MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it GIPC participates in G protein signaling downstream of insulin-like growth factor 1 receptor. GIPC participates in G protein signaling downstream of insulin-like growth factor 1 receptor. J. Biol. Chem. (0021-9258) 2002 Booth RA., Cummings C., Tiberi M., Liu XJ. chlae-cos_7 Cercopithecus aethiops simian cells transformed with SV40 Grivet cos_7 cercopithecus aethiops, by transformation with SV40 anti tag coip anti tag coimmunoprecipitation anti tag coip nucleotide sequence nucleotide sequence identification sequence cloning sequence cloning nucleotide sequence Booth RA., Cummings C., Tiberi M., Liu XJ. J. Biol. Chem. (0021-9258) 2002 GIPC participates in G protein signaling downstream of insulin-like growth factor 1 receptor. GIPC participates in G protein signaling downstream of insulin-like growth factor 1 receptor. J. Biol. Chem. (0021-9258) 2002 Booth RA., Cummings C., Tiberi M., Liu XJ. yeast Saccharomyces cerevisiae Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid nucleotide sequence nucleotide sequence identification sequence cloning sequence cloning nucleotide sequence Booth RA., Cummings C., Tiberi M., Liu XJ. J. Biol. Chem. (0021-9258) 2002 q5hz83_xenla gipc2.S GIPC gipc2 XELAEV_18025065mg protein protein xenla Xenopus laevis (African clawed frog) African clawed frog MPLGLRVKKKNKSKEVSSKLVDSDEIANRASGSAGKVSSSANGAAGLPPPPVNLRPKLVFHTQLAHGSPTGRIEGFTNVKELYSKIAEAFLITPEEILFCTLNTHKIDMDKLLGGQIGLEDFIFAHVKGTKKEVEVLKSEDALGLTITDNGAGVAFIKRIKEESTIDKVKVINVGDHIEAINGKNIVGSRHYEVAKMLKELEKGQPFTLKLIEPLKAFEMIEPRARGGKTEGKISTGRETLRLRSKGPATVEEMPSVFEEKAIKKVDDLLESYMGIRDIELAATMVEAGRDKKNPDEFAVALDEALGDFAFPDEFVFDVWGAIGDAKQGRF mint 3367521FCFDA79D6 igf1r_xenla Insulin-like growth factor 1 receptor igf1r protein protein xenla Xenopus laevis (African clawed frog) African clawed frog MKAELVPVCTAWILGLLLCLGPAAAKVCGPNMDIRNDVSELKQLRDCVVIEGYLQILLISNAKAEDFRNLRFPNLTVITDYLLLFRVSGLVSLSNLFPNLTVIRGRVLFYNYALVIFEMTDLKEIGLYNLRNITRGAVRIEKNSELCYVSTVDWSLVLDAVYNNYIVGNKPPKECVDLCPGAREKMQICEKSSINNEFADRCWSDEHCQKVCPSVCGKRACSDNNECCHPECLGSCTAPDNDTACVACHHYFYEGRCVPTCPSNTYKFEGWRCITREVCAKMHIWIHSTIPFIIHKGECVYECPSGYMLNKSQSMTCSPCEGPCPKICEEKMKTIDSVTSAQMLEGCTVLKGNLQLNIRKGQNIAAELENFLGLIETVTGYVKIRHSHALVSLSFLKSLRYILGEEQMPGNYSFYVFDNNNLQQLWDWSKHNLTIKEGKIRFAFNSKLCASEIYRMEEVTGTKGRQAEEDISLSTNGNMASCESHVLNFTSRSKIKNRIKLTWERYRPPDYRDLISFTVYYKEAPFRNVTEYDGQDACGSNSWNMVDVDLPASKESDPGILLQGLKPWTQYAIYVKAITLTMLENRHIHGAKSKIIYMRTDAAVPSIPQDMISASNSSSQLVVKWNPPSLPNGNLSYYIVRWQQQPQDRHLYQYNYCFKDKVPNRKYANGTIDTEGGTEPTKPEGSVGEKGHYCACPKTEAEEKAEKDEAEYRKVFENFLHNSIFVPRPNRRRRDVLAVGNSTVTSYEKNSTTEDFSNFSDSERDDIEYPFYETKVDYKWERTVISNLQPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAAGADDIPGIVNTKEEDDGVIFLGWPEPLRPNGLILMYEIEYKHQGEVHRECVSRQDYRKNGGIKLVRLPPGNYSAQVQAISLYGNGSWTEMVSFCVKLKPDVRNNILQMVVAIPLALSFLLVGIISIVCFVFKKRNSNRLGNGVLYASVNPEYFSAAEMYVPDKWEVPREKITMNRELGQGSFGMVYEGIAKGVVKDEAETKVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPDTESNSGQPTPSLKKMIQMAGEIADGMSYLNANKFVHRDLAARNCMVTEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFVMEGGLLEKPDNCPDMLFELMRMCWQFNPKMRPSFLEIISSIKDELDPGFKEVSFFYSEENKPPDTEELDLEAENMESIPLDPSCALQNSEHHAGHKSENGPGVVVLRASFDERQPYAHMNGGRKNERALPLPQSSAC mint This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. Plays a role in oocyte maturation. Promotes head development by inhibiting Wnt signaling during embryogenesis 2E4E1F8EA6696776 igf1r-gipc2 2 4 nucleotide sequence nucleotide sequence identification sequence cloning sequence cloning nucleotide sequence predetermined predetermined participant predetermined enzyme enzyme bait bait purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain range MINT-609387: original sequence: 958-1358 : RNSNRLGNGVLYASVNPEYFSAAEMYVPDKWEVPREKITMNRELGQGSFGMVYEGIAKGVVKDEAETKVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPDTESNSGQPTPSLKKMIQMAGEIADGMSYLNANKFVHRDLAARNCMVTEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFVMEGGLLEKPDNCPDMLFELMRMCWQFNPKMRPSFLEIISSIKDELDPGFKEVSFFYSEENKPPDTEELDLEAENMESIPLDPSCALQNSEHHAGHKSENGPGVVVLRASFDERQPYAHMNGGRKNERALPLPQSSA ha tagged ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Stoichiometry: 1.0 3 nucleotide sequence nucleotide sequence identification sequence cloning sequence cloning nucleotide sequence predetermined predetermined participant predetermined unspecified role unspecified role prey prey purified purified tagged molecule tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain range MINT-609396: original sequence: 1-232 : MPLGLRVKKKNKSKEVSSKLVDSDEIANRASGSAGKVSSSANGAAGLPPPPVNLRPKLVFHTQLAHGSPTGRIEGFTNVKELYSKIAEAFLITPEEILFCTLNTHKIDMDKLLGGQIGLEDFIFAHVKGTKKEVEVLKSEDALGLTITDNGAGVAFIKRIKEESTIDKVKVINVGDHIEAINGKNIVGSRHYEVAKMLKELEKGQPFTLKLIEPLKAFEMIEPRARGGKTE Stoichiometry: 1.0 physical association physical association F3B mint gipc2-igf1r 1 4 nucleotide sequence nucleotide sequence identification sequence cloning sequence cloning nucleotide sequence predetermined predetermined participant predetermined unspecified role unspecified role prey prey over-expressed over expressed level over-expressed myc tagged myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Stoichiometry: 1.0 3 nucleotide sequence nucleotide sequence identification sequence cloning sequence cloning nucleotide sequence predetermined predetermined participant predetermined unspecified role unspecified role bait bait over-expressed over expressed level over-expressed binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain range MINT-609417: original sequence: 1-320 : MPLGLRVKKKNKSKEVSSKLVDSDEIANRASGSAGKVSSSANGAAGLPPPPVNLRPKLVFHTQLAHGSPTGRIEGFTNVKELYSKIAEAFLITPEEILFCTLNTHKIDMDKLLGGQIGLEDFIFAHVKGTKKEVEVLKSEDALGLTITDNGAGVAFIKRIKEESTIDKVKVINVGDHIEAINGKNIVGSRHYEVAKMLKELEKGQPFTLKLIEPLKAFEMIEPRARGGKTEGKISTGRETLRLRSKGPATVEEMPSVFEEKAIKKVDDLLESYMGIRDIELAATMVEAGRDKKNPDEFAVALDEALGDFAFPDEFVFDV ha tagged ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Stoichiometry: 1.0 physical association physical association F4B mint