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  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>MINT</shortLabel>
        <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
        <alias type="synonym" typeAc="MI:1041">MINT</alias>
      </names>
      <bibref>
        <xref>
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      <xref>
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      </xref>
      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it/mint</attribute>
        <attribute name="url" nameAc="MI:0614">url&amp;gt;http://mint.bio.uniroma2.it/mint/</attribute>
        <attribute name="url" nameAc="MI:0614">https://mint.bio.uniroma2.it</attribute>
        <attribute name="id-validation-regexp" nameAc="MI:0628">MINT-[0-9]+</attribute>
        <attribute name="search-url" nameAc="MI:0615">https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac}</attribute>
        <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="9491887" refType="primary-reference" refTypeAc="MI:0358"/>
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            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8679471" refType="identity" refTypeAc="MI:0356"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA.</attribute>
            <attribute name="journal" nameAc="MI:0885">Cell (0092-8674)</attribute>
            <attribute name="publication year" nameAc="MI:0886">1998</attribute>
            <attribute name="author-list" nameAc="MI:0636">Wei P., Garber ME., Fang SM., Fischer WH., Jones KA.</attribute>
            <attribute name="dataset" nameAc="MI:0875">Virus - Publications including interactions involving viral proteins</attribute>
            <attribute name="uniprot-dr-export">no</attribute>
          </attributeList>
        </bibref>
        <xref>
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        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="-4">
            <names>
              <shortLabel>in vivo</shortLabel>
              <fullName>in vivo</fullName>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>coip</shortLabel>
            <fullName>coimmunoprecipitation</fullName>
            <alias type="go synonym" typeAc="MI:0303">co-immunoprecipitation</alias>
            <alias type="go synonym" typeAc="MI:0303">CoIp</alias>
            <alias type="go synonym" typeAc="MI:0303">immunoprecipitation</alias>
            <alias type="go synonym" typeAc="MI:0303">Co-IP</alias>
            <alias type="synonym" typeAc="MI:1041">co-immunoprecipitation</alias>
            <alias type="synonym" typeAc="MI:1041">CoIp</alias>
            <alias type="synonym" typeAc="MI:1041">immunoprecipitation</alias>
            <alias type="synonym" typeAc="MI:1041">Co-IP</alias>
            <alias type="synonym" typeAc="MI:1041">coip</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0019" refType="identity" refTypeAc="MI:0356"/>
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          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
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          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Wei P., Garber ME., Fang SM., Fischer WH., Jones KA.</attribute>
          <attribute name="dataset" nameAc="MI:0875">Virus - Publications including interactions involving viral proteins</attribute>
          <attribute name="uniprot-dr-export">no</attribute>
          <attribute name="journal" nameAc="MI:0885">Cell (0092-8674)</attribute>
          <attribute name="publication year" nameAc="MI:0886">1998</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>cdk9_human</shortLabel>
          <fullName>Cyclin-dependent kinase 9</fullName>
          <alias type="gene name" typeAc="MI:0301">CDK9</alias>
          <alias type="gene name synonym" typeAc="MI:0302">CDC2L4</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Cell division protein kinase 9</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Serine/threonine-protein kinase PITALRE</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Cell division cycle 2-like protein kinase 4</alias>
          <alias type="gene name synonym" typeAc="MI:0302">C-2K</alias>
          <alias type="gene name synonym" typeAc="MI:0302">TAK</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Tat-associated kinase complex catalytic subunit</alias>
        </names>
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          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q96TF1" version="SP_95" refType="secondary-ac" refTypeAc="MI:0360"/>
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          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001252.1"/>
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          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3MIA" version="SP_232"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
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            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P50750 original sequence version: 100</attribute>
          <attribute name="remark-internal">DIP protein P50750 original sequence version: 115</attribute>
          <attribute name="remark-internal">DIP protein P50750-1 original sequence version: 119</attribute>
          <attribute name="remark-internal">DIP protein P50750 original sequence version: 170</attribute>
          <attribute name="remark-internal">DIP protein P50750 original sequence version: 184</attribute>
          <attribute name="remark-internal">DIP protein P50750-1 original sequence version: 144</attribute>
          <attribute name="remark-internal">DIP protein P50750 original sequence version: 70</attribute>
          <attribute name="remark-internal">DIP protein P50750 original sequence version: 120</attribute>
          <attribute name="crc64">69E851CC6F7A0388</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>ccnt1_human</shortLabel>
          <fullName>Cyclin-T1</fullName>
          <alias type="gene name" typeAc="MI:0301">CCNT1</alias>
        </names>
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          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4OR5" version="SP_212"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5L1Z" version="SP_212"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6CYT" version="SP_212"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6GZH" version="SP_212"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6Z45" version="SP_212"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-112382" version="SP_212"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-167152" version="SP_212"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-167200" version="SP_212"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-167238" version="SP_212"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-167243" version="SP_212"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-167246" version="SP_212"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-167287" version="SP_212"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-167290" version="SP_212"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-176034" version="SP_212"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2173796" version="SP_212"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-674695" version="SP_212"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6796648" version="SP_212"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6807505" version="SP_212"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-75955" version="SP_212"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9018519" version="SP_212"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000129315" version="SP_212" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000261900" version="SP_212" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000079" version="SP_212"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000976" version="SP_212"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003677" version="SP_212"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003682" version="SP_212"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="SP_212"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" version="SP_212"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" version="SP_212"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006357" version="SP_212"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006366" version="SP_212"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006468" version="SP_212"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007049" version="SP_212"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008024" version="SP_212"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008134" version="SP_212"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016538" version="SP_212"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0019901" version="SP_212"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0032786" version="SP_212"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043923" version="SP_212"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045944" version="SP_212"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051301" version="SP_212"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0061575" version="SP_212"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070063" version="SP_212"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001231.2"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001264771.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-29891N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein O60563 original sequence version: 85</attribute>
          <attribute name="remark-internal">DIP protein O60563 original sequence version: 79</attribute>
          <attribute name="remark-internal">DIP protein O60563 original sequence version: 98</attribute>
          <attribute name="remark-internal">DIP protein O60563 original sequence version: 102</attribute>
          <attribute name="remark-internal">DIP protein O60563 original sequence version: 164</attribute>
          <attribute name="remark-internal">DIP protein O60563 original sequence version: 125</attribute>
          <attribute name="remark-internal">DIP protein O60563 original sequence version: 103</attribute>
          <attribute name="crc64">4637EFB2DDEDFE13</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4">
        <names>
          <shortLabel>ccnt1-cdk9-5</shortLabel>
        </names>
        <xref>
          <primaryRef db="mint" dbAc="MI:0471" id="MINT-15817" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8679485" refType="identity" refTypeAc="MI:0356"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-1532859" refType="identity" refTypeAc="MI:0356"/>
            </xref>
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>physiological level</shortLabel>
                  <fullName>physiological level</fullName>
                  <alias type="go synonym" typeAc="MI:0303">endogenous level</alias>
                  <alias type="go synonym" typeAc="MI:0303">endogenous</alias>
                  <alias type="synonym" typeAc="MI:1041">endogenous</alias>
                  <alias type="synonym" typeAc="MI:1041">endogenous level</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
            <attributeList>
              <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
            </attributeList>
          </participant>
          <participant id="6">
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-1532856" refType="identity" refTypeAc="MI:0356"/>
            </xref>
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>physiological level</shortLabel>
                  <fullName>physiological level</fullName>
                  <alias type="go synonym" typeAc="MI:0303">endogenous level</alias>
                  <alias type="go synonym" typeAc="MI:0303">endogenous</alias>
                  <alias type="synonym" typeAc="MI:1041">endogenous</alias>
                  <alias type="synonym" typeAc="MI:1041">endogenous level</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
            <attributeList>
              <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
            </attributeList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="comment" nameAc="MI:0612">homomint</attribute>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>