag western anti tag western blot anti tag western predetermined predetermined participant predetermined unspecified role unspecified role bait bait in vitro translated in vitro translated protein in vitro translated myc tagged myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined tcf3 6 anti tag western anti tag western blot anti tag western predetermined predetermined participant predetermined unspecified role unspecified role prey prey in vitro translated in vitro translated protein in vitro translated flag tagged flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association EMBO-Journal F6I mint ctnnb1-tshz3-2 3 Tsh3 5 anti tag western anti tag western blot anti tag western predetermined predetermined participant predetermined unspecified role unspecified role prey prey over-expressed over expressed level over-expressed living cell living cell ha tagged ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined beta catenin 4 western blot western blot Immuno blot Immuno blot predetermined predetermined participant predetermined unspecified role unspecified role bait bait living cell living cell physiological level physiological level endogenous level endogenous endogenous endogenous level physical association physical association F6C EMBO-Journal mint