<?xml version='1.0' encoding='UTF-8'?>
<entrySet xmlns="http://psi.hupo.org/mi/mif300" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://psi.hupo.org/mi/mif300 https://raw.githubusercontent.com/HUPO-PSI/miXML/master/3.0/src/MIF300.xsd" level="3" version="0" minorVersion="0">
  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>IntAct</shortLabel>
        <fullName>European Bioinformatics Institute</fullName>
        <alias type="synonym" typeAc="MI:1041">IntAct</alias>
        <alias type="synonym" typeAc="MI:1041">intact</alias>
      </names>
      <bibref>
        <xref>
          <primaryRef db="pubmed" dbAc="MI:0446" id="14681455" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
      </bibref>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0469" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-10" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="14681455" refType="primary-reference" refTypeAc="MI:0358"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="22121220" refType="method reference" refTypeAc="MI:0357"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="19850723" refType="method reference" refTypeAc="MI:0357"/>
      </xref>
      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/</attribute>
        <attribute name="search-url" nameAc="MI:0615">http://www.ebi.ac.uk/intact/query/${ac}</attribute>
        <attribute name="id-validation-regexp" nameAc="MI:0628">EBI-[0-9]+|IA:[0-9]+</attribute>
        <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact</attribute>
        <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact/</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="10567585" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1992848" refType="identity" refTypeAc="MI:0356"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export.</attribute>
            <attribute name="journal" nameAc="MI:0885">Mol. Cell. Biol. (0270-7306)</attribute>
            <attribute name="publication year" nameAc="MI:0886">1999</attribute>
            <attribute name="author-list" nameAc="MI:0636">Black BE., Levesque L., Holaska JM., Wood TC., Paschal BM.</attribute>
            <attribute name="exp-modification" nameAc="MI:0627">solid phase assay</attribute>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="pubmed" dbAc="MI:0446" id="10567585" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="-1">
            <names>
              <shortLabel>in vitro</shortLabel>
              <fullName>In vitro</fullName>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>affinity techniques</shortLabel>
            <fullName>affinity technology</fullName>
            <alias type="synonym" typeAc="MI:1041">affinity techniques</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0400" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608485" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Black BE., Levesque L., Holaska JM., Wood TC., Paschal BM.</attribute>
          <attribute name="exp-modification" nameAc="MI:0627">solid phase assay</attribute>
          <attribute name="accepted">Accepted 2010-JAN-10 by SKERRIEN (applied to all records created before 2005-Sep-01).</attribute>
          <attribute name="journal" nameAc="MI:0885">Mol. Cell. Biol. (0270-7306)</attribute>
          <attribute name="publication year" nameAc="MI:0886">1999</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>nxf2_human</shortLabel>
          <fullName>Nuclear RNA export factor 2</fullName>
          <alias type="gene name" typeAc="MI:0301">NXF2B</alias>
          <alias type="gene name synonym" typeAc="MI:0302">TAP-like protein 2</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Cancer/testis antigen 39</alias>
          <alias type="gene name" typeAc="MI:0301">NXF2</alias>
          <alias type="gene name synonym" typeAc="MI:0302">TAPL2</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q9GZY0" version="SP_75" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000472530" version="SP_201" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000474598" version="SP_201" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000474659" version="SP_201" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000485586" version="SP_201" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9BXU4" version="SP_75" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9NSS1" version="SP_75" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9NX66" version="SP_75" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-444173" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000269405" version="SP_201" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000269437" version="SP_201" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000602195" version="SP_201" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000604395" version="SP_201" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000604790" version="SP_201" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000625106" version="SP_201" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003723" version="SP_201"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="SP_201"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" version="SP_201"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" version="SP_201"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" version="SP_201"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006406" version="SP_201"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007275" version="SP_201"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016973" version="SP_201"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042272" version="SP_201"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0050658" version="SP_201"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001611" version="SP_201"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002075" version="SP_201"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR005637" version="SP_201"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR009060" version="SP_201"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR012677" version="SP_201"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR015245" version="SP_201"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018222" version="SP_201"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR030217" version="SP_201"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR030218" version="SP_201"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR032675" version="SP_201"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR032710" version="SP_201"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR035979" version="SP_201"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-159236" version="SP_201"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001093156.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_071336.1"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MCSTLKKCGTYRTEVAECHDHGSTFQGRKKGGSSFRDNFDKRSCHYEHGGYERPPSHCQENDGSVEMRDVHKDQQLRHTPYSIRCERRMKWHSEDEIRITTWRNRKPPERKMSQNTQDGYTRNWFKVTIPYGIKYDKAWLMNSIQSHCSDRFTPVDFHYVRNRACFFVQDASAASALKDVSYKIYDDENQKICIFVNHSTAPYSVKNKLKPGQMEMLKLTMNKRYNVSQQALDLQNLRFDPDLMGRDIDIILNRRNCMAATLKIIERNFPELLSLNLCNNKLYQLDGLSDITEKAPKVKTLNLSKNKLESAWELGKVKGLKLEELWLEGNPLCSTFSDQSAYVSAIRDCFPKLLRLDGRELSAPVIVDIDSSETMKPCKENFTGSETLKHLVLQFLQQYYSIYDSGDRQGLLGAYHDEACFSLAIPFDPKDSAPSSLCKYFEDSRNMKTLKDPYLKGELLRRTKRDIVDSLSALPKTQHDLSSILVDVWCQTERMLCFSVNGVFKEVEGQSQGSVLAFTRTFIATPGSSSSLCIVNDELFVRDASPQETQSAFSIPVSTLSSSSEPSLSQEQQEMVQAFSAQSGMKLEWSQKCLQDNEWNYTRAGQAFTMLQTEGKIPAEAFKQIS</sequence>
        <attributeList>
          <attribute name="crc64">319CFEDF3E67A163</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>nxt1_mouse</shortLabel>
          <fullName>NTF2-related export protein 1</fullName>
          <alias type="gene name" typeAc="MI:0301">Nxt1</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q9QZV9" version="SP_52" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000038329" version="SP_141" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000105587" version="SP_141" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q3THE3" version="SP_52" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9D1P7" version="SP_52" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-444161" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSG00000036992" version="SP_141" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000047177" version="SP_141" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000109961" version="SP_141" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005643" version="SP_141"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" version="SP_141"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" version="SP_141"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006405" version="SP_141"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006606" version="SP_141"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006611" version="SP_141"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006913" version="SP_141"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016607" version="SP_141"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031267" version="SP_141"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0044613" version="SP_141"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051028" version="SP_141"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002075" version="SP_141"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018222" version="SP_141"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="Q9QZV9" version="SP_141"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-159236" version="SP_141"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR032710" version="SP_141"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001103629.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_062735.4"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10090">
          <names>
            <shortLabel>mouse</shortLabel>
            <fullName>Mus musculus</fullName>
            <alias type="synonym" typeAc="MI:1041">Mouse</alias>
          </names>
        </organism>
        <sequence>MASVDFKTYVDQACRAAEEFVNVYYTTMDKRRRLLSRLYMGTATLVWNGNAVSGQESLSEFFEMLPSSEFQISVVDCQPVHDDATPSQTTVLVVICGTVKFEGNKQRDFNQNFILTAQASPSNTVWKIASDCFRFQDWAS</sequence>
        <attributeList>
          <attribute name="crc64">358EAFDC19FE4594</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4">
        <names>
          <shortLabel>nxf2-nxt1-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-444193" refType="identity" refTypeAc="MI:0356"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="511693">
                <names>
                  <shortLabel>ecobb</shortLabel>
                  <fullName>Escherichia coli (strain B / BL21)</fullName>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
          <participant id="6">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="9606">
                <names>
                  <shortLabel>human-hela</shortLabel>
                  <fullName>Homo sapiens epitheloid cervix carcinoma cells</fullName>
                  <alias type="synonym" typeAc="MI:1041">Human</alias>
                </names>
                <cellType>
                  <names>
                    <shortLabel>hela</shortLabel>
                    <fullName>Human epitheloid cervix carcinoma HeLa cells</fullName>
                  </names>
                  <xref>
                    <primaryRef db="cabri" dbAc="MI:0246" id="ACC 57" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="IA:0055" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="MINT-93029" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-300790" refType="identity" refTypeAc="MI:0356"/>
                  </xref>
                  <attributeList>
                    <attribute name="comment" nameAc="MI:0612">derivation: cervix; epithelial; adenocarcinoma</attribute>
                    <attribute name="comment" nameAc="MI:0612">ATCC no:CCL-2</attribute>
                  </attributeList>
                </cellType>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
      </interaction>
    </interactionList>
  </entry>
</entrySet>