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    <source releaseDate="2022-02-04">
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        <shortLabel>UniProt</shortLabel>
        <fullName>UniProt</fullName>
      </names>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0486" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-3989247" refType="identity" refTypeAc="MI:0356"/>
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    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Mitochondria-to-nuclear signaling is regulated by the subcellular localization of the transcription factors Rtg1p and Rtg3p.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="10848632" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1989811" refType="identity" refTypeAc="MI:0356"/>
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          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Mitochondria-to-nuclear signaling is regulated by the subcellular localization of the transcription factors Rtg1p and Rtg3p.</attribute>
            <attribute name="journal" nameAc="MI:0885">Mol. Biol. Cell (1059-1524)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2000</attribute>
            <attribute name="author-list" nameAc="MI:0636">Sekito T., Thornton J., Butow RA.</attribute>
            <attribute name="remark-internal">see remarks in sekito-2000-2</attribute>
            <attribute name="contact-email" nameAc="MI:0634">butow@swmed.edu</attribute>
            <attribute name="author-announcement">01-DEC-2006: Contacted by JYOTI. Returned mail.</attribute>
          </attributeList>
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        <xref>
          <primaryRef db="pubmed" dbAc="MI:0446" id="10848632" refType="primary-reference" refTypeAc="MI:0358"/>
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          <hostOrganism ncbiTaxId="4932">
            <names>
              <shortLabel>yeasx</shortLabel>
              <fullName>Saccharomyces cerevisiae (Baker's yeast)</fullName>
              <alias type="synonym" typeAc="MI:1041">Baker's yeast</alias>
            </names>
          </hostOrganism>
        </hostOrganismList>
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          <names>
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            <fullName>anti tag coimmunoprecipitation</fullName>
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        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>western blot</shortLabel>
            <fullName>western blot</fullName>
            <alias type="go synonym" typeAc="MI:0303">Immuno blot</alias>
            <alias type="synonym" typeAc="MI:1041">Immuno blot</alias>
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        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Sekito T., Thornton J., Butow RA.</attribute>
          <attribute name="remark-internal">see remarks in sekito-2000-2</attribute>
          <attribute name="contact-email" nameAc="MI:0634">butow@swmed.edu</attribute>
          <attribute name="accepted">Accepted 2006-NOV-20 by DAVET.</attribute>
          <attribute name="author-announcement">01-DEC-2006: Contacted by JYOTI. Returned mail.</attribute>
          <attribute name="journal" nameAc="MI:0885">Mol. Biol. Cell (1059-1524)</attribute>
          <attribute name="publication year" nameAc="MI:0886">2000</attribute>
        </attributeList>
      </experimentDescription>
      <experimentDescription id="2">
        <names>
          <fullName>Mitochondria-to-nuclear signaling is regulated by the subcellular localization of the transcription factors Rtg1p and Rtg3p.</fullName>
        </names>
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            <attribute name="publication year" nameAc="MI:0886">2000</attribute>
            <attribute name="author-list" nameAc="MI:0636">Sekito T., Thornton J., Butow RA.</attribute>
            <attribute name="remark-internal">see remarks in sekito-2000-2</attribute>
            <attribute name="contact-email" nameAc="MI:0634">butow@swmed.edu</attribute>
            <attribute name="author-announcement">01-DEC-2006: Contacted by JYOTI. Returned mail.</attribute>
          </attributeList>
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          <hostOrganism ncbiTaxId="4932">
            <names>
              <shortLabel>yeasx</shortLabel>
              <fullName>Saccharomyces cerevisiae (Baker's yeast)</fullName>
              <alias type="synonym" typeAc="MI:1041">Baker's yeast</alias>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>anti bait coip</shortLabel>
            <fullName>anti bait coimmunoprecipitation</fullName>
            <alias type="synonym" typeAc="MI:1041">anti bait coip</alias>
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          <xref>
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        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>western blot</shortLabel>
            <fullName>western blot</fullName>
            <alias type="go synonym" typeAc="MI:0303">Immuno blot</alias>
            <alias type="synonym" typeAc="MI:1041">Immuno blot</alias>
          </names>
          <xref>
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        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Sekito T., Thornton J., Butow RA.</attribute>
          <attribute name="remark-internal">see remarks in sekito-2000-2</attribute>
          <attribute name="contact-email" nameAc="MI:0634">butow@swmed.edu</attribute>
          <attribute name="accepted">Accepted 2006-NOV-20 by DAVET.</attribute>
          <attribute name="author-announcement">01-DEC-2006: Contacted by JYOTI. Returned mail.</attribute>
          <attribute name="journal" nameAc="MI:0885">Mol. Biol. Cell (1059-1524)</attribute>
          <attribute name="publication year" nameAc="MI:0886">2000</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="3">
        <names>
          <shortLabel>rtg3_yeast</shortLabel>
          <fullName>Retrograde regulation protein 3</fullName>
          <alias type="gene name" typeAc="MI:0301">RTG3</alias>
          <alias type="orf name" typeAc="MI:0306">YBL0810</alias>
          <alias type="locus name" typeAc="MI:0305">YBL103C</alias>
        </names>
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          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="D6VPQ0" version="SP_96" refType="secondary-ac" refTypeAc="MI:0360"/>
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          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_009447.1"/>
          <secondaryRef db="sgd" dbAc="MI:0484" id="S000000199"/>
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          <secondaryRef db="ensemblfungi" id="YBL103C_mRNA" version="SP_186" refType="transcript"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000981" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0061629" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071400" version="SP_186"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011598" version="SP_186"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036638" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-SCE-3232118" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006357" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031930" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043565" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045944" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0046983" version="SP_186"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-2501N"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="P38165"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
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            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="559292">
          <names>
            <shortLabel>yeast</shortLabel>
            <fullName>Saccharomyces cerevisiae</fullName>
            <alias type="synonym" typeAc="MI:1041">Baker's yeast</alias>
          </names>
        </organism>
        <sequence>MMNNNESEAENQRLLDELMNQTKVLQETLDFSLVTPTPHHNDDYKIHGSAYPGGETPAQQHEKLSYINTHNSNDNNNLMGSQARSNSQTPTASTIYEEAESQSSYLDDMFRTSQGGRPVTQNSISSIGQGPLRSSYSMAYDSPVDRAMNTPLQQQEGLKAELPHDFLFQHGTDDTMYNLTDDLSSSLSSSINSDMMTPNTYSSSFSYNPQSLGPASVSSTYSPKVRSPSSSFRAGSFLSSSFRHGSINTPRTRHTSISSNMTENIGPGSVPKILGGLTSDEKLRRKREFHNAVERRRRELIKQKIKELGQLVPPSLLNYDDLGKQIKPNKGIILDRTVEYLQYLAEILEIQARKKKALLAKIKELEEKKSSVAALSPFTNNHHASSGQNNSENSEERIIDIRSVPNALMNEQNSKAELHNWEPPLYDSVGNHNHAGTMESHPHTNIHEELKEFLSGDLIEAEDNAKLMFGDDNSNPADYLLEFGSG</sequence>
        <attributeList>
          <attribute name="crc64">DB635FFDEC740C11</attribute>
        </attributeList>
      </interactor>
      <interactor id="4">
        <names>
          <shortLabel>rtg1_yeast</shortLabel>
          <fullName>Retrograde regulation protein 1</fullName>
          <alias type="gene name" typeAc="MI:0301">RTG1</alias>
          <alias type="locus name" typeAc="MI:0305">YOL067C</alias>
        </names>
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          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q08228" version="SP_62" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensemblfungi" id="YOL067C" version="SP_176" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="D6W200" version="SP_91" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-16312" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000981" version="SP_176"/>
          <secondaryRef db="ensemblfungi" id="YOL067C" version="SP_176" refType="gene"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0046983" version="SP_176"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071400" version="SP_176"/>
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          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-2500N"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="P32607"/>
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        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
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          <xref>
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        </interactorType>
        <organism ncbiTaxId="559292">
          <names>
            <shortLabel>yeast</shortLabel>
            <fullName>Saccharomyces cerevisiae</fullName>
            <alias type="synonym" typeAc="MI:1041">Baker's yeast</alias>
          </names>
        </organism>
        <sequence>MSSIPAGTDPGSCGANFKNDRKRRDKINDRIQELLSIIPKDFFRDYYGNSGSNDTLSESTPGALGLSSKAKGTGTKDGKPNKGQILTQAVEYISHLQNQVDTQNREEVELMVKATQLAKQTGTIVNDINLENTSAEVALSRIGVGPLAATNDDSVRPPAKRLSSFEYGGYGEYGNGS</sequence>
        <attributeList>
          <attribute name="crc64">396A6C3A34C49E50</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
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        <names>
          <shortLabel>rtg3-rtg-1-1</shortLabel>
        </names>
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          <primaryRef db="intact" dbAc="MI:0469" id="EBI-1149611" refType="identity" refTypeAc="MI:0356"/>
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        </experimentList>
        <participantList>
          <participant id="6">
            <interactorRef>4</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
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                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
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            </experimentalRoleList>
          </participant>
          <participant id="7">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
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            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
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            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
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        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">1</attribute>
        </attributeList>
      </interaction>
      <interaction id="8">
        <names>
          <shortLabel>rtg3-rtg-1-2</shortLabel>
        </names>
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          <primaryRef db="intact" dbAc="MI:0469" id="EBI-1149635" refType="identity" refTypeAc="MI:0356"/>
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        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="9">
            <interactorRef>4</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
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            </biologicalRole>
            <experimentalRoleList>
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                  <fullName>prey</fullName>
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            </experimentalRoleList>
          </participant>
          <participant id="10">
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              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
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            </biologicalRole>
            <experimentalRoleList>
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                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
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                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <featureList>
              <feature id="11">
                <names>
                  <shortLabel>c-terminus</shortLabel>
                </names>
                <xref>
                  <primaryRef db="intact" dbAc="MI:0469" id="EBI-1149638" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <featureType>
                  <names>
                    <shortLabel>gfp tag</shortLabel>
                    <fullName>green fluorescent protein tag</fullName>
                    <alias type="go synonym" typeAc="MI:0303">GFP</alias>
                    <alias type="go synonym" typeAc="MI:0303">green fluorescent protein</alias>
                    <alias type="synonym" typeAc="MI:1041">GFP</alias>
                    <alias type="synonym" typeAc="MI:1041">green fluorescent protein</alias>
                    <alias type="synonym" typeAc="MI:1041">gfp tag</alias>
                  </names>
                  <xref>
                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0367" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608965" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="pubmed" dbAc="MI:0446" id="7491768" refType="primary-reference" refTypeAc="MI:0358"/>
                  </xref>
                </featureType>
                <featureRangeList>
                  <featureRange>
                    <startStatus>
                      <names>
                        <shortLabel>c-term range</shortLabel>
                        <fullName>C-terminal range</fullName>
                        <alias type="synonym" typeAc="MI:1041">c-term range</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1039" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2929799" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14760721" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </startStatus>
                    <endStatus>
                      <names>
                        <shortLabel>c-term range</shortLabel>
                        <fullName>C-terminal range</fullName>
                        <alias type="synonym" typeAc="MI:1041">c-term range</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1039" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2929799" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14760721" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </endStatus>
                  </featureRange>
                </featureRangeList>
              </feature>
            </featureList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">6A</attribute>
          <attribute name="comment" nameAc="MI:0612">Several RTG3 deletion constructs have been found to interact with RTG1: delta376-486 (most strongly), delta280-298 and delta 2-279 (weakest).</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>