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        <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
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          <fullName>Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells.</fullName>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070527" version="SP_201"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1900747" version="SP_201"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1903671" version="SP_201"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000369" version="SP_201"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000341" version="SP_201"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000403" version="SP_201"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001263" version="SP_201"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002420" version="SP_201"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003113" version="SP_201"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011009" version="SP_201"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR015433" version="SP_201"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016024" version="SP_201"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018936" version="SP_201"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR029071" version="SP_201"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR035892" version="SP_201"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036940" version="SP_201"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR037702" version="SP_201"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR042236" version="SP_201"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-109704" version="SP_201"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-112399" version="SP_201"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-114604" version="SP_201"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1257604" version="SP_201"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1660499" version="SP_201"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-186763" version="SP_201"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-198203" version="SP_201"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-202424" version="SP_201"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2029485" version="SP_201"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-210993" version="SP_201"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2219530" version="SP_201"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2424491" version="SP_201"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2730905" version="SP_201"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-373753" version="SP_201"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-4420097" version="SP_201"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-512988" version="SP_201"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5673001" version="SP_201"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6811558" version="SP_201"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8853659" version="SP_201"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9027276" version="SP_201"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-912526" version="SP_201"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-912631" version="SP_201"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9673767" version="SP_201"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9673770" version="SP_201"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000051382" version="SP_201" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000289153" version="SP_201" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000477593" version="SP_201" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000674063" version="SP_201" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000187" version="SP_201"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001952" version="SP_201"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0002931" version="SP_201"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003376" version="SP_201"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005524" version="SP_201"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="SP_201"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_006713722.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_016862108.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-44775N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGEKLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEHEPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDEVSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAIEAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHGTELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQTNPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKEILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P42338 original sequence version: 107</attribute>
          <attribute name="remark-internal">DIP protein P42338 original sequence version: 106</attribute>
          <attribute name="crc64">81135FE93452C00E</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="5">
        <names>
          <shortLabel>ywhaq-pik3cb</shortLabel>
        </names>
        <xref>
          <primaryRef db="mint" dbAc="MI:0471" id="MINT-16257" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8553502" refType="identity" refTypeAc="MI:0356"/>
        </xref>
        <experimentList>
          <experimentRef>2</experimentRef>
        </experimentList>
        <participantList>
          <participant id="6">
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-1505472" refType="identity" refTypeAc="MI:0356"/>
            </xref>
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>purified</shortLabel>
                  <fullName>purified</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
            <attributeList>
              <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
            </attributeList>
          </participant>
          <participant id="7">
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-1505475" refType="identity" refTypeAc="MI:0356"/>
            </xref>
            <interactorRef>4</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>purified</shortLabel>
                  <fullName>purified</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
            <attributeList>
              <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
            </attributeList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>direct interaction</shortLabel>
            <fullName>direct interaction</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="comment" nameAc="MI:0612">Overexpressio of 14-3-3 Theta reduce the enzymatic activity of the tyrosine phosphorylated PI3-K from activated T cells.</attribute>
          <attribute name="comment" nameAc="MI:0612">homomint</attribute>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
        </attributeList>
      </interaction>
      <interaction id="8">
        <names>
          <shortLabel>ywhaq-pik3cb-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="mint" dbAc="MI:0471" id="MINT-16256" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8553521" refType="identity" refTypeAc="MI:0356"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="9">
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-1505486" refType="identity" refTypeAc="MI:0356"/>
            </xref>
            <interactorRef>4</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>over-expressed</shortLabel>
                  <fullName>over expressed level</fullName>
                  <alias type="synonym" typeAc="MI:1041">over-expressed</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
            <attributeList>
              <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
            </attributeList>
          </participant>
          <participant id="10">
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-1505483" refType="identity" refTypeAc="MI:0356"/>
            </xref>
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>over-expressed</shortLabel>
                  <fullName>over expressed level</fullName>
                  <alias type="synonym" typeAc="MI:1041">over-expressed</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
            <attributeList>
              <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
            </attributeList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="comment" nameAc="MI:0612">Overexpressio of 14-3-3 Theta reduce the enzymatic activity of the tyrosine phosphorylated PI3-K from activated T cells.</attribute>
          <attribute name="comment" nameAc="MI:0612">homomint</attribute>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>