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  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>MINT</shortLabel>
        <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
        <alias type="synonym" typeAc="MI:1041">MINT</alias>
      </names>
      <bibref>
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      </bibref>
      <xref>
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      </xref>
      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it/mint</attribute>
        <attribute name="url" nameAc="MI:0614">url&amp;gt;http://mint.bio.uniroma2.it/mint/</attribute>
        <attribute name="url" nameAc="MI:0614">https://mint.bio.uniroma2.it</attribute>
        <attribute name="id-validation-regexp" nameAc="MI:0628">MINT-[0-9]+</attribute>
        <attribute name="search-url" nameAc="MI:0615">https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac}</attribute>
        <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Cartilage oligomeric matrix protein interacts with type IX collagen, and disruptions to these interactions identify a pathogenetic mechanism in a bone dysplasia family.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="11087755" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="doi" dbAc="MI:0574" id="10.1074/jbc.M009507200" refType="secondary-ac" refTypeAc="MI:0360"/>
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            <secondaryRef db="mint" dbAc="MI:0471" id="MINT-434592" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7447193" refType="identity" refTypeAc="MI:0356"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Cartilage oligomeric matrix protein interacts with type IX collagen, and disruptions to these interactions identify a pathogenetic mechanism in a bone dysplasia family.</attribute>
            <attribute name="journal" nameAc="MI:0885">J. Biol. Chem. (0021-9258)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2001</attribute>
            <attribute name="author-list" nameAc="MI:0636">Holden P., Meadows RS., Chapman KL., Grant ME., Kadler KE., Briggs MD.</attribute>
            <attribute name="uniprot-dr-export">no</attribute>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="mint" dbAc="MI:0471" id="MINT-434592" refType="identity" refTypeAc="MI:0356"/>
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          <secondaryRef db="pubmed" dbAc="MI:0446" id="11087755" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="-1">
            <names>
              <shortLabel>in vitro</shortLabel>
              <fullName>In vitro</fullName>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>x-ray diffraction</shortLabel>
            <fullName>x-ray crystallography</fullName>
            <alias type="go synonym" typeAc="MI:0303">X-ray</alias>
            <alias type="synonym" typeAc="MI:1041">X-ray</alias>
            <alias type="synonym" typeAc="MI:1041">x-ray diffraction</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0114" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1272" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Holden P., Meadows RS., Chapman KL., Grant ME., Kadler KE., Briggs MD.</attribute>
          <attribute name="uniprot-dr-export">no</attribute>
          <attribute name="journal" nameAc="MI:0885">J. Biol. Chem. (0021-9258)</attribute>
          <attribute name="publication year" nameAc="MI:0886">2001</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>comp_bovin</shortLabel>
          <fullName>Cartilage oligomeric matrix protein</fullName>
          <alias type="gene name" typeAc="MI:0301">COMP</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P35445" version="SP_84" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSBTAP00000006074" version="SP_146" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-5281240" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008201" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009306" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010259" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010260" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010468" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0014829" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016485" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030199" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030282" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030500" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030509" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0032991" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0035264" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0035988" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0035989" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0036122" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043066" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043395" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043588" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0048844" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0050881" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0060173" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0062023" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070527" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0097084" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1900047" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1902732" version="SP_146"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000742" version="SP_146"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001881" version="SP_146"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003367" version="SP_146"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008859" version="SP_146"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013320" version="SP_146"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR017897" version="SP_146"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018097" version="SP_146"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR024665" version="SP_146"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR028492" version="SP_146"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR028974" version="SP_146"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR039081" version="SP_146"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSBTAG00000004630" version="SP_146" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSBTAT00000006074" version="SP_146" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0002020" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0002063" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003417" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005178" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005509" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005518" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005615" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006915" version="SP_146"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006986" version="SP_146"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9913">
          <names>
            <shortLabel>bovin</shortLabel>
            <fullName>Bos taurus (Bovine)</fullName>
            <alias type="synonym" typeAc="MI:1041">Bovine</alias>
          </names>
        </organism>
        <sequence>MVLAAARVLLLTLAALGASGQGQMPLGGDLGPQMLRELQETNAALQDVRDLLRQQVKEITFLKNTVMECDACGMQPARTPKLTVRPLSQCSPGFCFPGVACTETANGARCGPCPEGFTGNGSHCADVNECTAHPCFPRVRCINTSPGFRCEACPPGFSGPTHEGVGLAFAKANKQVCTDINECETGQHNCVPNSVCVNTVGSFQCGPCQPGFVGDQASGCRRRPQRFCPDGTPSPCHEKADCVLERDGSRSCVCAVGWAGNGLICGRDTDLDGFPDEKLRCSERQCRKDNCVTVPNSGQEDVDQDGIGDACDPDADGDGVLNEKDNCPLVRNPDQRNTDGDKWGDACDNCRSQKNDDQKDTDKDGRGDACDDDIDGDRIRNPVDNCPKVPNSDQKDTDGDGVGDACDNCPQKSNADQRDVDHDFVGDACDSDQDQDGDGHQDSKDNCPTVPNSAQQDSDHDGQGDACDDDDDNDGVPDSRDNCRLVPNPGQEDMDRDGVGDACQGDFDADKVVDKIDVCPENAEVTLTDFRAFQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTATDDDYAGFIFGYQDSSSFYVVMWKQMEQTYWQANPFRAVAEPGIQLKAVKSSTGPGEQLRNALWHTGDTASQVRLLWKDPRNVGWKDKTSYRWFLQHRPQVGYIRVRFYEGPELVADSNVILDTTMRGGRLGVFCFSQENIIWANLRYRCNDTIPEDYEAQRLLQA</sequence>
        <attributeList>
          <attribute name="crc64">DC2D84FE1C18FCA2</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>q90800_chick</shortLabel>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q90800" version="TrEMBL_44" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="MINT-151160" refType="intact-secondary"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7447242" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008160" version="TrEMBL_113"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_990636.1"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005581" version="TrEMBL_113"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9031">
          <names>
            <shortLabel>chick</shortLabel>
            <fullName>Gallus gallus (Chicken)</fullName>
            <alias type="synonym" typeAc="MI:1041">Chicken</alias>
          </names>
        </organism>
        <sequence>MTVFPTLGLLFLCQLLATTSAQRVGPQGPPGPRGPPGPSGKDGIDGEPGPSGLPGPPGPKGAPGKPGAAGEAGLPGLPGVDGLTGTDGPPGPNGPPGDRGALGPAGPPGPAGKGLPGPPGPPGPSGLPGGNGFRGPPGPSGLPGFPGPPGPPGPPGLAGIIPEGGGDLQCPALCPPGPPGPPGMPGFKGHTGHKGEPGEIGKEGEKGSPGPPGPPGIPGSVGLQGPRGLRGLPGPMGPAGDRGDIGFRGPPGIPGPPGRAGDQGNKGPQGFRGPKGDTGRPGPKGNPGARGLIGEPGIPGKDGRDGAPGLDGEKGDAARMGVPGEKGPNGLPGLPGRAGIKGSKGEPGSPGEMGEAGPSGEPGIPGDVGIPGDRGLPGPRGATGPVGLPGPIGAPGVRGFQGPKGASGEPGLPGPTGIRGESGDRGPAGVIGAKGSQGIAGADGLPGDKGELGPFGPPGQKGEPGKRGELGPKGAQGPNGTAGAPGIPGHPGPMGHQGEQGVPGITGKPGPPGKEASEQHIRELCGEMINDQIAQLAANLRKPLSPGMTGRPGPAGPPGPPGATGSVGHPGARGPPGYRGPTGELGDPGPRGDTGEKGDKGPAGQGIDGPDGDQGPQGLPGVPGISKNGRDGAQGEPGLPGDPGTPGAVGAQGTPGICDTSACMGAVGASTSKKS</sequence>
        <attributeList>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
          <attribute name="crc64">95094637A339D72D</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4">
        <names>
          <shortLabel>comp-q90800</shortLabel>
        </names>
        <xref>
          <primaryRef db="mint" dbAc="MI:0471" id="MINT-18923" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7447239" refType="identity" refTypeAc="MI:0356"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-434598" refType="identity" refTypeAc="MI:0356"/>
            </xref>
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>purified</shortLabel>
                  <fullName>purified</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
            <stoichiometry value="1"/>
            <attributeList>
              <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
            </attributeList>
          </participant>
          <participant id="6">
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-434594" refType="identity" refTypeAc="MI:0356"/>
            </xref>
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>purified</shortLabel>
                  <fullName>purified</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
            <stoichiometry value="1"/>
            <attributeList>
              <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
            </attributeList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>direct interaction</shortLabel>
            <fullName>direct interaction</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>