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        <shortLabel>IntAct</shortLabel>
        <fullName>European Bioinformatics Institute</fullName>
        <alias type="synonym" typeAc="MI:1041">IntAct</alias>
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        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/</attribute>
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        <attribute name="id-validation-regexp" nameAc="MI:0628">EBI-[0-9]+|IA:[0-9]+</attribute>
        <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
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        <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact/</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Cell cycle progression of chronic lymphocytic leukemia cells is controlled by cyclin D2, cyclin D3, cyclin-dependent kinase (cdk) 4 and the cdk inhibitor p27.</fullName>
        </names>
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            <attribute name="publication title" nameAc="MI:1091">Cell cycle progression of chronic lymphocytic leukemia cells is controlled by cyclin D2, cyclin D3, cyclin-dependent kinase (cdk) 4 and the cdk inhibitor p27.</attribute>
            <attribute name="journal" nameAc="MI:0885">Leukemia (0887-6924)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2002</attribute>
            <attribute name="author-list" nameAc="MI:0636">Decker T., Schneller F., Hipp S., Miething C., Jahn T., Duyster J., Peschel C.</attribute>
            <attribute name="remark-internal">Revisit when complex editor available to annotate Fig. 7</attribute>
            <attribute name="figure legend" nameAc="MI:0599">Fig. 6</attribute>
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        <hostOrganismList>
          <hostOrganism ncbiTaxId="9606">
            <names>
              <shortLabel>human-b-cell lymphoma</shortLabel>
              <fullName>Homo sapiens</fullName>
            </names>
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              <names>
                <shortLabel>b-cell lymphoma</shortLabel>
                <fullName>B-cell lymphoma</fullName>
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        <interactionDetectionMethod>
          <names>
            <shortLabel>anti bait coip</shortLabel>
            <fullName>anti bait coimmunoprecipitation</fullName>
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        <participantIdentificationMethod>
          <names>
            <shortLabel>monoclonal western</shortLabel>
            <fullName>monoclonal antibody western blot</fullName>
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          <attribute name="author-list" nameAc="MI:0636">Decker T., Schneller F., Hipp S., Miething C., Jahn T., Duyster J., Peschel C.</attribute>
          <attribute name="remark-internal">Revisit when complex editor available to annotate Fig. 7</attribute>
          <attribute name="figure legend" nameAc="MI:0599">Fig. 6</attribute>
          <attribute name="accepted">Annotation to indicate that this entry has been checked and accepted by a senior curator.</attribute>
          <attribute name="journal" nameAc="MI:0885">Leukemia (0887-6924)</attribute>
          <attribute name="publication year" nameAc="MI:0886">2002</attribute>
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      </experimentDescription>
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      <interactor id="2">
        <names>
          <shortLabel>ccnd2_human</shortLabel>
          <fullName>G1/S-specific cyclin-D2</fullName>
          <alias type="gene name" typeAc="MI:0301">CCND2</alias>
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            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
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        </organism>
        <sequence>MELLCHEVDPVRRAVRDRNLLRDDRVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCMFLASKLKETSPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLPQQREKLSLIRKHAQTFIALCATDFKFAMYPPSMIATGSVGAAICGLQQDEEVSSLTCDALTELLAKITNTDVDCLKACQEQIEAVLLNSLQQYRQDQRDGSKSEDELDQASTPTDVRDIDL</sequence>
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          <attribute name="crc64">E4E5FEF476D76D90</attribute>
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          <shortLabel>cdk4_human</shortLabel>
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          <alias type="gene name synonym" typeAc="MI:0302">Cell division protein kinase 4</alias>
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            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P11802 original sequence version: 177</attribute>
          <attribute name="remark-internal">DIP protein P11802 original sequence version: 135</attribute>
          <attribute name="remark-internal">DIP protein P11802 original sequence version: 136</attribute>
          <attribute name="remark-internal">DIP protein P11802 original sequence version: 200</attribute>
          <attribute name="remark-internal">DIP protein P11802 original sequence version: 86</attribute>
          <attribute name="crc64">0916A0C07403A33A</attribute>
        </attributeList>
      </interactor>
      <interactor id="4">
        <names>
          <shortLabel>ccnd3_human</shortLabel>
          <fullName>G1/S-specific cyclin-D3</fullName>
          <alias type="gene name" typeAc="MI:0301">CCND3</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P30281" version="SP_82" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q5T8J0" version="SP_82" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q96F49" version="SP_82" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B2RD63" version="SP_92" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6FG62" version="SP_104" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000362082" version="SP_210" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B3KQ22" version="SP_127" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="E9PAS4" version="SP_136" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="E9PB36" version="SP_136" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-10979075" refType="intact-secondary"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-11132276" refType="intact-secondary"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-375013" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001129489.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001129597.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001129598.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001751.1"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9661069" version="SP_210"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000112576" version="SP_210" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000372991" version="SP_210" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000079" version="SP_210"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000122" version="SP_210"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000307" version="SP_210"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001934" version="SP_210"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004693" version="SP_210"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="SP_210"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" version="SP_210"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" version="SP_210"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007165" version="SP_210"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016020" version="SP_210"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016538" version="SP_210"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0019901" version="SP_210"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042098" version="SP_210"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042127" version="SP_210"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0044772" version="SP_210"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045737" version="SP_210"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0046626" version="SP_210"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051301" version="SP_210"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1900087" version="SP_210"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR004367" version="SP_210"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR006671" version="SP_210"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013763" version="SP_210"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR015451" version="SP_210"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036915" version="SP_210"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR039361" version="SP_210"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="P30281" version="SP_210"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3G33" version="SP_210"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-381340" version="SP_210"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5687128" version="SP_210"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-69231" version="SP_210"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8934593" version="SP_210"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001274356.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001274363.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-31734N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P30281 original sequence version: 150</attribute>
          <attribute name="remark-internal">DIP protein P30281 original sequence version: 111</attribute>
          <attribute name="crc64">16E7B1604FEB0029</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="5">
        <names>
          <shortLabel>ccnd2-cdk4-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-768365" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030332" refType="function" refTypeAc="MI:0355"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="6">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="7">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
      </interaction>
      <interaction id="8">
        <names>
          <shortLabel>ccnd2-cdk4-2</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-768369" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030332" refType="function" refTypeAc="MI:0355"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="9">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="10">
            <interactorRef>4</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
      </interaction>
    </interactionList>
  </entry>
</entrySet>