IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ TRPV2-spike protein interaction mediates the entry of SARS-CoV-2 into macrophages in febrile conditions. TRPV2-spike protein interaction mediates the entry of SARS-CoV-2 into macrophages in febrile conditions. Theranostics 2020 imex curation Xu J., Yang Y., Hou Z., Jia H., Wang Y. Virus - Publications including interactions involving viral proteins Coronavirus - Interactions investigated in the context of Coronavirus Results from Figures 2 G and H have not been added as no Methods or constructs used are described. GST Pulldown image (2H) does not even show the Prey protein -His-Spike -RBD. Email sent asking for species of GST-TRPV2 -7/7/21;NO reply by 19/7/21. fonney@sjtu.edu.cn,houzy@sjtu.edu.cn,wyj@nxu.edu.cn Only protein-protein interactions imex curation bovin-alveolar macrophages bovin alveolar macrophages Bovine alveolar_macrophage Alveolar macrophage anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Xu J., Yang Y., Hou Z., Jia H., Wang Y. Virus - Publications including interactions involving viral proteins Results from Figures 2 G and H have not been added as no Methods or constructs used are described. GST Pulldown image (2H) does not even show the Prey protein -His-Spike -RBD. Email sent asking for species of GST-TRPV2 -7/7/21;NO reply by 19/7/21. fonney@sjtu.edu.cn,houzy@sjtu.edu.cn,wyj@nxu.edu.cn Accepted 2021-AUG-20 AT 12:01 BST AT 12:01 BST by KALPANAP Theranostics 2020 Only protein-protein interactions imex curation imex curation TRPV2-spike protein interaction mediates the entry of SARS-CoV-2 into macrophages in febrile conditions. TRPV2-spike protein interaction mediates the entry of SARS-CoV-2 into macrophages in febrile conditions. Theranostics 2020 imex curation Xu J., Yang Y., Hou Z., Jia H., Wang Y. Virus - Publications including interactions involving viral proteins Coronavirus - Interactions investigated in the context of Coronavirus Results from Figures 2 G and H have not been added as no Methods or constructs used are described. GST Pulldown image (2H) does not even show the Prey protein -His-Spike -RBD. Email sent asking for species of GST-TRPV2 -7/7/21;NO reply by 19/7/21. fonney@sjtu.edu.cn,houzy@sjtu.edu.cn,wyj@nxu.edu.cn Only protein-protein interactions imex curation mouse-raw264_7 Mus musculus monocyte macrophage cell line RAW264 raw264_7 Mouse monocyte macrophage cellline RAW264.7 anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Xu J., Yang Y., Hou Z., Jia H., Wang Y. Virus - Publications including interactions involving viral proteins Results from Figures 2 G and H have not been added as no Methods or constructs used are described. GST Pulldown image (2H) does not even show the Prey protein -His-Spike -RBD. Email sent asking for species of GST-TRPV2 -7/7/21;NO reply by 19/7/21. fonney@sjtu.edu.cn,houzy@sjtu.edu.cn,wyj@nxu.edu.cn Accepted 2021-AUG-20 AT 12:01 BST AT 12:01 BST by KALPANAP Theranostics 2020 Only protein-protein interactions imex curation imex curation TRPV2-spike protein interaction mediates the entry of SARS-CoV-2 into macrophages in febrile conditions. TRPV2-spike protein interaction mediates the entry of SARS-CoV-2 into macrophages in febrile conditions. Theranostics 2020 imex curation Xu J., Yang Y., Hou Z., Jia H., Wang Y. Virus - Publications including interactions involving viral proteins Coronavirus - Interactions investigated in the context of Coronavirus Results from Figures 2 G and H have not been added as no Methods or constructs used are described. GST Pulldown image (2H) does not even show the Prey protein -His-Spike -RBD. Email sent asking for species of GST-TRPV2 -7/7/21;NO reply by 19/7/21. fonney@sjtu.edu.cn,houzy@sjtu.edu.cn,wyj@nxu.edu.cn Only protein-protein interactions imex curation human-thp-1 Homo sapiens acute monocytic leukemia cells thp-1 Human acute monocytic leukemia cell line anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot temperature kelvin kelvin K 310.15 312.65 Xu J., Yang Y., Hou Z., Jia H., Wang Y. Virus - Publications including interactions involving viral proteins Results from Figures 2 G and H have not been added as no Methods or constructs used are described. GST Pulldown image (2H) does not even show the Prey protein -His-Spike -RBD. Email sent asking for species of GST-TRPV2 -7/7/21;NO reply by 19/7/21. fonney@sjtu.edu.cn,houzy@sjtu.edu.cn,wyj@nxu.edu.cn Accepted 2021-AUG-20 AT 12:01 BST AT 12:01 BST by KALPANAP Theranostics 2020 Only protein-protein interactions imex curation imex curation TRPV2-spike protein interaction mediates the entry of SARS-CoV-2 into macrophages in febrile conditions. TRPV2-spike protein interaction mediates the entry of SARS-CoV-2 into macrophages in febrile conditions. Theranostics 2020 imex curation Xu J., Yang Y., Hou Z., Jia H., Wang Y. Virus - Publications including interactions involving viral proteins Coronavirus - Interactions investigated in the context of Coronavirus Results from Figures 2 G and H have not been added as no Methods or constructs used are described. GST Pulldown image (2H) does not even show the Prey protein -His-Spike -RBD. Email sent asking for species of GST-TRPV2 -7/7/21;NO reply by 19/7/21. fonney@sjtu.edu.cn,houzy@sjtu.edu.cn,wyj@nxu.edu.cn Only protein-protein interactions imex curation in vitro In vitro confocal microscopy confocal microscopy immunocytochemistry immunocytochemistry Xu J., Yang Y., Hou Z., Jia H., Wang Y. Virus - Publications including interactions involving viral proteins Results from Figures 2 G and H have not been added as no Methods or constructs used are described. GST Pulldown image (2H) does not even show the Prey protein -His-Spike -RBD. Email sent asking for species of GST-TRPV2 -7/7/21;NO reply by 19/7/21. fonney@sjtu.edu.cn,houzy@sjtu.edu.cn,wyj@nxu.edu.cn Accepted 2021-AUG-20 AT 12:01 BST AT 12:01 BST by KALPANAP Theranostics 2020 Only protein-protein interactions imex curation imex curation TRPV2-spike protein interaction mediates the entry of SARS-CoV-2 into macrophages in febrile conditions. TRPV2-spike protein interaction mediates the entry of SARS-CoV-2 into macrophages in febrile conditions. Theranostics 2020 imex curation Xu J., Yang Y., Hou Z., Jia H., Wang Y. Virus - Publications including interactions involving viral proteins Coronavirus - Interactions investigated in the context of Coronavirus Results from Figures 2 G and H have not been added as no Methods or constructs used are described. GST Pulldown image (2H) does not even show the Prey protein -His-Spike -RBD. Email sent asking for species of GST-TRPV2 -7/7/21;NO reply by 19/7/21. fonney@sjtu.edu.cn,houzy@sjtu.edu.cn,wyj@nxu.edu.cn Only protein-protein interactions imex curation in vitro In vitro anti tag coip anti tag coimmunoprecipitation anti tag coip ms participant Identification by mass spectrometry ms participant Xu J., Yang Y., Hou Z., Jia H., Wang Y. Virus - Publications including interactions involving viral proteins Results from Figures 2 G and H have not been added as no Methods or constructs used are described. GST Pulldown image (2H) does not even show the Prey protein -His-Spike -RBD. Email sent asking for species of GST-TRPV2 -7/7/21;NO reply by 19/7/21. fonney@sjtu.edu.cn,houzy@sjtu.edu.cn,wyj@nxu.edu.cn Accepted 2021-AUG-20 AT 12:01 BST AT 12:01 BST by KALPANAP Theranostics 2020 Only protein-protein interactions imex curation imex curation trpv2_human Transient receptor potential cation channel subfamily V member 2 TRPV2 VRL Osm-9-like TRP channel 2 Vanilloid receptor-like protein 1 protein protein human Homo sapiens Human MTSPSSSPVFRLETLDGGQEDGSEADRGKLDFGSGLPPMESQFQGEDRKFAPQIRVNLNYRKGTGASQPDPNRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQREFSGLSHLSRKFTEWCYGPVRVSLYDLASVDSCEENSVLEIIAFHCKSPHRHRMVVLEPLNKLLQAKWDLLIPKFFLNFLCNLIYMFIFTAVAYHQPTLKKQAAPHLKAEVGNSMLLTGHILILLGGIYLLVGQLWYFWRRHVFIWISFIDSYFEILFLFQALLTVVSQVLCFLAIEWYLPLLVSALVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFLFGFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLELFKFTIGMGELAFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSIWKLQKAISVLEMENGYWWCRKKQRAGVMLTVGTKPDGSPDERWCFRVEEVNWASWEQTLPTLCEDPSGAGVPRTLENPVLASPPKEDEDGASEENYVPVQLLQSN ap2m1_bovin AP-2 complex subunit mu AP2M1 AP-2 mu chain Adaptor protein complex AP-2 subunit mu Adaptor-related protein complex 2 subunit mu Clathrin assembly protein complex 2 mu medium chain Clathrin coat assembly protein AP50 Clathrin coat-associated protein AP50 HA2 50 kDa subunit Mu2-adaptin Plasma membrane adaptor AP-2 50 kDa protein protein protein bovin Bos taurus (Bovine) Bovine MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHVKRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFGYPQNSETGALKTFITQQGIKSQHQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGMKESQISAEIELLPTNDKKKWARPPISMNFEVPFAPSGLKVRYLKVFEPKLNYSDHDVIKWVRYIGRSGIYETRC 82803219BA279954 q5ea32_bovin TRPV2 protein protein bovin Bos taurus (Bovine) Bovine MTTPSSSPAFRLETSDGGDEDGAQGDTGNGGRSSEPPPMESRFQSEDRNSSPQIRVNLNFRRAAGASQPDPNRFGRDRLFSAVARGAPEDLAGLPEYLRRTSKYLTDSEYREGSTGKTCLMKALLNLRDGANACIEPLLQIDRDSGNPHPLVNAQCMDEYYRGHSALHIAIEKRSLVCVKLLVENGADVHARACGQFFQKRREETCFYFGELPLSLAACTQQWDVVTYLLKNTHQPASLQATDSLGNTVLHALVMIADNSPENSMLVTHMYDRLLQVGGLQLEDMTNLQGLTPLKLAAKEGKIEIFRHILQRELPEPYQSLSRKFTEWSYGPVRVSLYDLASVDSWEENSVLEIIAFHSRSPLRHRMVVLEPLNKLLKAKSNLLIPRFLFNFLCYLTYMLIFTAVTYYQPALEKDFLPLEVTAGNTMLLLGHVLLLLGGVNLLMGQLWYFWRRRLFIWISFMDSYFEILFLVQALLTVLSQVLRFLAVKGYLPLLVCSLVLGWLNLLYYMRGFQYTGIYSVMIQKVILRDLLRFLGVYLVFLFGFAVALVSLSREPQDTGAPAGSNTTEVAGKEDKEAPYRGILDTSLELFKFTIGMGELAFQDQLHFRGVVLLLLLAYVLLTYVLLLNMLIALMSETVNSVATDSWSIWKLQKAISVLEMEKGYWWCRRKQQRAGVKLTVGSRPDGSPDERWCFRVEEVNWAAWEQTLPTVFEEPSGRGGPGAITSPALASQSSQDSAVEEDHVPLQPLESH 5D13F07EFC175056 spike_sars2 Spike glycoprotein S E2 Peplomer protein 2 protein protein SARS-CoV-2 SARS-CoV-2 SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 2019-nCoV MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT trpv2_mouse Transient receptor potential cation channel subfamily V member 2 Trpv2 Grc Growth factor-regulated calcium channel Osm-9-like TRP channel 2 protein protein mouse Mus musculus Mouse MTSASNPPAFRLETSDGDEEGSAEVNKGKNEPPPMESPFQGEDRNFSPQIKVNLNYRKGLGPSQQDPNRFDRDRLFSVVSRGVPEELTGLLEYLRRTSKYLTDSAYTEGSTGKTCLMKAVLNLQDGVNACILPLLQIDRDSGNPQPLVNAQCTDEFYRGHSALHIAIEKRSLWCVKLLVENGANVHIRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDSLLQMGARLCPTVQLEDICNHQGLTPLKLAAKEGKIEIFRHILQREFSGLYQPLSRKFTEWCYGPVRVSLYDLSSVDSWEKNSVLEIIAFHCKSPHRHRMVVLEPLNKLLQEKWDRLIPRFFFNFACYLVYMIIFTIVAYHQPSLEQPAIPSSKATFGDSMLLLGHILILLGGIYLLLGQLWYFWRRRLFIWISFMDSYFEILFLVQALLTVLSQVLRFVETEWYLPLLVSSLVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLVYLVFLFGFAVALVSLSREARSPKAPEDSNTTVTEKPTLGQEEEPVPYGGILDASLELFKFTIGMGELAFQEQLRFRGVVLLLLLAYVLLTYVLLLNMLIALMSETVNSVATDSWSIWKLQKAISVLEMENGYWWCRRKRHRAGRLLKVGTKGDGIPDERWCFRVEEVNWAAWEKTLPTLSEDPSGAGITGYKKNPTSKPGKNSASEEDHLPLQVLQSH C0E537AB2C86E1A8 ace2_bovin Angiotensin-converting enzyme 2 ACE2 ACE-related carboxypeptidase protein protein bovin Bos taurus (Bovine) Bovine MTGSFWLLLSLVAVTAAQSTTEEQAKTFLEKFNHEAEDLSYQSSLASWNYNTNITDENVQKMNEARAKWSAFYEEQSRMAKTYSLEEIQNLTLKRQLKALQHSGTSALSAEKSKRLNTILNKMSTIYSTGKVLDPNTQECLALEPGLDDIMENSRDYNRRLWAWEGWRAEVGKQLRPLYEEYVVLENEMARANNYEDYGDYWRGDYEVTGAGDYDYSRDQLMKDVERTFAEIKPLYEQLHAYVRAKLMHTYPSYISPTGCLPAHLLGDMWGRFWTNLYSLTVPFEHKPSIDVTEKMENQSWDAERIFKEAEKFFVSISLPYMTQGFWDNSMLTEPGDGRKVVCHPTAWDLGKGDFRIKMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPYLLRNGANEGFHEAVGEIMSLSAATPHYLKALGLLAPDFHEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKQQWMEKWWEMKREIVGVVEPLPHDETYCDPACLFHVAEDYSFIRYYTRTIYQFQFHEALCKTAKHEGALFKCDISNSTEAGQRLLQMLRLGKSEPWTLALENIVGIKTMDVKPLLNYFEPLFTWLKEQNRNSFVGWSTEWTPYSDQSIKVRISLKSALGENAYEWNDNEMYLFQSSVAYAMRKYFSEARNETVLFGEDNVWVSDKKPRISFKFFVTSPNNVSDIIPRTEVENAIRLSRDRINDVFQLDDNSLEFLGIQPTLGPPYEPPVTIWLIIFGVVMGVVVIGIVVLIFTGIRNRRKKNQASSEENPYGSVDLNKGENNSGFQNIDDVQTSL E81570A96872A963 q2kiw2_bovin CD68 protein protein bovin Bos taurus (Bovine) Bovine MRLAVFFSGALLGLLAAQGTGNDCPHKKSATLLPSFTVTPTATESTPSPGTTSHRTTKSHRTTTWRISTTTHTTNTTGTTSSESPTATHSPATTTSHQNTTVHPTSNITATSPGPSTRSPHPEPPPSPSPSPGSKEAIGDYTWSNGSQPCVRLQAQIQIRVLYPTQGGGEAWGISVLNPNRTKAQGGCEGTHSHLLLSFPSGQLSFGFKQDPLQSAVYLNYMAVEYNVSFPQAVQWTFSVQNSSLRDLQTPLGHSFSCRNASIIVSPALHLDLLSLKLQAAQLSPSGAFGPSFSCPNDKSILLPLIIGLILLGLLTLVLVTFCIIRRRPPTYQPL 085E44ED1FB628FA a0a3q1na52_bovin CD82 protein protein bovin Bos taurus (Bovine) Bovine GRQERADCNRELQDRQDGVSLHQSHQVLPLPLQLALLCPGRGDPGLRDVDPGRQEQFHLHLTDLLHLVQGGGLRLHQRGGPHHAHGLPGLPGCRQRGPLPAGDGECGPPSTTHPAPPSHPARGALAQSGWGHPRGGGRGGDPADSVSALHPQYFAFLLLILIAQVTAGVFFYFNMGQLKQEMGSIVTKLIHNYTDGSGDNLQEAWDYVQAQVKCCGWVSYLNWTENTELMNRTSITFPCSCKKSDEDDALMMPQKGFCEVPFGNKTQSGNNPKDWPVYQEGCMEKVQGWLQENLGVILGVCVGVAVIELLGMFLSMFLCRRVHSEDYSKVPKY C3FDD1A29EB75848 ace2_human Angiotensin-converting enzyme 2 ACE2 UNQ868/PRO1885 Angiotensin-converting enzyme homolog Metalloprotease MPROT15 Angiotensin-converting enzyme-related carboxypeptidase protein protein human Homo sapiens Human MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLKVKNQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRINDAFRLNDNSLEFLGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKKNKARSGENPYASIDISKGENNPGFQNTDDVQTSF mint Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses 8EE6EB0A931550E8 a0a3q1lrj9_bovin CCDC88A protein protein bovin Bos taurus (Bovine) Bovine MENEVFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKSESQRVNKKVNNDASLRIHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEEIEPLLKNMVLHLKRLIDERDEHSETIVELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRSTMDSAEGTTSKILKIEKENQRLSKKVEILENEIIQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKTEFEKRQIRKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKFKKTLDSFKNLTFQLESLEKENSQLDEENLELRRSVESLKCASMKMAQLQLENKELESEKEQLKKGLELMKASFKKTERLEVSYQGLDTENQRLQKALENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLFKEIGIYKESCIRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPAAGEDKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLVKDHEKLELLHERQASEYETLIAKHGTLKSAHKNLEVEHKDLEDRYNQLLKQKGQLEDLEKTLKVEQEKMLLKNKNHETVAAEFKKLCGENDRLNHTYNQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDVNRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMVLAGGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSTGFRSKQLVNNKDTTSFEDVSPQGISDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNIQSRPPSHSSGEFSLLHEHEAWSSSGSSPVQYLKRQTRSSPALQHRTQESRAHHKTKTGSPGSEVVTLQQFLEESNKLTSMQLKPSSQENLLDEVMKSLSVSSDFLGKNKPVSCGLARSVSGKTPGDFHDRRTTKPEQFVRSGPQKAEDACFMSSSGKPTRGAQGKIKLIKETSLSRQSKDSNPYATLPRASSVISTAEGTTRRTSIHDFLTKDSRLPMSVDSPPATADSSITATSNVDKVQENRNSKSRSREQQSS C2EF7479736FF3A8 can2_bovin Calpain-2 catalytic subunit CAPN2 Calpain-2 large subunit Calpain M-type Millimolar-calpain Calcium-activated neutral proteinase 2 protein protein bovin Bos taurus (Bovine) Bovine MAGIAAKLAKDREAAEGLGSHERAVKYLNQDYAALRDECLEAGALFQDPSFPALPSSLGFKELGPYSSKTRGIEWKRPTEICDNPQFITGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLDQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELRKAPPNLFRIIQKALQKGSLLGCSIDITSAADSEAITFQKLVKGHAYSVTGAEEVESRGSLQKLIRIRNPWGEVEWTGQWNDNCPNWNTVDPEVRETLTRQHEDGEFWMSFNDFLRHYSRLEICNLTPDTLTSDSYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDQEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELTGQTNIHLSKKFFLTTRARERSDTFINLREVLNRFKLPPGEYIVVPSTFEPNKDGDFCIRVFSEKKADYQVVDDEIEANIDEIDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDDLIIDFDNFVRCLIRLETLFRIFKQLDPENTGMIQLDLISWLSFSVL mint Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction 00FD932E9C6AB268 e1bb51_bovin CD207 protein protein bovin Bos taurus (Bovine) Bovine MKTADSEVLDAHFTVDKQNVSLWPPDPPPKTCPSQVLGRLLTVRAVVIFLMLVTITSVLLQAILYPWFMGTISDVKTNAQLLKGRVDNISSLSSEIKRNRGGLVAVGIQVRMVNASLDRISSQIRRLETGLKEASAQLQVLTSSWKAVDELNAQIPELKQDLDKASALNAKVRELQSGLESISKLLQQQKDILQVVSQGWKYFGGHFYYFSKISKTWYSAQQICISRDSHLTSVTSEREQEFLYRTAGGLPYWIGLTKAGSEGDWHWVDGTPYNKVQSEKFWIPGEPNNVGNNEHCVTLKTSLLRSWNDASCDNTFLFICKRSYKPSEP A61B637DA18775A9 ace2_mouse Angiotensin-converting enzyme 2 Ace2 ACE-related carboxypeptidase protein protein mouse Mus musculus Mouse MSSSSWLLLSLVAVTTAQSLTEENAKTFLNNFNQEAEDLSYQSSLASWNYNTNITEENAQKMSEAAAKWSAFYEEQSKTAQSFSLQEIQTPIIKRQLQALQQSGSSALSADKNKQLNTILNTMSTIYSTGKVCNPKNPQECLLLEPGLDEIMATSTDYNSRLWAWEGWRAEVGKQLRPLYEEYVVLKNEMARANNYNDYGDYWRGDYEAEGADGYNYNRNQLIEDVERTFAEIKPLYEHLHAYVRRKLMDTYPSYISPTGCLPAHLLGDMWGRFWTNLYPLTVPFAQKPNIDVTDAMMNQGWDAERIFQEAEKFFVSVGLPHMTQGFWANSMLTEPADGRKVVCHPTAWDLGHGDFRIKMCTKVTMDNFLTAHHEMGHIQYDMAYARQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLPSDFQEDSETEINFLLKQALTIVGTLPFTYMLEKWRWMVFRGEIPKEQWMKKWWEMKREIVGVVEPLPHDETYCDPASLFHVSNDYSFIRYYTRTIYQFQFQEALCQAAKYNGSLHKCDISNSTEAGQKLLKMLSLGNSEPWTKALENVVGARNMDVKPLLNYFQPLFDWLKEQNRNSFVGWNTEWSPYADQSIKVRISLKSALGANAYEWTNNEMFLFRSSVAYAMRKYFSIIKNQTVPFLEEDVRVSDLKPRVSFYFFVTSPQNVSDVIPRSEVEDAIRMSRGRINDVFGLNDNSLEFLGIHPTLEPPYQPPVTIWLIIFGVVMALVVVGIIILIVTGIKGRKKKNETKREENPYDSMDIGKGESNAGFQNSDDAQTSF mint Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. May have a protective role in acute lung injury D8B883AAC966A8D9 s-ap2m1-1 7 18 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level bovin-alveolar macrophages bovin alveolar macrophages Bovine alveolar_macrophage Alveolar macrophage 15 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level bovin-alveolar macrophages bovin alveolar macrophages Bovine alveolar_macrophage Alveolar macrophage 9 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level bovin-alveolar macrophages bovin alveolar macrophages Bovine alveolar_macrophage Alveolar macrophage 17 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level bovin-alveolar macrophages bovin alveolar macrophages Bovine alveolar_macrophage Alveolar macrophage 19 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level bovin-alveolar macrophages bovin alveolar macrophages Bovine alveolar_macrophage Alveolar macrophage 14 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level bovin-alveolar macrophages bovin alveolar macrophages Bovine alveolar_macrophage Alveolar macrophage 10 sequence tag sequence tag identification sequence tag ms participant Identification by mass spectrometry ms participant unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level bovin-alveolar macrophages bovin alveolar macrophages Bovine alveolar_macrophage Alveolar macrophage 11 unspecified role unspecified role bait bait purified purified rbd sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain n-terminus his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecoli Escherichia coli (strain K12) association association 1 s-ap2m1-2 1 13 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 10 sequence tag sequence tag identification sequence tag western blot western blot Immuno blot Immuno blot unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 11 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed rbd sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain n-terminus his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range association association 5 2A s-ace2-78 1 13 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 11 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed rbd sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain n-terminus his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range physical association physical association 4 2A s-ace2-81 2 20 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 11 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed rbd sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain n-terminus his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range 12 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level association association 2B s-ace2-82 2 20 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 11 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed rbd sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain n-terminus his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range physical association physical association 2B s-ace2-83 3 16 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 8 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 11 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed rbd sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain n-terminus his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range association association 2C s-ace2-84 3 16 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 11 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed rbd sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain n-terminus his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range physical association physical association 2C s-ace2-85 1 10 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 11 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed rbd sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain region ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range physical association physical association 5 2D s-ace2-86 2 11 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed rbd sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain region ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 12 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level association association 2D s-ace2-87 3 8 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 11 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed rbd sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain region ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association 2F s-trpv2-1 6 12 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level mouse-raw264_7 Mus musculus monocyte macrophage cell line RAW264 raw264_7 Mouse monocyte macrophage cellline RAW264.7 11 unspecified role unspecified role neutral component neutral component purified purified rbd sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain n-terminus his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecoli Escherichia coli (strain K12) colocalization colocalization 2I not sure what figure S1 is meant to be showing - so not added.