IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Protein-protein interactions among human 20S proteasome subunits and proteassemblin. Protein-protein interactions among human 20S proteasome subunits and proteassemblin. Biochem. Biophys. Res. Commun. (0006-291X) 2004 Jayarapu K., Griffin TA. Directed yeast two hybrid assay Figure 1 and Table 1 for interaction data. Figure 2 shows a diagram of interactions for proteasome subunits and proteassemblin. grift0@chmcc.org yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined Jayarapu K., Griffin TA. Directed yeast two hybrid assay Figure 1 and Table 1 for interaction data. Figure 2 shows a diagram of interactions for proteasome subunits and proteassemblin. grift0@chmcc.org Annotation to indicate that this entry has been checked and accepted by a senior curator. Biochem. Biophys. Res. Commun. (0006-291X) 2004 psb6_human Proteasome subunit beta type-6 PSMB6 LMPY Proteasome delta chain Macropain delta chain Multicatalytic endopeptidase complex delta chain Proteasome subunit Y Y protein protein human Homo sapiens Human MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYIANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVATLPPA DIP protein P28072 original sequence version: 163 7DF4081DC735930C psa3_human Proteasome subunit alpha type-3 PSMA3 PSC8 Proteasome component C8 Macropain subunit C8 Multicatalytic endopeptidase complex subunit C8 HC8 protein protein human Homo sapiens Human MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYAKESLKEEDESDDDNM DIP protein P25788 original sequence version: 173 A1854ED3C0650FB1 psa4_human Proteasome subunit alpha type-4 PSMA4 PSC9 Proteasome component C9 Macropain subunit C9 Multicatalytic endopeptidase complex subunit C9 Proteasome subunit L HC9 protein protein human Homo sapiens Human MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKEGEMTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKKHEEEEAKAEREKKEKEQKEKDK DIP protein P25789 original sequence version: 160 DIP protein P25789 original sequence version: 133 DIP protein P25789 original sequence version: 114 DIP protein P25789 original sequence version: 149 7867422B1B31F3B9 q5jnw7_human PSMB8 protein protein human Homo sapiens Human MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYINCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ 043E12419E2F43DB psb3_human Proteasome subunit beta type-3 PSMB3 Proteasome theta chain Proteasome chain 13 Proteasome component C10-II protein protein human Homo sapiens Human MSIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDVQTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPFICSLDLIGCPMVTDDFVVSGTCAEQMYGMCESLWEPNMDPDHLFETISQAMLNAVDRDAVSGMGVIVHIIEKDKITTRTLKARMD DIP protein P49720 original sequence version: 156 624972384C0112FD psa7_human Proteasome subunit alpha type-7 PSMA7 Proteasome subunit RC6-1 Proteasome subunit XAPC7 HSPC protein protein human Homo sapiens Human MSYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGRDIVVLGVEKKSVAKLQDERTVRKICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQSNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDEAIETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQSLKILNPEEIEKYVAEIEKEKEENEKKKQKKAS DIP protein O14818 original sequence version: 160 DIP protein O14818 original sequence version: 149 5DD0276A1C2DEF91 pomp_human Proteasome maturation protein Proteassemblin Protein UMP1 homolog Voltage-gated K channel beta subunit 4.1 POMP C13orf12 UMP1 HSPC014 HSPC036 PNAS-110 protein protein human Homo sapiens Human MNARGLGSELKDSIPVTELSASGPFESHDLLRKGFSCVKNELLPSHPLELSEKNFQLNQDKMNFSTLRNIQGLFAPLKLQMEFKAVQQVQRLPFLSSSNLSLDVLRGNDETIGFEDILNDPSQSEVMGEPHLMVEYKLGLL 2136624D232EF1C7 psb9_human Proteasome subunit beta type-9 PSMB9 LMP2 RING12 Proteasome subunit beta-1i Proteasome chain 7 Macropain chain 7 Multicatalytic endopeptidase complex chain 7 Really interesting new gene 12 protein Low molecular mass protein 2 PSMB6i protein protein human Homo sapiens Human MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAANVVRNISYKYREDLSAHLMVAGWDQREGGQVYGTLGGMLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE 3B321F83641941AC psa2_human Proteasome subunit alpha type-2 PSMA2 PSC3 Proteasome component C3 Macropain subunit C3 Multicatalytic endopeptidase complex subunit C3 HC3 protein protein human Homo sapiens Human MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYLAAIA DIP protein P25787 original sequence version: 161 63CB56A233583836 psa1_human Proteasome subunit alpha type-1 PSMA1 PROS30 PSC2 Proteasome component C2 Macropain subunit C2 Multicatalytic endopeptidase complex subunit C2 Proteasome nu chain 30 kDa prosomal protein HC2 NU protein protein human Homo sapiens Human MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQKKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERPQRKAQPAQPADEPAEKADEPMEH DIP protein P25786 original sequence version: 102 DIP protein P25786 original sequence version: 174 3F159C5BCEFE8DED psb1_human Proteasome subunit beta type-1 PSMB1 PSC5 Proteasome component C5 Macropain subunit C5 Multicatalytic endopeptidase complex subunit C5 Proteasome gamma chain protein protein human Homo sapiens Human MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRKD DIP protein P20618 original sequence version: 164 AE8FC42799F39157 psb5_human Proteasome subunit beta type-5 PSMB5 LMPX Proteasome epsilon chain Macropain epsilon chain Multicatalytic endopeptidase complex epsilon chain Proteasome subunit X Proteasome chain 6 Proteasome subunit MB1 MB1 X protein protein human Homo sapiens Human MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP DIP protein P28074 original sequence version: 171 DIP protein P28074 original sequence version: 132 AED4A73DF41AA6EF psb10_human Proteasome subunit beta type-10 PSMB10 MECL1 Proteasome subunit beta-2i Proteasome MECl-1 Macropain subunit MECl-1 Multicatalytic endopeptidase complex subunit MECl-1 LMP10 Low molecular mass protein 10 protein protein human Homo sapiens Human MLKPALEPRGGFSFENCQRNASLERVLPGLKVPHARKTGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGRYHFVPGTTAVLTQTVKPLTLELVEETVQAMEVE D6728E50513A45B9 psb2_human Proteasome subunit beta type-2 PSMB2 Multicatalytic endopeptidase complex subunit C7-I Proteasome component C7-I Macropain subunit C7-I protein protein human Homo sapiens Human MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS DIP protein P49721 original sequence version: 156 04D085D7BAA76130 psb7_human Proteasome subunit beta type-7 PSMB7 Proteasome subunit Z Macropain chain Z Multicatalytic endopeptidase complex chain Z Z protein protein human Homo sapiens Human MAAVSVYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS DIP protein Q99436 original sequence version: 152 A610C949A0ACF1CE psa6_human Proteasome subunit alpha type-6 PSMA6 PROS27 Proteasome iota chain Macropain iota chain Multicatalytic endopeptidase complex iota chain 27 kDa prosomal protein protein protein human Homo sapiens Human MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAERD DIP protein P60900 original sequence version: 129 DIP protein P60900 original sequence version: 80 94D1FD3C0A7CC72A alpha1-alpha2 1 10 unspecified role unspecified role prey prey 11 unspecified role unspecified role bait bait physical association physical association alpha1-alpha7 1 7 unspecified role unspecified role prey prey 11 unspecified role unspecified role bait bait physical association physical association alpha1-beta2 1 11 unspecified role unspecified role bait bait 15 unspecified role unspecified role prey prey physical association physical association alpha1-beta2i 1 11 unspecified role unspecified role bait bait 14 unspecified role unspecified role prey prey physical association physical association alpha2-alpha1 1 10 unspecified role unspecified role bait bait 11 unspecified role unspecified role prey prey physical association physical association alpha2-alpha4 1 4 unspecified role unspecified role prey prey 10 unspecified role unspecified role bait bait physical association physical association alpha3-alpha4 1 3 unspecified role unspecified role bait bait 4 unspecified role unspecified role prey prey physical association physical association alpha3-alpha2 1 10 unspecified role unspecified role prey prey 3 unspecified role unspecified role bait bait physical association physical association alpha4-alpha3 1 4 unspecified role unspecified role bait bait 3 unspecified role unspecified role prey prey physical association physical association alpha4-alpha2 1 10 unspecified role unspecified role prey prey 4 unspecified role unspecified role bait bait physical association physical association alpha4-alpha7 1 4 unspecified role unspecified role bait bait 7 unspecified role unspecified role prey prey physical association physical association alpha6-alpha2 1 17 unspecified role unspecified role bait bait 10 unspecified role unspecified role prey prey physical association physical association alpha6-alpha7 1 17 unspecified role unspecified role bait bait 7 unspecified role unspecified role prey prey physical association physical association alpha7-alpha1 1 11 unspecified role unspecified role prey prey 7 unspecified role unspecified role bait bait physical association physical association alpha7-alpha4 1 7 unspecified role unspecified role bait bait 4 unspecified role unspecified role prey prey physical association physical association alpha7-alpha6 1 7 unspecified role unspecified role bait bait 17 unspecified role unspecified role prey prey physical association physical association beta2-beta3 1 15 unspecified role unspecified role bait bait 6 unspecified role unspecified role prey prey physical association physical association beta1-beta3 1 6 unspecified role unspecified role prey prey 12 unspecified role unspecified role bait bait physical association physical association beta1-beta7 1 16 unspecified role unspecified role prey prey 12 unspecified role unspecified role bait bait physical association physical association beta1-beta5 1 13 unspecified role unspecified role prey prey 12 unspecified role unspecified role bait bait physical association physical association beta1-beta5i 1 12 unspecified role unspecified role bait bait 5 unspecified role unspecified role prey prey physical association physical association beta1-pnas 1 12 unspecified role unspecified role bait bait 8 unspecified role unspecified role prey prey physical association physical association beta1i-beta7 1 16 unspecified role unspecified role prey prey 9 unspecified role unspecified role bait bait physical association physical association beta1i-beta5i 1 9 unspecified role unspecified role bait bait 5 unspecified role unspecified role prey prey physical association physical association beta1i-pnas 1 8 unspecified role unspecified role prey prey 9 unspecified role unspecified role bait bait physical association physical association beta2i-beta3 1 14 unspecified role unspecified role bait bait 6 unspecified role unspecified role prey prey physical association physical association beta3-beta2i 1 6 unspecified role unspecified role bait bait 14 unspecified role unspecified role prey prey physical association physical association beta3-beta2 1 6 unspecified role unspecified role bait bait 15 unspecified role unspecified role prey prey physical association physical association beta5-beta1 1 13 unspecified role unspecified role bait bait 12 unspecified role unspecified role prey prey physical association physical association beta5-beta2 1 13 unspecified role unspecified role bait bait 15 unspecified role unspecified role prey prey physical association physical association beta5-beta3 1 6 unspecified role unspecified role prey prey 13 unspecified role unspecified role bait bait physical association physical association beta5-alpha3 1 13 unspecified role unspecified role bait bait 3 unspecified role unspecified role prey prey physical association physical association beta5-beta7 1 13 unspecified role unspecified role bait bait 16 unspecified role unspecified role prey prey physical association physical association beta5-pnas 1 8 unspecified role unspecified role prey prey 13 unspecified role unspecified role bait bait physical association physical association beta5i-beta7 1 16 unspecified role unspecified role prey prey 5 unspecified role unspecified role bait bait physical association physical association beta6-beta7 1 2 unspecified role unspecified role bait bait 16 unspecified role unspecified role prey prey physical association physical association beta6-pnas 1 8 unspecified role unspecified role prey prey 2 unspecified role unspecified role bait bait physical association physical association beta7-beta3 1 6 unspecified role unspecified role prey prey 16 unspecified role unspecified role bait bait physical association physical association beta7-beta7 1 16 unspecified role unspecified role prey prey 16 unspecified role unspecified role bait bait physical association physical association beta7-beta5i 1 5 unspecified role unspecified role prey prey 16 unspecified role unspecified role bait bait physical association physical association beta7-pnas 1 16 unspecified role unspecified role bait bait 8 unspecified role unspecified role prey prey physical association physical association